IT1317031B1 - Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi. - Google Patents

Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi.

Info

Publication number: IT1317031B1
Authority: IT; Italy
Prior art keywords: preparation; androstane; dione; analogues; ethoxy
Prior art date: 2000-05-17

Application number

IT2000RM000266A

Other languages

English (en)

Inventor

Mauro Gobbini

Giulio Carzana

Simona Sputore

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-17

Filing date

2000-05-17

Publication date

2003-05-26

2000-05-17 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

2000-05-17 Publication of ITRM20000266A0 publication Critical patent/ITRM20000266A0/it

2000-05-17 Priority to IT2000RM000266A priority Critical patent/IT1317031B1/it

2001-05-10 Priority to US09/852,265 priority patent/US6384250B2/en

2001-05-14 Priority to ES01830306T priority patent/ES2282225T3/es

2001-05-14 Priority to EP01830306A priority patent/EP1156058B1/en

2001-05-14 Priority to DE60126864T priority patent/DE60126864T2/de

2001-05-14 Priority to PT01830306T priority patent/PT1156058E/pt

2001-05-14 Priority to AT01830306T priority patent/ATE355296T1/de

2001-05-14 Priority to DK01830306T priority patent/DK1156058T3/da

2001-11-19 Publication of ITRM20000266A1 publication Critical patent/ITRM20000266A1/it

2003-05-26 Application granted granted Critical

2003-05-26 Publication of IT1317031B1 publication Critical patent/IT1317031B1/it

2007-05-09 Priority to CY20071100620T priority patent/CY1107662T1/el

Links

238000000034 method Methods 0.000 title abstract 2
-1 3- (2-AMINO-ETHOXY) -ANDROSTANE-6, 17-DIONE Chemical compound 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
MPYLDWFDPHRTEG-IFVNMTGRSA-N (5s,8r,9s,10r,13s,14s)-3-(2-aminoethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione Chemical compound C1C(=NOCCN)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC(=O)[C@H]21 MPYLDWFDPHRTEG-IFVNMTGRSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IT2000RM000266A 2000-05-17 2000-05-17 Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi. IT1317031B1 (it)

Priority Applications (9)

Application Number	Priority Date	Filing Date	Title
IT2000RM000266A IT1317031B1 (it)	2000-05-17	2000-05-17	Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi.
US09/852,265 US6384250B2 (en)	2000-05-17	2001-05-10	Process for the preparation of (E,Z) 3-(2-aminoethoxyimino)-androstane-6, 17-dione and its analogues
DE60126864T DE60126864T2 (de)	2000-05-17	2001-05-14	Verfahren zur Herstellung von (E,Z) 3-(2-aminoethoxyimino)-androstane-6,17-dione und Analoge
EP01830306A EP1156058B1 (en)	2000-05-17	2001-05-14	Process for the preparation of (E,Z) 3-(2-aminoethoxyimino)-androstane-6,17-dione and its analogues
ES01830306T ES2282225T3 (es)	2000-05-17	2001-05-14	Proceso para la prepacion de (e,z) 3-(2-aminoetoxiimino)-androstane-6,17-diona y sus analogos.
PT01830306T PT1156058E (pt)	2000-05-17	2001-05-14	Processo para a preparação de ( e, z )-3- (2-aminoetoxi-imino )-androstano -6, 17- diona e dos seus análogos.
AT01830306T ATE355296T1 (de)	2000-05-17	2001-05-14	Verfahren zur herstellung von (e,z) 3-(2- aminoethoxyimino)-androstane-6,17-dione und analoge
DK01830306T DK1156058T3 (da)	2000-05-17	2001-05-14	Fremgangsmåde til fremstilling af (E,Z) 3-(2-aminoethoxyimino)-androstan-6,17-dion og analoger deraf
CY20071100620T CY1107662T1 (el)	2000-05-17	2007-05-09	Μεθοδος παρασκευης της (ε, ζ) 3-(2-aminoethoxyimino)-androstane-6,17-dione και αναλογων της

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2000RM000266A IT1317031B1 (it)	2000-05-17	2000-05-17	Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi.

Publications (3)

Publication Number	Publication Date
ITRM20000266A0 ITRM20000266A0 (it)	2000-05-17
ITRM20000266A1 ITRM20000266A1 (it)	2001-11-19
IT1317031B1 true IT1317031B1 (it)	2003-05-26

Family

ID=11454735

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT2000RM000266A IT1317031B1 (it)	2000-05-17	2000-05-17	Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi.

Country Status (9)

Country	Link
US (1)	US6384250B2 (it)
EP (1)	EP1156058B1 (it)
AT (1)	ATE355296T1 (it)
CY (1)	CY1107662T1 (it)
DE (1)	DE60126864T2 (it)
DK (1)	DK1156058T3 (it)
ES (1)	ES2282225T3 (it)
IT (1)	IT1317031B1 (it)
PT (1)	PT1156058E (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US10174070B2 (en)	2005-09-30	2019-01-08	Endece Llc	6-substituted estradiol derivatives and methods of use
US8168621B2 (en)	2005-09-30	2012-05-01	Endece, Llc	6-substituted estradiol derivatives and methods of use
US20080119447A1 (en) *	2005-09-30	2008-05-22	James Yarger	6-alkoxyalkyl estradiol derivatives and methods of use
JP5290189B2 (ja)	2006-11-30	2013-09-18	エンディースエルエルシー	６−アルコキシアルキルエストラジオール誘導体およびその使用
EA017497B1 (ru) *	2007-10-12	2012-12-28	Сигма-Тау Индустрие Фармасьютике Риуните С.П.А.	Аминооксимные производные 2- и/или 4-замещенных андростанов и андростенов в качестве лекарственных средств для лечения сердечно-сосудистых нарушений
WO2010149666A1 (en)	2009-06-22	2010-12-29	Medexis S.A.	Methods for treating neoplasia
ES2605960T3 (es)	2010-09-14	2017-03-17	Endece, Llc	Derivados de desmetil-estradiol 6-sustituido como agonistas del RE-beta
CN103315968B (zh) *	2013-06-26	2015-04-01	中国生命药物治疗有限公司	一种注射用粉针剂及其制备方法
CN103360457B (zh) *	2013-07-31	2015-10-07	中国生命药物治疗有限公司	一种雄甾烷二酮衍生物晶型及其制备方法
EP3934654A1 (en)	2019-03-05	2022-01-12	Windtree Therapeutics, Inc.	Istaroxime-containing intravenous formulation for the treatment of acute heart failure (ahf)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19633349A1 (de) *	1996-08-19	1998-02-26	Sigma Tau Ind Farmaceuti	Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten

2000
- 2000-05-17 IT IT2000RM000266A patent/IT1317031B1/it active
2001
- 2001-05-10 US US09/852,265 patent/US6384250B2/en not_active Expired - Lifetime
- 2001-05-14 ES ES01830306T patent/ES2282225T3/es not_active Expired - Lifetime
- 2001-05-14 DK DK01830306T patent/DK1156058T3/da active
- 2001-05-14 DE DE60126864T patent/DE60126864T2/de not_active Expired - Lifetime
- 2001-05-14 AT AT01830306T patent/ATE355296T1/de active
- 2001-05-14 PT PT01830306T patent/PT1156058E/pt unknown
- 2001-05-14 EP EP01830306A patent/EP1156058B1/en not_active Expired - Lifetime
2007
- 2007-05-09 CY CY20071100620T patent/CY1107662T1/el unknown

Also Published As

Publication number	Publication date
EP1156058A3 (en)	2005-06-08
PT1156058E (pt)	2007-05-31
EP1156058A2 (en)	2001-11-21
EP1156058B1 (en)	2007-02-28
DE60126864D1 (de)	2007-04-12
DE60126864T2 (de)	2007-09-06
ATE355296T1 (de)	2006-03-15
US20010056182A1 (en)	2001-12-27
ITRM20000266A1 (it)	2001-11-19
ITRM20000266A0 (it)	2000-05-17
US6384250B2 (en)	2002-05-07
ES2282225T3 (es)	2007-10-16
CY1107662T1 (el)	2013-04-18
DK1156058T3 (da)	2007-06-18

Publication	Publication Date	Title
IL159418A0 (en)	2004-06-01	Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
PT931788E (pt)	2003-01-31	Inibidores de metaloprotease
ES2172864T3 (es)	2002-10-01	2-metoxibenzofenonas fungicidas.
CY1107662T1 (el)	2013-04-18	Μεθοδος παρασκευης της (ε, ζ) 3-(2-aminoethoxyimino)-androstane-6,17-dione και αναλογων της
DE69920923D1 (de)	2004-11-11	Anthranilsäurederivate
NO995963D0 (no)	1999-12-03	Karboksamider anvendelige som 5-HTIF-agonister
EA199900798A1 (ru)	2000-04-24	Соединения
TR200402546T4 (tr)	2004-12-21	Taksan türevleri hazırlamak için işlem.
BR9713176A (pt)	2000-02-08	Benzotiofenos amorfos,métodos de preparação e métodos de uso
WO2003018565A8 (en)	2003-08-07	Method for synthesizing oxazinones
DK1619185T3 (da)	2011-07-18	4,4-difluor-1,2,3,4-tetrahydro-5H-1-benzazepinderivat eller salt deraf
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BR9902096A (pt)	2000-04-11	Pitazóis.
ATE282608T1 (de)	2004-12-15	Chinoxalindionen
EA200400661A1 (ru)	2004-12-30	Фенилалкины
CO5160345A1 (es)	2002-05-30	Nuevos androgenos oralmente activos derivados de 7 alfa- metil-19-nortestosterona
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DK1392672T3 (da)	2005-08-29	Chlormethylering af thiopen
DE60039695D1 (de)	2008-09-11	Antifucoidan antikörper
BR0210201A (pt)	2004-06-08	Composição
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BR0013100A (pt)	2002-04-30	Processo para a preparação de um composto de 2-arilvinil alquil éter
DK1140932T3 (da)	2004-07-05	Derivater af benzo-1,8-naphtyridin