IT1274355B - Lattoni ad attivita' antiossidante ed ipolipidemica utili nella terapia dell'aterosclerosi - Google Patents
Lattoni ad attivita' antiossidante ed ipolipidemica utili nella terapia dell'aterosclerosiInfo
- Publication number
- IT1274355B IT1274355B ITBO940562A ITBO940562A IT1274355B IT 1274355 B IT1274355 B IT 1274355B IT BO940562 A ITBO940562 A IT BO940562A IT BO940562 A ITBO940562 A IT BO940562A IT 1274355 B IT1274355 B IT 1274355B
- Authority
- IT
- Italy
- Prior art keywords
- atherosclerosis
- lattons
- antioxidant
- therapy
- lipoproteins
- Prior art date
Links
- 201000001320 Atherosclerosis Diseases 0.000 title abstract 3
- 230000000055 hyoplipidemic effect Effects 0.000 title abstract 2
- 239000003963 antioxidant agent Substances 0.000 title 1
- 230000003078 antioxidant effect Effects 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 102000007330 LDL Lipoproteins Human genes 0.000 abstract 2
- 108010007622 LDL Lipoproteins Proteins 0.000 abstract 2
- 230000004048 modification Effects 0.000 abstract 2
- 238000012986 modification Methods 0.000 abstract 2
- 230000001590 oxidative effect Effects 0.000 abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 200000000007 Arterial disease Diseases 0.000 abstract 1
- 206010008132 Cerebral thrombosis Diseases 0.000 abstract 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 abstract 1
- 102000004895 Lipoproteins Human genes 0.000 abstract 1
- 108090001030 Lipoproteins Proteins 0.000 abstract 1
- 230000002596 correlated effect Effects 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 150000002596 lactones Chemical class 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 230000008506 pathogenesis Effects 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 238000005502 peroxidation Methods 0.000 abstract 1
- 230000036470 plasma concentration Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000002000 scavenging effect Effects 0.000 abstract 1
- 230000006439 vascular pathology Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITBO940562A IT1274355B (it) | 1994-12-21 | 1994-12-21 | Lattoni ad attivita' antiossidante ed ipolipidemica utili nella terapia dell'aterosclerosi |
| US08/556,648 US5608084A (en) | 1994-12-21 | 1995-11-13 | Lactones with antioxidising and hypolipidaemic activity useful in the therapy of the atherosclerosis |
| AT95118629T ATE165354T1 (de) | 1994-12-21 | 1995-11-27 | Lactone mit antioxidativer und hypolipidaemischer wirkung zur behandlung von atherosklerose |
| EP95118629A EP0718295B1 (en) | 1994-12-21 | 1995-11-27 | Lactones with antioxidising and hypolipidaemic activity useful in the therapy of the atherosclerosis |
| DE69502168T DE69502168T2 (de) | 1994-12-21 | 1995-11-27 | Lactone mit antioxidativer und hypolipidaemischer Wirkung zur Behandlung von Atherosklerose |
| ES95118629T ES2115308T3 (es) | 1994-12-21 | 1995-11-27 | Lactonas con actividad antioxidante e hipolipidemica, utiles en la terapia de la aterosclerosis. |
| DK95118629T DK0718295T3 (da) | 1994-12-21 | 1995-11-27 | Lactoner med antioxiderende og hypolipidæmisk virkning, hvilke lactoner er nyttige i terapien af atherosklerose |
| JP7332407A JP2820652B2 (ja) | 1994-12-21 | 1995-12-20 | アテローム性動脈硬化症治療に有用な抗酸化活性および脂質低下活性を有するラクトン |
| GR980400836T GR3026702T3 (en) | 1994-12-21 | 1998-04-23 | Lactones with antioxidising and hypolipidaemic activity useful in the therapy of the atherosclerosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITBO940562A IT1274355B (it) | 1994-12-21 | 1994-12-21 | Lattoni ad attivita' antiossidante ed ipolipidemica utili nella terapia dell'aterosclerosi |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITBO940562A0 ITBO940562A0 (it) | 1994-12-21 |
| ITBO940562A1 ITBO940562A1 (it) | 1996-06-21 |
| IT1274355B true IT1274355B (it) | 1997-07-17 |
Family
ID=11340165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITBO940562A IT1274355B (it) | 1994-12-21 | 1994-12-21 | Lattoni ad attivita' antiossidante ed ipolipidemica utili nella terapia dell'aterosclerosi |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5608084A (it) |
| EP (1) | EP0718295B1 (it) |
| JP (1) | JP2820652B2 (it) |
| AT (1) | ATE165354T1 (it) |
| DE (1) | DE69502168T2 (it) |
| DK (1) | DK0718295T3 (it) |
| ES (1) | ES2115308T3 (it) |
| GR (1) | GR3026702T3 (it) |
| IT (1) | IT1274355B (it) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6680340B2 (en) * | 2000-08-21 | 2004-01-20 | Merck & Co., Inc. | Anti-hypercholesterolemic drug combination |
| DE10261067A1 (de) * | 2002-12-24 | 2004-08-05 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | Cholesterinsenkendes Mittel, enthaltend eine n-3-Fettsäure |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3674836A (en) * | 1968-05-21 | 1972-07-04 | Parke Davis & Co | 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof |
| US4665091A (en) * | 1985-11-04 | 1987-05-12 | Merck & Co., Inc. | Macrocyclic lactone HMG-CoA reductase inhibitors |
| US5196447A (en) * | 1991-08-08 | 1993-03-23 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting On Behalf Of Arizona State University | Neristatin 1 |
-
1994
- 1994-12-21 IT ITBO940562A patent/IT1274355B/it active IP Right Grant
-
1995
- 1995-11-13 US US08/556,648 patent/US5608084A/en not_active Expired - Fee Related
- 1995-11-27 ES ES95118629T patent/ES2115308T3/es not_active Expired - Lifetime
- 1995-11-27 EP EP95118629A patent/EP0718295B1/en not_active Expired - Lifetime
- 1995-11-27 DE DE69502168T patent/DE69502168T2/de not_active Expired - Fee Related
- 1995-11-27 DK DK95118629T patent/DK0718295T3/da active
- 1995-11-27 AT AT95118629T patent/ATE165354T1/de not_active IP Right Cessation
- 1995-12-20 JP JP7332407A patent/JP2820652B2/ja not_active Expired - Lifetime
-
1998
- 1998-04-23 GR GR980400836T patent/GR3026702T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0718295B1 (en) | 1998-04-22 |
| ITBO940562A0 (it) | 1994-12-21 |
| JPH08231535A (ja) | 1996-09-10 |
| DK0718295T3 (da) | 1999-01-11 |
| DE69502168D1 (de) | 1998-05-28 |
| ES2115308T3 (es) | 1998-06-16 |
| ATE165354T1 (de) | 1998-05-15 |
| GR3026702T3 (en) | 1998-07-31 |
| DE69502168T2 (de) | 1998-08-13 |
| US5608084A (en) | 1997-03-04 |
| ITBO940562A1 (it) | 1996-06-21 |
| EP0718295A1 (en) | 1996-06-26 |
| JP2820652B2 (ja) | 1998-11-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |