[go: up one dir, main page]

IN2015DN01609A - - Google Patents

Download PDF

Info

Publication number
IN2015DN01609A
IN2015DN01609A IN1609DEN2015A IN2015DN01609A IN 2015DN01609 A IN2015DN01609 A IN 2015DN01609A IN 1609DEN2015 A IN1609DEN2015 A IN 1609DEN2015A IN 2015DN01609 A IN2015DN01609 A IN 2015DN01609A
Authority
IN
India
Prior art keywords
presented
methods
amplicons
approaches
quantifying
Prior art date
Application number
Other languages
English (en)
Inventor
Imran R Malik
Xiomara L Madero
Erika F Garcia
Sheel M Shah
Axel Scherer
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Publication of IN2015DN01609A publication Critical patent/IN2015DN01609A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Algebra (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Physics (AREA)
  • Pure & Applied Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Time-Division Multiplex Systems (AREA)
IN1609DEN2015 2012-08-03 2013-08-02 IN2015DN01609A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261679547P 2012-08-03 2012-08-03
PCT/US2013/053512 WO2014022827A1 (fr) 2012-08-03 2013-08-02 Multiplexage et quantification dans pcr avec exigences et matériel réduits

Publications (1)

Publication Number Publication Date
IN2015DN01609A true IN2015DN01609A (fr) 2015-07-03

Family

ID=50025861

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1609DEN2015 IN2015DN01609A (fr) 2012-08-03 2013-08-02

Country Status (5)

Country Link
US (3) US9791372B2 (fr)
EP (2) EP3901243A1 (fr)
CN (2) CN104662172B (fr)
IN (1) IN2015DN01609A (fr)
WO (1) WO2014022827A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4361608A3 (fr) 2012-02-03 2024-07-24 California Institute of Technology Codage et décodage de signaux dans des dosages biochimiques multiplexés
EP3901243A1 (fr) 2012-08-03 2021-10-27 California Institute of Technology Multiplexage et quantification dans pcr avec exigences et matériel réduits
WO2015147370A1 (fr) 2014-03-28 2015-10-01 Seegene, Inc. Détection de séquences d'acide nucléique cible à l'aide de différentes températures de détection
DE102014105129B3 (de) * 2014-04-10 2015-07-02 Kist Europe-Korea Institute of Science and Technologie Europe Forschungsgesellschaft mbh Verfahren und Master-Mix für die quantitative Echtzeit-PCR für Multiplex-Ziel-Nukleinsäuremoleküle
CN103884679B (zh) * 2014-04-18 2016-01-20 山西大学 结合卡尔曼滤波器的腔衰荡光谱技术气体浓度监测方法
CN107208139B (zh) 2014-12-09 2020-11-10 Seegene株式会社 与靶核酸序列有关的信号的分辨
EP3130679B1 (fr) * 2015-08-13 2018-02-28 Cladiac GmbH Procede et systeme d'essai destines a la verification et/ou la quantification d'un acide nucleique cible dans un echantillon
WO2017218777A1 (fr) 2016-06-17 2017-12-21 California Institute Of Technology Réactions d'acides nucléiques et procédés et compositions associés
WO2018119443A1 (fr) * 2016-12-23 2018-06-28 The Regents Of The University Of California Procédé et dispositif de fusion numérique haute résolution
US20190112636A1 (en) * 2017-10-16 2019-04-18 ChromaCode, Inc. Methods and compositions for nucleic acid detection
US12454720B2 (en) 2018-04-17 2025-10-28 ChromaCode, Inc. Methods and systems for multiplex analysis
CN108841939B (zh) * 2018-06-21 2020-09-22 北京致雨生物科技有限公司 多重数字pcr浓度测量方法及微滴式数字pcr系统
US12203129B2 (en) 2018-07-03 2025-01-21 ChromaCode, Inc. Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays
JP7221491B2 (ja) * 2018-09-18 2023-02-14 株式会社ミズホメディー 複数の標的核酸を検出するキットを用いる検出方法
EP3999624A4 (fr) 2019-07-16 2023-02-22 Meliolabs Inc. Procédés et dispositifs pour fusion haute résolution numérique à cellule unique
WO2025235889A1 (fr) * 2024-05-10 2025-11-13 Guardant Health, Inc. Procédés impliquant une pcr groupée multiplexée

Family Cites Families (152)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE88761T1 (de) 1986-01-10 1993-05-15 Amoco Corp Kompetitiver homogener test.
US6127155A (en) 1986-08-22 2000-10-03 Roche Molecular Systems, Inc. Stabilized thermostable nucleic acid polymerase compositions containing non-ionic polymeric detergents
US5618711A (en) 1986-08-22 1997-04-08 Hoffmann-La Roche Inc. Recombinant expression vectors and purification methods for Thermus thermophilus DNA polymerase
US5079351A (en) 1986-11-26 1992-01-07 Cetus Corporation Oligonucleotides and kits for detection of htlvi and htlvii viruses by hybridization
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
ES2091976T3 (es) 1991-06-20 1996-11-16 Hoffmann La Roche Metodos perfeccionados para la amplificacion del acido nucleico.
DE69333650T2 (de) 1992-02-19 2006-01-12 The Public Health Research Institute Of The City Of New York, Inc. Neue anordnungn von oligonukleotiden und ihr nutzen zum sortieren, isolieren, sequenzieren und manipulieren von nukleinsäuren
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5948360A (en) 1994-07-11 1999-09-07 Tekmar Company Autosampler with robot arm
EP0807816A4 (fr) 1995-02-02 1999-09-22 Chugai Pharmaceutical Co Ltd Procede pour tester la substance d'un echantillon en ajustant la dose de chimioluminescence
CN1181720A (zh) 1995-04-25 1998-05-13 伊萝莉公司 可远程编程的存储器材料及其应用
AU693023B2 (en) 1995-05-05 1998-06-18 Applied Biosystems, Llc Methods and reagents for combined PCR amplification and hybridization probing assay
US5882856A (en) 1995-06-07 1999-03-16 Genzyme Corporation Universal primer sequence for multiplex DNA amplification
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
US20050112637A1 (en) 1995-09-08 2005-05-26 Chatterjee Deb K. Mutant DNA polymerases and uses thereof
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US6007994A (en) 1995-12-22 1999-12-28 Yale University Multiparametric fluorescence in situ hybridization
AU2324997A (en) 1996-03-15 1997-10-01 Penn State Research Foundation, The Detection of extracellular tumor-associated nucleic acid in blood plasma or ser um using nucleic acid amplification assays
ES2347854T5 (es) 1996-03-26 2014-07-24 Michael S. Kopreski Método que permite el uso de RNA extracelular extraído de plasma o suero para detectar, monitorizar o evaluar un cáncer
DE69739357D1 (de) 1996-06-04 2009-05-28 Univ Utah Res Found Überwachung der hybridisierung während pcr
US5834203A (en) * 1997-08-25 1998-11-10 Applied Spectral Imaging Method for classification of pixels into groups according to their spectra using a plurality of wide band filters and hardwire therefore
JP4357112B2 (ja) 1997-10-14 2009-11-04 ルミネックス コーポレイション 精密蛍光染色された粒子及びその製造及び使用方法
US6235480B1 (en) 1998-03-13 2001-05-22 Promega Corporation Detection of nucleic acid hybrids
AU3555599A (en) 1998-04-13 1999-11-01 Luminex Corporation Liquid labeling with fluorescent microparticles
CA2335951C (fr) 1998-06-24 2013-07-30 Mark S. Chee Decodage de detecteurs matriciels a microspheres
DE69941333D1 (de) 1998-07-02 2009-10-08 Gen Probe Inc Molekulare fackeln
US6642062B2 (en) 1998-09-03 2003-11-04 Trellis Bioinformatics, Inc. Multihued labels
JP2002542793A (ja) 1999-04-22 2002-12-17 ザ アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ 多蛍光ｆｉｓｈによる遺伝子発現パターンのアッセイ法
NZ531466A (en) 1999-07-23 2005-06-24 Sec Dep Home Dept Use of single nucleotide polymorphisms (SNPs) to identify individuals in forensic investigations
CA2387306C (fr) 1999-10-22 2010-04-27 The Public Health Research Institute Of The City Of New York, Inc. Dosages de variantes de sequences courtes
US6506568B2 (en) * 2000-02-10 2003-01-14 The Penn State Research Foundation Method of analyzing single nucleotide polymorphisms using melting curve and restriction endonuclease digestion
US20040053230A1 (en) 2001-03-07 2004-03-18 Schaffer Michael Edward Real time quantitative pcr with intercalating dye for single and multiplex target dna
US7348141B2 (en) 2000-03-29 2008-03-25 Lgc Limited Hybridization beacon and method of rapid sequence detection and discrimination
US6759235B2 (en) 2000-04-06 2004-07-06 Quantum Dot Corporation Two-dimensional spectral imaging system
CA2314398A1 (fr) 2000-08-10 2002-02-10 Edward Shipwash Jeux ordonnes de microechantillons et microsystemes pour l'analyse d'acides amines et le sequencage de proteines
US20020142345A1 (en) 2000-12-22 2002-10-03 Nelsen Anita J. Methods for encoding and decoding complex mixtures in arrayed assays
CA2445960A1 (fr) 2001-02-21 2002-12-19 Amnis Corporation Procede et dispositif servant a marquer et a analyser des constituants cellulaires
WO2002070751A1 (fr) 2001-03-02 2002-09-12 University Of Pittsburgh Of The Commonwealth System Of Higher Education Procede de reaction en chaine de la polymerase
AU2002322457A1 (en) 2001-06-28 2003-03-03 Illumina, Inc. Multiplex decoding of array sensors with microspheres
JP2005508493A (ja) 2001-06-28 2005-03-31 アドヴァンスト リサーチ アンド テクノロジー インスティテュート、インコーポレイティッド 多色量子ドット標識ビーズおよびそのコンジュゲートの製造方法
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
EP1288308A1 (fr) 2001-08-28 2003-03-05 Roche Diagnostics GmbH Procédé de détermination d'analytes multiples
US6852491B2 (en) 2001-09-04 2005-02-08 Abbott Laboratories Amplification and detection reagents for HIV-1
US20030134320A1 (en) 2002-01-15 2003-07-17 Myriad Genetics, Incorporated Method system and computer program product for quality assurance in detecting biochemical markers
EP1426448A1 (fr) 2002-12-03 2004-06-09 bioMérieux BV Procédé pour réduire les effects des variations de séquence dans un procédé d'hybridisation diagnostique, sonde de l'usage dans un tel procédé, et procédé
ES2384170T3 (es) 2003-04-04 2012-07-02 F. Hoffmann-La Roche Ag Sistema mejorado de PCR multicolor a tiempo real
US7385043B1 (en) 2003-04-30 2008-06-10 The Public Health Research Institute Of The City Of New York, Inc. Homogeneous multiplex screening assays and kits
US20050053950A1 (en) 2003-09-08 2005-03-10 Enrique Zudaire Ubani Protocol and software for multiplex real-time PCR quantification based on the different melting temperatures of amplicons
US20050064435A1 (en) 2003-09-24 2005-03-24 Xing Su Programmable molecular barcodes
JP2007534308A (ja) 2003-11-19 2007-11-29 アレロジック・バイオサイエンシズ・コーポレーション 複数のフルオロフォアで標識したオリゴヌクレオチド
TWI232934B (en) 2003-11-19 2005-05-21 Ind Tech Res Inst A biochip containing splitable reaction confinement and method for producing same and application thereof
JP2007530051A (ja) 2004-03-24 2007-11-01 アプレラ コーポレイション 標的分子を決定するためのライゲーション反応および増幅反応
CA2560945C (fr) 2004-04-01 2013-06-18 Bio-Rad Laboratories, Inc. Amplification quantitative a l'aide d'une sonde etiquetee et activite exonuclease 3'-5'
ES2527426T3 (es) 2004-05-07 2015-01-23 Cepheid Detección combinada de agentes biológicos
US7575864B2 (en) 2004-05-27 2009-08-18 E.I. Du Pont De Nemours And Company Method for the direct detection of diagnostic RNA
DE102004043870B4 (de) 2004-09-10 2009-11-19 Eppendorf Ag Verfahren zur Erweiterung des dynamischen Erfassungsbereich bei Mikroarrays
EP1799853A2 (fr) 2004-09-24 2007-06-27 Universität Bern Balises moleculaires
RU2460804C2 (ru) * 2004-10-18 2012-09-10 Брандейс Юнивесити Способ гомогенной детекции по меньшей мере одного продукта одноцепочечной амплификации
KR20070073935A (ko) 2004-10-27 2007-07-10 세페이드 폐쇄 시스템의 다단계 핵산 증폭 반응
EP1838880A2 (fr) 2005-01-21 2007-10-03 Third Wave Technologies, Inc. Procédés et compositions pour détection à plage dynamique augmentée de molécules d'acide nucléique
US7507575B2 (en) * 2005-04-01 2009-03-24 3M Innovative Properties Company Multiplex fluorescence detection device having removable optical modules
US7709249B2 (en) * 2005-04-01 2010-05-04 3M Innovative Properties Company Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
AU2005333512A1 (en) 2005-06-16 2006-12-28 Biotools Biotechnological & Medical Laboratories, S.A. Nucleic acid detection method involving the direct generation of a measurable signal
US20070072211A1 (en) 2005-06-30 2007-03-29 Roche Molecular Systems, Inc. Asymmetric PCR coupled with post-PCR characterization for the identification of nucleic acids
EP1937834B1 (fr) 2005-09-01 2014-06-11 AusDiagnostics Pty Ltd. Procedes pour l'amplification, la quantification et l'identification d'acides nucleiques
US7553955B2 (en) 2005-09-01 2009-06-30 The Trustees Of The University Of Pennsylvania Molecular beacons, methods and kits for detecting DNA damage response
CN1936019B (zh) 2005-10-18 2013-01-30 厦门大学 用于多重实时核酸扩增检测的探针编码方法
EP1963500B1 (fr) 2005-12-23 2013-02-13 Nanostring Technologies, Inc. Compositions comprenant des macromolecules immobilisees et orientees et leurs procedes de preparation
WO2007076129A2 (fr) 2005-12-23 2007-07-05 Nanostring Technologies, Inc. Nanorapporteurs et procedes de production et d'utilisation de ceux-ci
US9133506B2 (en) 2006-01-10 2015-09-15 Applied Spectral Imaging Ltd. Methods and systems for analyzing biological samples
US8455184B2 (en) 2006-04-18 2013-06-04 The United States Of America As Represented By The Secretary Of The Air Force Differential multiplexing with pattern recognition
CN101495654A (zh) 2006-04-19 2009-07-29 阿普里拉股份有限公司 无凝胶珠基测序的试剂、方法和文库
AU2007268027B2 (en) 2006-05-22 2012-08-09 Bruker Spatial Biology, Inc. Systems and methods for analyzing nanoreporters
WO2007137291A1 (fr) 2006-05-23 2007-11-29 Molecular Detection, Inc. Kits stables à la température ambiante pour des diagnostics moléculaires
US7608399B2 (en) 2006-06-26 2009-10-27 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
WO2008014485A2 (fr) 2006-07-28 2008-01-31 California Institute Of Technology Ensembles de pcr-q multiplex
US8187541B2 (en) 2006-09-18 2012-05-29 California Institute Of Technology Apparatus for detecting target molecules and related methods
EP2407558A1 (fr) 2006-10-31 2012-01-18 Noxxon Pharma AG Procédés de détection d'une molécule d'acide nucléique à double ou simple brin
US9201063B2 (en) 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
EP2102773B1 (fr) 2006-11-30 2012-08-01 Gen-Probe Incorporated Procédé de quantification utilisant l'ajustement de courbes d'étalonnage mères prédéfinies
KR101433208B1 (ko) * 2006-12-13 2014-08-22 루미넥스 코포레이션 실시간으로 ｐｃｒ의 다중 분석을 위한 시스템과 방법
CA2580589C (fr) 2006-12-19 2016-08-09 Fio Corporation Systeme de detection microfluidique
EP2132334A4 (fr) 2007-03-05 2010-07-28 Univ Utah Res Found Procédés et compositions associés à la détection d'acides nucléiques
WO2008118998A2 (fr) 2007-03-27 2008-10-02 Primera Biosystems Inc. Procédé de détection multiplex et de quantification d'acides nucléiques
EP2155899A2 (fr) 2007-04-10 2010-02-24 Nanostring Technologies, Inc. Procédés et systèmes informatiques pour identifier des séquences spécifiques d'une cible afin de les utiliser dans des nanoreporteurs
WO2009003493A2 (fr) 2007-07-03 2009-01-08 Dako Denmark A/S Procédés compilés pour analyser et trier des échantillons
CN101821609A (zh) * 2007-08-29 2010-09-01 艾本德股份有限公司 用于多个样品的辐射度测量的设备和方法
EP2195453A4 (fr) 2007-09-20 2011-02-02 Molecular Plant Breeding Nominees Ltd Procédé d'amplification d'un acide nucléique
WO2009081967A1 (fr) 2007-12-26 2009-07-02 Arkray, Inc. Procédé pour l'amplification d'une séquence d'acide nucléique cible et sonde utilisée à cet effet
EP2336358A1 (fr) 2008-05-06 2011-06-22 QIAGEN GmbH Détection simultanée de plusieurs séquences d'acide nucléique dans une réaction
GB0812862D0 (en) 2008-07-14 2008-08-20 Lumora Ltd Nucleic acid amplification
US9234232B2 (en) 2008-07-31 2016-01-12 Oxitec Limited Multiplex amplification and detection
KR20110052681A (ko) * 2008-08-08 2011-05-18 스미스 디텍션 인크. Ｐｃｒ 검정을 위한 검출 알고리즘
EP2331704B1 (fr) 2008-08-14 2016-11-30 Nanostring Technologies, Inc Nanoreporteurs stables
US9921154B2 (en) 2011-03-18 2018-03-20 Bio-Rad Laboratories, Inc. Multiplexed digital assays
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
RU2011125332A (ru) * 2008-11-21 2012-12-27 Конинклейке Филипс Электроникс Н.В. Определение множественной пцр в реальном времени на твердых поверхностях с использованием красителей со специфичностью к двухцепочечным нуклеиновым кислотам
CN102232118B (zh) 2008-12-01 2015-07-08 恰根有限公司 用于核酸检测的新型荧光染料组合物
US9534255B2 (en) 2008-12-17 2017-01-03 Life Technologies Corporation Methods, compositions, and kits for detecting allelic variants
CN107083444B (zh) * 2008-12-22 2023-03-14 犹他大学研究基金会 单色多重定量pcr
US8361738B2 (en) 2009-03-06 2013-01-29 California Institute Of Technology Methods for quantitative target detection and related devices and systems
US8039215B2 (en) 2009-03-10 2011-10-18 Roche Molecular Systems, Inc. Multiplex quantitative nucleic acid amplification and melting assay
CN101570782B (zh) 2009-03-20 2012-01-11 曹际娟 乳制品中8种致病菌检测试剂盒及其检测方法
FI20095514A0 (fi) * 2009-05-07 2009-05-07 Expression Analytics Oy Menetelmä, laitteisto ja tietokoneohjelmatuote PCR-tuotteiden kvantifioimiseksi
WO2010130877A2 (fr) 2009-05-12 2010-11-18 Abacus Diagnostica Oy Procédé de détection d'acides nucléiques
WO2010135917A1 (fr) 2009-05-26 2010-12-02 厦门大学 Méthode de détection des variations dans des séquences d'acide nucléique
US9359639B2 (en) 2009-05-26 2016-06-07 Xiamen University Method for the detection of multiple single nucleotide variations or single nucleotide polymorphisms in a single tube
EP2280080A1 (fr) 2009-07-31 2011-02-02 Qiagen GmbH Procédé de quantification normalisée d'acides nucléiques utilisant des oligonucléotides d'ancrage et oligonucléotides d'adaptateur
EP3375891B1 (fr) 2009-09-10 2020-02-19 DiaSorin S.p.A. Procédés et dispositifs pour la compensation de l'intermodulation spectrale dans une amplification d'acides nucléiques multiplex
US9447457B2 (en) 2009-09-24 2016-09-20 Seegene, Inc. Detection of target nucleic acid sequences by cyclic exonucleolytic reactions
US8962251B2 (en) 2009-10-08 2015-02-24 Medical Service Consultation International, Llc Methods and compositions for identifying sulfur and iron modifying bacteria
EP3236264A3 (fr) 2009-10-13 2017-11-08 Nanostring Technologies, Inc Détection de protéine par l'intermédiaire de nanorapporteurs
US9752187B2 (en) 2009-12-11 2017-09-05 Nucleix Categorization of DNA samples
CA2785529C (fr) 2010-02-11 2019-01-08 Nanostring Technologies, Inc. Compositions et procedes de detection de petits arn
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
EP4484577A3 (fr) 2010-02-12 2025-03-26 Bio-Rad Laboratories, Inc. Analyse numérique d'analyte
EP2547795B1 (fr) 2010-03-16 2015-01-14 Nanostring Technologies, Inc Compositions et procédés permettant de rechercher des caractéristiques génomiques
AU2011255638B2 (en) 2010-05-19 2016-08-25 Qiagen Gaithersburg, Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
CN102269759B (zh) * 2010-06-07 2014-05-07 常州楚天生物科技有限公司 一种基于免疫pcr和dna熔解曲线分析的多重检测方法
US9822397B2 (en) 2010-06-30 2017-11-21 Gen-Probe Incorporated Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
US8877464B2 (en) 2010-07-29 2014-11-04 Roche Molecular Systems, Inc. Qualitative and quantitative detection of microbial nucleic acids
GB201017978D0 (en) * 2010-10-25 2010-12-08 Oxitec Ltd Multiplex amplification and detection
JP5978220B2 (ja) 2010-10-29 2016-08-24 プレジデント アンド フェローズ オブ ハーバード カレッジ 核酸ナノ構造バーコードプローブ
WO2012100198A2 (fr) 2011-01-20 2012-07-26 University Of Washington Through Its Center For Commercialization Procédés, dispositifs et systèmes pour effectuer des mesures numériques
WO2012106428A2 (fr) 2011-02-03 2012-08-09 University Of Florida Research Foundation, Inc. Procédés de détection d'adn cible
WO2012129115A2 (fr) 2011-03-18 2012-09-27 University Of South Florida Substances et procédés utilisables en vue du profilage de micro-arn
WO2012129187A1 (fr) 2011-03-18 2012-09-27 Bio-Rad Laboratories, Inc. Essais numériques multiplexés avec utilisation combinée de signaux
US9758834B2 (en) 2011-03-28 2017-09-12 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
CA2839705A1 (fr) 2011-06-24 2012-12-27 Nanostring Technologies, Inc. Dosages diagnostiques multivaries et procedes d'utilisation de ceux-ci
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US8858623B2 (en) 2011-11-04 2014-10-14 Valtech Cardio, Ltd. Implant having multiple rotational assemblies
CN102559868B (zh) * 2011-11-28 2014-11-05 厦门大学 一种单管定性并定量检测多个目标核酸序列的方法
EP4108782B1 (fr) 2011-12-22 2023-06-07 President and Fellows of Harvard College Compositions et procédés de détection d'analyte
EP4361608A3 (fr) 2012-02-03 2024-07-24 California Institute of Technology Codage et décodage de signaux dans des dosages biochimiques multiplexés
US10900072B2 (en) 2012-06-27 2021-01-26 Rutgers, The State University Of New Jersey Rapid assays for T-cell activation by RNA measurements using flow cytometry
EP3901243A1 (fr) 2012-08-03 2021-10-27 California Institute of Technology Multiplexage et quantification dans pcr avec exigences et matériel réduits
GB201218909D0 (en) 2012-10-22 2012-12-05 Univ Singapore Assay for the parallel detection of biological material based on PCR
WO2014116884A1 (fr) 2013-01-24 2014-07-31 California Institute Of Technology Caractérisation à base de chromophore et procédés de détection
EP2971095B1 (fr) 2013-03-12 2019-11-20 Life Technologies Corporation Procédés de génotypage fondés sur des indicateurs universels, et mixtures et trousses appropriés
EP2873740A1 (fr) 2013-11-19 2015-05-20 Oncodiag Procédés pour la surveillance, le diagnostic et le dépistage du cancer de la vessie
US9670530B2 (en) 2014-01-30 2017-06-06 Illumina, Inc. Haplotype resolved genome sequencing
WO2015147370A1 (fr) 2014-03-28 2015-10-01 Seegene, Inc. Détection de séquences d'acide nucléique cible à l'aide de différentes températures de détection
CN107223159A (zh) 2014-05-09 2017-09-29 科戴克斯生命股份公司 源自特定细胞类型的dna的检测及相关方法
CN109072205A (zh) 2016-02-10 2018-12-21 密歇根大学董事会 核酸的检测
CN109601008B (zh) 2016-04-01 2023-02-28 克罗玛科德公司 用于工程化信号产生的竞争性探针
WO2017218777A1 (fr) 2016-06-17 2017-12-21 California Institute Of Technology Réactions d'acides nucléiques et procédés et compositions associés
EP3440456B1 (fr) 2016-10-24 2020-12-23 Ontera Inc. Abondance fractionnaire de séquences polynucléotidiques dans un échantillon
CN118668012A (zh) 2017-06-28 2024-09-20 克罗玛科德公司 使用微滴式pcr系统的多重荧光测量
US20190112636A1 (en) 2017-10-16 2019-04-18 ChromaCode, Inc. Methods and compositions for nucleic acid detection
WO2019169043A1 (fr) 2018-02-28 2019-09-06 ChromaCode, Inc. Cibles moléculaires pour analyse d'acides nucléiques foetaux

Also Published As

Publication number Publication date
CN104662172B (zh) 2018-07-06
CN104662172A (zh) 2015-05-27
EP2880184A4 (fr) 2016-03-30
CN108753932B (zh) 2022-12-02
EP2880184B1 (fr) 2021-03-31
US9791372B2 (en) 2017-10-17
EP2880184A1 (fr) 2015-06-10
US20140038195A1 (en) 2014-02-06
US11959856B2 (en) 2024-04-16
WO2014022827A1 (fr) 2014-02-06
EP3901243A1 (fr) 2021-10-27
US20240201090A1 (en) 2024-06-20
US20180052110A1 (en) 2018-02-22
CN108753932A (zh) 2018-11-06

Similar Documents

Publication Publication Date Title
IN2015DN01609A (fr)
MY194686A (en) Detection of chromosome interactions
EP4524972A3 (fr) Analyse de variants génétiques
EP3816303A3 (fr) Kit ou dispositif de détection du cancer du sein et procédé de détection du cancer du sein
IN2014DN10121A (fr)
PH12014500063A1 (en) Methods and nucleic acids for determining the prognosis of a cancer subject
EP3757225A3 (fr) Kit ou dispositif de détection du cancer du pancréas et procédé de détection
IN2014DN08831A (fr)
GB2497693A (en) Managing a user interface for an application program
EP3608021A3 (fr) Dispositifs de détection d'analytes, dispositifs multiplex et de type comptoir pour la détection d'analytes et leurs utilisations
EP2939082A4 (fr) Procédé et système d'analyse du niveau d'engagement d'un utilisateur dans un document électronique
GB2502715A (en) Malware Detection
EP2695127A4 (fr) Système et procédé de validation de spectateurs basés sur des entrées contextuelles inter-dispositifs
BR112012026536A2 (pt) sistemas e métodos para predizer deficiência gastrointestinal
EP2948407A4 (fr) Système de production d'hydrogène et procédés d'utilisation de celui-ci
CL2015001568A1 (es) Métodos de detección multiplex de ácidos nucleicos
EP2293609A4 (fr) Procédé et système de génération de clés
GB2496557A (en) Products and methods for identifying rock samples
MX368815B (es) Método y dispositivo para analizar relación social.
EP3572529A3 (fr) Diagnostic du cancer colorectal basé sur la méthylation de gènes
EP3798316A3 (fr) Gènes et signatures génétiques pour le diagnostic et le traitement du mélanome
AU2011257540A1 (en) Device for testing the authenticity of valuable documents
WO2012075069A3 (fr) Signatures et déterminants associés au cancer et leurs méthodes d'utilisation
EP3001410A4 (fr) Système d'enregistrement d'interprétation musicale, procédé d'enregistrement d'interprétation musicale et instrument de musique
GB2545850A (en) System and method using a combined modality optical probe