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IT202200011705A1 - CHOLESTEROL DERIVATIVES AND THEIR USES - Google Patents

CHOLESTEROL DERIVATIVES AND THEIR USES Download PDF

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Publication number
IT202200011705A1
IT202200011705A1 IT102022000011705A IT202200011705A IT202200011705A1 IT 202200011705 A1 IT202200011705 A1 IT 202200011705A1 IT 102022000011705 A IT102022000011705 A IT 102022000011705A IT 202200011705 A IT202200011705 A IT 202200011705A IT 202200011705 A1 IT202200011705 A1 IT 202200011705A1
Authority
IT
Italy
Prior art keywords
cholesterol derivatives
cholesterol
derivatives
Prior art date
Application number
IT102022000011705A
Other languages
Italian (it)
Inventor
Angela Zampella
Stefano Fiorucci
Original Assignee
Prec Bio Therapeutics S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prec Bio Therapeutics S R L filed Critical Prec Bio Therapeutics S R L
Priority to IT102022000011705A priority Critical patent/IT202200011705A1/en
Priority to PCT/IB2023/055628 priority patent/WO2023233346A1/en
Publication of IT202200011705A1 publication Critical patent/IT202200011705A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT102022000011705A 2022-06-01 2022-06-01 CHOLESTEROL DERIVATIVES AND THEIR USES IT202200011705A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT102022000011705A IT202200011705A1 (en) 2022-06-01 2022-06-01 CHOLESTEROL DERIVATIVES AND THEIR USES
PCT/IB2023/055628 WO2023233346A1 (en) 2022-06-01 2023-06-01 Cholesterol derivatives and their uses

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102022000011705A IT202200011705A1 (en) 2022-06-01 2022-06-01 CHOLESTEROL DERIVATIVES AND THEIR USES

Publications (1)

Publication Number Publication Date
IT202200011705A1 true IT202200011705A1 (en) 2023-12-01

Family

ID=83188269

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102022000011705A IT202200011705A1 (en) 2022-06-01 2022-06-01 CHOLESTEROL DERIVATIVES AND THEIR USES

Country Status (2)

Country Link
IT (1) IT202200011705A1 (en)
WO (1) WO2023233346A1 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010035119A2 (en) * 2008-09-29 2010-04-01 Cadila Pharmaceuticals Ltd. Vaccine adjuvants
WO2010049144A2 (en) * 2008-10-28 2010-05-06 Phenex Pharmaceuticals Ag Methods of identification of novel ligands for modulation of orphan nuclear receptor rar-related orphan receptor-gamma (nr1f3) activity
WO2012106581A1 (en) * 2011-02-03 2012-08-09 The University Of Chicago Fxr inhibitor, bile acid sequestrant as combination therapy for cholesterol reduction
WO2015181275A1 (en) * 2014-05-29 2015-12-03 Bar Pharmaceuticals S.R.L. Cholane derivatives for use in the treatment and/or prevention of fxr and tgr5/gpbar1 mediated diseases
WO2017147137A1 (en) * 2016-02-23 2017-08-31 Enanta Pharmaceuticals, Inc. Benzoic acid derivatives of bile acid as fxr/tgr5 agonists and methods of use thereof
EP3409684A1 (en) * 2016-01-28 2018-12-05 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Steroid derivative fxr agonist

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010035119A2 (en) * 2008-09-29 2010-04-01 Cadila Pharmaceuticals Ltd. Vaccine adjuvants
WO2010049144A2 (en) * 2008-10-28 2010-05-06 Phenex Pharmaceuticals Ag Methods of identification of novel ligands for modulation of orphan nuclear receptor rar-related orphan receptor-gamma (nr1f3) activity
WO2012106581A1 (en) * 2011-02-03 2012-08-09 The University Of Chicago Fxr inhibitor, bile acid sequestrant as combination therapy for cholesterol reduction
WO2015181275A1 (en) * 2014-05-29 2015-12-03 Bar Pharmaceuticals S.R.L. Cholane derivatives for use in the treatment and/or prevention of fxr and tgr5/gpbar1 mediated diseases
EP3409684A1 (en) * 2016-01-28 2018-12-05 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Steroid derivative fxr agonist
WO2017147137A1 (en) * 2016-02-23 2017-08-31 Enanta Pharmaceuticals, Inc. Benzoic acid derivatives of bile acid as fxr/tgr5 agonists and methods of use thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
"Remington's pharmaceutical Sciences", 2000, WILLIAMS & WILKINS PA
"The Science and practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS & WILKINS ED
LOYD V. ALLENHOWARD C.. ANSEL: "Ansel's pharmaceutical Dosage Forms and Drug Delivery Systems", 2014, LIPPINCOTT WILLIAMS & WILKINS
MEADOWS ET AL., FRONT. MED., 2020
TERASAWA TAKESHI ET AL: "Photochemical reaction of cholesterol analogs with a carbene-generating substituent on the side chain.", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 34, no. 2, 1 January 1986 (1986-01-01), JP, pages 935 - 936, XP093015255, ISSN: 0009-2363, DOI: 10.1248/cpb.34.935 *
THOMAS ET AL., CELL. METAB., vol. 10, 2009, pages 167
WATANABE ET AL., NATURE, vol. 439, 2006, pages 484

Also Published As

Publication number Publication date
WO2023233346A1 (en) 2023-12-07

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