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IT201700039562A1 - Derivati isoindolinici quali attivatori di ampk - Google Patents

Derivati isoindolinici quali attivatori di ampk

Info

Publication number
IT201700039562A1
IT201700039562A1 IT102017000039562A IT201700039562A IT201700039562A1 IT 201700039562 A1 IT201700039562 A1 IT 201700039562A1 IT 102017000039562 A IT102017000039562 A IT 102017000039562A IT 201700039562 A IT201700039562 A IT 201700039562A IT 201700039562 A1 IT201700039562 A1 IT 201700039562A1
Authority
IT
Italy
Prior art keywords
isoindolinic
derivatives
ampk activators
ampk
activators
Prior art date
Application number
IT102017000039562A
Other languages
English (en)
Inventor
Edoardo Paolini
Luca Quattrini
Vito Coviello
Luca Antonioli
Matteo Fornai
Corrado Blandizzi
Won Keun Oh
Motta Concettina La
Original Assignee
Univ Pisa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pisa filed Critical Univ Pisa
Priority to IT102017000039562A priority Critical patent/IT201700039562A1/it
Priority to PCT/IB2018/052509 priority patent/WO2018189679A1/en
Publication of IT201700039562A1 publication Critical patent/IT201700039562A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
IT102017000039562A 2017-04-10 2017-04-10 Derivati isoindolinici quali attivatori di ampk IT201700039562A1 (it)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT102017000039562A IT201700039562A1 (it) 2017-04-10 2017-04-10 Derivati isoindolinici quali attivatori di ampk
PCT/IB2018/052509 WO2018189679A1 (en) 2017-04-10 2018-04-10 Isoindoline derivatives for use as ampk activators

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102017000039562A IT201700039562A1 (it) 2017-04-10 2017-04-10 Derivati isoindolinici quali attivatori di ampk

Publications (1)

Publication Number Publication Date
IT201700039562A1 true IT201700039562A1 (it) 2018-10-10

Family

ID=59700063

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102017000039562A IT201700039562A1 (it) 2017-04-10 2017-04-10 Derivati isoindolinici quali attivatori di ampk

Country Status (2)

Country Link
IT (1) IT201700039562A1 (it)
WO (1) WO2018189679A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023526625A (ja) 2020-05-19 2023-06-22 キャリーオペ，インク． Ａｍｐｋアクチベーター
CN116390925A (zh) 2020-06-26 2023-07-04 卡尔优普公司 Ampk活化剂
AU2022306297A1 (en) 2021-07-09 2024-02-08 Plexium, Inc. Aryl compounds and pharmaceutical compositions that modulate ikzf2

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120057716A (ko) * 2010-08-24 2012-06-07 서울대학교산학협력단 Ａｍｐｋ를 활성화시키는 화합물을 함유하는 약학조성물
EP2769974A1 (en) * 2013-02-21 2014-08-27 Debiopharm S.A. Novel AMPK activator
WO2015150565A1 (en) * 2014-04-04 2015-10-08 Sanofi Isoindolinone compounds as gpr119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120057716A (ko) * 2010-08-24 2012-06-07 서울대학교산학협력단 Ａｍｐｋ를 활성화시키는 화합물을 함유하는 약학조성물
EP2769974A1 (en) * 2013-02-21 2014-08-27 Debiopharm S.A. Novel AMPK activator
WO2015150565A1 (en) * 2014-04-04 2015-10-08 Sanofi Isoindolinone compounds as gpr119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
EL-AZAB ADEL S ET AL: "Inhibition of carbonic anhydrase isoforms I, II, IV, VII and XII with carboxylates and sulfonamides incorporating phthalimide/phthalic anhydride scaffolds", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 24, no. 1, 26 November 2015 (2015-11-26), pages 20 - 25, XP029350657, ISSN: 0968-0896, DOI: 10.1016/J.BMC.2015.11.034 *
FELLS J I ET AL: "2D binary QSAR modeling of LPA3 receptor antagonism", JOURNAL OF MOLECULAR GRAPHICS AND MODELLING, ELSEVIER SCIENCE, NEW YORK, NY, US, vol. 28, no. 8, 1 June 2010 (2010-06-01), pages 828 - 833, XP027045036, ISSN: 1093-3263, [retrieved on 20100307] *
JAEYOUNG HWANG ET AL: "Synthesis and characterization of phenylpyridine derivative containing an imide functional group on an iridium (III) complex for solution-processable orange-phosphorescent organic light-emitting diodes", DYES AND PIGMENTS., vol. 121, 12 March 2015 (2015-03-12), GB, pages 73 - 78, XP055415168, ISSN: 0143-7208, DOI: 10.1016/j.dyepig.2015.05.004 *
JOSE R. CABRERO-ANTONINO ET AL: "Selective Ruthenium-Catalyzed Reductive Alkoxylation and Amination of Cyclic Imides", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 55, no. 1, 11 November 2015 (2015-11-11), pages 387 - 391, XP055415164, ISSN: 1433-7851, DOI: 10.1002/anie.201508575 *
KATHARINA FRITZSCHE ET AL: "Elektronenreiche Heterocyclen als Donorgruppen in Fluoreszenzfarbstoffen", CHEMISCHE BERICHTE, vol. 117, no. 6, 1 June 1984 (1984-06-01), pages 2275 - 2286, XP055046243, ISSN: 0009-2940, DOI: 10.1002/cber.19841170619 *
LUKE R. ODELL ET AL: "The Pthaladyns : GTP Competitive Inhibitors of Dynamin I and II GTPase Derived from Virtual Screening", JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, no. 14, 22 July 2010 (2010-07-22), pages 5267 - 5280, XP055081563, ISSN: 0022-2623, DOI: 10.1021/jm100442u *
MOHAMED MENSHAWY A ET AL: "Synthesis and human/bacterial carbonic anhydrase inhibition with a series of sulfonamides incorporating phthalimido moieties", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 25, no. 8, 9 March 2017 (2017-03-09), pages 2524 - 2529, XP029960692, ISSN: 0968-0896, DOI: 10.1016/J.BMC.2017.03.017 *
NISAN BHATTACHARYYA ET AL: "A High Throughput Screening Assay System for the Identification of Small Molecule Inhibitors of gsp", PLOS ONE, vol. 9, no. 3, 25 March 2014 (2014-03-25), pages e90766, XP055415228, DOI: 10.1371/journal.pone.0090766 *
SHILPA A. WORLIKAR ET AL: "Palladium-Catalyzed One-Step Synthesis of Isoindole-1,3-diones by Carbonylative Cyclization of o -Halobenzoates and Primary Amines", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 73, no. 18, 19 September 2008 (2008-09-19), US, pages 7175 - 7180, XP055415154, ISSN: 0022-3263, DOI: 10.1021/jo800936h *
TOMAS KINDAHL ET AL: "Efficient one-step synthesis of 4-amino substituted phthalimides and evaluation of their potential as fluorescent probes", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 12, no. 25, 1 January 2014 (2014-01-01), GB, pages 4461, XP055415156, ISSN: 1477-0520, DOI: 10.1039/c4ob00342j *

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Publication number Publication date
WO2018189679A1 (en) 2018-10-18

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