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IN2012DN01975A - - Google Patents

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Publication number
IN2012DN01975A
IN2012DN01975A IN1975DEN2012A IN2012DN01975A IN 2012DN01975 A IN2012DN01975 A IN 2012DN01975A IN 1975DEN2012 A IN1975DEN2012 A IN 1975DEN2012A IN 2012DN01975 A IN2012DN01975 A IN 2012DN01975A
Authority
IN
India
Prior art keywords
hydrogen
pharmaceutically acceptable
alkali metal
metal ion
acceptable cation
Prior art date
Application number
Inventor
Bonneville George
Delahanty Greg
J Walz Andrew
Original Assignee
Eisai Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Inc filed Critical Eisai Inc
Publication of IN2012DN01975A publication Critical patent/IN2012DN01975A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Anesthesiology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A process for preparing water-soluble phosphonooxymethyl derivatives comprising the steps of: wherein R—OH represents an alcohol- or phenol-containing drug, n represents an integer of 1 or 2, R1 is hydrogen, an alkali metal ion, or a pharmaceutically acceptable cation, and R2 is hydrogen, an alkali metal ion, or a pharmaceutically acceptable cation.
IN1975DEN2012 2001-12-21 2002-12-20 IN2012DN01975A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34186701P 2001-12-21 2001-12-21
PCT/US2002/040748 WO2003059255A2 (en) 2001-12-21 2002-12-20 Process for preparing water-soluble phosphonooxymethyl derivatives of alcohol and phenol

Publications (1)

Publication Number Publication Date
IN2012DN01975A true IN2012DN01975A (en) 2015-08-21

Family

ID=23339347

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1975DEN2012 IN2012DN01975A (en) 2001-12-21 2002-12-20

Country Status (20)

Country Link
US (2) US7229978B2 (en)
EP (2) EP1471920B1 (en)
JP (2) JP4369237B2 (en)
KR (3) KR101016969B1 (en)
CN (2) CN101367834B (en)
AT (1) ATE423563T1 (en)
AU (2) AU2002360682B2 (en)
CA (1) CA2470423C (en)
DE (1) DE60231336D1 (en)
ES (1) ES2322245T3 (en)
HU (1) HU230216B1 (en)
IL (1) IL162550A (en)
IN (1) IN2012DN01975A (en)
MX (1) MXPA04005892A (en)
NZ (1) NZ533535A (en)
PL (1) PL205940B1 (en)
RU (1) RU2310659C2 (en)
UA (1) UA77033C2 (en)
WO (1) WO2003059255A2 (en)
ZA (1) ZA200404579B (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA008775B1 (en) 2002-04-26 2007-08-31 Джилид Сайэнс, Инк. Hiv protease inhibitors for treating of hiv infections and a pharmaceutical composition thereof
US7470724B2 (en) 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
US7452901B2 (en) 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
EA200501678A1 (en) * 2003-04-25 2006-10-27 Джилид Сайэнс, Инк. PHOSPHONATE-CONTAINING IMMUNOMODULATING COMPOUNDS (OPTIONS), FIRMWARE FIRMING CENTERS, PHARMACEUTICAL COMPOSITION FACILITIES, AND THEIR BASED MODULE AND MODULATION OF FIRMWARE OF MEASUREMENTS OF THEIR DIAGNOSTICS OF AGREEMENTS OF INFORMATION
WO2005002626A2 (en) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Therapeutic phosphonate compounds
US7417055B2 (en) 2003-04-25 2008-08-26 Gilead Sciences, Inc. Kinase inhibitory phosphonate analogs
US7427636B2 (en) 2003-04-25 2008-09-23 Gilead Sciences, Inc. Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
US7432261B2 (en) 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
WO2004096285A2 (en) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Anti-infective phosphonate conjugates
CA2523083C (en) 2003-04-25 2014-07-08 Gilead Sciences, Inc. Antiviral phosphonate analogs
US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
US20040225022A1 (en) * 2003-05-09 2004-11-11 Desai Neil P. Propofol formulation containing reduced oil and surfactants
CA2543294A1 (en) 2003-10-24 2005-05-26 Gilead Sciences, Inc. Methods and compositions for identifying therapeutic compounds
US7432273B2 (en) 2003-10-24 2008-10-07 Gilead Sciences, Inc. Phosphonate analogs of antimetabolites
US7427624B2 (en) 2003-10-24 2008-09-23 Gilead Sciences, Inc. Purine nucleoside phosphorylase inhibitory phosphonate compounds
AU2004309418B2 (en) 2003-12-22 2012-01-19 Gilead Sciences, Inc. 4'-substituted carbovir-and abacavir-derivatives as well as related compounds with HIV and HCV antiviral activity
JP2008508291A (en) 2004-07-27 2008-03-21 ギリアード サイエンシーズ， インコーポレイテッド Nucleoside phosphonate conjugates as anti-HIV agents
EP2307435B1 (en) 2008-07-08 2012-06-13 Gilead Sciences, Inc. Salts of hiv inhibitor compounds
KR20100032803A (en) * 2008-09-18 2010-03-26 씨제이제일제당 (주) Improved method for preparation of adefovir dipivoxil
CN101845057B (en) * 2009-03-27 2013-10-23 四川大学 Phenol-substituted methylal phosphate anesthetic and sedative medicinal compound and preparation method
US9150600B2 (en) 2009-05-07 2015-10-06 Regents Of The University Of Minnesota Triptolide prodrugs
PL2427467T3 (en) * 2009-05-07 2016-04-29 Univ Minnesota Triptolide prodrugs
JP2012140330A (en) * 2010-12-28 2012-07-26 Tosoh Corp Method for purifying water soluble phosphoric ester
ITMI20110580A1 (en) * 2011-04-08 2012-10-09 Chemelectiva S R L USEFUL INTERMEDIATES FOR THE PREPARATION OF FOSPROPOFOL AND PROCESS FOR THEIR PREPARATION
UY34072A (en) 2011-05-17 2013-01-03 Novartis Ag INDOL SUBSTITUTED DERIVATIVES
CN102351895A (en) * 2011-08-08 2012-02-15 陕西合成药业有限公司 Fospropofol disodium hydrate, preparation method and purpose thereof
CN102382133B (en) * 2011-12-02 2016-03-23 陕西合成药业股份有限公司 A kind of preparation of phosphorus propofol sodium and purification process
CN102516099B (en) * 2011-12-02 2013-07-17 成都苑东药业有限公司 Water-soluble triethanolamine derivative
CN102399236A (en) * 2011-12-27 2012-04-04 上海立科药物化学有限公司 Synthesis method of fospropofol disodium
CN102603798A (en) * 2012-02-14 2012-07-25 陕西合成药业有限公司 Preparation method of water soluble prodrugs of azole compounds
JP6254681B2 (en) * 2013-05-09 2017-12-27 スーチュアン ハイスーク ファーマシューティカル カンパニー リミテッド Phenol derivative, its production method and medicinal application
US11331271B2 (en) 2016-05-27 2022-05-17 The Johns Hopkins University Buccal, sublingual and intranasal delivery of fospropofol
EP3661937B1 (en) 2017-08-01 2021-07-28 Gilead Sciences, Inc. Crystalline forms of ethyl ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-l-alaninate (gs-9131) for treating viral infections
CN109456360B (en) * 2018-12-17 2021-05-14 河南中医药大学 Preparation method of fospropofol disodium

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GB814278A (en) 1956-11-13 1959-06-03 Bataafsche Petroleum Process for the preparation of 2.4.6 trialkylated phenols
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Also Published As

Publication number Publication date
US20050124787A1 (en) 2005-06-09
AU2008212060A1 (en) 2008-10-02
CN101367834B (en) 2012-04-18
EP2058320B1 (en) 2012-11-21
ES2322245T3 (en) 2009-06-18
JP2009149682A (en) 2009-07-09
IL162550A (en) 2013-08-29
HUP0500139A2 (en) 2005-05-30
AU2002360682A1 (en) 2003-07-30
EP1471920A2 (en) 2004-11-03
US20070043206A1 (en) 2007-02-22
DE60231336D1 (en) 2009-04-09
MXPA04005892A (en) 2004-11-01
EP2058320A1 (en) 2009-05-13
KR101016969B1 (en) 2011-02-25
CN100413508C (en) 2008-08-27
US7229978B2 (en) 2007-06-12
WO2003059255A3 (en) 2004-02-19
US7534776B2 (en) 2009-05-19
JP4617382B2 (en) 2011-01-26
CN101367834A (en) 2009-02-18
HUP0500139A3 (en) 2005-11-28
EP1471920B1 (en) 2009-02-25
ATE423563T1 (en) 2009-03-15
KR20080033551A (en) 2008-04-16
WO2003059255A2 (en) 2003-07-24
HU230216B1 (en) 2015-10-28
EP1471920A4 (en) 2006-02-15
AU2008212060B2 (en) 2011-10-27
RU2310659C2 (en) 2007-11-20
NZ533535A (en) 2005-12-23
KR20040072659A (en) 2004-08-18
PL205940B1 (en) 2010-06-30
CA2470423A1 (en) 2003-07-24
CA2470423C (en) 2011-03-15
KR20100101011A (en) 2010-09-15
PL370489A1 (en) 2005-05-30
ZA200404579B (en) 2006-03-29
JP2005514431A (en) 2005-05-19
JP4369237B2 (en) 2009-11-18
AU2002360682B2 (en) 2008-06-26
CN1671395A (en) 2005-09-21
RU2004120071A (en) 2006-01-10
KR100937162B1 (en) 2010-01-15
UA77033C2 (en) 2006-10-16

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