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IN2012DN02214A - - Google Patents

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Publication number
IN2012DN02214A
IN2012DN02214A IN2214DEN2012A IN2012DN02214A IN 2012DN02214 A IN2012DN02214 A IN 2012DN02214A IN 2214DEN2012 A IN2214DEN2012 A IN 2214DEN2012A IN 2012DN02214 A IN2012DN02214 A IN 2012DN02214A
Authority
IN
India
Prior art keywords
compounds useful
automated
novel
fastlab
yielding
Prior art date
Application number
Inventor
Woodcraft John
Jones Clare
Gaeta Alessandra
Trigg William
Jones Paul
Plant Stuart
Jackson Alexander
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Publication of IN2012DN02214A publication Critical patent/IN2012DN02214A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention provides a method to obtain radiofluorinated compounds useful for in vivo imaging GABAA receptors. The method of the invention is high-yielding and may conveniently be carried out on an automated synthesizer such as Fastlab™. A further aspect of the invention is a cassette suitable for carrying out the automated method of synthesis of the invention. Novel precursor compounds useful in the method of the invention are also provided, as are a number of novel compounds obtained by the method of the invention.
IN2214DEN2012 2009-10-08 2010-10-08 IN2012DN02214A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0917611.6A GB0917611D0 (en) 2009-10-08 2009-10-08 Automated radiosynthesis
US25089209P 2009-10-13 2009-10-13
PCT/EP2010/065077 WO2011042529A1 (en) 2009-10-08 2010-10-08 Automated radiosynthesis

Publications (1)

Publication Number Publication Date
IN2012DN02214A true IN2012DN02214A (en) 2015-08-21

Family

ID=41402710

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2214DEN2012 IN2012DN02214A (en) 2009-10-08 2010-10-08

Country Status (15)

Country Link
US (1) US8946410B2 (en)
EP (1) EP2486040B1 (en)
JP (1) JP5870031B2 (en)
KR (1) KR20120095359A (en)
CN (1) CN102548996B (en)
AU (1) AU2010305355B2 (en)
BR (1) BR112012007701A2 (en)
CA (1) CA2774031A1 (en)
GB (1) GB0917611D0 (en)
IL (1) IL218454A0 (en)
IN (1) IN2012DN02214A (en)
MX (1) MX2012003994A (en)
NZ (1) NZ598659A (en)
RU (1) RU2012113138A (en)
WO (1) WO2011042529A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201105445D0 (en) * 2011-03-31 2011-05-18 Ge Healthcare Ltd Radiolabelled flumazenil derivatives
KR101441406B1 (en) * 2011-05-25 2014-11-04 주식회사 바이오이미징코리아 Preparation of florazin-18-labeled flumazenil using a diaryliodonium salt precursor
GB201209082D0 (en) * 2012-05-24 2012-07-04 Ge Healthcare Ltd Purification method
CN112979658B (en) * 2021-02-22 2022-05-31 南湖实验室 A kind of preparation method of flumazenil

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA806016B (en) * 1979-10-04 1981-09-30 Hoffmann La Roche Imidazodiazepine derivatives
CA1184175A (en) * 1981-02-27 1985-03-19 Walter Hunkeler Imidazodiazepines
GB8927928D0 (en) * 1989-12-11 1990-02-14 Roussel Lab Ltd Chemical compounds
JP3537914B2 (en) * 1995-05-18 2004-06-14 株式会社生体機能研究所 Method for producing [18F] fluoroaromatic compound
FI101305B1 (en) * 1996-03-18 1998-05-29 Map Medical Technologies Oy Radiopharmaceutical preparations of radioiodinated bentsodiazepine analogs and their use in diagnostics
GB0407952D0 (en) * 2004-04-08 2004-05-12 Amersham Plc Fluoridation method
WO2007141529A1 (en) * 2006-06-09 2007-12-13 Ge Healthcare Limited Fluoridation method
GB0803729D0 (en) * 2008-02-29 2008-04-09 Ge Healthcare Ltd Imaging the central nervous system

Also Published As

Publication number Publication date
AU2010305355A1 (en) 2012-04-05
CN102548996B (en) 2016-06-01
NZ598659A (en) 2014-02-28
EP2486040B1 (en) 2017-06-21
CA2774031A1 (en) 2011-04-14
EP2486040A1 (en) 2012-08-15
JP5870031B2 (en) 2016-02-24
GB0917611D0 (en) 2009-11-25
JP2013507343A (en) 2013-03-04
MX2012003994A (en) 2012-04-30
IL218454A0 (en) 2012-04-30
BR112012007701A2 (en) 2015-09-08
RU2012113138A (en) 2013-11-20
US20120190843A1 (en) 2012-07-26
KR20120095359A (en) 2012-08-28
WO2011042529A1 (en) 2011-04-14
CN102548996A (en) 2012-07-04
US8946410B2 (en) 2015-02-03
AU2010305355B2 (en) 2015-09-24

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