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IN2012DN01972A - - Google Patents

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Publication number
IN2012DN01972A
IN2012DN01972A IN1972DEN2012A IN2012DN01972A IN 2012DN01972 A IN2012DN01972 A IN 2012DN01972A IN 1972DEN2012 A IN1972DEN2012 A IN 1972DEN2012A IN 2012DN01972 A IN2012DN01972 A IN 2012DN01972A
Authority
IN
India
Prior art keywords
hydrophilic
hydrophobic
emulsions
common intersection
channels
Prior art date
Application number
Inventor
David A Weitz
Mark Romanowsky
Christian Holtze
Original Assignee
Harvard College
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Basf Se filed Critical Harvard College
Publication of IN2012DN01972A publication Critical patent/IN2012DN01972A/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3035—Micromixers using surface tension to mix, move or hold the fluids
    • B01F33/30351—Micromixers using surface tension to mix, move or hold the fluids using hydrophilic/hydrophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/414—Emulsifying characterised by the internal structure of the emulsion
    • B01F23/4144—Multiple emulsions, in particular double emulsions, e.g. water in oil in water; Three-phase emulsions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/80—Forming a predetermined ratio of the substances to be mixed
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/0318—Processes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems
    • Y10T137/87571—Multiple inlet with single outlet

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Colloid Chemistry (AREA)

Abstract

The present invention generally relates to emulsions, and more particularly, to multiple emulsions. In one aspect, multiple emulsions are formed using a plurality of channels, such as microfluidic channels, that meet at a common intersection. The multiple emulsions may be created at a single common intersection in some embodiments, unlike other prior art systems where multiple channel intersections are required to create multiple emulsions. For instance, in one set of embodiments, three, four, or more microfluidic channels may intersect at a common intersection, with two or three serving as inlets and one serving as the outlet. In some embodiments, a first fluidic channel may be relatively hydrophobic, while a second fluidic channel is relatively hydrophilic. The third channel, if present, may be relatively hydrophilic or hydrophobic, depending on the application. The outlet channel may be hydrophobic, hydrophilic, or may comprise at least one portion that is relatively hydrophilic and at least one portion that is relatively hydrophilic. By controlling the flow of fluids through the hydrophilic and hydrophobic portions of the channels, multiple emulsions may be created proximate the common intersection, due to interactions between the fluids entering the common intersection. In other embodiments, different patterns of hydrophilic or hydrophobic channels may be used. Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like.
IN1972DEN2012 2009-09-02 2010-09-01 IN2012DN01972A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23940209P 2009-09-02 2009-09-02
PCT/US2010/047458 WO2011028760A2 (en) 2009-09-02 2010-09-01 Multiple emulsions created using junctions

Publications (1)

Publication Number Publication Date
IN2012DN01972A true IN2012DN01972A (en) 2015-08-21

Family

ID=43649932

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1972DEN2012 IN2012DN01972A (en) 2009-09-02 2010-09-01

Country Status (8)

Country Link
US (1) US20120199226A1 (en)
EP (1) EP2473262A4 (en)
JP (1) JP2013503742A (en)
KR (1) KR20120089662A (en)
CN (1) CN102481529A (en)
BR (1) BR112012004715A2 (en)
IN (1) IN2012DN01972A (en)
WO (1) WO2011028760A2 (en)

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WO2006096571A2 (en) 2005-03-04 2006-09-14 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
US20110218123A1 (en) 2008-09-19 2011-09-08 President And Fellows Of Harvard College Creation of libraries of droplets and related species
US9399215B2 (en) 2012-04-13 2016-07-26 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
US20140024023A1 (en) * 2012-07-23 2014-01-23 Bio- Rad Laboratories, Inc Droplet generation system with features for sample positioning
GB2471522B (en) * 2009-07-03 2014-01-08 Cambridge Entpr Ltd Microfluidic devices
WO2011028764A2 (en) 2009-09-02 2011-03-10 President And Fellows Of Harvard College Multiple emulsions created using jetting and other techniques
KR101243147B1 (en) 2011-03-15 2013-03-13 충남대학교산학협력단 Method for selective surface modification of microfluidic chip channel and preparation of microfluidic chip for multiple emulsion
BR112013029729A2 (en) 2011-05-23 2017-01-24 Basf Se emulsion control including multiple emulsions
US20140220350A1 (en) 2011-07-06 2014-08-07 President And Fellows Of Harvard College Multiple emulsions and techniques for the formation of multiple emulsions
WO2013032709A2 (en) 2011-08-30 2013-03-07 President And Fellows Of Harvard College Systems and methods for shell encapsulation
CN102553504B (en) * 2012-01-18 2014-12-17 朗盛（常州）有限公司 Preparation method of emulsion, leather care emulsion, and use leather care emulsion
EP2986385B1 (en) * 2013-04-17 2018-02-14 Bio-rad Laboratories, Inc. Method of making a droplet-generating device
US20160279068A1 (en) 2013-11-08 2016-09-29 President And Fellows Of Harvard College Microparticles, methods for their preparation and use
WO2015160919A1 (en) 2014-04-16 2015-10-22 President And Fellows Of Harvard College Systems and methods for producing droplet emulsions with relatively thin shells
CN106999361B (en) 2014-11-24 2019-12-24 宝洁公司 Compositions containing encapsulated active substances in droplets and other compartments
CA3001679A1 (en) 2015-10-13 2017-04-20 President And Fellows Of Harvard College Systems and methods for making and using gel microspheres
CN106492716B (en) * 2016-12-20 2024-01-30 中国工程物理研究院激光聚变研究中心 Integrated double-emulsion particle generating device and processing method thereof
US10544413B2 (en) 2017-05-18 2020-01-28 10X Genomics, Inc. Methods and systems for sorting droplets and beads
WO2018213643A1 (en) 2017-05-18 2018-11-22 10X Genomics, Inc. Methods and systems for sorting droplets and beads
US10549279B2 (en) 2017-08-22 2020-02-04 10X Genomics, Inc. Devices having a plurality of droplet formation regions
WO2019083852A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. Microfluidic channel networks for partitioning
US20190321791A1 (en) * 2018-04-19 2019-10-24 President And Fellows Of Harvard College Apparatus and method for forming emulsions
US12138629B2 (en) 2019-01-31 2024-11-12 Samplix Aps Microfluidic device and a method for provision of double emulsion droplets
JPWO2022107898A1 (en) * 2020-11-20 2022-05-27

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DE60221036T2 (en) * 2001-02-23 2007-10-11 Japan Science And Technology Agency, Kawaguchi Device for producing emulsions and microcapsules
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JP4186637B2 (en) * 2002-11-06 2008-11-26 東ソー株式会社 Particle manufacturing method and microchannel structure therefor
US7595195B2 (en) * 2003-02-11 2009-09-29 The Regents Of The University Of California Microfluidic devices for controlled viscous shearing and formation of amphiphilic vesicles
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Also Published As

Publication number Publication date
BR112012004715A2 (en) 2017-05-23
EP2473262A2 (en) 2012-07-11
WO2011028760A2 (en) 2011-03-10
WO2011028760A3 (en) 2011-07-14
KR20120089662A (en) 2012-08-13
JP2013503742A (en) 2013-02-04
US20120199226A1 (en) 2012-08-09
EP2473262A4 (en) 2015-12-02
CN102481529A (en) 2012-05-30

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