IN2012DN02301A - - Google Patents
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- Publication number
- IN2012DN02301A IN2012DN02301A IN2301DEN2012A IN2012DN02301A IN 2012DN02301 A IN2012DN02301 A IN 2012DN02301A IN 2301DEN2012 A IN2301DEN2012 A IN 2301DEN2012A IN 2012DN02301 A IN2012DN02301 A IN 2012DN02301A
- Authority
- IN
- India
- Prior art keywords
- formula
- compound
- resulting
- 6alkyl
- alkylating
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 7
- 238000000034 method Methods 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 238000006277 sulfonation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A method for preparing a compound of formula (6), wherein said method comprises the steps of: alkylating a compound of formula (1) resulting into a compound of formula (2); wherein E is a C1-6alkyl; reacting compound of formula (2) with a sulfonation agent, resulting in a compound of formula (3); wherein LG is a leaving group; and coupling compound of formula (3) with a compound of formula (5). wherein PG is a protecting group; and wherein R2, R3, and R4 are as defined in the description.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03103630 | 2003-09-30 | ||
| US50799603P | 2003-10-02 | 2003-10-02 | |
| PCT/EP2004/052382 WO2005030739A1 (en) | 2003-09-30 | 2004-09-30 | Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN02301A true IN2012DN02301A (en) | 2015-08-14 |
Family
ID=34395298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2301DEN2012 IN2012DN02301A (en) | 2003-09-30 | 2004-09-30 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20070123574A1 (en) |
| EP (1) | EP1670773B1 (en) |
| JP (1) | JP4919802B2 (en) |
| KR (1) | KR101090102B1 (en) |
| CN (1) | CN1860107B (en) |
| AP (1) | AP1985A (en) |
| AT (1) | ATE353323T1 (en) |
| AU (1) | AU2004276017B2 (en) |
| BR (1) | BRPI0414916A (en) |
| CA (1) | CA2537877C (en) |
| DE (1) | DE602004004674T2 (en) |
| DK (1) | DK1670773T3 (en) |
| EA (1) | EA011891B1 (en) |
| ES (1) | ES2281828T3 (en) |
| IL (1) | IL173891A0 (en) |
| IN (1) | IN2012DN02301A (en) |
| MX (1) | MXPA06003575A (en) |
| NO (1) | NO20061951L (en) |
| NZ (1) | NZ546279A (en) |
| PL (1) | PL1670773T3 (en) |
| PT (1) | PT1670773E (en) |
| SI (1) | SI1670773T1 (en) |
| WO (1) | WO2005030739A1 (en) |
| ZA (1) | ZA200602603B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR053845A1 (en) * | 2005-04-15 | 2007-05-23 | Tibotec Pharm Ltd | 5-TIAZOLILMETIL [(1S, 2R) -3 - [[(2-AMINO-6-BENZOXAZOLIL) SULFONIL)] (2-METHYLPROPIL) AMINO] -2-HYDROXY-1- (PHENYLMETIL) PROPIL] CARBAMATE AS A PHARMACY IMPROVER METABOLIZED BY THE CYCROCHROME P450 |
| WO2011044134A1 (en) * | 2009-10-05 | 2011-04-14 | Albany Molecular Research, Inc. | Epiminocycloalkyl(b)indole derivatives as serotonin sub-type 6 (5-ht6) modulators and uses thereof |
| AU2012207335A1 (en) | 2011-01-19 | 2013-07-25 | Albany Molecular Research, Inc. | Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia |
| WO2014194519A1 (en) | 2013-06-07 | 2014-12-11 | Merck Sharp & Dohme Corp. | Imidazole derivatives and methods of use thereof for improving pharmacokinetics of drug |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5968942A (en) * | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| ES2190793T3 (en) * | 1995-03-10 | 2003-08-16 | Searle & Co | INHIBITORS OF RETROVIRAL PROTEASES OF HETEROCICLOCARBONIL AMINO ACID HYDROXYETHYLAMINE SULFONAMIDE. |
| JP2000515488A (en) * | 1995-11-15 | 2000-11-21 | ジー．ディー．サール アンド カンパニー | Substituted sulfonylalkanoylaminohydroxyethylaminosulfonamide retroviral protease inhibitors |
| CA2372352A1 (en) * | 2000-04-07 | 2001-10-18 | Hyun-Gyu Park | Sulfonamide derivative as a matrix metalloproteinase inhibitor |
| US6455738B1 (en) * | 2000-07-13 | 2002-09-24 | Rhodia Chimie | Process for the sulfonation of an aromatic compound |
| SK287582B6 (en) * | 2001-02-14 | 2011-03-04 | Tibotec Pharmaceuticals Ltd. | 2-(substituted amino) benztiazolsulfonamid compound, process of its preparation and use and farmaceutical composition containig its. |
| BR0209594A (en) * | 2001-05-11 | 2004-03-30 | Tibotec Pharm Ltd | 2-Amino-benzoxazole sulfonamide broad spectrum hiv protease inhibitors |
| TWI286476B (en) * | 2001-12-12 | 2007-09-11 | Tibotec Pharm Ltd | Combination of cytochrome P450 dependent protease inhibitors |
| MY142238A (en) * | 2002-03-12 | 2010-11-15 | Tibotec Pharm Ltd | Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors |
-
2004
- 2004-09-30 EP EP04766869A patent/EP1670773B1/en not_active Expired - Lifetime
- 2004-09-30 AP AP2006003603A patent/AP1985A/en active
- 2004-09-30 DK DK04766869T patent/DK1670773T3/en active
- 2004-09-30 WO PCT/EP2004/052382 patent/WO2005030739A1/en not_active Ceased
- 2004-09-30 AT AT04766869T patent/ATE353323T1/en active
- 2004-09-30 US US10/574,157 patent/US20070123574A1/en not_active Abandoned
- 2004-09-30 PT PT04766869T patent/PT1670773E/en unknown
- 2004-09-30 EA EA200600699A patent/EA011891B1/en not_active IP Right Cessation
- 2004-09-30 NZ NZ546279A patent/NZ546279A/en not_active IP Right Cessation
- 2004-09-30 CN CN2004800280971A patent/CN1860107B/en not_active Expired - Fee Related
- 2004-09-30 AU AU2004276017A patent/AU2004276017B2/en not_active Ceased
- 2004-09-30 KR KR1020067005992A patent/KR101090102B1/en not_active Expired - Fee Related
- 2004-09-30 BR BRPI0414916-5A patent/BRPI0414916A/en not_active IP Right Cessation
- 2004-09-30 PL PL04766869T patent/PL1670773T3/en unknown
- 2004-09-30 IN IN2301DEN2012 patent/IN2012DN02301A/en unknown
- 2004-09-30 CA CA2537877A patent/CA2537877C/en not_active Expired - Fee Related
- 2004-09-30 JP JP2006530265A patent/JP4919802B2/en not_active Expired - Fee Related
- 2004-09-30 ES ES04766869T patent/ES2281828T3/en not_active Expired - Lifetime
- 2004-09-30 SI SI200430265T patent/SI1670773T1/en unknown
- 2004-09-30 DE DE602004004674T patent/DE602004004674T2/en not_active Expired - Lifetime
- 2004-09-30 MX MXPA06003575A patent/MXPA06003575A/en active IP Right Grant
-
2006
- 2006-02-22 IL IL173891A patent/IL173891A0/en not_active IP Right Cessation
- 2006-03-29 ZA ZA200602603A patent/ZA200602603B/en unknown
- 2006-05-02 NO NO20061951A patent/NO20061951L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1860107A (en) | 2006-11-08 |
| NZ546279A (en) | 2008-09-26 |
| DE602004004674T2 (en) | 2007-11-22 |
| JP4919802B2 (en) | 2012-04-18 |
| AU2004276017B2 (en) | 2010-08-19 |
| KR20060092224A (en) | 2006-08-22 |
| IL173891A0 (en) | 2006-07-05 |
| CA2537877A1 (en) | 2005-04-07 |
| EA011891B1 (en) | 2009-06-30 |
| PL1670773T3 (en) | 2007-06-29 |
| NO20061951L (en) | 2006-05-02 |
| AP2006003603A0 (en) | 2006-04-30 |
| CN1860107B (en) | 2013-08-21 |
| DK1670773T3 (en) | 2007-05-29 |
| SI1670773T1 (en) | 2007-06-30 |
| ZA200602603B (en) | 2008-05-28 |
| EP1670773B1 (en) | 2007-02-07 |
| EP1670773A1 (en) | 2006-06-21 |
| AP1985A (en) | 2009-03-30 |
| AU2004276017A1 (en) | 2005-04-07 |
| BRPI0414916A (en) | 2006-11-07 |
| MXPA06003575A (en) | 2006-06-05 |
| WO2005030739A1 (en) | 2005-04-07 |
| DE602004004674D1 (en) | 2007-03-22 |
| US20070123574A1 (en) | 2007-05-31 |
| PT1670773E (en) | 2007-05-31 |
| ES2281828T3 (en) | 2007-10-01 |
| JP2007507468A (en) | 2007-03-29 |
| CA2537877C (en) | 2015-03-17 |
| ATE353323T1 (en) | 2007-02-15 |
| KR101090102B1 (en) | 2011-12-07 |
| EA200600699A1 (en) | 2006-08-25 |
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