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IT1397621B1 - Frammento anticorpale della regione variabile a singola catena (scfv) in grado di riconoscere e legare la proteina umana cd99. - Google Patents

Frammento anticorpale della regione variabile a singola catena (scfv) in grado di riconoscere e legare la proteina umana cd99.

Info

Publication number
IT1397621B1
IT1397621B1 ITMI2009A001994A ITMI20091994A IT1397621B1 IT 1397621 B1 IT1397621 B1 IT 1397621B1 IT MI2009A001994 A ITMI2009A001994 A IT MI2009A001994A IT MI20091994 A ITMI20091994 A IT MI20091994A IT 1397621 B1 IT1397621 B1 IT 1397621B1
Authority
IT
Italy
Prior art keywords
anticorpal
scfv
bind
fragment
recognize
Prior art date
Application number
ITMI2009A001994A
Other languages
English (en)
Inventor
Mara Gellini
Alessandra Mallano
Michela Flego
Piero Picci
Maria Luisa Dupuis
Maurizio Cianfriglia
Alessandro Ascione
Katia Scotlandi
Original Assignee
Istituto Ortopedico Rizzoli
Ist Superiore Sanita
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Ortopedico Rizzoli, Ist Superiore Sanita filed Critical Istituto Ortopedico Rizzoli
Priority to ITMI2009A001994A priority Critical patent/IT1397621B1/it
Priority to EP10800783.2A priority patent/EP2499163B1/en
Priority to PCT/IB2010/055135 priority patent/WO2011058517A1/en
Priority to CA2780708A priority patent/CA2780708C/en
Priority to US13/509,276 priority patent/US8710194B2/en
Publication of ITMI20091994A1 publication Critical patent/ITMI20091994A1/it
Application granted granted Critical
Publication of IT1397621B1 publication Critical patent/IT1397621B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
  • Superstructure Of Vehicle (AREA)
ITMI2009A001994A 2009-11-13 2009-11-13 Frammento anticorpale della regione variabile a singola catena (scfv) in grado di riconoscere e legare la proteina umana cd99. IT1397621B1 (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ITMI2009A001994A IT1397621B1 (it) 2009-11-13 2009-11-13 Frammento anticorpale della regione variabile a singola catena (scfv) in grado di riconoscere e legare la proteina umana cd99.
EP10800783.2A EP2499163B1 (en) 2009-11-13 2010-11-12 Single-chain variable fragment (scfv) able to recognize and bind cd99 human protein
PCT/IB2010/055135 WO2011058517A1 (en) 2009-11-13 2010-11-12 Single-chain variable fragment (scfv) able to recognize and bind cd99 human protein
CA2780708A CA2780708C (en) 2009-11-13 2010-11-12 Single-chain variable fragment (scfv) able to recognize and bind cd99 human protein
US13/509,276 US8710194B2 (en) 2009-11-13 2010-11-12 Single-chain variable fragment (scFv) able to recognize and bind CD99 human protein

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2009A001994A IT1397621B1 (it) 2009-11-13 2009-11-13 Frammento anticorpale della regione variabile a singola catena (scfv) in grado di riconoscere e legare la proteina umana cd99.

Publications (2)

Publication Number Publication Date
ITMI20091994A1 ITMI20091994A1 (it) 2011-05-14
IT1397621B1 true IT1397621B1 (it) 2013-01-18

Family

ID=42235226

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2009A001994A IT1397621B1 (it) 2009-11-13 2009-11-13 Frammento anticorpale della regione variabile a singola catena (scfv) in grado di riconoscere e legare la proteina umana cd99.

Country Status (5)

Country Link
US (1) US8710194B2 (it)
EP (1) EP2499163B1 (it)
CA (1) CA2780708C (it)
IT (1) IT1397621B1 (it)
WO (1) WO2011058517A1 (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101740030B1 (ko) * 2014-03-07 2017-05-29 사회복지법인 삼성생명공익재단 ScFv 항체 라이브러리, 이의 제조방법 및 이를 이용한 ScFv 항체 스크리닝 방법
ES2811274T3 (es) 2014-04-18 2021-03-11 Univ Leland Stanford Junior Anticuerpos monoclonales humanizados y quiméricos para CD99
AU2019205422B2 (en) 2018-01-08 2025-08-28 H. Lee Moffitt Cancer Center And Research Institute Inc. Compositions and methods for targeting CD99-expressing cancers
IT201800005991A1 (it) * 2018-06-04 2019-12-04 Complesso anticorpale ed usi derivati
KR20210015842A (ko) * 2018-06-04 2021-02-10 디아테바 에스.알.엘. 항-cd99 다이아바디 또는 igg 항체 및 그의 용도
IT201800005993A1 (it) * 2018-06-04 2019-12-04 Complesso anticorpale ed usi derivati
US20250032616A1 (en) * 2023-03-10 2025-01-30 The Regents Of The University Of Colorado, A Body Corporate Anti-cd99 car-t cells for the treatment of cancer
AU2024236108A1 (en) 2023-03-10 2025-09-25 The Regents Of The University Of Colorado, A Body Corporate Anti-cd276 and anti-cd99 logic gated chimeric antigen receptors for the treatment of cancer
WO2024191919A1 (en) 2023-03-10 2024-09-19 The Regents Of The University Of Colorado, A Body Corporate Anti-cd56 and anti-cd99 logic gated chimeric antigen receptors for the treatment of cancer
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8207128B2 (en) * 2005-09-28 2012-06-26 Supadelixir Inc. Polypeptide inhibiting transmigration of leukocytes or growth and/or metastasis of cancer cells, and fusion protein thereof

Also Published As

Publication number Publication date
WO2011058517A1 (en) 2011-05-19
US20120282257A1 (en) 2012-11-08
ITMI20091994A1 (it) 2011-05-14
US8710194B2 (en) 2014-04-29
CA2780708C (en) 2017-10-31
EP2499163A1 (en) 2012-09-19
CA2780708A1 (en) 2011-05-19
EP2499163B1 (en) 2015-01-07

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