IT1283635B1 - Composti a scheletro camptotecinico isolati da mappia foetida e loro uso come sintoni per farmaci o come principi attivi - Google Patents
Composti a scheletro camptotecinico isolati da mappia foetida e loro uso come sintoni per farmaci o come principi attiviInfo
- Publication number
- IT1283635B1 IT1283635B1 IT96MI000944A ITMI960944A IT1283635B1 IT 1283635 B1 IT1283635 B1 IT 1283635B1 IT 96MI000944 A IT96MI000944 A IT 96MI000944A IT MI960944 A ITMI960944 A IT MI960944A IT 1283635 B1 IT1283635 B1 IT 1283635B1
- Authority
- IT
- Italy
- Prior art keywords
- group
- pct
- optionally substituted
- alkaloids
- mappia foetida
- Prior art date
Links
- 241000261227 Mappia foetida Species 0.000 title abstract 3
- 239000004480 active ingredient Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 229930013930 alkaloid Natural products 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000004754 (C2-C12) dialkylamino group Chemical group 0.000 abstract 1
- WSXJPXFVULHYMX-KRWDZBQOSA-N 7-[(1s)-1-hydroxypropyl]-8-methyl-11h-indolizino[1,2-b]quinolin-9-one Chemical compound C1=CC=C2C=C(CN3C4=CC(=C(C3=O)C)[C@@H](O)CC)C4=NC2=C1 WSXJPXFVULHYMX-KRWDZBQOSA-N 0.000 abstract 1
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 abstract 1
- 101100295738 Gallus gallus COR3 gene Proteins 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- WSXJPXFVULHYMX-UHFFFAOYSA-N S-Mappicine Natural products C1=CC=C2C=C(CN3C4=CC(=C(C3=O)C)C(O)CC)C4=NC2=C1 WSXJPXFVULHYMX-UHFFFAOYSA-N 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 1
- 229940127093 camptothecin Drugs 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (21)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI000944A IT1283635B1 (it) | 1996-05-10 | 1996-05-10 | Composti a scheletro camptotecinico isolati da mappia foetida e loro uso come sintoni per farmaci o come principi attivi |
| CN97194492A CN1082509C (zh) | 1996-05-10 | 1997-05-02 | 从马比木分离的喜树碱骨架化合物及其作为新药物及治疗剂的合成子的用途 |
| US09/155,960 US6121277A (en) | 1996-05-10 | 1997-05-02 | Camptothecin-skeleton compounds isolated from Mappia foetida and the use thereof as syntones for novel medicaments as well as therapeutical agents |
| DE69709357T DE69709357T2 (de) | 1996-05-10 | 1997-05-02 | Campothecinderivate, isoliert aus mappia foetida, und ihre verwendung als arzneimittel |
| KR1019980709040A KR20000010893A (ko) | 1996-05-10 | 1997-05-02 | 마피아 포에티다(mappia foetida)에서 분리한캄토테신골격화합물 및 이들의 신규한 치료제 및 의약품기질로서의 용도 |
| DK97922937T DK0912573T3 (da) | 1996-05-10 | 1997-05-02 | Camptothecinderivater, som er isoleret fra Mappia foetida, og anvendelse deraf som syntoner for nye lægemidler og som terapeutiske midler |
| SK1540-98A SK283050B6 (sk) | 1996-05-10 | 1997-05-02 | Kamptotecínové alkaloidy, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie |
| ES97922937T ES2169389T3 (es) | 1996-05-10 | 1997-05-02 | Compuestos de esqueleto de camptotecina aislados a partir de mappia foetida y el uso de los mismos como sintones para nuevos medicamentos, asi como agentes terapeuticos. |
| RU98122224/04A RU2169149C2 (ru) | 1996-05-10 | 1997-05-02 | Соединения со структурой камптотецина, способы их получения, фармацевтические композиции |
| AU28901/97A AU715482B2 (en) | 1996-05-10 | 1997-05-02 | Camptothecin-skeleton compounds isolated from mappia foetida and the use thereof as syntones for novel medicaments as well as therapeutical agents |
| CA002253914A CA2253914C (en) | 1996-05-10 | 1997-05-02 | Camptothecin-skeleton compounds isolated from mappia foetida and the use thereof as syntones for novel medicaments as well as therapeutical agents |
| EP97922937A EP0912573B1 (en) | 1996-05-10 | 1997-05-02 | Camptothecin-skeleton compounds isolated from mappia foetida and the use thereof as syntones for novel medicaments as well as therapeutical agents |
| CZ19983620A CZ287901B6 (cs) | 1996-05-10 | 1997-05-02 | Deriváty camptothecinu a farmaceutický prostředek |
| HK99104790.6A HK1019600B (en) | 1996-05-10 | 1997-05-02 | Camtothecin-skeleton compounds isolated from mappia foetida and the use thereof as syntones for novel medicaments as well as therapeutical agents |
| PCT/EP1997/002244 WO1997043290A1 (en) | 1996-05-10 | 1997-05-02 | Camptothecin-skeleton compounds isolated from mappia foetida and the use thereof as syntones for novel medicaments as well as therapeutical agents |
| SI9730181T SI0912573T1 (en) | 1996-05-10 | 1997-05-02 | Camptothecin-skeleton compounds isolated from mappia foetida and the use thereof as syntones for novel medicaments as well as therapeutical agents |
| AT97922937T ATE211140T1 (de) | 1996-05-10 | 1997-05-02 | Campothecinderivate, isoliert aus mappia foetida, und ihre verwendung als arzneimittel |
| PL97329765A PL188228B1 (pl) | 1996-05-10 | 1997-05-02 | Związki o szkielecie kamptotecyny, sposób ich wytwarzania i kompozycja farmaceutyczna je zawierająca |
| JP54044797A JP3483257B2 (ja) | 1996-05-10 | 1997-05-02 | Ｍａｐｐｉａ ｆｏｅｔｉｄａから単離したカンプトセシン―骨格化合物および新規な医薬ならびに治療薬のためのシントンとしてのその使用 |
| PT97922937T PT912573E (pt) | 1996-05-10 | 1997-05-02 | Compostos com o esqueleto da camptotecina isolados a partir de mappia foetida e sua utilizacao como sintoes para novos medicamentos bem como agentes terapeuticos |
| NO19985186A NO311839B1 (no) | 1996-05-10 | 1998-11-06 | Forbindelser med camptothecin-grunnstruktur, isolert fra Mappia foetida, og anvendelse derav som utgangsmaterialer for nyelegemidler samt som terapeutiske midler |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI000944A IT1283635B1 (it) | 1996-05-10 | 1996-05-10 | Composti a scheletro camptotecinico isolati da mappia foetida e loro uso come sintoni per farmaci o come principi attivi |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI960944A0 ITMI960944A0 (it) | 1996-05-10 |
| ITMI960944A1 ITMI960944A1 (it) | 1997-11-10 |
| IT1283635B1 true IT1283635B1 (it) | 1998-04-23 |
Family
ID=11374242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT96MI000944A IT1283635B1 (it) | 1996-05-10 | 1996-05-10 | Composti a scheletro camptotecinico isolati da mappia foetida e loro uso come sintoni per farmaci o come principi attivi |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6121277A (it) |
| EP (1) | EP0912573B1 (it) |
| JP (1) | JP3483257B2 (it) |
| KR (1) | KR20000010893A (it) |
| CN (1) | CN1082509C (it) |
| AT (1) | ATE211140T1 (it) |
| AU (1) | AU715482B2 (it) |
| CA (1) | CA2253914C (it) |
| CZ (1) | CZ287901B6 (it) |
| DE (1) | DE69709357T2 (it) |
| DK (1) | DK0912573T3 (it) |
| ES (1) | ES2169389T3 (it) |
| IT (1) | IT1283635B1 (it) |
| NO (1) | NO311839B1 (it) |
| PL (1) | PL188228B1 (it) |
| PT (1) | PT912573E (it) |
| RU (1) | RU2169149C2 (it) |
| SK (1) | SK283050B6 (it) |
| WO (1) | WO1997043290A1 (it) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2792937B1 (fr) | 1999-04-27 | 2001-08-10 | Cemaf | NOUVEAUX DERIVES DE PYRROLO-(3,4-b) QUINOLEINE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION A TITRE DE MEDICAMENT |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| WO2004100891A2 (en) | 2003-05-12 | 2004-11-25 | Purdue Research Foundation | Cytotoxic indeno and isoindoloisoquinolones |
| ITMI20051348A1 (it) * | 2005-07-14 | 2007-01-15 | Indena Spa | Analoghi della camptotecina loro processo di ottenimento loro uso e formulazioni che li contengono |
| CN100339377C (zh) * | 2005-09-05 | 2007-09-26 | 合肥中科大生物技术有限公司 | 喜树碱衍生物及其制备 |
| CN1319971C (zh) * | 2005-09-09 | 2007-06-06 | 合肥中科大生物技术有限公司 | 喜树碱衍生物及其用途 |
| WO2012176145A1 (en) * | 2011-06-22 | 2012-12-27 | Council Of Scientific & Industrial Research | Insecticidal compositions isolated from nothapodites foetida and process for the extraction thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1269862B (it) * | 1994-05-30 | 1997-04-15 | Indena Spa | Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono |
| RU2133732C1 (ru) * | 1995-03-27 | 1999-07-27 | Глитч, Инк. | Способ извлечения карбоновых кислот из водного раствора |
-
1996
- 1996-05-10 IT IT96MI000944A patent/IT1283635B1/it active IP Right Grant
-
1997
- 1997-05-02 PL PL97329765A patent/PL188228B1/pl not_active IP Right Cessation
- 1997-05-02 PT PT97922937T patent/PT912573E/pt unknown
- 1997-05-02 CZ CZ19983620A patent/CZ287901B6/cs not_active IP Right Cessation
- 1997-05-02 AU AU28901/97A patent/AU715482B2/en not_active Ceased
- 1997-05-02 SK SK1540-98A patent/SK283050B6/sk not_active IP Right Cessation
- 1997-05-02 KR KR1019980709040A patent/KR20000010893A/ko not_active Ceased
- 1997-05-02 WO PCT/EP1997/002244 patent/WO1997043290A1/en not_active Ceased
- 1997-05-02 DE DE69709357T patent/DE69709357T2/de not_active Expired - Lifetime
- 1997-05-02 ES ES97922937T patent/ES2169389T3/es not_active Expired - Lifetime
- 1997-05-02 JP JP54044797A patent/JP3483257B2/ja not_active Expired - Fee Related
- 1997-05-02 EP EP97922937A patent/EP0912573B1/en not_active Expired - Lifetime
- 1997-05-02 CN CN97194492A patent/CN1082509C/zh not_active Expired - Fee Related
- 1997-05-02 US US09/155,960 patent/US6121277A/en not_active Expired - Fee Related
- 1997-05-02 AT AT97922937T patent/ATE211140T1/de not_active IP Right Cessation
- 1997-05-02 CA CA002253914A patent/CA2253914C/en not_active Expired - Fee Related
- 1997-05-02 DK DK97922937T patent/DK0912573T3/da active
- 1997-05-02 RU RU98122224/04A patent/RU2169149C2/ru not_active IP Right Cessation
-
1998
- 1998-11-06 NO NO19985186A patent/NO311839B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2253914C (en) | 2002-10-22 |
| SK283050B6 (sk) | 2003-02-04 |
| PT912573E (pt) | 2002-06-28 |
| NO985186D0 (no) | 1998-11-06 |
| US6121277A (en) | 2000-09-19 |
| AU2890197A (en) | 1997-12-05 |
| KR20000010893A (ko) | 2000-02-25 |
| AU715482B2 (en) | 2000-02-03 |
| CA2253914A1 (en) | 1997-11-20 |
| JP3483257B2 (ja) | 2004-01-06 |
| SK154098A3 (en) | 1999-04-13 |
| DK0912573T3 (da) | 2002-04-15 |
| CZ287901B6 (cs) | 2001-03-14 |
| NO985186L (no) | 1998-11-06 |
| EP0912573A1 (en) | 1999-05-06 |
| CN1218474A (zh) | 1999-06-02 |
| RU2169149C2 (ru) | 2001-06-20 |
| ATE211140T1 (de) | 2002-01-15 |
| CZ362098A3 (cs) | 1999-06-16 |
| ITMI960944A1 (it) | 1997-11-10 |
| NO311839B1 (no) | 2002-02-04 |
| DE69709357D1 (de) | 2002-01-31 |
| ES2169389T3 (es) | 2002-07-01 |
| PL329765A1 (en) | 1999-04-12 |
| PL188228B1 (pl) | 2004-12-31 |
| ITMI960944A0 (it) | 1996-05-10 |
| DE69709357T2 (de) | 2002-08-22 |
| WO1997043290A1 (en) | 1997-11-20 |
| JP2000503666A (ja) | 2000-03-28 |
| CN1082509C (zh) | 2002-04-10 |
| EP0912573B1 (en) | 2001-12-19 |
| HK1019600A1 (en) | 2000-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |