[go: up one dir, main page]

IN2012DN04853A - - Google Patents

Download PDF

Info

Publication number
IN2012DN04853A
IN2012DN04853A IN4853DEN2012A IN2012DN04853A IN 2012DN04853 A IN2012DN04853 A IN 2012DN04853A IN 4853DEN2012 A IN4853DEN2012 A IN 4853DEN2012A IN 2012DN04853 A IN2012DN04853 A IN 2012DN04853A
Authority
IN
India
Prior art keywords
diastereoisomer
tautomer
enantiomer
inhibitor
ester
Prior art date
Application number
Inventor
S Tsantrizos Youla
Chabot Catherine
Beaulieu Pierre
Brochu Christian
Poirier Martin
A Stammers Timothy
Thavonkeham Bounkham
Rancourt Jean
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34886250&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2012DN04853(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of IN2012DN04853A publication Critical patent/IN2012DN04853A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein, or a salt or ester thereof, as an inhibitor of HCV NS5B polymerase.
IN4853DEN2012 2004-02-20 2005-02-18 IN2012DN04853A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54621304P 2004-02-20 2004-02-20
PCT/CA2005/000208 WO2005080388A1 (en) 2004-02-20 2005-02-18 Viral polymerase inhibitors

Publications (1)

Publication Number Publication Date
IN2012DN04853A true IN2012DN04853A (en) 2015-09-25

Family

ID=34886250

Family Applications (1)

Application Number Title Priority Date Filing Date
IN4853DEN2012 IN2012DN04853A (en) 2004-02-20 2005-02-18

Country Status (30)

Country Link
US (3) US7582770B2 (en)
EP (2) EP2626354A1 (en)
JP (4) JP4648333B2 (en)
KR (2) KR20120091276A (en)
CN (6) CN102911161A (en)
AR (2) AR047706A1 (en)
AU (1) AU2005215829C1 (en)
BR (1) BRPI0507861A (en)
CA (1) CA2553879C (en)
DK (1) DK1718608T3 (en)
EA (3) EA013207B1 (en)
EC (1) ECSP066780A (en)
ES (1) ES2431314T3 (en)
HR (1) HRP20130971T1 (en)
IL (2) IL177537A (en)
IN (1) IN2012DN04853A (en)
MY (1) MY144718A (en)
NO (1) NO20064004L (en)
NZ (1) NZ549079A (en)
PE (1) PE20051141A1 (en)
PL (1) PL1718608T3 (en)
PT (1) PT1718608E (en)
RS (1) RS52931B (en)
SG (2) SG150511A1 (en)
SI (1) SI1718608T1 (en)
TW (2) TWI368508B (en)
UA (2) UA86962C2 (en)
UY (1) UY28758A1 (en)
WO (1) WO2005080388A1 (en)
ZA (1) ZA200605151B (en)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227742B1 (en) 1996-10-18 2012-02-28 Vertex Pharma Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
SV2003000617A (en) 2000-08-31 2003-01-13 Lilly Co Eli INHIBITORS OF PROTEASA PEPTIDOMIMETICA REF. X-14912M
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
US20050075279A1 (en) * 2002-10-25 2005-04-07 Boehringer Ingelheim International Gmbh Macrocyclic peptides active against the hepatitis C virus
US7098231B2 (en) 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
PE20050374A1 (en) 2003-09-05 2005-05-30 Vertex Pharma SERINE PROTEASE INHIBITORS, IN PARTICULAR HCV PROTEASE NS3-NS4A
KR20120091276A (en) * 2004-02-20 2012-08-17 베링거 인겔하임 인터내셔날 게엠베하 Viral polymerase inhibitors
CA2573185A1 (en) 2004-07-14 2006-02-23 Ptc Therapeutics, Inc. Methods for treating hepatitis c
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7645881B2 (en) 2004-07-22 2010-01-12 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7153848B2 (en) 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
TWI437990B (en) 2004-10-29 2014-05-21 Vertex Pharma Medical use of vx-950
KR20140022796A (en) 2005-02-11 2014-02-25 베링거 인겔하임 인터내셔날 게엠베하 Process for preparing 2,3-disubstituted indoles
EP1915378A4 (en) 2005-08-12 2009-07-22 Boehringer Ingelheim Int VIRAL POLYMERASE INHIBITORS
AR055395A1 (en) 2005-08-26 2007-08-22 Vertex Pharma INHIBITING COMPOUNDS OF THE ACTIVITY OF SERINA PROTEASA NS3-NS4A OF HEPATITIS C VIRUS
US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
US7816348B2 (en) 2006-02-03 2010-10-19 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
EP1991229A2 (en) 2006-02-27 2008-11-19 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical compositions comprising the same
EP2194039A1 (en) 2006-03-16 2010-06-09 Vertex Pharmceuticals Incorporated Process for preparing optically enriched compounds
GB0608928D0 (en) 2006-05-08 2006-06-14 Angeletti P Ist Richerche Bio Therapeutic agents
CA2660555A1 (en) 2006-08-17 2008-02-21 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7999001B2 (en) * 2007-01-15 2011-08-16 The United States Of America As Represented By The Secretary Of The Army Antiviral compounds and methods of using thereof
BRPI0807907A2 (en) 2007-02-27 2017-05-16 Vertex Pharma cocrystals and pharmaceutical compositions comprising them.
CN101903392A (en) 2007-02-27 2010-12-01 弗特克斯药品有限公司 Inhibitors of serine proteases
CN102872461A (en) 2007-05-04 2013-01-16 弗特克斯药品有限公司 Combination therapy for the treatment of hcv infection
AU2008277442A1 (en) 2007-07-17 2009-01-22 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Macrocyclic indole derivatives for the treatment of hepatitis C infections
JP2010535156A (en) 2007-08-03 2010-11-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Viral polymerase inhibitor
TW200922933A (en) 2007-08-30 2009-06-01 Vertex Pharma Co-crystals and pharmaceutical compositions comprising the same
MX2010006210A (en) 2007-12-05 2010-08-10 Enanta Pharm Inc Fluorinated tripeptide hcv serine protease inhibitors.
MX2010006313A (en) 2007-12-19 2010-06-25 Boehringer Ingelheim Int Viral polymerase inhibitors.
AR072297A1 (en) 2008-06-27 2010-08-18 Novartis Ag DERIVATIVES OF INDOL-2-IL-PIRIDIN-3-ILO, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND ITS USE IN MEDICINES FOR THE TREATMENT OF DISEASES MEDIATED BY THE SYNTHESIS ALDOSTERONE.
JP2011530562A (en) 2008-08-11 2011-12-22 グラクソスミスクライン エルエルシー Purine derivatives for the treatment of allergic, inflammatory and infectious diseases
CN104530048B (en) 2008-08-11 2016-09-14 葛兰素史密丝克莱恩有限责任公司 Adenine derivatives
UA103195C2 (en) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк PURCHASE DERIVATIVES FOR THE APPLICATION IN THE TREATMENT OF ALLERGIES, INFLAMMATORY AND INFECTIOUS DISEASES
EA019965B1 (en) * 2008-09-17 2014-07-30 Бёрингер Ингельхайм Интернациональ Гмбх Combination of hcv ns3 protease inhibitor with interferon and ribavirin
JP2012051803A (en) * 2008-12-25 2012-03-15 Kyorin Pharmaceutical Co Ltd Production method of cyclic aminobenzoic acid ester derivative
JP2012514605A (en) 2009-01-07 2012-06-28 サイネクシス，インコーポレーテッド Cyclosporine derivatives for use in the treatment of HCV and HIV infection
WO2010093843A2 (en) 2009-02-12 2010-08-19 Vertex Pharmaceuticals Incorporated Hcv combination therapies
CA2756870A1 (en) 2009-03-31 2010-10-07 Arqule, Inc. Substituted indolo-pyridinone compounds
CN102458444A (en) 2009-05-13 2012-05-16 英安塔制药有限公司 Macrocyclic compounds as hepatitis c virus inhibitors
CA2737601C (en) * 2009-06-11 2014-10-21 Abbott Laboratories Anti-viral compounds
US8937150B2 (en) * 2009-06-11 2015-01-20 Abbvie Inc. Anti-viral compounds
WO2010149359A1 (en) * 2009-06-26 2010-12-29 Lonza Ltd Process and intermediates for the preparation of benzimidazolecarboxylic acids
IN2012DN00999A (en) * 2009-07-16 2015-04-10 Vertex Pharma
BR112012010110A2 (en) 2009-10-30 2019-09-24 Boehringer Ingelheim Int hcv combination therapy dosage regimens comprising bi201335, interferon alfa and ribavirin
EP2528605A1 (en) 2010-01-29 2012-12-05 Vertex Pharmaceuticals Incorporated Therapies for treating hepatitis c virus infection
JP2013519644A (en) 2010-02-10 2013-05-30 グラクソスミスクライン エルエルシー Purine derivatives and their pharmaceutical use
CA2786973C (en) 2010-02-10 2018-04-10 Robert Hermann Gibbon 6-amino-2-{[(1s)-1-methylbutyl] oxy}-9-[5-(1-piperidinyl)-7,9-dihydro-8h-purin-8-one maleate
WO2011156545A1 (en) 2010-06-09 2011-12-15 Vertex Pharmaceuticals Incorporated Viral dynamic model for hcv combination therapy
AR082215A1 (en) 2010-07-14 2012-11-21 Vertex Pharma PHARMACEUTICAL COMPOSITION NICE TO THE PALATE
KR101894704B1 (en) 2010-09-21 2018-09-05 이난타 파마슈티칼스, 인코포레이티드 Macrocyclic proline derived hcv serine protease inhibitors
US8598183B2 (en) * 2010-09-30 2013-12-03 Boehringer Ingelheim International Gmbh Solid state forms of a potent HCV inhibitor
CN103228278A (en) * 2010-09-30 2013-07-31 贝林格尔.英格海姆国际有限公司 Combination Therapies for HCV Infection
WO2012109646A1 (en) 2011-02-11 2012-08-16 Vertex Pharmaceuticals Incorporated Treatment of hcv in hiv infection patients
US20130195797A1 (en) 2012-01-31 2013-08-01 Vertex Pharmaceuticals Incorporated High potency formulations of vx-950
WO2013147750A1 (en) 2012-03-27 2013-10-03 Boehringer Ingelheim International Gmbh Oral combination therapy for treating hcv infection in specific patient sub-population
WO2013147749A1 (en) 2012-03-27 2013-10-03 Boehringer Ingelheim International Gmbh Oral combination therapy for treating hcv infection in specific patient subgenotype populations
US20130261134A1 (en) 2012-03-30 2013-10-03 Boehringer Ingelheim International Gmbh Mesylate salt forms of a potent hcv inhibitor
WO2014138374A1 (en) 2013-03-08 2014-09-12 Boehringer Ingelheim International Gmbh Oral combination therapy for treating hcv infection in specific patient sub-population
CN103408430B (en) * 2013-08-30 2014-09-17 南京理工大学 Synthesis method of 2-methyl-4-nitrobenzoic acid
CN106029668B (en) 2014-02-20 2018-02-23 葛兰素史克知识产权第二有限公司 Pyrrolo- [3,2] pyrimidine derivatives are as human interferon derivant
CN104130143B (en) * 2014-08-06 2017-02-15 江苏鼎龙科技有限公司 Method for preparing 3-methylamino-4-nitrophenoxyethanol
MX2017006302A (en) 2014-11-13 2018-02-16 Glaxosmithkline Biologicals Sa Adenine derivatives which are useful in the treatment of allergic diseases or other inflammatory conditions.
CR20180286A (en) 2015-12-03 2018-07-16 Glaxosmithkline Ip Dev Ltd CYCLIC PURINE DINUCLEOTIDES AS STING MODULATORS
BR112018070602A2 (en) 2016-04-07 2019-02-05 Glaxosmithkline Ip Dev Ltd compound, pharmaceutical composition, use of the compound, and method for treating a disease or disorder
SI3440076T1 (en) 2016-04-07 2022-09-30 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides useful as protein modulators
CN105884627A (en) * 2016-04-22 2016-08-24 成都东电艾尔科技有限公司 Synthetic method of oxprenolol drug intermediate ortho-aminophenol
EP3241830A1 (en) 2016-05-04 2017-11-08 Bayer CropScience Aktiengesellschaft Condensed bicyclic heterocyclic derivatives as pesticides
MX2019001918A (en) 2016-08-15 2019-09-06 Bayer Cropscience Ag Condensed bicyclic heterocycle derivatives as pest control agents.
JOP20190024A1 (en) 2016-08-26 2019-02-19 Gilead Sciences Inc Substituted pyrrolizine compounds and uses thereof
TW201927771A (en) 2017-10-05 2019-07-16 英商葛蘭素史密斯克藍智慧財產發展有限公司 Heterocyclic amides useful as protein modulators and methods of using the same
JP7291130B2 (en) 2017-10-05 2023-06-14 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド A modulator of the stimulator of the interferon gene (STING)
KR20200122353A (en) 2018-02-21 2020-10-27 바이엘 악티엔게젤샤프트 Condensed bicyclic heterocyclic derivatives as pest control agents
GB201807924D0 (en) 2018-05-16 2018-06-27 Ctxt Pty Ltd Compounds
JP2022533194A (en) 2019-05-16 2022-07-21 スティングセラ インコーポレイテッド Benzo [B] [1,8] Diazanaphthalene Acetic Acid Derivatives and Usage
EP3969438A1 (en) 2019-05-16 2022-03-23 Stingthera, Inc. Oxoacridinyl acetic acid derivatives and methods of use
GB201910305D0 (en) 2019-07-18 2019-09-04 Ctxt Pty Ltd Compounds
GB201910304D0 (en) 2019-07-18 2019-09-04 Ctxt Pty Ltd Compounds
AU2020409429A1 (en) 2019-12-18 2022-06-16 Ctxt Pty Ltd Compounds
US20230357125A1 (en) * 2022-05-06 2023-11-09 AMPAC Fine Chemicals Process for Catalytic Reduction of Nitro Compounds to Amines
CN115304584B (en) * 2022-07-25 2023-05-26 云南大学 3-thiomethyl- (5' -aryl-1H-pyrazole) -indole compound and preparation method and application thereof

Family Cites Families (215)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1094903A (en) 1964-03-26 1967-12-13 Smith Kline French Lab Improvements in or relating to nitrofuran derivatives
FR1604809A (en) 1965-11-26 1972-04-17 Thiazolyl benzimidazoles - animal feed additives
GB1186504A (en) 1966-10-15 1970-04-02 Fisons Pest Control Ltd Substituted Heterocyclic Compounds
NL6917115A (en) 1968-11-22 1970-05-26
US3565912A (en) * 1969-01-27 1971-02-23 Upjohn Co 5-lower-alkanoyl-2,3-bis(p-methoxyphenyl)indoles
DE2346316C2 (en) 1973-09-14 1985-02-14 Bayer Ag, 5090 Leverkusen Process for the preparation of 2-furylbenzimidazoles
GB1509527A (en) 1974-06-05 1978-05-04 Ici Ltd 1-(aryl-or heteroaryl)oxy-3-(substituted-amino)propan-2-ol derivatives processes for their manufacture and pharmaceutical compositions containing them
FR2291749A1 (en) 1974-11-20 1976-06-18 Delalande Sa 5-carboxyalkyl-benzimidazole derivs - with analgesic, sedative, hypertensive or hypotensive, bronchodilatory, anticholinergic and vasodilatory activity
US4003908A (en) * 1976-03-11 1977-01-18 E. R. Squibb & Sons, Inc. Derivatives of imidazo(4,5-b)pyridines
CH632628B (en) * 1976-07-26 Ciba Geigy Ag PROCESS FOR THE PREPARATION OF BENZOFURANYL-BENZIMIDAZOLES AND THEIR USE AS OPTICAL BRIGHTENERS.
DE2641060A1 (en) 1976-09-11 1978-03-16 Hoechst Ag Penicillanic acid and cephalosporanic acid derivs. - are antibiotics esp. effective against Gram negative microorganisms e.g. Pseudomonas and Proteus
US4264325A (en) * 1977-02-22 1981-04-28 Ciba-Geigy Corporation Phenyl-benzimidazolyl-furanes for optical brightening of organic materials
DE2720111A1 (en) 1977-05-05 1978-11-16 Agfa Gevaert Ag CORROSION PROTECTION AGENT FOR TWO BATHROOM STABILIZER BATHS
DE2964427D1 (en) 1978-10-04 1983-02-03 Ciba Geigy Ag Process for the preparation of furanyl-benzazoles
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
DE2852531A1 (en) 1978-12-05 1980-06-19 Bayer Ag BENZOFURANYL-BENZIMIDAZOLES
DE2853765A1 (en) 1978-12-13 1980-06-26 Bayer Ag METHOD FOR PRODUCING BENZIMIDAZOLYLBENZOFURANES
DE2904829A1 (en) 1979-02-08 1980-08-14 Bayer Ag METHOD FOR PRODUCING BENZIMIDAZOLYLBENZOFURANE
EP0029003B1 (en) * 1979-11-01 1984-12-05 Ciba-Geigy Ag Salts of cationic brighteners, their preparation and their use on organic materials as well as their concentrated aqueous solutions
GR75101B (en) 1980-10-23 1984-07-13 Pfizer
GB8707798D0 (en) 1987-04-01 1987-05-07 Ici Plc Recovery of metals
ZA825413B (en) * 1981-08-26 1983-06-29 Pfizer Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them
GB2118552A (en) 1982-04-15 1983-11-02 Pfizer Ltd Thromboxane synthetase inhibitors
JPS60149502A (en) 1984-01-12 1985-08-07 Kuraray Co Ltd Indole-type agricultural and horticultural fungicide
LU85544A1 (en) 1984-09-19 1986-04-03 Cird AROMATIC HETEROCYCLIC DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THE THERAPEUTIC AND COSMETIC FIELDS
DE3522230A1 (en) 1985-06-21 1987-01-02 Thomae Gmbh Dr K NEW 2-ARYLIMIDAZOLES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS, AND METHOD FOR THE PRODUCTION THEREOF
GB8707051D0 (en) 1986-04-15 1987-04-29 Ici America Inc Heterocyclic carboxamides
GB8609175D0 (en) * 1986-04-15 1986-05-21 Ici America Inc Heterocyclic carboxamides
US4859684A (en) * 1986-09-15 1989-08-22 Janssen Pharmaceutica N.V. (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders
CA1322005C (en) 1987-11-25 1993-09-07 Robert N. Young Benzoheterazoles
JP2700475B2 (en) 1988-07-30 1998-01-21 コニカ株式会社 Nonlinear optical materials and elements
JPH03157646A (en) 1989-11-15 1991-07-05 Konica Corp Silver halide photographic sensitive material
JPH03219232A (en) 1990-01-24 1991-09-26 Konica Corp Spectrally sensitized silver halide photographic sensitive material
AU7759591A (en) 1990-04-13 1991-11-11 Smithkline Beecham Corporation Substituted benzimidazoles
JP2909645B2 (en) 1990-05-28 1999-06-23 コニカ株式会社 Silver halide color photographic materials
US5110494A (en) 1990-08-24 1992-05-05 Man-Gill Chemical Company Alkaline cleaner and process for reducing stain on aluminum surfaces
WO1992010097A1 (en) 1990-12-14 1992-06-25 Smithkline Beecham Corporation Angiotensin ii receptor blocking compositions
US5527819A (en) * 1991-09-06 1996-06-18 Merck & Co., Inc. Inhibitors of HIV reverse transcriptase
PT100905A (en) 1991-09-30 1994-02-28 Eisai Co Ltd BICYCLE HYGIENEOUS HETEROCYCLIC COMPOUNDS CONTAINING BENZENE, CYCLOHEXAN OR PYRIDINE AND PYRIMIDINE, PYRIDINE OR IMIDAZOLE SUBSTITUTES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
GB9121463D0 (en) 1991-10-10 1991-11-27 Smithkline Beecham Corp Medicament
GB9122590D0 (en) * 1991-10-24 1991-12-04 Lilly Industries Ltd Pharmaceutical compounds
JPH05165163A (en) 1991-12-11 1993-06-29 Konica Corp Dye image forming method
JP3013124B2 (en) 1991-12-26 2000-02-28 コニカ株式会社 Color image forming method
US5216003A (en) * 1992-01-02 1993-06-01 G. D. Searle & Co. Diacid-containing benzimidazole compounds for treatment of neurotoxic injury
US5314796A (en) 1992-04-02 1994-05-24 Konica Corporation Silver halide color photographic light sensitive material
US5387600A (en) 1992-07-30 1995-02-07 Fuji Photo Film Co., Ltd. Treating arteriosclerosis using benzimidazole compositions
DE4237617A1 (en) * 1992-11-06 1994-05-11 Bayer Ag Use of substituted benzimidazoles
DE4237557A1 (en) 1992-11-06 1994-05-11 Bayer Ag Substituted benzimidazoles
ATE234270T1 (en) 1992-12-02 2003-03-15 Pfizer CATHECOLDIETHER AS A SELECTIVE PDE IV INHIBITANT
JP3213426B2 (en) 1993-02-19 2001-10-02 エーザイ株式会社 6,7-dihydro-5H-cyclopenta [d] pyrimidine derivative
EP0615159B1 (en) 1993-03-04 2004-09-22 Fuji Photo Film Co., Ltd. Silver halide photographic material
DE4309969A1 (en) 1993-03-26 1994-09-29 Bayer Ag Substituted hetero-fused imidazoles
US6169107B1 (en) * 1993-04-28 2001-01-02 Sumitomo Pharmaceutical Co., Ltd. Indoloylguanidine derivatives
JP3156444B2 (en) 1993-06-02 2001-04-16 松下電器産業株式会社 Short wavelength laser light source and method of manufacturing the same
DE4330959A1 (en) 1993-09-09 1995-03-16 Schering Ag New benzimidazole derivatives, processes for their preparation and their pharmaceutical use
EP0669323B2 (en) 1994-02-24 2004-04-07 Haarmann & Reimer Gmbh Cosmetic and dermatological preparations, containing phenylene-1,4-bisbenzimidazole sulfonic acids
CA2124169A1 (en) 1994-05-24 1995-11-25 Richard Mcculloch Keenan Chemical compounds
JPH10504525A (en) * 1994-05-27 1998-05-06 ジェイムズ・ブラック・ファウンデーション・リミテッド Gastrin and CCK antagonist
SK281865B6 (en) 1994-11-29 2001-08-06 Dainippon Pharmaceutical Co., Ltd. INDOLE DERIVATIVE AND ITS OPTICAL ISOMER, METHOD OF PREPARATION AND PHARMACEUTICAL PRODUCT
EP0717143A1 (en) 1994-12-16 1996-06-19 Lignozym GmbH Multicomponents system for modifying decomposing or bleaching of lignin or materials containing it or similar components and the way to use it
DE19507913C2 (en) 1995-03-07 1998-04-16 Agfa Gevaert Ag Color photographic silver halide material
US6069156A (en) * 1995-04-10 2000-05-30 Fujisawa Pharmaceutical Co., Ltd. Indole derivatives as cGMP-PDE inhibitors
US6444694B1 (en) 1995-06-06 2002-09-03 Wyeth Styryl benzimidazole derivatives
JP3544245B2 (en) 1995-06-09 2004-07-21 富士写真フイルム株式会社 Processing method of silver halide color photographic light-sensitive material
WO1997006141A1 (en) * 1995-08-04 1997-02-20 Otsuka Kagaku Kabushiki Kaisha Indole-2-carboxylic ester derivatives and agricultural and horticultural bacteriocides containing the same as the active ingredient
WO1997012860A1 (en) * 1995-10-05 1997-04-10 Kyoto Pharmaceutical Industries, Ltd. Novel heterocyclic derivatives and medicinal use thereof
AU6966696A (en) 1995-10-05 1997-04-28 Warner-Lambert Company Method for treating and preventing inflammation and atherosclerosis
JPH09124632A (en) 1995-10-31 1997-05-13 Sankyo Co Ltd Benzo-heterocyclic derivative
CA2241186C (en) 1995-12-28 2006-02-14 Fujisawa Pharmaceutical Co., Ltd. Benzimidazole derivatives
GB9610811D0 (en) 1996-05-23 1996-07-31 Pharmacia Spa Combinatorial solid phase synthesis of a library of indole derivatives
WO1997048697A1 (en) 1996-06-19 1997-12-24 Rhone-Poulenc Rorer Limited Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
GB9614347D0 (en) 1996-07-09 1996-09-04 Smithkline Beecham Spa Novel compounds
AUPO118896A0 (en) 1996-07-23 1996-08-15 Fujisawa Pharmaceutical Co., Ltd. New use
CZ68199A3 (en) 1996-08-28 1999-11-17 Pfizer Inc. 6,5-heterobicyclic derivatives, pharmaceutical composition based thereon and method of treating diseases
JPH10114654A (en) 1996-10-09 1998-05-06 Fujisawa Pharmaceut Co Ltd New use
EP0949259B1 (en) 1996-12-26 2001-06-20 Nikken Chemicals Company, Limited N-hydroxyurea derivatives and medicinal compositions containing the same
JPH10204059A (en) 1997-01-22 1998-08-04 Ono Pharmaceut Co Ltd Phenylsulfonamide derivative
EP1754703A3 (en) 1997-02-19 2007-02-28 Berlex, Inc. N-Heterocyclic derivatives as nos inhibitors
CA2279211A1 (en) 1997-02-20 1998-08-27 Shionogi & Co., Ltd. Indole dicarboxylic acid derivatives
NZ503263A (en) 1997-08-11 2002-10-25 Boehringer Ingelheim Ca Ltd Hepatitis C NS3 protease inhibitor peptides and peptide analogues
JP4354632B2 (en) 1997-08-11 2009-10-28 ベーリンガー インゲルハイム （カナダ） リミテッド Hepatitis C inhibitor peptide
US5932743A (en) * 1997-08-21 1999-08-03 American Home Products Corporation Methods for the solid phase synthesis of substituted indole compounds
DE19753522A1 (en) 1997-12-03 1999-06-10 Boehringer Ingelheim Pharma Substituted indoles, their preparation and their use as pharmaceuticals
SE9704544D0 (en) 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
SE9704545D0 (en) 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
JPH11177218A (en) 1997-12-12 1999-07-02 Tamura Kaken Co Ltd Component equipped with metal surface for electronic circuit, and surface protecting agent therefor
HUP0102128A3 (en) 1998-05-22 2002-05-28 Avanir Pharmaceuticals San Die Mediciaments containing benzimidazole derivatives as modulators of ige
US6232320B1 (en) * 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
AR019678A1 (en) 1998-06-18 2002-03-13 Novartis Ag ORGANIC COMPOUNDS
US7223879B2 (en) * 1998-07-10 2007-05-29 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
US6445525B1 (en) * 1998-07-16 2002-09-03 Seagate Technology Llc Disc drive performance by reducing areal data storage density
WO2000006529A1 (en) 1998-07-27 2000-02-10 Istituto Di Ricerche Di Biologia Molecolare P Angeletti S.P.A. Diketoacid-derivatives as inhibitors of polymerases
WO2000006556A1 (en) 1998-07-27 2000-02-10 Abbott Laboratories Substituted oxazolines as antiproliferative agents
US6228868B1 (en) * 1998-07-27 2001-05-08 Abbott Laboratories Oxazoline antiproliferative agents
GB9816654D0 (en) 1998-07-30 1998-09-30 Zeneca Ltd Chemical compounds
US6323180B1 (en) 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
AR022061A1 (en) 1998-08-10 2002-09-04 Boehringer Ingelheim Ca Ltd INHIBITING PEPTIDES OF HEPATITIS C, A PHARMACEUTICAL COMPOSITION CONTAINING THEM, THE USE OF THE SAME TO PREPARE A PHARMACEUTICAL COMPOSITION, THE USE OF AN INTERMEDIATE PRODUCT FOR THE PREPARATION OF THESE PEPTIDES AND A PROCEDURE FOR THE PREPARATION OF ANOGRAPH .
ID27787A (en) 1998-08-21 2001-04-26 Viro Pharma Inc COMPOUND, COMPOSITION AND METHODS FOR TREATMENT OR PREVENTION OF INFECTIONS CAUSED BY VIRUSES AND RELATED DISEASES
EP1109580A4 (en) 1998-09-04 2004-05-26 Viropharma Inc Methods for treating or preventing viral infections and associated diseases
CA2345347A1 (en) 1998-09-25 2000-04-06 Viropharma Incorporated Methods for treating or preventing viral infections and associated diseases
GB9823871D0 (en) 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
KR20010080990A (en) 1998-11-12 2001-08-25 추후기재 CRF receptor antagonists and methods relating thereto
US6531475B1 (en) 1998-11-12 2003-03-11 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
US6358992B1 (en) * 1998-11-25 2002-03-19 Cell Pathways, Inc. Method of inhibiting neoplastic cells with indole derivatives
EP1142880A4 (en) 1998-12-24 2002-02-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
AU4327600A (en) * 1999-04-02 2000-10-23 Du Pont Pharmaceuticals Company Aryl sulfonyls as factor xa inhibitors
UA74546C2 (en) 1999-04-06 2006-01-16 Boehringer Ingelheim Ca Ltd Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
US6478874B1 (en) 1999-08-06 2002-11-12 Engelhard Corporation System for catalytic coating of a substrate
DE19951360A1 (en) 1999-10-26 2001-05-03 Aventis Pharma Gmbh Substituted indoles
JP2001122855A (en) 1999-10-27 2001-05-08 Japan Tobacco Inc Indole compound and its pharmaceutical use
WO2001030744A1 (en) 1999-10-28 2001-05-03 Eoc Surfactants Nv Process for the preparation of flowable concentrated betaine solution
EP1225899A2 (en) 1999-11-04 2002-07-31 Virochem Pharma Inc. Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues
US6455525B1 (en) 1999-11-04 2002-09-24 Cephalon, Inc. Heterocyclic substituted pyrazolones
CN1615873A (en) * 1999-12-24 2005-05-18 阿文蒂斯药物有限公司 Azaindoles compound
US6770666B2 (en) * 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
NZ514403A (en) 1999-12-27 2002-10-25 Japan Tobacco Inc Fused-ring compounds and use thereof as drugs
KR20020067050A (en) 1999-12-28 2002-08-21 화이자 프로덕츠 인코포레이티드 Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases
GB0003397D0 (en) * 2000-02-14 2000-04-05 Merck Sharp & Dohme Therapeutic agents
MXPA02008078A (en) 2000-02-18 2002-11-29 Julio Javier Cristiani Method for the treatment or prevention of flavivirus.
AU2001253206A1 (en) 2000-04-05 2001-10-23 Tularik, Inc. Ns5b hcv polymerase inhibitors
WO2001085720A1 (en) 2000-05-05 2001-11-15 Smithkline Beecham Corporation Novel anti-infectives
JP2004509066A (en) 2000-05-10 2004-03-25 スミスクライン・ビーチャム・コーポレイション New anti-infective drug
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
KR100372218B1 (en) 2000-06-29 2003-02-14 바이오인포메틱스 주식회사 Organic Acid Producing Microorganism and Process for Preparing Organic Acids Employing the Same
US6448281B1 (en) * 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
US20030008841A1 (en) 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
AU2001282528A1 (en) 2000-09-01 2002-03-22 Shionogi And Co., Ltd. Compounds having anti-hepatitis c virus effect
US6846806B2 (en) 2000-10-23 2005-01-25 Bristol-Myers Squibb Company Peptide inhibitors of Hepatitis C virus NS3 protein
AU2002248147B2 (en) 2000-11-20 2006-04-06 Bristol-Myers Squibb Company Hepatitis C tripeptide inhibitors
CA2437209A1 (en) 2000-12-26 2002-07-04 Mitsubishi Pharma Corporation Remedies for hepatitis c
CN1267446C (en) 2001-01-22 2006-08-02 默克公司 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerases
GB0102109D0 (en) 2001-01-26 2001-03-14 Syngenta Ltd Chemical process
AU2002252183A1 (en) 2001-03-06 2002-09-19 Biocryst Pharmaceuticals, Inc. Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases
HUP0400039A3 (en) 2001-03-08 2004-10-28 Boehringer Ingelheim Ca Ltd Hcv polymerase inhibitor assay
KR100798579B1 (en) 2001-03-31 2008-01-28 동화약품공업주식회사 Novel methoxy-1,3,5-triazine derivatives and pharmaceutical compositions comprising the same
EP1256628A3 (en) 2001-05-10 2003-03-19 Agouron Pharmaceuticals, Inc. Hepatitis c virus (hcv) ns5b rna polymerase and mutants thereof
GB0112617D0 (en) 2001-05-23 2001-07-18 Hoffmann La Roche Antiviral nucleoside derivatives
AR036081A1 (en) 2001-06-07 2004-08-11 Smithkline Beecham Corp COMPOSITE OF 1,2-DIHYDROQUINOLINE, ITS USE TO PREPARE A PHARMACEUTICAL COMPOSITION, METHODS TO PREPARE IT AND N-RENTED 2-AMINOBENZOIC ACID OF UTILITY AS INTERMEDIARY IN SUCH METHODS
BR0210357A (en) 2001-06-11 2004-06-29 Shire Biochem Inc Compound and methods for the treatment or prevention of flavivirus infections
WO2002100846A1 (en) 2001-06-11 2002-12-19 Shire Biochem Inc. Compounds and methods for the treatment or prevention of flavivirus infections
GB0114286D0 (en) 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
GB0115109D0 (en) * 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
EP1404694A1 (en) 2001-06-21 2004-04-07 Glaxo Group Limited Nucleoside compounds in hcv
AR035543A1 (en) * 2001-06-26 2004-06-16 Japan Tobacco Inc THERAPEUTIC AGENT FOR HEPATITIS C THAT INCLUDES A CONDENSED RING COMPOUND, CONDENSED RING COMPOUND, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS, BENZIMIDAZOL, THIAZOL AND BIFENYL COMPOUNDS USED AS INTERMEDIARY COMPARTMENTS OF COMPARTMENTS
KR100713137B1 (en) 2001-06-28 2007-05-02 동화약품공업주식회사 Novel 2,4-difluorobenzamide derivatives
CA2448737C (en) 2001-07-20 2010-06-01 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
EP2335700A1 (en) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
US7294457B2 (en) 2001-08-07 2007-11-13 Boehringer Ingelheim (Canada) Ltd. Direct binding assay for identifying inhibitors of HCV polymerase
JP2005503393A (en) * 2001-08-22 2005-02-03 チバ　スペシャルティ　ケミカルズ　ホールディング　インコーポレーテッド Method for producing indole derivatives
AU2002329970A1 (en) 2001-09-04 2003-03-18 Isis Pharmaceuticals, Inc. Pyrrolo(2,3-d)pyrimidines for inhibiting rna-dependent rna viral polymerase
US20030134853A1 (en) 2001-09-26 2003-07-17 Priestley Eldon Scott Compounds useful for treating hepatitis C virus
JP2005504087A (en) 2001-09-28 2005-02-10 イデニクス（ケイマン）リミテツド Methods and compositions for the treatment of hepatitis C virus using 4 'modified nucleosides
WO2003026675A1 (en) 2001-09-28 2003-04-03 Idenix (Cayman) Limited Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside
WO2003037262A2 (en) 2001-10-29 2003-05-08 Smithkline Beecham Corporation Novel anit-infectives
AU2002365198A1 (en) 2001-10-30 2003-07-30 Smithkline Beecham Corporation Novel anti-infectives
WO2003037894A1 (en) 2001-11-02 2003-05-08 Glaxo Group Limited 4-(5-membered)-heteroaryl acyl pyrrolidine derivatives as hcv inhibitors
ATE370137T1 (en) 2001-11-02 2007-09-15 Glaxo Group Ltd 4-(6-MEMBED)-HETEROARYL-ACYL-PYRROLIDINE DERIVATIVES AS HCV INHIBITORS
EP1440068A1 (en) 2001-11-02 2004-07-28 Glaxo Group Limited Acyl dihydro pyrrole derivatives as hcv inhibitors
MY151199A (en) 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
WO2003042265A1 (en) 2001-11-13 2003-05-22 Toray Industries, Inc. Polymer and ophthalmic lenses made by using the same
KR20040054775A (en) 2001-11-14 2004-06-25 바이오크리스트 파마수티컬즈, 인코퍼레이티드 Nucleosides preparation thereof and use as inhibitors of rna viral polymerases
US6867185B2 (en) 2001-12-20 2005-03-15 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus
US6936629B2 (en) 2001-12-21 2005-08-30 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of flavivirus infections
WO2003061385A1 (en) 2002-01-17 2003-07-31 Ribapharm Inc. Tricyclic nucleoside library compounds, synthesis, and use as antiviral agents
US20070032448A1 (en) 2002-01-17 2007-02-08 Zhi Hong Sugar modified nucleosides as viral replication inhibitors
WO2003062256A1 (en) 2002-01-17 2003-07-31 Ribapharm Inc. 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents
GB0201179D0 (en) 2002-01-18 2002-03-06 Angeletti P Ist Richerche Bio Therapeutic agents
CA2369711A1 (en) 2002-01-30 2003-07-30 Boehringer Ingelheim (Canada) Ltd. Macrocyclic peptides active against the hepatitis c virus
CA2369970A1 (en) 2002-02-01 2003-08-01 Boehringer Ingelheim (Canada) Ltd. Hepatitis c inhibitor tri-peptides
CA2370396A1 (en) 2002-02-01 2003-08-01 Boehringer Ingelheim (Canada) Ltd. Hepatitis c inhibitor tri-peptides
ES2268394T3 (en) 2002-04-01 2007-03-16 Pfizer Inc. INHIBITORS OF PIRANONA AND PIRANDIONA OF THE RNA POLYMERASE DEPENDENT ON THE RNA OF THE VIRUS OF HEPATITIS C.
KR100516434B1 (en) 2002-04-04 2005-09-22 (주) 비엔씨바이오팜 6-(4-substituted-anilino)pyrimidine derivatives, method for preparing thereof and antiviral pharmaceutical composition comprising the same
AU2003237088A1 (en) 2002-04-23 2003-11-10 Viropharma Incorporated Compounds, compositions and methods for treating or preventing viral infections and associated diseases
US20040063658A1 (en) 2002-05-06 2004-04-01 Roberts Christopher Don Nucleoside derivatives for treating hepatitis C virus infection
DOP2003000641A (en) 2002-05-10 2003-11-15 Pfizer INHIBITORS OF RNA-DEPENDENT RNA POLYMERASE OF HEPATITIS C VIRUSES AND COMPOSITIONS AND TREATMENT USED
GB0211418D0 (en) 2002-05-17 2002-06-26 Glaxo Group Ltd Compounds
ES2361011T3 (en) 2002-05-20 2011-06-13 Bristol-Myers Squibb Company HEPATITIS VIRUS INHIBITORS C.
ES2315568T3 (en) 2002-05-20 2009-04-01 Bristol-Myers Squibb Company HEPATITIS C VIRUS INHIBITORS BASED ON P1 'CYCLALKYL SUBSTITUTED.
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
JP4312711B2 (en) 2002-05-20 2009-08-12 ブリストル−マイヤーズ スクイブ カンパニー Heterocyclic sulfonamide hepatitis C virus inhibitor
TW200400963A (en) 2002-05-21 2004-01-16 Wyeth Corp R-enantiomers of pyranoindole derivatives and the use thereof for the treatment of hepatitis C virus infection or disease
TW200400818A (en) 2002-05-21 2004-01-16 Wyeth Corp Method for the use of pyranoindole derivatives to treat infection with hepatitis C virus
WO2003099801A1 (en) 2002-05-24 2003-12-04 Smithkline Beecham Corporation Novel anti-infectives
DE60319820T2 (en) 2002-06-04 2009-03-26 Schering Corp. PYRAZOLOE1,5-ATPYRIMIDIN COMPOUNDS AS ANTIVIRAL AGENTS
WO2003105770A2 (en) 2002-06-17 2003-12-24 Merck & Co., Inc. Carbocyclic nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
KR20050059000A (en) 2002-06-25 2005-06-17 코즈메스틱 솔루션즈 프로퍼티 리미티드 Topical cosmetic compositions
CA2488484A1 (en) 2002-06-27 2004-01-08 Merck & Co., Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
PT1523489E (en) 2002-06-28 2014-06-24 Centre Nat Rech Scient MODIFIED 2 'AND 3' NUCLEOUS PROPERTIES FOR THE TREATMENT OF FLAVIRIDAE INFECTIONS
KR20050055630A (en) 2002-06-28 2005-06-13 이데닉스 (케이만) 리미티드 1'-, 2' and 3'-modified nucleoside derivatives for treating flaviviridae infections
AU2003248748A1 (en) 2002-06-28 2004-01-19 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
AU2003265255A1 (en) 2002-07-01 2004-01-19 Finzel, Barry, C. Inhibitors of hcv ns5b polymerase
WO2004002940A1 (en) 2002-07-01 2004-01-08 Pharmacia & Upjohn Company Inhibitors of hcv ns5b polymerase
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
WO2004007512A2 (en) 2002-07-16 2004-01-22 Merck & Co., Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
US20050075279A1 (en) 2002-10-25 2005-04-07 Boehringer Ingelheim International Gmbh Macrocyclic peptides active against the hepatitis C virus
US7098231B2 (en) 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7223785B2 (en) * 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
CA2515216A1 (en) 2003-02-07 2004-08-26 Enanta Pharmaceuticals, Inc. Macrocyclic hepatitis c serine protease inhibitors
WO2004101602A2 (en) 2003-03-05 2004-11-25 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor peptide analogs
EP1601685A1 (en) 2003-03-05 2005-12-07 Boehringer Ingelheim International GmbH Hepatitis c inhibiting compounds
GB0307891D0 (en) * 2003-04-04 2003-05-14 Angeletti P Ist Richerche Bio Chemical compounds,compositions and uses
ATE422895T1 (en) 2003-04-16 2009-03-15 Bristol Myers Squibb Co MACROCYCLIC ISOQUINOLINE PEPTIDE INHIBITORS OF HEPATITIS C VIRUS
DE602004023924D1 (en) 2003-04-18 2009-12-17 Enanta Pharm Inc Ease-hemmer
AP2042A (en) 2003-05-12 2009-09-07 Affymax Inc Novel peptides that bind to the erythropoietin receptor
CL2004001161A1 (en) 2003-05-21 2005-04-08 Boehringer Ingelheim Int COMPOUNDS DESCRIBES COMPOUNDS DERIVED FROM QUINOLINA; PHARMACEUTICAL COMPOSITION; AND ITS USE TO TREAT AN ILLNESS CAUSED BY THE HEPATITIS C VIRUS.
EP1493440A1 (en) * 2003-07-03 2005-01-05 Rinoru Oil Mills Co., Ltd. Prophylactic agent of hypertension containing a conjugated fatty acid as an effective ingredient and the use thereof
TW200517381A (en) 2003-08-01 2005-06-01 Genelabs Tech Inc Bicyclic heteroaryl derivatives
WO2005014543A1 (en) 2003-08-06 2005-02-17 Japan Tobacco Inc. Condensed ring compound and use thereof as hcv polymerase inhibitor
KR20120091276A (en) * 2004-02-20 2012-08-17 베링거 인겔하임 인터내셔날 게엠베하 Viral polymerase inhibitors
US7332614B2 (en) * 2004-03-08 2008-02-19 Boehringer Ingelheim International, Gmbh Process for cross coupling indoles
EP1727796A2 (en) * 2004-03-16 2006-12-06 Boehringer Ingelheim International Gmbh Palladium catalyzed indolization of 2-bromo or chloroanilines
PE20060569A1 (en) * 2004-07-16 2006-06-22 Boehringer Ingelheim Int INDOL CARBONYLAMINE COMPOUNDS AS INHIBITORS OF HCV POLYMERASE NE5B
KR20140022796A (en) 2005-02-11 2014-02-25 베링거 인겔하임 인터내셔날 게엠베하 Process for preparing 2,3-disubstituted indoles

Also Published As

Publication number Publication date
CA2553879A1 (en) 2005-09-01
US20110015203A1 (en) 2011-01-20
MY144718A (en) 2011-10-31
EP1718608A4 (en) 2009-10-28
EA200601457A1 (en) 2007-06-29
NO20064004L (en) 2006-09-06
WO2005080388A1 (en) 2005-09-01
SG184700A1 (en) 2012-10-30
TWI368507B (en) 2012-07-21
EA200901463A1 (en) 2010-08-30
EA201301284A1 (en) 2014-03-31
AU2005215829A1 (en) 2005-09-01
KR101320907B1 (en) 2013-10-22
CN1922174A (en) 2007-02-28
IL177537A0 (en) 2006-12-10
JP4648333B2 (en) 2011-03-09
JP2010195818A (en) 2010-09-09
IL177537A (en) 2013-04-30
US20090170859A1 (en) 2009-07-02
AU2005215829B2 (en) 2012-02-09
NZ549079A (en) 2010-08-27
SG150511A1 (en) 2009-03-30
JP5394978B2 (en) 2014-01-22
US7879851B2 (en) 2011-02-01
US20050222236A1 (en) 2005-10-06
CN103333162A (en) 2013-10-02
KR20070005635A (en) 2007-01-10
ZA200605151B (en) 2008-04-30
CN103304541A (en) 2013-09-18
CN101648944A (en) 2010-02-17
PE20051141A1 (en) 2006-01-30
JP2007523094A (en) 2007-08-16
EA013207B1 (en) 2010-04-30
CA2553879C (en) 2011-02-22
PL1718608T3 (en) 2013-11-29
AU2005215829C1 (en) 2012-08-30
CN102911161A (en) 2013-02-06
HRP20130971T1 (en) 2013-11-08
TW200539878A (en) 2005-12-16
BRPI0507861A (en) 2007-07-17
KR20120091276A (en) 2012-08-17
TW201138770A (en) 2011-11-16
TWI368508B (en) 2012-07-21
UY28758A1 (en) 2005-09-30
AR093144A2 (en) 2015-05-20
ES2431314T3 (en) 2013-11-26
CN103319464A (en) 2013-09-25
UA94602C2 (en) 2011-05-25
AR047706A1 (en) 2006-02-08
EP1718608A1 (en) 2006-11-08
IL219150A0 (en) 2012-06-28
EP2626354A1 (en) 2013-08-14
EP1718608B1 (en) 2013-07-17
SI1718608T1 (en) 2013-11-29
JP2013237708A (en) 2013-11-28
US8030309B2 (en) 2011-10-04
US7582770B2 (en) 2009-09-01
ECSP066780A (en) 2006-12-20
JP2010280740A (en) 2010-12-16
DK1718608T3 (en) 2013-10-14
UA86962C2 (en) 2009-06-10
PT1718608E (en) 2013-08-01
RS52931B (en) 2014-02-28

Similar Documents

Publication Publication Date Title
IN2012DN04853A (en)
TW200617003A (en) Viral polymerase inhibitors
UA83651C2 (en) Viral polymerase inhibitors
DE602004017126D1 (en) ACYLSULFONAMIDE COMPOUNDS AS INHIBITORS OF THE RNA-DEPENDENT RNA POLYMERASE
TW200626559A (en) Anilino-pyrimidine analogs
TW200724540A (en) Heterocyclic antiviral compounds
TW200615275A (en) Hepatitis C inhibitor dipeptide analogs
TW200716133A (en) Anti-infective agents
EA200601701A1 (en) DIPEPTIDYLPEPTIDASE INHIBITORS
MY141255A (en) Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
GB0412769D0 (en) Organic compounds
MXPA05011962A (en) Substituted oxyarenes, and use thereof for controlling pests.
MX2010001566A (en) Aminopyrazole amide derivative.
MXPA05013584A (en) Cyclic tertiary amine compound.
TW200518759A (en) Anti-infective agents
MX2011012541A (en) Heterocyclic antiviral compound.
TNSN07439A1 (en) Derivatives of,4,5 - diarylpyrrole, preparation method thereof and use of same in therapeutics
TW200637539A (en) CTGF inhibitors
TW200637870A (en) Novel pyrimidine nucleoside compound and salt thereof
TW200606163A (en) Imidazopyridine compound
IL173582A0 (en) A process for the preparation of phenyltetrazole derivatives
MX2007007554A (en) Substituted oxyarenes.
TW200801016A (en) Thienopyridine-2-carboxamide derivatives
IL193113A0 (en) Heterocyclic antiviral compounds
TW200728301A (en) Pyrrolidine compound