IT1400395B1 - Processo one-pot per la sintesi di dalfampridine. - Google Patents
Processo one-pot per la sintesi di dalfampridine.Info
- Publication number
- IT1400395B1 IT1400395B1 ITMI2010A001015A ITMI20101015A IT1400395B1 IT 1400395 B1 IT1400395 B1 IT 1400395B1 IT MI2010A001015 A ITMI2010A001015 A IT MI2010A001015A IT MI20101015 A ITMI20101015 A IT MI20101015A IT 1400395 B1 IT1400395 B1 IT 1400395B1
- Authority
- IT
- Italy
- Prior art keywords
- dalfampridine
- synthesis
- pot process
- pot
- Prior art date
Links
- NUKYPUAOHBNCPY-UHFFFAOYSA-N 4-aminopyridine Chemical compound NC1=CC=NC=C1 NUKYPUAOHBNCPY-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 229960004979 fampridine Drugs 0.000 title 1
- 238000005580 one pot reaction Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Catalysts (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2010A001015A IT1400395B1 (it) | 2010-06-08 | 2010-06-08 | Processo one-pot per la sintesi di dalfampridine. |
| ES11168652T ES2401377T3 (es) | 2010-06-08 | 2011-06-03 | Proceso de una sola operación para la síntesis de dalfampridina |
| EP20110168652 EP2394994B1 (en) | 2010-06-08 | 2011-06-03 | One-pot process for the synthesis of dalfampridine |
| US13/154,866 US8877935B2 (en) | 2010-06-08 | 2011-06-07 | One-pot process for the synthesis of dalfampridine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2010A001015A IT1400395B1 (it) | 2010-06-08 | 2010-06-08 | Processo one-pot per la sintesi di dalfampridine. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITMI20101015A1 ITMI20101015A1 (it) | 2011-12-09 |
| IT1400395B1 true IT1400395B1 (it) | 2013-05-31 |
Family
ID=42985424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI2010A001015A IT1400395B1 (it) | 2010-06-08 | 2010-06-08 | Processo one-pot per la sintesi di dalfampridine. |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8877935B2 (it) |
| EP (1) | EP2394994B1 (it) |
| ES (1) | ES2401377T3 (it) |
| IT (1) | IT1400395B1 (it) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102442942A (zh) * | 2010-10-08 | 2012-05-09 | 天津和美生物技术有限公司 | 4-氨基吡啶的多晶型物及其制备和应用 |
| CN102993144B (zh) * | 2012-12-07 | 2016-04-13 | 青岛前线生物工程有限公司 | 4-氨基四氢吡喃的一锅法合成工艺 |
| US10172842B2 (en) | 2015-09-11 | 2019-01-08 | PharmaDax Inc. | Sustained release oral dosage form containing dalfampridine |
| CN107963990A (zh) * | 2018-01-24 | 2018-04-27 | 沧州临港亚诺化工有限公司 | 一种一步法制备3-氨基吡啶的方法 |
| CN108840820B (zh) * | 2018-07-25 | 2020-04-21 | 安徽星宇化工有限公司 | 一步合成4-氨基吡啶的方法 |
| CN114516833A (zh) * | 2022-03-14 | 2022-05-20 | 江苏梦得新材料科技有限公司 | 一种4-氨基吡啶的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE566693C (de) | 1931-04-28 | 1932-12-19 | Ernst Koenigs Dr | Verfahren zur Darstellung von Pyridinderivaten |
| US4140853A (en) | 1975-04-18 | 1979-02-20 | Schering Aktiengesellschaft | Process for the preparation of aminopyridines |
| DE3241429A1 (de) | 1982-11-05 | 1984-05-10 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verfahren zur herstellung von 4-aminopyridinen |
| US4672121A (en) * | 1985-01-16 | 1987-06-09 | Nepera Chemical Co. | Preparation of 4-substituted pyridines using quaternary pyridine salts |
| WO1999005306A1 (de) | 1997-07-22 | 1999-02-04 | Lonza Ag | Verfahren zur herstellung von amiden |
| CN1159104C (zh) * | 1997-08-01 | 2004-07-28 | 莱利工业公司 | 超亲核的4-取代吡啶催化剂及其制备方法 |
| JP2001204485A (ja) | 2000-01-27 | 2001-07-31 | Showa Denko Kk | 微生物によるカルボニル化合物の製法 |
| CN1311185A (zh) | 2000-03-03 | 2001-09-05 | 山东新华制药股份有限公司 | 4－氨基吡啶及衍生物的制备方法 |
| MX268424B (es) | 2001-01-09 | 2009-07-17 | Lonza Ag | Procedimiento microbiologico para la produccion de amidas. |
| ATE309219T1 (de) | 2002-11-28 | 2005-11-15 | Jubilant Organosys Ltd | Verfahren zur herstellung von 4- dimethylaminopyridin (4-dmap) |
| US7455827B2 (en) * | 2003-03-20 | 2008-11-25 | Council Of Scientific And Industrial Research | Process for preparing a catalyst for conversion of cyanopyridines to nicotinamides |
| CN1319947C (zh) | 2005-01-21 | 2007-06-06 | 北京化工大学 | 一种4－氨基吡啶的制备方法 |
-
2010
- 2010-06-08 IT ITMI2010A001015A patent/IT1400395B1/it active
-
2011
- 2011-06-03 ES ES11168652T patent/ES2401377T3/es active Active
- 2011-06-03 EP EP20110168652 patent/EP2394994B1/en active Active
- 2011-06-07 US US13/154,866 patent/US8877935B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US8877935B2 (en) | 2014-11-04 |
| ES2401377T3 (es) | 2013-04-19 |
| EP2394994B1 (en) | 2013-02-13 |
| US20110319628A1 (en) | 2011-12-29 |
| EP2394994A1 (en) | 2011-12-14 |
| ITMI20101015A1 (it) | 2011-12-09 |
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