[go: up one dir, main page]

IN2012DN06277A - - Google Patents

Info

Publication number
IN2012DN06277A
IN2012DN06277A IN6277DEN2012A IN2012DN06277A IN 2012DN06277 A IN2012DN06277 A IN 2012DN06277A IN 6277DEN2012 A IN6277DEN2012 A IN 6277DEN2012A IN 2012DN06277 A IN2012DN06277 A IN 2012DN06277A
Authority
IN
India
Prior art keywords
microalgal
extracellular bodies
heterologous
heterologous polypeptides
compositions
Prior art date
Application number
Other languages
English (en)
Inventor
Anne Cecile V BAYNE
James Casey Lippmeier
Kirk Emil Apt
Ross Eric Zirkle
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of IN2012DN06277A publication Critical patent/IN2012DN06277A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16123—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151—Methods of production or purification of viral material
    • C12N2760/16152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IN6277DEN2012 2009-12-28 2010-12-28 IN2012DN06277A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29046909P 2009-12-28 2009-12-28
US29044109P 2009-12-28 2009-12-28
US41335310P 2010-11-12 2010-11-12
PCT/US2010/062276 WO2011090731A1 (fr) 2009-12-28 2010-12-28 Production de polypeptides hétérologues dans micro-algues, corps extracellulaires de micro-algues, compositions et leurs procédés de fabrication et leurs utilisations

Publications (1)

Publication Number Publication Date
IN2012DN06277A true IN2012DN06277A (fr) 2015-09-25

Family

ID=44307127

Family Applications (1)

Application Number Title Priority Date Filing Date
IN6277DEN2012 IN2012DN06277A (fr) 2009-12-28 2010-12-28

Country Status (9)

Country Link
US (3) US20110189228A1 (fr)
EP (3) EP2519635B1 (fr)
JP (5) JP6339548B2 (fr)
CN (2) CN107746869A (fr)
AU (4) AU2010343095B2 (fr)
CA (3) CA3153553A1 (fr)
EA (1) EA022841B1 (fr)
IN (1) IN2012DN06277A (fr)
WO (1) WO2011090731A1 (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI377253B (en) 2001-04-16 2012-11-21 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
KR101939014B1 (ko) * 2009-03-16 2019-01-15 디에스엠 아이피 어셋츠 비.브이. 라비린툴로바이코타문 미생물에서의 단백질 생산
EP2519636B8 (fr) * 2009-12-28 2017-08-09 DSM IP Assets B.V. Production de protéine hémagglutinine-neuraminidase dans des microalgues
CN103260643A (zh) * 2009-12-28 2013-08-21 梅里亚有限公司 重组ndv抗原及其用途
EP2444495A1 (fr) * 2010-10-20 2012-04-25 Algenics Sécrétion de polypeptides recombinants dans le support extracellulaire de diatomées
WO2012120375A1 (fr) 2011-03-07 2012-09-13 Ocean Nutrition Canada Limited Microorganismes thraustochytrides manipulés
EP2748321A2 (fr) * 2011-08-24 2014-07-02 Novozymes, Inc. Procédés permettant d'obtenir des transformants positifs d'une cellule hôte fongique filamenteuse
US9982249B2 (en) 2012-07-24 2018-05-29 Bp Corporation North America Inc. Xylose isomerases and their uses
WO2014045191A2 (fr) * 2012-09-18 2014-03-27 Myko Tech Private Limited Polysaccharides extracellulaire provenant de labyrinthulomycetes ayant des activités antivirales à large spectre
CA2958439C (fr) 2014-10-02 2022-09-20 Evonik Industries Ag Aliment pour animaux contenant des acides gras polyinsatures, a haute resistance a l'abrasion et a grande hydrostabilite
CN118813731A (zh) 2014-10-02 2024-10-22 赢创运营有限公司 用于制备具有高细胞稳定性的含pufa生物质的方法
BR112017005388B1 (pt) 2014-10-02 2022-09-13 Evonik Operations Gmbh Alimento para animais contendo biomassa de aurantiochytrium
CN106793803B (zh) * 2014-10-02 2021-03-09 赢创运营有限公司 通过挤压含pufa的生物质来制备含pufa的饲料的方法
CA2977271A1 (fr) 2015-03-02 2016-09-09 Synthetic Genomics, Inc. Elements de regulation provenant de micro-organismes labyrinthulomycetes
BR112018000690A2 (pt) * 2015-07-13 2018-09-18 MARA Renewables Corporation micro-organismo recombinante, e, métodos para preparar um micro-organismo de metabolização de xilose e para produzir óleo.
FR3038913B1 (fr) * 2015-07-17 2020-05-01 Fermentalg Biomasse de thraustochytrides, procede de culture et utilisations
CN109890964A (zh) * 2016-09-09 2019-06-14 康奈尔大学 核酸、蛋白和小分子在玻璃体囊泡体中的递送
US10633454B2 (en) 2016-11-01 2020-04-28 Conagen Inc. Expression of modified glycoproteins and glycopeptides
US10954280B2 (en) 2016-11-27 2021-03-23 Triton Algae Innovations, Inc. Method of purification of recombinant osteopontin from micro algae
CN111954713A (zh) * 2018-03-05 2020-11-17 科纳根公司 用于产生具有低硫酸化的糖分子的生物体和方法
AU2019293111A1 (en) 2018-06-27 2021-01-07 Sumitomo Electric Industries, Ltd. Original form body of flexible printed-wiring board, method of manufacturing flexible printed-wiring board, concentrated photovoltaic power generation module, and light emitting module
EP3852608A4 (fr) 2018-09-21 2022-09-28 Aufbau Medical Innovations Limited Compositions et méthodes destinées à traiter le glaucome
CN109161576B (zh) * 2018-09-26 2020-08-07 武汉中科光谷绿色生物技术有限公司 促进枯草芽孢杆菌发酵生产n-乙酰神经氨酸的方法
EP4063482A4 (fr) * 2019-11-21 2022-12-21 Panasonic Intellectual Property Management Co., Ltd. Cyanobacterie modifiee, procede de production de cyanobacterie modifiee et procede de production de proteine
IT201900024580A1 (it) 2019-12-18 2021-06-18 Consiglio Nazionale Ricerche Vescicole extracellulari da microalghe
CN111363045B (zh) * 2020-02-18 2021-12-17 厦门大学 一种流感、hiv嵌合蛋白及嵌合病毒疫苗的制备方法
JP2021186420A (ja) * 2020-06-03 2021-12-13 株式会社三洋物産 遊技機
CN111621471B (zh) * 2020-06-12 2022-03-11 成都世联康健生物科技有限公司 一种软组织胞外囊泡的提取方法及应用
JP2022028997A (ja) * 2020-07-31 2022-02-17 株式会社三洋物産 遊技機
CN112452506A (zh) * 2020-11-06 2021-03-09 五原县沃丰生物科技有限责任公司 一种培养基粉末的生产方法
US11175293B1 (en) 2021-01-04 2021-11-16 University Of Utah Research Foundation Rapid assay for detection of SARS-CoV-2 antibodies
US20240287443A1 (en) * 2021-06-24 2024-08-29 Reliance Industries Limited Recombinant algae and production of spider silk protein from the recombinant algae
CN113698451B (zh) * 2021-08-02 2023-04-11 广东海洋大学 一种微藻多肽及其制备方法和应用
IL312545A (en) 2021-11-05 2024-07-01 Sanofi Pasteur Inc Multivalent Influenza Vaccines Including Hemagglutinin and Recombinant Neuraminidase and Methods of Using Them
KR20240105413A (ko) 2021-11-05 2024-07-05 사노피 헤마글루티닌과 뉴라미니다제를 포함하는 하이브리드 다가 인플루엔자 백신 및 이의 사용 방법
IL312997A (en) 2021-11-30 2024-07-01 Sanofi Pasteur Inc Human metapneumovirus vaccines
WO2023232976A1 (fr) * 2022-06-03 2023-12-07 Ags Therapeutics Sas Vésicules extracellulaires provenant de microalgues génétiquement modifiées contenant une cargaison chargée de manière endogène, leur préparation et utilisations
CN119604298A (zh) 2022-06-14 2025-03-11 亨仁资助研究组办公室 用于疗法的细胞外囊泡
CN115992052A (zh) * 2022-11-18 2023-04-21 暨南大学 一种微藻类外泌体、其制备方法和应用
JP7546136B1 (ja) 2023-12-27 2024-09-05 ロート製薬株式会社 微細藻類由来の細胞外小胞を含有する組成物

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659669A (en) * 1981-03-02 1987-04-21 Regents Of The Univ. Of California Microbial expression of human influenza hemagglutinin proteins
US4537769A (en) * 1982-04-06 1985-08-27 American Cyanamid Company Stabilization of influenza virus vaccine
US4752473A (en) * 1984-10-12 1988-06-21 The Regents Of The University Of California Expression of glycosylated human influenza hemagglutinin proteins
US5340742A (en) * 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US5762939A (en) * 1993-09-13 1998-06-09 Mg-Pmc, Llc Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
WO1995018861A1 (fr) * 1994-01-11 1995-07-13 Vlaams Interuniversitair Instituut Voor Biotechnologie Vaccin contre la grippe
WO1997020854A1 (fr) * 1995-12-05 1997-06-12 University Of Massachusetts Vesicules gazeuses de recombinaison et leur utilisation
US8003772B2 (en) * 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
KR20000075076A (ko) * 1999-05-28 2000-12-15 최태진 형질전환된 미세조류를 이용하여 외래 단백질을 생산하는 방법
ES2295175T3 (es) * 2000-06-23 2008-04-16 Wyeth Holdings Corporation Ensamblaje de particulas similares al virus (vlp) de la gripe de tipo salvaje y quimericas.
US20060257399A1 (en) 2000-06-28 2006-11-16 Glycofi, Inc. Immunoglobulins comprising predominantly a Man5GIcNAc2 glycoform
US7625756B2 (en) * 2000-06-28 2009-12-01 GycoFi, Inc. Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
US7795002B2 (en) 2000-06-28 2010-09-14 Glycofi, Inc. Production of galactosylated glycoproteins in lower eukaryotes
ATE309385T1 (de) 2000-06-28 2005-11-15 Glycofi Inc Verfahren für die herstellung modifizierter glykoproteine
US20060029604A1 (en) 2000-06-28 2006-02-09 Gerngross Tillman U Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform
AU2007249124B2 (en) * 2001-04-16 2012-05-17 Dsm Ip Assets B.V. Product and process for transformation of thraustochytriales microorganisms
TWI377253B (en) * 2001-04-16 2012-11-21 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
US20040063188A1 (en) * 2002-02-14 2004-04-01 Novavax, Inc. Kit for treating gastrointestinal tract
AU2002253542B2 (en) 2002-04-12 2007-06-07 Ilaria Capua Purified subfragment encoding neuroaminidase, recombinant neuroaminidase and its use in zooprophylaxis
WO2004042001A2 (fr) * 2002-05-17 2004-05-21 Emory University Particules pseudovirales, procede de fabrication et compositions immunogeniques
US7332299B2 (en) 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
US20070026076A1 (en) * 2003-02-24 2007-02-01 Tzyy-Choou Wu Molecular vaccines employing nucleic acid encoding anti-apoptotic proteins
WO2005016961A1 (fr) * 2003-06-05 2005-02-24 Wyeth Holdings Corporation Compositions immunogenes comprenant des vecteurs de replicon du virus de l'encephalite equine du venezuela et des antigenes de proteine de paramyxovirus
ES2393492T3 (es) * 2004-05-25 2012-12-21 Medimmune, Llc Variantes de hemaglutinina y neuraminidasa de influenza
EP1789530B1 (fr) * 2004-08-05 2015-10-07 Ben Gurion University of the Negev Research and Development Autority Microalgues rouges exprimant des polypeptides exogenes et leurs procedes de generation et d'utilisation
WO2006073970A2 (fr) * 2005-01-06 2006-07-13 The Johns Hopkins University Interference arn bloquant l'expression de l'immunite potentialisee de proteines pro-apoptotiques induite par adn et des vaccins de cellules dendritiques transfectes
JP4796786B2 (ja) * 2005-04-28 2011-10-19 富士フイルム株式会社 ラビリンチュラ類を形質転換可能なベクター
JP4796787B2 (ja) 2005-04-28 2011-10-19 富士フイルム株式会社 ラビリンチュラ類への遺伝子導入法
US9216212B2 (en) * 2005-08-05 2015-12-22 University Of Massachusetts Virus-like particles as vaccines for paramyxovirus
EP1945250A4 (fr) * 2005-08-16 2010-05-19 Hawaii Biotech Inc Vaccin à sous-unités recombinées du virus de la grippe
US20090208531A1 (en) * 2006-02-16 2009-08-20 National Institutes Of Health Office Of Technology Antiviral agents and vaccines against influenza
ES2555544T3 (es) * 2006-03-07 2016-01-04 Vaxinnate Corporation Composiciones que incluyen hemaglutinina, métodos de preparación y métodos de uso de las mismas
MX339812B (es) * 2006-03-15 2016-06-08 Dsm Ip Assets B V * Produccion de acido graso poli-insaturado en organismos heterologos usando sistemas de sintasa de policetido pufa.
WO2007130327A2 (fr) * 2006-05-01 2007-11-15 Technovax, Inc. Compositions de particules de type viral (vlp) de la grippe
JP2009544322A (ja) * 2006-07-27 2009-12-17 リゴサイト ファーマシューティカルズ インコーポレイテッド キメラウイルス様粒子
US20100330105A1 (en) * 2006-08-22 2010-12-30 John Hopkins University Anticancer Combination Therapies
CA2615372A1 (fr) * 2007-07-13 2009-01-13 Marc-Andre D'aoust Particules semblables au virus grippal a comprenant de l'hemagglutinine
CN103122354B (zh) * 2007-11-27 2018-03-23 麦迪卡格公司 表达血凝素之转基因植物中生产的重组流感病毒样颗粒(vlp)
EP2090648A1 (fr) * 2008-02-12 2009-08-19 Institut Francais de Recherche pour l'Exploitation de la Mere(Ifremer) Production de polypeptides glycosylés dans des microalgues
KR20090096890A (ko) * 2008-03-10 2009-09-15 전남대학교산학협력단 대장균에서 조류인플루엔자 바이러스의 뉴라미니다제 ｎ1을발현하기 위한 벡터 및 방법, 이의 사용방법, 및뉴라미니다제 저해제
FR2928926B1 (fr) * 2008-03-18 2015-08-21 Centre Nat Rech Scient Polynucleotides et polypeptides chimeriques permettant la secretion d'un polypeptide d'interet en association avec des exosomes et leur utilisation pour la production de compositions immunogenes
US8252106B2 (en) * 2008-03-19 2012-08-28 Momentive Specialty Chemicals Inc. Modifier for concrete and cement formulations and methods of preparing the same
KR101939014B1 (ko) 2009-03-16 2019-01-15 디에스엠 아이피 어셋츠 비.브이. 라비린툴로바이코타문 미생물에서의 단백질 생산
EP2519636B8 (fr) * 2009-12-28 2017-08-09 DSM IP Assets B.V. Production de protéine hémagglutinine-neuraminidase dans des microalgues
CN103260643A (zh) * 2009-12-28 2013-08-21 梅里亚有限公司 重组ndv抗原及其用途

Also Published As

Publication number Publication date
US20200063174A1 (en) 2020-02-27
CA3028175A1 (fr) 2011-07-28
US20110189228A1 (en) 2011-08-04
EP2519635A1 (fr) 2012-11-07
AU2017202195B2 (en) 2019-04-18
JP6666950B2 (ja) 2020-03-18
EP2519635B1 (fr) 2018-11-21
JP2013515503A (ja) 2013-05-09
JP6339548B2 (ja) 2018-06-06
AU2022203980B2 (en) 2024-12-12
JP2016047055A (ja) 2016-04-07
EP3505632A1 (fr) 2019-07-03
EP2519635A4 (fr) 2013-06-26
US20150110826A1 (en) 2015-04-23
JP7745996B2 (ja) 2025-09-30
JP2023101420A (ja) 2023-07-20
CA3028175C (fr) 2022-05-24
EP3505632B1 (fr) 2022-08-03
JP7585382B2 (ja) 2024-11-18
CN107746869A (zh) 2018-03-02
JP5838496B2 (ja) 2016-01-06
CA2785971C (fr) 2019-02-12
EP4130273C0 (fr) 2024-06-12
AU2010343095B2 (en) 2017-01-05
EA201290567A1 (ru) 2013-02-28
CA2785971A1 (fr) 2011-07-28
JP2020096635A (ja) 2020-06-25
AU2022203980A1 (en) 2022-06-30
CA3153553A1 (fr) 2011-07-28
AU2010343095A1 (en) 2012-08-09
AU2019206054A1 (en) 2019-08-08
EP4130273B1 (fr) 2024-06-12
CN102822343A (zh) 2012-12-12
CN102822343B (zh) 2017-10-20
AU2017202195A1 (en) 2017-04-20
EP4130273A1 (fr) 2023-02-08
EA022841B1 (ru) 2016-03-31
JP2025114812A (ja) 2025-08-05
AU2019206054B2 (en) 2022-03-10
WO2011090731A1 (fr) 2011-07-28
JP2018121660A (ja) 2018-08-09

Similar Documents

Publication Publication Date Title
IN2012DN06277A (fr)
EP3358000A3 (fr) Cellules fongiques filamenteuses déficientes en protéases et leurs procédés d'utilisation
MX2016000306A (es) Celulas de hongos filamentosos deficientes en multiples proteasas y métodos de uso de las mismas.
WO2011130624A3 (fr) Expression de polypeptide prolongée à partir d'arn synthétiques modifiés et utilisations de celle-ci
MX340971B (es) Fragmento cristalizable (fc) de anticuerpo monomerico.
MX2013003681A (es) Ácidos nucleicos manipulados y métodos de uso de los mismos.
MX363788B (es) Métodos para la producción de polipéptidos procesados proteolíticamente.
MX2011011911A (es) Polipeptidos de amilasa.
IN2014CN02100A (fr)
IN2015DN01404A (fr)
ZA201400490B (en) Arginine- free tnfr: fc- fusion polypeptide compositions and methods of use
IN2014DN05756A (fr)
HRP20182165T1 (hr) Postupak proizvodnje polipeptida ili virusa od interesa u kontinuiranoj staničnoj kulturi
MX2015005384A (es) Miembros de union para il-1 beta.
IN2013MN01394A (fr)
MX358864B (es) Polipeptidos antibacterianos quimericos.
SG10201901713RA (en) Extracellular matrix compositions
IN2014DN03298A (fr)
MX349301B (es) Polipéptidos de somatotropina bovina modificados y sus usos.
MY180183A (en) Methods and compositions for preventing norleucine misincorporation into proteins
MX2011012623A (es) Construcciones de casb7439.
WO2012175745A9 (fr) Protéines secrétées par une cellule pour le traitement d'un infarctus du myocarde
IN2014CN02963A (fr)
SG11201403223PA (en) Expression vector organization, novel production cell generation methods and their use for the recombinant production of polypeptides
EP2902413A4 (fr) Polypeptide, composition d'échafaudage, composition de restauration de tissu cartilagineux, composition de culture de cellules cartilagineuses et composition de promotion de la production de glycosaminoglycane