[go: up one dir, main page]

ITMC20060080A1 - CHEMICAL SYNTHESIS OF (64-COPPER (I) ASPARAGINASE; [64CU (I)] ASPARAGINASI), AND USE OF THE SAME AS AN AGENT FOR PET INVESTIGATIONS (POSITRON EMISSION TOMOGRAPHY) AND FOR RADIOTHERAPY. - Google Patents

CHEMICAL SYNTHESIS OF (64-COPPER (I) ASPARAGINASE; [64CU (I)] ASPARAGINASI), AND USE OF THE SAME AS AN AGENT FOR PET INVESTIGATIONS (POSITRON EMISSION TOMOGRAPHY) AND FOR RADIOTHERAPY.

Info

Publication number
ITMC20060080A1
ITMC20060080A1 IT000080A ITMC20060080A ITMC20060080A1 IT MC20060080 A1 ITMC20060080 A1 IT MC20060080A1 IT 000080 A IT000080 A IT 000080A IT MC20060080 A ITMC20060080 A IT MC20060080A IT MC20060080 A1 ITMC20060080 A1 IT MC20060080A1
Authority
IT
Italy
Prior art keywords
asparaginasi
asparaginase
radiotherapy
copper
agent
Prior art date
Application number
IT000080A
Other languages
Italian (it)
Inventor
Domenico Martini
Paola Panichelli
Gianluca Valentini
Original Assignee
Acom Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acom Spa filed Critical Acom Spa
Priority to IT000080A priority Critical patent/ITMC20060080A1/en
Priority to PCT/EP2007/001317 priority patent/WO2007147454A1/en
Publication of ITMC20060080A1 publication Critical patent/ITMC20060080A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/78Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/82Asparaginase (3.5.1.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008Peptides; Proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IT000080A 2006-06-23 2006-06-23 CHEMICAL SYNTHESIS OF (64-COPPER (I) ASPARAGINASE; [64CU (I)] ASPARAGINASI), AND USE OF THE SAME AS AN AGENT FOR PET INVESTIGATIONS (POSITRON EMISSION TOMOGRAPHY) AND FOR RADIOTHERAPY. ITMC20060080A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT000080A ITMC20060080A1 (en) 2006-06-23 2006-06-23 CHEMICAL SYNTHESIS OF (64-COPPER (I) ASPARAGINASE; [64CU (I)] ASPARAGINASI), AND USE OF THE SAME AS AN AGENT FOR PET INVESTIGATIONS (POSITRON EMISSION TOMOGRAPHY) AND FOR RADIOTHERAPY.
PCT/EP2007/001317 WO2007147454A1 (en) 2006-06-23 2007-02-15 Chemical synthesis of cu-64asp (copper-64asparaginase; [64cu]asparaginase) for pet scans and radiotheraphy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000080A ITMC20060080A1 (en) 2006-06-23 2006-06-23 CHEMICAL SYNTHESIS OF (64-COPPER (I) ASPARAGINASE; [64CU (I)] ASPARAGINASI), AND USE OF THE SAME AS AN AGENT FOR PET INVESTIGATIONS (POSITRON EMISSION TOMOGRAPHY) AND FOR RADIOTHERAPY.

Publications (1)

Publication Number Publication Date
ITMC20060080A1 true ITMC20060080A1 (en) 2007-12-24

Family

ID=37946266

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000080A ITMC20060080A1 (en) 2006-06-23 2006-06-23 CHEMICAL SYNTHESIS OF (64-COPPER (I) ASPARAGINASE; [64CU (I)] ASPARAGINASI), AND USE OF THE SAME AS AN AGENT FOR PET INVESTIGATIONS (POSITRON EMISSION TOMOGRAPHY) AND FOR RADIOTHERAPY.

Country Status (2)

Country Link
IT (1) ITMC20060080A1 (en)
WO (1) WO2007147454A1 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005069994A2 (en) * 2004-01-22 2005-08-04 Immunomedics, Inc. Folate conjugates and complexes

Also Published As

Publication number Publication date
WO2007147454A1 (en) 2007-12-27

Similar Documents

Publication Publication Date Title
BRPI0806531A2 (en) COMPOUND, PHARMACEUTICAL COMPOSITION, THERAPEUTIC AGENT, AND USE OF THE COMPOUND.
PT103200B (en) POSITRON EMISSION TOMOGRAPHY SYSTEM (PET)
DK1472541T3 (en) Imaging agents and methods for imaging NAALADase and PSMA
DK2092065T3 (en) The antisense compounds
IL185517A0 (en) Pharmaceutical composition comprising an omega-carboxyaryl substituted diphenyl urea for the treatment of cancer
LTPA2017011I1 (en) Antibody against PDGFR-alpha for use in the treatment of tumors
WO2008124703A3 (en) Development of molecular imaging probes for carbonic anhydrase-ix using click chemistry
BRPI0507684B8 (en) contrast agents for myocardial perfusion imaging
BRPI0519317A2 (en) Method for labeling a vector, compound, radiopharmaceutical composition, use of a compound, and methods for generating an image of a human or animal body and for monitoring the effect of treating a human or animal body with a drug to combat an associated condition. with cancer
BRPI0814593A2 (en) COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING AND USE OF THE COMPOUND.
DE502004002801D1 (en) DRILLING TREATMENT AGENT, CONTAINING ETHERCARBOXYLIC ACIDS
DE60333736D1 (en) USE OF MINIATURIZED DEVICES FOR THE PRODUCTION OF RADIOMARKED COMPOUNDS
WO2009026657A8 (en) Flavonoid ppar agonists
BRPI0918739A2 (en) antibody, composition, nucleic acid molecule, method of treating malignant tumor in animals, and use of the composition.
WO2007148089A3 (en) Radiolabelling methods
BRPI0409101A (en) method to produce a radiolabeled gallium complex
WO2009134405A3 (en) Substrate based pet imaging agents
WO2009045535A3 (en) Fluorine-18 derivative of dasatinib and uses thereof
PL371784A1 (en) Pentafluorosulfanyl-benzoylguanidine, method for the production thereof and its utilization as medicament or diagnostic agent and medicament containing same
NZ591824A (en) Butyrylcholinesterase ligands as diagnostic tools and treatment for deseases of the nervous system
WO2007008232A3 (en) Locoregional internal radionuclide ablation of abnormal tissues.
ITMC20060080A1 (en) CHEMICAL SYNTHESIS OF (64-COPPER (I) ASPARAGINASE; [64CU (I)] ASPARAGINASI), AND USE OF THE SAME AS AN AGENT FOR PET INVESTIGATIONS (POSITRON EMISSION TOMOGRAPHY) AND FOR RADIOTHERAPY.
BRPI0608287A2 (en) endoparasiticidal agent
ITMC20050119A1 (en) CHEMICAL SYNTHESIS OF (RAMEDEOSSIGLUCOSE; [64Cu] TETA-DEOSSIGLUCOSIO), AND USE OF THE SAME AS AN AGENT FOR PET INVESTIGATIONS (POSITRON EMISSION TOMOGRAPHY IMAGING) AND FOR RADIOTHERAPY.
TN2009000233A1 (en) Radiolabelling via fluorination of aziridines