IT1276711B1 - Process for the preparation of an intermediate which is useful in the synthesis of organic compounds - Google Patents
Process for the preparation of an intermediate which is useful in the synthesis of organic compoundsInfo
- Publication number
- IT1276711B1 IT1276711B1 IT95MI001258A ITMI951258A IT1276711B1 IT 1276711 B1 IT1276711 B1 IT 1276711B1 IT 95MI001258 A IT95MI001258 A IT 95MI001258A IT MI951258 A ITMI951258 A IT MI951258A IT 1276711 B1 IT1276711 B1 IT 1276711B1
- Authority
- IT
- Italy
- Prior art keywords
- amino
- synthesis
- useful
- triiodoisophthalic acid
- preparation
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 150000002894 organic compounds Chemical class 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- JEZJSNULLBSYHV-UHFFFAOYSA-N 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid Chemical compound NC1=C(I)C(C(O)=O)=C(I)C(C(O)=O)=C1I JEZJSNULLBSYHV-UHFFFAOYSA-N 0.000 abstract 3
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical group CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229940039231 contrast media Drugs 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000004714 phosphonium salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical group CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
- 125000003944 tolyl group Chemical group 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A process for preparing the dichloride of 5-amino-2,4,6- triiodoisophthalic acid by chlorinating 5-amino-2,4,6- triiodoisophthalic acid with thionyl chloride in the presence of a suitable solvent characterised in that the reaction is performed in the presence of catalytic quantities of a phosphonium salt of formula R1R2R3R4PX (I) in which R1, R2 and R3, which are the same or different, represent C1-C4 alkyl groups, phenyl or tolyl groups, R4 represents a hydrogen atom or a C1-C6 alkyl group and X represents halogen, mesylate or tosylate is described. The dichloride of 5-amino-2,4,6-triiodoisophthalic acid obtained according to the process according to the invention is useful as an intermediate in the synthesis of iodine-containing contrast media.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95MI001258A IT1276711B1 (en) | 1995-06-14 | 1995-06-14 | Process for the preparation of an intermediate which is useful in the synthesis of organic compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95MI001258A IT1276711B1 (en) | 1995-06-14 | 1995-06-14 | Process for the preparation of an intermediate which is useful in the synthesis of organic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI951258A0 ITMI951258A0 (en) | 1995-06-14 |
| ITMI951258A1 ITMI951258A1 (en) | 1996-12-14 |
| IT1276711B1 true IT1276711B1 (en) | 1997-11-03 |
Family
ID=11371810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT95MI001258A IT1276711B1 (en) | 1995-06-14 | 1995-06-14 | Process for the preparation of an intermediate which is useful in the synthesis of organic compounds |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1276711B1 (en) |
-
1995
- 1995-06-14 IT IT95MI001258A patent/IT1276711B1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI951258A1 (en) | 1996-12-14 |
| ITMI951258A0 (en) | 1995-06-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |