[go: up one dir, main page]

IN2012DN02736A - - Google Patents

Download PDF

Info

Publication number
IN2012DN02736A
IN2012DN02736A IN2736DEN2012A IN2012DN02736A IN 2012DN02736 A IN2012DN02736 A IN 2012DN02736A IN 2736DEN2012 A IN2736DEN2012 A IN 2736DEN2012A IN 2012DN02736 A IN2012DN02736 A IN 2012DN02736A
Authority
IN
India
Prior art keywords
compounds
toll
vaccine
adjuvants
receptors
Prior art date
Application number
Inventor
Alex Cortez
Yongkai Li
Manmohan Singh
David Skibinski
Tom Yao-Hsiang Wu
Kathy Yue
Xiaoyue Zhang
Original Assignee
Irm Llc
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43625759&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2012DN02736(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Irm Llc, Novartis Ag filed Critical Irm Llc
Publication of IN2012DN02736A publication Critical patent/IN2012DN02736A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • AIDS & HIV (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Otolaryngology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
IN2736DEN2012 2009-09-02 2010-09-01 IN2012DN02736A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23921709P 2009-09-02 2009-09-02
PCT/US2010/047587 WO2011049677A1 (en) 2009-09-02 2010-09-01 Compounds and compositions as tlr activity modulators

Publications (1)

Publication Number Publication Date
IN2012DN02736A true IN2012DN02736A (en) 2015-09-11

Family

ID=43625759

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2736DEN2012 IN2012DN02736A (en) 2009-09-02 2010-09-01

Country Status (27)

Country Link
US (2) US9045470B2 (en)
EP (1) EP2473508B1 (en)
JP (1) JP5525614B2 (en)
CN (1) CN102712636B (en)
AR (1) AR078153A1 (en)
AU (1) AU2010308524B2 (en)
BR (1) BR112012004696B8 (en)
CA (1) CA2772657C (en)
CL (1) CL2012000535A1 (en)
CY (1) CY1119618T1 (en)
DK (1) DK2473508T3 (en)
EA (1) EA020962B1 (en)
ES (1) ES2627669T3 (en)
HR (1) HRP20170707T1 (en)
HU (1) HUE032323T2 (en)
IN (1) IN2012DN02736A (en)
JO (1) JO3257B1 (en)
LT (1) LT2473508T (en)
MX (1) MX2012002654A (en)
PE (1) PE20121156A1 (en)
PL (1) PL2473508T3 (en)
PT (1) PT2473508T (en)
SI (1) SI2473508T1 (en)
SM (1) SMT201700276T1 (en)
TW (1) TWI445708B (en)
UY (1) UY32874A (en)
WO (1) WO2011049677A1 (en)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10149889B2 (en) 2005-11-25 2018-12-11 Rutgers, The State University Of New Jersey Compositions for the treatment of cancer, and methods for testing and using the same
US8926990B2 (en) 2009-10-13 2015-01-06 Rutgers, The State University Of New Jersey Treatment and diagnosis of inflammatory disorders and HIV
NZ593110A (en) 2008-12-09 2013-06-28 Gilead Sciences Inc pteridinone derivatives as MODULATORS OF TOLL-LIKE RECEPTORS
ES2443952T3 (en) 2009-09-02 2014-02-21 Novartis Ag Immunogenic compositions that include modulators of TLR activity
US9408907B2 (en) 2009-12-15 2016-08-09 Glaxosmithkline Biologicals Sa Homogenous suspension of immunopotentiating compounds and uses thereof
EP2402028A1 (en) * 2010-07-01 2012-01-04 Sanofi Pasteur Enterovirus vaccines for preventing and treating type 1 diabetes (II)
DK3243526T3 (en) 2010-07-06 2020-02-17 Glaxosmithkline Biologicals Sa SUPPLY OF RNA TO TRACT MULTIPLE IMMUNE SIGNAL WAYS
BR112013000244A2 (en) 2010-07-06 2016-05-17 Novartis Ag lipid liposomes having advantageous pka for administration of rna
EP2591114B1 (en) 2010-07-06 2016-06-08 GlaxoSmithKline Biologicals SA Immunisation of large mammals with low doses of rna
RS63315B1 (en) 2010-08-31 2022-07-29 Glaxosmithkline Biologicals Sa PEGYLATED LIPOSOMES FOR THE DELIVERY OF IMMUNOGENE-ENCODING RNA
CN105999275A (en) 2010-09-01 2016-10-12 诺华有限公司 Adsorption of immunopotentiators to insoluble metal salts
CA2814386C (en) 2010-10-11 2019-08-20 Novartis Ag Antigen delivery platforms
US20140112950A1 (en) 2011-03-02 2014-04-24 Manmohan Singh Combination vaccines with lower doses of antigen and/or adjuvant
US9352017B2 (en) 2011-03-16 2016-05-31 Rutgers, The State University Of New Jersey Combination therapy with leukotoxin
US8900626B2 (en) * 2011-06-20 2014-12-02 Senju Usa, Inc. Transdermal drug delivery system and method of using the same
CA2840989A1 (en) * 2011-07-06 2013-01-10 Novartis Ag Immunogenic combination compositions and uses thereof
KR20140066212A (en) 2011-09-01 2014-05-30 노파르티스 아게 Adjuvanted formulations of staphylococcus aureus antigens
FI123955B (en) 2011-11-25 2014-01-15 Oncos Therapeutics Ltd Oncolytic adenovirus
HRP20161354T1 (en) * 2012-03-07 2016-12-02 Glaxosmithkline Biologicals Sa TLR7 AGONIST ARGININE SALTS
EP2822589A1 (en) * 2012-03-07 2015-01-14 Novartis AG Adjuvanted formulations of rabies virus immunogens
JP2015510872A (en) 2012-03-07 2015-04-13 ノバルティス アーゲー Enhanced formulation of Streptococcus pneumoniae antigen
US9375471B2 (en) * 2012-03-08 2016-06-28 Glaxosmithkline Biologicals Sa Adjuvanted formulations of booster vaccines
EP2674170B1 (en) 2012-06-15 2014-11-19 Invivogen Novel compositions of TLR7 and/or TLR8 agonists conjugated to lipids
AU2013295242C1 (en) 2012-07-27 2018-08-09 Institut National De La Sante Et De La Recherche Medicale CD147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia
EP2890387A1 (en) * 2012-08-31 2015-07-08 Novartis AG Stabilised proteins for immunising against staphylococcus aureus
EP2732825B1 (en) 2012-11-19 2015-07-01 Invivogen Conjugates of a TLR7 and/or TLR8 agonist and a TLR2 agonist
CN103845731B (en) * 2012-12-05 2015-12-02 复旦大学 Anti-ST2/IL-1R4 antibody is preparing the application prevented and treated in pruritus medicine
AU2014204826A1 (en) * 2013-01-10 2015-07-09 Seqirus UK Limited Influenza virus immunogenic compositions and uses thereof
TR201807340T4 (en) * 2013-02-01 2018-06-21 Glaxosmithkline Biologicals Sa Intradermal administration of immunological compositions comprising bell-like receptor agonists.
EP2769738B1 (en) 2013-02-22 2016-07-20 Invivogen Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists
WO2014180999A1 (en) 2013-05-10 2014-11-13 Novartis Ag Avoiding narcolepsy risk in influenza vaccines
CN104338129B (en) * 2013-07-26 2017-05-24 中国科学院上海巴斯德研究所 Application of Rapamycin as vaccine adjuvant and preparation method thereof
EA201790024A1 (en) 2014-07-11 2017-07-31 Джилид Сайэнс, Инк. MODULATORS OF TOLL-LIKE RECEPTORS FOR HIV TREATMENT
US9738646B2 (en) 2014-09-16 2017-08-22 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
EP3061826A1 (en) 2015-02-27 2016-08-31 Novartis AG Flavivirus replicons
DK3478711T3 (en) * 2016-06-30 2022-12-12 Us Health HERV-E-REACTIVE T CELL RECEPTORS AND METHODS OF USING THEM
EP3511320A4 (en) * 2016-09-09 2020-04-15 Takeda Pharmaceutical Company Limited CYCLIC COMPOUND
AR111760A1 (en) 2017-05-19 2019-08-14 Novartis Ag COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF SOLID TUMORS THROUGH INTRATUMORAL ADMINISTRATION
BR112020011044A2 (en) 2017-12-04 2020-11-17 Intervet International B.V. vaccination with replicon particles and oil adjuvant
AR114910A1 (en) * 2018-06-04 2020-10-28 Apros Therapeutics Inc PYRIMIDINE COMPOUNDS CONTAINING ACID GROUPS
AR116109A1 (en) 2018-07-10 2021-03-31 Novartis Ag DERIVATIVES OF 3- (5-AMINO-1-OXOISOINDOLIN-2-IL) PIPERIDINE-2,6-DIONA AND USES OF THE SAME
WO2020128972A1 (en) 2018-12-20 2020-06-25 Novartis Ag Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
MX2021009496A (en) 2019-02-08 2021-09-08 Progeneer Inc Toll-like receptor 7 or 8 agonist-cholesterol complex, and use of same.
ES3032659T3 (en) 2019-02-15 2025-07-23 Novartis Ag 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
ES2982474T3 (en) 2019-02-15 2024-10-16 Novartis Ag Substituted 3-(1-oxoisoindolin-2-yl)piperidine-1,6-dione derivatives and their uses
CA3136182A1 (en) * 2019-04-05 2020-10-08 Sumitomo Dainippon Pharma Co., Ltd. Water soluble adjuvant
CN114007737B (en) * 2019-07-03 2024-07-05 默克专利股份公司 Antibody Drug Conjugate Purification
WO2021001388A1 (en) * 2019-07-03 2021-01-07 Merck Patent Gmbh Glycoform purification
MX2022007759A (en) 2019-12-20 2022-07-19 Novartis Ag Combination of anti tim-3 antibody mbg453 and anti tgf-beta antibody nis793, with or without decitabine or the anti pd-1 antibody spartalizumab, for treating myelofibrosis and myelodysplastic syndrome.
AU2020407871A1 (en) 2019-12-20 2022-06-30 Nammi Therapeutics, Inc. Formulated and/or co-formulated liposome compositions containing toll-like receptor ("TLR") agonist prodrugs useful in the treatment of cancer and methods thereof
WO2021177679A1 (en) 2020-03-02 2021-09-10 성균관대학교산학협력단 Live-pathogen-mimetic nanoparticles based on pathogen cell wall skeleton, and production method thereof
MX2022015852A (en) 2020-06-23 2023-01-24 Novartis Ag Dosing regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6- dione derivatives.
WO2022009157A1 (en) 2020-07-10 2022-01-13 Novartis Ag Lhc165 and spartalizumab combinations for treating solid tumors
EP4188549A1 (en) 2020-08-03 2023-06-07 Novartis AG Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
JP2023536954A (en) 2020-08-04 2023-08-30 プロジェニア インコーポレイテッド Conjugate of Toll-like Receptor 7 or 8 Agonist with Temporarily Inactivated Activation Site and Functional Drug, and Use of the Same
EP4194006A4 (en) 2020-08-04 2024-12-04 Progeneer Inc. Mrna vaccine comprising adjuvant capable of kinetic control
US20230355750A1 (en) 2020-08-04 2023-11-09 Progeneer Inc. Kinetically acting adjuvant ensemble
TW202304979A (en) 2021-04-07 2023-02-01 瑞士商諾華公司 USES OF ANTI-TGFβ ANTIBODIES AND OTHER THERAPEUTIC AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
AR125874A1 (en) 2021-05-18 2023-08-23 Novartis Ag COMBINATION THERAPIES
CA3241173A1 (en) * 2021-12-15 2023-06-22 Innovstone Therapeutics Limited Aromatic heterocyclic compounds, preparation method therefor and uses thereof
WO2023214325A1 (en) 2022-05-05 2023-11-09 Novartis Ag Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors
CN119497716A (en) * 2023-06-15 2025-02-21 石药集团中奇制药技术（石家庄）有限公司 A crystal form of ENPP1 inhibitor

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2848965A1 (en) 1978-11-11 1980-05-22 Behringwerke Ag METHOD FOR PRODUCING MEMBRANE PROTEINS FROM NEISSERIA MENINGITIDIS AND VACCINE CONTAINING THEM
US5389640A (en) * 1991-03-01 1995-02-14 Minnesota Mining And Manufacturing Company 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
IL117483A (en) 1995-03-17 2008-03-20 Bernard Brodeur Proteinase k resistant surface protein of neisseria meningitidis
US6180111B1 (en) 1995-05-18 2001-01-30 University Of Maryland Vaccine delivery system
JP2000511769A (en) 1996-04-02 2000-09-12 スミスクライン・ビーチャム・コーポレイション New compound
EP0934336A1 (en) 1996-05-14 1999-08-11 Smithkline Beecham Corporation Novel compounds
WO1998018931A2 (en) 1996-10-31 1998-05-07 Human Genome Sciences, Inc. Streptococcus pneumoniae polynucleotides and sequences
GB9711964D0 (en) 1997-06-09 1997-08-06 Medical Res Council Live attenuated vaccines
US6800744B1 (en) 1997-07-02 2004-10-05 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
CA2300854C (en) 1997-08-21 2011-04-05 Peter Andre Van Der Ley Novel mutants of gram negative mucosal bacteria and application thereof in vaccines
JPH1180156A (en) * 1997-09-04 1999-03-26 Hokuriku Seiyaku Co Ltd 1- (substituted aryl) alkyl-1H-imidazopyridin-4-amine derivatives
ATE476508T1 (en) 1997-11-06 2010-08-15 Novartis Vaccines & Diagnostic NEISSERIAL ANTIGENS
AU1537699A (en) 1997-11-26 1999-06-15 Bioresearch Ireland a division of Eolas - The Irish Science and Technology Agency Extracellular matrix-binding proteins from (staphylococcus aureus)
SG152917A1 (en) 1998-01-14 2009-06-29 Chiron Srl Neisseria meningitidis antigens
EP1073450A4 (en) 1998-04-23 2003-04-23 Uab Research Foundation PNEUMOCOCCAL SURFACE PROTEIN C (PSPC), EPITOPE REGIONS AND SELECTION OF STRAINS OF SUCH PROTEIN, AND USES THEREOF
EP2261341A3 (en) 1998-05-01 2012-01-04 Novartis Vaccines and Diagnostics, Inc. Neisseria meningitidis antigens and compositions
GB9810193D0 (en) 1998-05-12 1998-07-08 Smithkline Beecham Biolog Novel compounds
EP1144640A3 (en) 1998-07-27 2001-11-28 Microbial Technics Limited Nucleic acids and proteins from streptococcus pneumoniae
JP2002531055A (en) 1998-07-27 2002-09-24 マイクロビアル テクニクス リミティッド S. pneumoniae protein and nucleic acid molecules
WO2000012131A1 (en) 1998-08-31 2000-03-09 Inhibitex, Inc. Multicomponent vaccines
US6635473B1 (en) 1998-08-31 2003-10-21 The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Polypeptides and polynucleotides from coagulase-negative staphylococci
CN1338005A (en) 1998-10-09 2002-02-27 希龙公司 Neisserial genome sequence and its use
GB9823978D0 (en) 1998-11-02 1998-12-30 Microbiological Res Authority Multicomponent meningococcal vaccine
GB9828000D0 (en) 1998-12-18 1999-02-10 Chiron Spa Antigens
DK1140157T3 (en) 1998-12-21 2009-06-08 Medimmune Inc Streptococcus pneumoniae proteins and immunogenic fragments for vaccines
WO2000058475A2 (en) 1999-03-26 2000-10-05 Provalis Uk Limited Streptococcus pneumoniae antigens
ES2264419T3 (en) 1999-06-10 2007-01-01 Medimmune, Inc. STREPTOCOCCUS PNEUMONIAE VACCINES AND PROTEINS.
EP1075841A1 (en) 1999-08-13 2001-02-14 Erasmus Universiteit Rotterdam Pneumococcal vaccines
AU1917501A (en) 1999-11-12 2001-06-06 University Of Iowa Research Foundation, The Control of neisserial membrane synthesis
EP2275129A3 (en) 2000-01-17 2013-11-06 Novartis Vaccines and Diagnostics S.r.l. Outer membrane vesicle (OMV) vaccine comprising N. meningitidis serogroup B outer membrane proteins
CN101139590B (en) 2000-02-28 2012-07-18 启龙股份公司 Hybrid expression of neisserial proteins
EP1268774A2 (en) 2000-03-21 2003-01-02 Elitra Pharmaceuticals, Inc. Identification of essential genes in prokaryotes
AU5577201A (en) 2000-04-27 2001-11-07 Med Immune Inc Immunogenic pneumococcal protein and vaccine compositions thereof
NO20002828D0 (en) 2000-06-02 2000-06-02 Statens Inst For Folkehelse Proteinaceous vaccine against Neisseria meningtidis serogroup and method of preparation thereof
US6495079B1 (en) 2000-06-28 2002-12-17 Prisma Fibers, Inc. Process to prepare polymeric fibers with improved color and appearance
ATE440861T1 (en) 2000-07-03 2009-09-15 Novartis Vaccines & Diagnostic IMMUNIZATION AGAINST CHLAMYDIA PNEUMONIAE
AU2001287645A1 (en) 2000-07-20 2002-02-05 Hansa Medical Ab Fh-binding protein of streptococcus pneumiae
ES2519440T3 (en) 2000-07-27 2014-11-07 Children's Hospital & Research Center At Oakland Vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis
GB0103170D0 (en) 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
AU8743001A (en) 2000-08-28 2002-03-13 Aventis Pasteur Moraxella polypeptides and corresponding dna fragments and uses thereof
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
AU2001295795A1 (en) 2000-10-26 2002-05-06 Imperial College Innovations Ltd. Streptococcal genes
WO2002034771A2 (en) 2000-10-27 2002-05-02 Chiron Srl Nucleic acids and proteins from streptococcus groups a & b
AT410798B (en) 2001-01-26 2003-07-25 Cistem Biotechnologies Gmbh METHOD FOR IDENTIFYING, ISOLATING AND PRODUCING ANTIGENS AGAINST A SPECIFIC PATHOGEN
GB0103171D0 (en) 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
GB0103424D0 (en) 2001-02-12 2001-03-28 Chiron Spa Gonococcus proteins
WO2002077183A2 (en) 2001-03-21 2002-10-03 Elitra Pharmaceuticals, Inc. Identification of essential genes in microorganisms
GB0107661D0 (en) 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
GB0108079D0 (en) 2001-03-30 2001-05-23 Microbial Technics Ltd Protein
US7407664B2 (en) 2001-05-18 2008-08-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Peptide vaccines against group A streptococci
EP2320233A1 (en) 2001-06-15 2011-05-11 Inhibitex, Inc. Cross-reactive monoclonal and polyclonal antibodies which recognize surface proteins from coagulase-negative staphylococci and staphylococcus aureus
GB0121591D0 (en) 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
CA2808598A1 (en) 2001-08-02 2003-02-13 University Of Sheffield Antigenic polypeptides
ES2312649T3 (en) 2001-12-12 2009-03-01 Novartis Vaccines And Diagnostics S.R.L. IMMUNIZATION AGAINST CHLAMYDIA TRACHOMATIS.
GB0203403D0 (en) 2002-02-13 2002-04-03 Chiron Spa Chlamydia cytotoxic-T cell epitopes
EP1490104B1 (en) 2002-04-02 2012-06-06 Ben-Gurion University Of The Negev Research And Development Authority Protein-based streptococcus pneumoniae vaccines
GB0210128D0 (en) 2002-05-02 2002-06-12 Chiron Spa Nucleic acids and proteins from streptococcus groups A & B
US20060147477A1 (en) 2002-06-11 2006-07-06 Glaxo Group Limited Immunogenic compositions
GB0213622D0 (en) 2002-06-13 2002-07-24 Glaxosmithkline Biolog Sa Vaccine Corporation
DK2255826T3 (en) 2002-08-02 2016-06-20 Glaxosmithkline Biologicals Sa Neisserial vaccine compositions comprising a combination of antigens.
GB0220194D0 (en) 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
ES2504166T3 (en) 2002-09-13 2014-10-08 Novartis Vaccines And Diagnostics, Inc. Group B strep vaccine
DE60335477D1 (en) 2002-10-11 2011-02-03 Novartis Vaccines & Diagnostic POLYPEPTIDE FOR WIDE PROTECTION AGAINST HYPERVIRULENT MENINGOKOKKIN LINES
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
NZ543467A (en) 2003-04-10 2008-07-31 Novartis Vaccines & Diagnostic The severe acute respiratory syndrome coronavirus
EP2336357A1 (en) 2003-04-15 2011-06-22 Intercell AG S. pneumoniae antigens
DE10327439A1 (en) 2003-06-18 2005-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Novel imidazopyridazinone and imidazopyridone derivatives, their production and their use as pharmaceuticals
JP4896715B2 (en) 2003-06-26 2012-03-14 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Immunogenic composition against Chlamydiatrachomatis
GB0316560D0 (en) 2003-07-15 2003-08-20 Chiron Srl Vesicle filtration
EP1648500B1 (en) 2003-07-31 2014-07-09 Novartis Vaccines and Diagnostics, Inc. Immunogenic compositions for streptococcus pyogenes
CA2555342A1 (en) 2004-02-18 2005-09-01 Merck & Co., Inc. Polypeptides for inducing a protective immune response against staphylococcus aureus
GB0419627D0 (en) 2004-09-03 2004-10-06 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
ES2730275T3 (en) 2004-09-22 2019-11-11 Glaxosmithkline Biologicals Sa Immunogenic composition for use in staphylococcal vaccination
DK2682126T3 (en) 2005-01-27 2017-02-27 Children's Hospital & Res Center At Oakland GNA1870-based vesicle vaccines for broad-spectrum protection against diseases caused by Neisseria meningitidis
AU2006342053A1 (en) 2005-12-27 2007-10-25 Obetech, Llc Adipogenic adenoviruses as a biomarker for disease
CA2637598A1 (en) 2006-01-18 2007-02-14 University Of Chicago Compositions and methods related to staphylococcal bacterium proteins
MX2008010604A (en) 2006-02-17 2009-03-05 Novartis Ag Purification of bacterial antigens.
CA2646539A1 (en) * 2006-03-23 2007-09-27 Novartis Ag Imidazoquinoxaline compounds as immunomodulators
KR101541383B1 (en) 2006-03-30 2015-08-03 글락소스미스클라인 바이오로지칼즈 에스.에이. immunogenic composition
AR060188A1 (en) 2006-03-30 2008-05-28 Glaxosmithkline Biolog Sa CONJUGATION PROCEDURE
PL2268618T3 (en) * 2008-03-03 2015-11-30 Novartis Ag Compounds and compositions as tlr activity modulators
CN102762226A (en) * 2009-06-10 2012-10-31 诺华有限公司 Benzonaphthyridine-containing vaccines
CN102760226B (en) * 2011-04-29 2015-07-01 贵州师范大学 Solid square-based test paper objective item answer sheet locating method

Also Published As

Publication number Publication date
JP2013503884A (en) 2013-02-04
BR112012004696B8 (en) 2021-05-25
CN102712636A (en) 2012-10-03
SMT201700276T1 (en) 2017-07-18
CA2772657A1 (en) 2011-04-28
BR112012004696A2 (en) 2017-05-23
PT2473508T (en) 2017-05-29
AU2010308524A1 (en) 2012-04-19
US9045470B2 (en) 2015-06-02
CN102712636B (en) 2014-11-05
DK2473508T3 (en) 2017-06-06
PL2473508T3 (en) 2017-08-31
WO2011049677A1 (en) 2011-04-28
CL2012000535A1 (en) 2012-08-17
CA2772657C (en) 2015-11-24
EA201200406A1 (en) 2012-09-28
SI2473508T1 (en) 2017-07-31
ES2627669T3 (en) 2017-07-31
HRP20170707T1 (en) 2017-07-14
CY1119618T1 (en) 2018-04-04
BR112012004696B1 (en) 2021-01-05
LT2473508T (en) 2017-06-12
PE20121156A1 (en) 2012-08-23
EP2473508A1 (en) 2012-07-11
AU2010308524B2 (en) 2014-03-20
JO3257B1 (en) 2018-09-16
US20110053893A1 (en) 2011-03-03
HUE032323T2 (en) 2017-09-28
JP5525614B2 (en) 2014-06-18
TWI445708B (en) 2014-07-21
AR078153A1 (en) 2011-10-19
UY32874A (en) 2011-04-29
MX2012002654A (en) 2012-03-26
EP2473508B1 (en) 2017-03-08
TW201113281A (en) 2011-04-16
EA020962B1 (en) 2015-03-31
US20150225432A1 (en) 2015-08-13

Similar Documents

Publication Publication Date Title
IN2012DN02736A (en)
SG178954A1 (en) Immunogenic compositions including tlr activity modulators
JO3065B1 (en) Compounds and compositions as tlr activity modulators
MX341395B (en) Compounds (cystein based lipopeptides) and compositions as tlr2 agonists used for treating infections, inflammations, respiratory diseases etc.
AU2012253757A8 (en) Partially saturated tricyclic compounds and methods of making and using same
MX344238B (en) Tetrazole compounds and methods of making and using same.
MX347471B (en) Vaccines comprising cholesterol and cpg as sole adjuvant - carrier molecules.
UA115983C2 (en) Dna-pk inhibitors
UA103930C2 (en) Normal;heading 1;heading 2;heading 3;COMPOUNDS AND COMPOSITION FOR THE TREATMENT OF PARASITIC DISEASES
MX343687B (en) Tricyclic sulfonamide compounds and methods of making and using same.
MX375202B (en) NOVEL ADJUVANT COMPOSITIONS.
MX2012004078A (en) Compounds and compositions as modulators of gpr119 activity.
PH12015501637A1 (en) Inactivated dengue virus vaccine with aluminium-free adjuvant
MX2011013032A (en) Inhibitors of phosphatidylinositol 3-kinase.
MX2015005732A (en) Tricyclic compounds and methods of making and using same.
MX2011011618A (en) Therapeutic agents 713.
TN2012000217A1 (en) The use of an l3 and/or l5 source as a vaccine or as a diagnostic for a parasitic disease
BR112013023354A2 (en) equine rhinitis vaccine
EA201291384A1 (en) THERAPEUTIC AGENTS 976
TH158461A (en) Compounds and constituents as TLR modifiers
TN2010000338A1 (en) Vaccine comprising a ribosomal protein extract (rpe) and optionally a th1-promoting adjuvant
TN2010000463A1 (en) Compositions and methods for preparing and using same
MX361456B (en) The use of an l3 and/or l5 source as a vaccine or as a diagnostic for a parasitic disease.
UA97289C2 (en) Compounds and compositions thereof as grp119 activity modulators