IT1166614B - 2-Methoxy-phenoxy:acetate of talampicillin - prepd. by hydrolysis of metampicillin phthalidyl ester in two-phase solvent and treatment of aq. phase with 2-methoxy-phenoxyacetic acid sal - Google Patents
2-Methoxy-phenoxy:acetate of talampicillin - prepd. by hydrolysis of metampicillin phthalidyl ester in two-phase solvent and treatment of aq. phase with 2-methoxy-phenoxyacetic acid salInfo
- Publication number
- IT1166614B IT1166614B IT1989679A IT1989679A IT1166614B IT 1166614 B IT1166614 B IT 1166614B IT 1989679 A IT1989679 A IT 1989679A IT 1989679 A IT1989679 A IT 1989679A IT 1166614 B IT1166614 B IT 1166614B
- Authority
- IT
- Italy
- Prior art keywords
- methoxy
- phase
- treatment
- metampicillin
- talampicillin
- Prior art date
Links
- -1 2-Methoxy-phenoxy Chemical group 0.000 title abstract 3
- IHONYPFTXGQWAX-UHFFFAOYSA-N 2-(2-methoxyphenoxy)acetic acid Chemical compound COC1=CC=CC=C1OCC(O)=O IHONYPFTXGQWAX-UHFFFAOYSA-N 0.000 title abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 title 1
- 230000007062 hydrolysis Effects 0.000 title 1
- 238000006460 hydrolysis reaction Methods 0.000 title 1
- 229960003806 metampicillin Drugs 0.000 title 1
- 239000002904 solvent Substances 0.000 title 1
- 229960002780 talampicillin Drugs 0.000 title 1
- SOROUYSPFADXSN-SUWVAFIASA-N talampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(=O)OC2C3=CC=CC=C3C(=O)O2)(C)C)=CC=CC=C1 SOROUYSPFADXSN-SUWVAFIASA-N 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 abstract 2
- 229960000723 ampicillin Drugs 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 235000019658 bitter taste Nutrition 0.000 abstract 1
- 230000036765 blood level Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- RBKMMJSQKNKNEV-RITPCOANSA-N penicillanic acid Chemical compound OC(=O)[C@H]1C(C)(C)S[C@@H]2CC(=O)N21 RBKMMJSQKNKNEV-RITPCOANSA-N 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The 2-methoxyphenoxyacetate of the phthalidyl ester of 6- D(-)-alpha-aminophenylacetamido)penicillanic acid of formula (I) is new (I) is a stable white powder which readily lends itself to formation of pharmaceutical tablets and powders (e.g. for preparing oral syrups). Unlike the hydrochloride it does not have a bitter taste (and so tablets need not be coated) and it is well absorbed to give high blood levels of ampicillin. (I) is used in unit doses of 20-1000 mg., esp. 160, 320 or 480 mg (corresp. to doses of 125, 250 or 375 mg of the hydrochloride) for treatment of infections caused by microorganisms sensitive to ampicillin.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1989679A IT1166614B (en) | 1979-02-05 | 1979-02-05 | 2-Methoxy-phenoxy:acetate of talampicillin - prepd. by hydrolysis of metampicillin phthalidyl ester in two-phase solvent and treatment of aq. phase with 2-methoxy-phenoxyacetic acid sal |
| EP80400168A EP0014651B1 (en) | 1979-02-05 | 1980-02-04 | Talampicillin 2-methoxyphenoxy acetate, process for its preparation and medicaments containing it |
| DE8080400168T DE3060716D1 (en) | 1979-02-05 | 1980-02-04 | Talampicillin 2-methoxyphenoxy acetate, process for its preparation and medicaments containing it |
| US06/161,687 US4293560A (en) | 1979-02-05 | 1980-06-23 | Talampicillin 2-methoxyphenoxyacetate and pharmaceutical compositions containing it |
| BE0/201271A BE884126A (en) | 1979-02-05 | 1980-07-02 | 2-METHOXYPHENOXYACETATE OF TALAMPICILLIN, PROCESS FOR ITS PREPARATION AND MEDICAMENTS CONTAINING IT |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1989679A IT1166614B (en) | 1979-02-05 | 1979-02-05 | 2-Methoxy-phenoxy:acetate of talampicillin - prepd. by hydrolysis of metampicillin phthalidyl ester in two-phase solvent and treatment of aq. phase with 2-methoxy-phenoxyacetic acid sal |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT7919896A0 IT7919896A0 (en) | 1979-02-05 |
| IT1166614B true IT1166614B (en) | 1987-05-05 |
Family
ID=11162143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT1989679A IT1166614B (en) | 1979-02-05 | 1979-02-05 | 2-Methoxy-phenoxy:acetate of talampicillin - prepd. by hydrolysis of metampicillin phthalidyl ester in two-phase solvent and treatment of aq. phase with 2-methoxy-phenoxyacetic acid sal |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE3060716D1 (en) |
| IT (1) | IT1166614B (en) |
-
1979
- 1979-02-05 IT IT1989679A patent/IT1166614B/en active
-
1980
- 1980-02-04 DE DE8080400168T patent/DE3060716D1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IT7919896A0 (en) | 1979-02-05 |
| DE3060716D1 (en) | 1982-09-30 |
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