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IT1165076B - 5-Pyridoxinyl ester derivs. of pharmaceutically active acids - useful as antiinflammatories, analgesics and antipyretics - Google Patents

5-Pyridoxinyl ester derivs. of pharmaceutically active acids - useful as antiinflammatories, analgesics and antipyretics

Info

Publication number
IT1165076B
IT1165076B IT2293279A IT2293279A IT1165076B IT 1165076 B IT1165076 B IT 1165076B IT 2293279 A IT2293279 A IT 2293279A IT 2293279 A IT2293279 A IT 2293279A IT 1165076 B IT1165076 B IT 1165076B
Authority
IT
Italy
Prior art keywords
antiinflammatories
propionic
pyridoxinyl
antipyretics
analgesics
Prior art date
Application number
IT2293279A
Other languages
Italian (it)
Other versions
IT7922932A0 (en
Inventor
Reiner Alberto
Original Assignee
Crinos Industria Farmaco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crinos Industria Farmaco filed Critical Crinos Industria Farmaco
Publication of IT7922932A0 publication Critical patent/IT7922932A0/en
Priority to IT2293279A priority Critical patent/IT1165076B/en
Priority to US06/054,613 priority patent/US4233304A/en
Priority to AU48643/79A priority patent/AU514304B2/en
Priority to YU1753/79A priority patent/YU42488B/en
Priority to NLAANVRAGE7905774,A priority patent/NL185454C/en
Priority to AT0517679A priority patent/AT373582B/en
Priority to GB7926223A priority patent/GB2027022B/en
Priority to CH6972/79A priority patent/CH650774A5/en
Priority to DK320479A priority patent/DK156651C/en
Priority to MX798273U priority patent/MX5955E/en
Priority to ES482949A priority patent/ES482949A1/en
Priority to PT70002A priority patent/PT70002A/en
Priority to MX797079A priority patent/MX155145A/en
Priority to NO792511A priority patent/NO151933C/en
Priority to SE7906440A priority patent/SE431645B/en
Priority to CA332,909A priority patent/CA1123829A/en
Priority to DE19792931105 priority patent/DE2931105A1/en
Priority to FR7919714A priority patent/FR2433516A1/en
Priority to US06/131,020 priority patent/US4260613A/en
Priority to AT388582A priority patent/AT373583B/en
Priority to YU322/83A priority patent/YU42070B/en
Application granted granted Critical
Publication of IT1165076B publication Critical patent/IT1165076B/en

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  • Pyridine Compounds (AREA)

Abstract

Pyridoxine derivs. of formula (I) and their acid addn. salts are new: (R = H, or both R together are isopropylidene. R1 is the residue of one of the acids: 2-hydroxybenzoic, 2- (2,3-dimethylphenyl)amino benzoic, 4-allylloxy-3-chlorophenyl acetic, 2-(3-benzoylphenyl)propionic, 2-(4- isobutylphenyl) propionic, d-2-(6-methoxy-2-naphthyl)propionic, 2- 3-trifluoromethylphenylamino benzoic or 2- 3-trifluoromethylphenylamino nicotinic). They are made from isopropylidene-pyridoxine by reacting with an appropriate R1H deriv., then opt. hydrolysing. (I) are antiinflammatories, some also have analgesic and/or antipyretic effects. Compared with R1H they have lower toxicity and ulcerogenic effect, and have a partic. long-lasting action so smaller doses can be used. (I; R1 = 2-(4-isobutyphenyl)propionyl and both R = H; cpd. (Ia) has oral LD50 in mice >2g/kg and 50% ulcerogenic dose 365 mg/kg, c.f. 800 and 38 mg/kg for the corresp. acid.
IT2293279A 1978-07-31 1979-05-23 5-Pyridoxinyl ester derivs. of pharmaceutically active acids - useful as antiinflammatories, analgesics and antipyretics IT1165076B (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
IT2293279A IT1165076B (en) 1979-05-23 1979-05-23 5-Pyridoxinyl ester derivs. of pharmaceutically active acids - useful as antiinflammatories, analgesics and antipyretics
US06/054,613 US4233304A (en) 1978-07-31 1979-07-03 Pyridoxine derivatives
AU48643/79A AU514304B2 (en) 1978-07-31 1979-07-04 Pyridoxine derivatives
YU1753/79A YU42488B (en) 1978-07-31 1979-07-18 Process for obtaining a new pyridoxine derivative
NLAANVRAGE7905774,A NL185454C (en) 1978-07-31 1979-07-25 ESTER DERIVATIVE OF AN ANTI-INFLAMMATIC ACTIVE CARBONIC ACID, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL PREPARATION WITH ANTI-INFLAMMATIC EFFECT.
AT0517679A AT373582B (en) 1978-07-31 1979-07-26 METHOD FOR PRODUCING NEW PYRIDOXINE DERIVATIVES AND THEIR SALTS
GB7926223A GB2027022B (en) 1978-07-31 1979-07-27 Pyridoxine derivatives and their use
CH6972/79A CH650774A5 (en) 1978-07-31 1979-07-27 PYRIDOXY DERIVATIVES FOR PHARMACOLOGICAL ACTIVITY.
ES482949A ES482949A1 (en) 1978-07-31 1979-07-30 Pyridoxine derivatives
MX798273U MX5955E (en) 1978-07-31 1979-07-30 PROCEDURE FOR THE PREPARATION OF PIRIDOXINE DERIVATIVES
DK320479A DK156651C (en) 1978-07-31 1979-07-30 METHOD OF ANALOGY FOR PREPARING PYRIDOXIN DERIVATIVES
PT70002A PT70002A (en) 1978-07-31 1979-07-30 Process for preparing novel pyridoxine derivatives
MX797079A MX155145A (en) 1978-07-31 1979-07-30 PROCEDURE FOR THE PREPARATION OF PIRIDOXINE DERIVATIVES
NO792511A NO151933C (en) 1978-07-31 1979-07-30 ANALOGY PROCEDURE FOR THE PREPARATION OF ANTI-INFLAMMATORALLY EFFECTIVE PYRIDOX INGREDIATES
SE7906440A SE431645B (en) 1978-07-31 1979-07-30 PYRIDOXIN DERIVATIVE AND PHARMACEUTICAL COMPOSITION WITH ANTI-INFLAMMATORY ACTIVITY AND ANY ANALGETIC AND / OR ANTI-PYRETIC ACTIVITY
CA332,909A CA1123829A (en) 1978-07-31 1979-07-31 Pyridoxine derivatives
DE19792931105 DE2931105A1 (en) 1978-07-31 1979-07-31 PYRIDOXINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, MEDICINAL PRODUCTS CONTAINING THEM AND THEIR USE IN THE TREATMENT OF INFLAMMATION STATES
FR7919714A FR2433516A1 (en) 1978-07-31 1979-07-31 PYRIDOXINS, THEIR PREPARATION AND THEIR THERAPEUTIC USES
US06/131,020 US4260613A (en) 1978-07-31 1980-03-17 Pyridoxine derivatives
AT388582A AT373583B (en) 1978-07-31 1982-10-22 METHOD FOR PRODUCING NEW PYRIDOXINE DERIVATIVES AND THEIR SALTS
YU322/83A YU42070B (en) 1978-07-31 1983-02-11 Process for obtaining a new pyridoxine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2293279A IT1165076B (en) 1979-05-23 1979-05-23 5-Pyridoxinyl ester derivs. of pharmaceutically active acids - useful as antiinflammatories, analgesics and antipyretics

Publications (2)

Publication Number Publication Date
IT7922932A0 IT7922932A0 (en) 1979-05-23
IT1165076B true IT1165076B (en) 1987-04-22

Family

ID=11202022

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2293279A IT1165076B (en) 1978-07-31 1979-05-23 5-Pyridoxinyl ester derivs. of pharmaceutically active acids - useful as antiinflammatories, analgesics and antipyretics

Country Status (1)

Country Link
IT (1) IT1165076B (en)

Also Published As

Publication number Publication date
IT7922932A0 (en) 1979-05-23

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950504