IT1311967B1 - Composition for use in medicated chewing gums comprises particles of an active principle dispersed in the gum, which are coated with a mixture of a hydrosoluble element and a water insoluble element - Google Patents
Composition for use in medicated chewing gums comprises particles of an active principle dispersed in the gum, which are coated with a mixture of a hydrosoluble element and a water insoluble elementInfo
- Publication number
- IT1311967B1 IT1311967B1 ITMI990571A IT1311967B1 IT 1311967 B1 IT1311967 B1 IT 1311967B1 IT MI990571 A ITMI990571 A IT MI990571A IT 1311967 B1 IT1311967 B1 IT 1311967B1
- Authority
- IT
- Italy
- Prior art keywords
- mixture
- active principle
- gum
- composition
- hydrosoluble
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 7
- 235000015218 chewing gum Nutrition 0.000 title abstract 3
- 239000002245 particle Substances 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract 3
- 229960002715 nicotine Drugs 0.000 abstract 3
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 abstract 3
- 238000002156 mixing Methods 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000002738 anti-smoking effect Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 229940112822 chewing gum Drugs 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003825 pressing Methods 0.000 abstract 1
Landscapes
- Confectionery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
A composition for medicated chewing gums comprising particles of an active principle dispersed in the gum, which are coated with a mixture of a hydrosoluble element and a water insoluble element, is new. The coating allows a gradual and controlled release of the principle. An independent claim is also included for a process for obtaining the medicated chewing gum, which comprises: (a) heating the insoluble element until a complete solution is obtained; (b) mixing the soluble element with the active principle; (c) pouring the mixture in the solution of the insoluble element; (d) cooling the mixture obtained and mixing with the gum base and the additives; and (e) pressing at no higher than room temperature. ACTIVITY : Antismoking. Three tablets of the invention comprising 2 mg nicotine were administered, respectively, to 3 adult subjects and the plasmatic levels of nicotine were determined by taking blood samples. The results showed that nicotine reached high plasmatic levels within 40-75 minutes confirming good bioavailability and strong absorption of the active principle when the composition is used. MECHANISM OF ACTION : None given.
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI990571 IT1311967B1 (en) | 1999-03-22 | 1999-03-22 | Composition for use in medicated chewing gums comprises particles of an active principle dispersed in the gum, which are coated with a mixture of a hydrosoluble element and a water insoluble element |
| BR9917220-8A BR9917220A (en) | 1999-03-22 | 1999-10-18 | Composition for gum chewing gums, process for producing damesma, and tablets thus obtained |
| AU62037/99A AU6203799A (en) | 1999-03-22 | 1999-10-18 | Composition for medicated chewing gums, process for manufacturing the same and tablets so obtained |
| CN99816579A CN1348359A (en) | 1999-03-22 | 1999-10-18 | Composition for medicated chewing gums process for manufacturing the same and tablets so obtained |
| DE69941825T DE69941825D1 (en) | 1999-03-22 | 1999-10-18 | DRUG-CONTAINING RUBBER, THE METHOD OF MANUFACTURING THE SAME AND THE TABLET OBTAINED THEREWITH |
| EP99949008A EP1162946B1 (en) | 1999-03-22 | 1999-10-18 | Composition for medicated chewing gums, process for manufacturing the same and tablets so obtained |
| JP2000606188A JP2002539236A (en) | 1999-03-22 | 1999-10-18 | Composition for medicated chewing gum, and method for producing the composition and tablets thereof |
| AT99949008T ATE451912T1 (en) | 1999-03-22 | 1999-10-18 | MEDICATED CHEWING GUM, METHOD OF PRODUCTION THEREOF AND TABLET SO OBTAINED |
| CA002366845A CA2366845A1 (en) | 1999-03-22 | 1999-10-18 | Composition for medicated chewing gums, process for manufacturing the same and tablets so obtained |
| PCT/EP1999/007917 WO2000056281A1 (en) | 1999-03-22 | 1999-10-18 | Composition for medicated chewing gums, process for manufacturing the same and tablets so obtained |
| ARP000101294A AR023138A1 (en) | 1999-03-22 | 2000-03-22 | COMPOSITION FOR MEDICATED GUMS, MANUFACTURING PROCESS AND TABLETS OBTAINED WITH THIS PROCESS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI990571 IT1311967B1 (en) | 1999-03-22 | 1999-03-22 | Composition for use in medicated chewing gums comprises particles of an active principle dispersed in the gum, which are coated with a mixture of a hydrosoluble element and a water insoluble element |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITMI990571A1 ITMI990571A1 (en) | 2000-09-22 |
| IT1311967B1 true IT1311967B1 (en) | 2002-03-22 |
Family
ID=11382368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI990571 IT1311967B1 (en) | 1999-03-22 | 1999-03-22 | Composition for use in medicated chewing gums comprises particles of an active principle dispersed in the gum, which are coated with a mixture of a hydrosoluble element and a water insoluble element |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1311967B1 (en) |
-
1999
- 1999-03-22 IT ITMI990571 patent/IT1311967B1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI990571A1 (en) | 2000-09-22 |
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