IT1271453B - New tetracyclic diazepin cpds. - for treating viral infections, partic. for treating HIV infections - Google Patents
New tetracyclic diazepin cpds. - for treating viral infections, partic. for treating HIV infectionsInfo
- Publication number
- IT1271453B IT1271453B ITFI930007A IT1271453B IT 1271453 B IT1271453 B IT 1271453B IT FI930007 A ITFI930007 A IT FI930007A IT 1271453 B IT1271453 B IT 1271453B
- Authority
- IT
- Italy
- Prior art keywords
- treating
- diazepin
- cpds
- alkyl
- infections
- Prior art date
Links
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 title abstract 2
- 208000031886 HIV Infections Diseases 0.000 title 1
- 208000036142 Viral infection Diseases 0.000 title 1
- 230000009385 viral infection Effects 0.000 title 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- -1 acetamino Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000005257 alkyl acyl group Chemical group 0.000 abstract 2
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Tetracyclic diazepin cpds. of formula (I) are new; n = 0 or 1; X = =CH, =CR6, O, S or NR7; Z = N, opt. substd. by R2; or with =C-R5 Z is NO2, CN or azido; R5 = H, 1-3C alkyl, 1-3C hydroxyalkyl, 1-3 alkoxy, halo, trihalomethyl, OH, NH2 or acetamino; W = C=O, C=S or SO2; R1, R2 = halo, 1-6C alkyl, 1-6C fluoroalkyl, 3-5C cycloalkyl, 3-5C alkenyl or alkynyl, 2-6C alkoxy-alkyl, benzyl, 2-6C alkylacyl, phenylacyl wherein the phenyl is opt. substd. by NO2, CN or halo; R8, R9, R4, R6 = H, 1-3C alkyl, 1-3C hydroxy alkyl, 1-3C alkoxy, halo, trihalomethyl, OH, NH2, acetamino, NO2, CN or azido; or R8 + R9 = a gp. of formula (i). R3 = R4; A = N or -CR5; B = A, but cannot be =CR5 when A is =CR5; R7 = H, 1-3C alkyl, 2-6C alkylacyl, phenylacyl wherein the phenyl is opt. substd. by NO2, CN, halo; the ring having substits. R8 and R9 can be opt. or partially satd.; with provisos.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT93FI7 IT1271453B (en) | 1993-01-20 | 1993-01-20 | New tetracyclic diazepin cpds. - for treating viral infections, partic. for treating HIV infections |
| PCT/EP1994/000102 WO1994017075A1 (en) | 1993-01-20 | 1994-01-17 | Diazepin derivatives and antiviral compositions |
| AU58837/94A AU5883794A (en) | 1993-01-20 | 1994-01-17 | Diazepin derivatives and antiviral compositions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT93FI7 IT1271453B (en) | 1993-01-20 | 1993-01-20 | New tetracyclic diazepin cpds. - for treating viral infections, partic. for treating HIV infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITFI930007A0 ITFI930007A0 (en) | 1993-01-20 |
| ITFI930007A1 ITFI930007A1 (en) | 1994-07-20 |
| IT1271453B true IT1271453B (en) | 1997-05-28 |
Family
ID=11350289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT93FI7 IT1271453B (en) | 1993-01-20 | 1993-01-20 | New tetracyclic diazepin cpds. - for treating viral infections, partic. for treating HIV infections |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1271453B (en) |
-
1993
- 1993-01-20 IT IT93FI7 patent/IT1271453B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITFI930007A1 (en) | 1994-07-20 |
| ITFI930007A0 (en) | 1993-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19960130 |