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IN2012DN00866A - - Google Patents

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Publication number
IN2012DN00866A
IN2012DN00866A IN866DEN2012A IN2012DN00866A IN 2012DN00866 A IN2012DN00866 A IN 2012DN00866A IN 866DEN2012 A IN866DEN2012 A IN 866DEN2012A IN 2012DN00866 A IN2012DN00866 A IN 2012DN00866A
Authority
IN
India
Prior art keywords
nucleic acids
high quality
extractions
quality nucleic
prognosis
Prior art date
Application number
Inventor
Leileata M Russo
Kevin C Miranda
Johan Skog
Original Assignee
Gen Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp
Publication of IN2012DN00866A publication Critical patent/IN2012DN00866A/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1017Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by filtration, e.g. using filters, frits, membranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/178Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A method for extracting high quality nucleic acids from a biological sample are disclosed The extractions obtained by the methods described herein are characterized by high yield and high integrity, making the extracted nucleic acids useful for various applications in which high quality nucleic acid extractions are preferred, e g, a diagnosis, prognosis or therapy evaluation for a medical condition. Refer to Figure 2
IN866DEN2012 2009-07-16 2010-07-16 IN2012DN00866A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22610609P 2009-07-16 2009-07-16
US22602509P 2009-07-16 2009-07-16
PCT/US2010/042365 WO2011009104A1 (en) 2009-07-16 2010-07-16 Nucleic acid analysis

Publications (1)

Publication Number Publication Date
IN2012DN00866A true IN2012DN00866A (en) 2015-07-10

Family

ID=43449850

Family Applications (1)

Application Number Title Priority Date Filing Date
IN866DEN2012 IN2012DN00866A (en) 2009-07-16 2010-07-16

Country Status (13)

Country Link
US (3) US20110195426A1 (en)
EP (1) EP2454588B1 (en)
JP (3) JP5909444B2 (en)
KR (2) KR20120037992A (en)
CN (2) CN105779436A (en)
AU (1) AU2010273928A1 (en)
BR (1) BR112012001077A2 (en)
CA (1) CA2768371A1 (en)
DK (1) DK2454588T3 (en)
ES (1) ES2547715T3 (en)
IN (1) IN2012DN00866A (en)
SG (2) SG2014014617A (en)
WO (1) WO2011009104A1 (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2736726T3 (en) * 2006-03-09 2020-01-07 Aethlon Medical Inc Extracorporeal removal of microvesicular particles
US11266736B2 (en) 2008-04-17 2022-03-08 Vin De Bona Trading Company Pte Ltd Method of painting micro vesicles
EP3461912B1 (en) * 2009-09-09 2022-07-13 The General Hospital Corporation Use of microvesicles in analyzing nucleic acid profiles
EP2475989A4 (en) 2009-09-09 2013-02-27 Gen Hospital Corp USE OF MICROVESICLES IN THE ANALYSIS OF KRAS MUTATIONS
JP5755326B2 (en) * 2010-06-11 2015-07-29 日立化成株式会社 How to determine the characteristics of renal function
US20140045915A1 (en) 2010-08-31 2014-02-13 The General Hospital Corporation Cancer-related biological materials in microvesicles
EP2638057B1 (en) * 2010-11-10 2019-03-06 Exosome Diagnostics, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
US20120196285A1 (en) * 2011-01-31 2012-08-02 Esoterix Genetic Laboratories, Llc Methods for Enriching Microparticles or Nucleic Acids Using Binding Molecules
EP3569607A1 (en) 2011-05-11 2019-11-20 Exosome Diagnostics, Inc. Nucleic acid extraction from heterogeneous biological materials
WO2012170037A1 (en) 2011-06-10 2012-12-13 Hitachi Chemical Co., Ltd. Vesicle capturing devices and methods for using same
EP2748335B1 (en) 2011-08-22 2018-10-03 Exosome Diagnostics, Inc. Urine biomarkers
US10174361B2 (en) * 2011-11-10 2019-01-08 Exosome Diagnostics, Inc. Cerebrospinal fluid assay
CN104995311A (en) 2012-08-30 2015-10-21 外来体诊断公司 Controls for nucleic acid assays
CN105025878A (en) * 2012-10-03 2015-11-04 外来体诊断公司 Use of microbubbles in the diagnosis, prognosis and treatment of medical diseases and conditions
US20150275301A1 (en) * 2012-10-05 2015-10-01 Hitachi Chemical Co., Ltd. URINE EXOSOME mRNAS AND METHODS OF USING SAME TO DETECT DIABETIC NEPHROPATHY
DK2906717T3 (en) 2012-10-11 2019-04-01 Vin De Bona Trading Company Pte Ltd PROCEDURE FOR PAINTING MICROVESICS
CN105209881B (en) 2013-03-13 2021-01-22 迈阿密大学 Methods of isolation and purification of microvesicles from cell culture supernatants and biological fluids
DE212013000295U1 (en) 2013-05-06 2016-02-02 Hitachi Chemical Co. America, Ltd. Devices for capturing target molecules
US10301681B2 (en) 2013-08-06 2019-05-28 Exosome Diagnostics, Inc. Methods of treating a subject with a high gleason score prostate cancer
ES2923942T3 (en) 2013-11-06 2022-10-03 Us Health Procedure for the subtyping of lymphoma types by means of expression profiles
US10494676B2 (en) * 2013-12-02 2019-12-03 Albert-Ludwigs-Universitaet Freiburg Process for the diagnosis of cancer by using exosomes
EP3125907A4 (en) 2014-04-01 2017-11-29 Cornell University Use of double-stranded dna in exosomes: a novel biomarker in cancer detection
WO2015164435A1 (en) * 2014-04-22 2015-10-29 Trovagene, Inc. Concentrating nucleic acids in urine
CN104031915A (en) * 2014-06-17 2014-09-10 复旦大学附属肿瘤医院 Gene segments for prognosis of colorectal cancers and application of gene segments
US10266895B2 (en) 2014-11-05 2019-04-23 Hitachi Chemical Company Ltd. Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease
WO2016077537A1 (en) 2014-11-12 2016-05-19 Hitachi Chemical Co., Ltd. Method and device for diagnosing organ injury
WO2016172598A1 (en) * 2015-04-22 2016-10-27 The Broad Institute Inc. Exosomes and uses thereof
GB2539497A (en) 2015-06-19 2016-12-21 Airbus Operations Ltd A Rotational Joint For An Aircraft Folding Wing
WO2017040520A1 (en) 2015-08-31 2017-03-09 Hitachi Chemical Co., Ltd. Molecular methods for assessing urothelial disease
US11702702B2 (en) 2016-04-15 2023-07-18 Predicine, Inc. Systems and methods for detecting genetic alterations
WO2017197399A1 (en) * 2016-05-13 2017-11-16 Exosome Diagnostics, Inc. Automated and manual methods for isolation of extracellular vesicles and co-isolation of cell-free dna from biofluids
US11174503B2 (en) 2016-09-21 2021-11-16 Predicine, Inc. Systems and methods for combined detection of genetic alterations
CN110945145B (en) 2017-05-17 2024-06-11 外来体诊断公司 Microvesicle nucleic acids and/or proteins and their use as markers for renal transplant rejection
EP3652315A4 (en) 2017-07-12 2021-09-01 Exosome Diagnostics, Inc. METHOD OF ISOLATION AND ENRICHMENT OF POPULATIONS OF EXTRACELLULAR VESICULES FROM A BIOFLUID AND METHOD OF USING THEREOF
JP7069587B2 (en) * 2017-07-31 2022-05-18 東ソー株式会社 How to clean analytical equipment
WO2019116234A1 (en) * 2017-12-12 2019-06-20 Nestec S.A. Methods for determining microbiome ribosomal rna composition changes
JP7444386B2 (en) * 2018-06-07 2024-03-06 株式会社Lsiメディエンス Method for isolating and analyzing microvesicles from human urine
WO2020106853A1 (en) 2018-11-20 2020-05-28 Exosome Diagnostics, Inc. Compositions and methods for internal controls of microvesicle isolations
CN109856259A (en) * 2018-12-29 2019-06-07 南通大学附属医院 A kind of serum cancer of pancreas excretion body differential protein and its again verification process
CN111593093B (en) * 2020-03-09 2022-03-04 中山大学 Method for obtaining substrate sequence efficiently combined in ADAR protein cell, substrate sequence and application
US20230203587A1 (en) 2020-05-29 2023-06-29 Exosome Diagnostics, Inc. Use of microvesicle signature for the diagnosis and treatment of kidney transplant rejection
CA3190604A1 (en) 2020-08-15 2022-02-24 Regeneron Pharmaceuticals, Inc. Treatment of obesity in subjects having variant nucleic acid molecules encoding calcitonin receptor (calcr)
US20250075258A1 (en) 2021-07-16 2025-03-06 Exosome Diagnostics, Inc. Methods of detecting sjogren's syndrome using salivary exosomes
KR20240161644A (en) 2022-02-18 2024-11-12 엑소좀 디아그노스틱스, 인크. Use of microvesicle signatures in the identification and treatment of renal disorders
CN114480656B (en) * 2022-03-07 2023-12-26 温州医科大学附属眼视光医院 Application of SLC12A3 and/or SLC12A9 as grape membrane melanoma treatment and prognosis detection index
WO2024054572A1 (en) 2022-09-07 2024-03-14 Exosome Diagnostics, Inc. Methods of detecting sjögren's syndrome using salivary exosomes

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639611A (en) 1988-12-12 1997-06-17 City Of Hope Allele specific polymerase chain reaction
US5219727A (en) 1989-08-21 1993-06-15 Hoffmann-Laroche Inc. Quantitation of nucleic acids using the polymerase chain reaction
US5840867A (en) 1991-02-21 1998-11-24 Gilead Sciences, Inc. Aptamer analogs specific for biomolecules
CA2218875C (en) 1991-07-23 2000-11-07 The Research Foundation Of State University Of New York Improvements in the in situ pcr
US5582981A (en) 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5639606A (en) 1993-04-06 1997-06-17 The University Of Rochester Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
US5556773A (en) 1993-08-06 1996-09-17 Yourno; Joseph Method and apparatus for nested polymerase chain reaction (PCR) with single closed reaction tubes
ES2347854T5 (en) * 1996-03-26 2014-07-24 Michael S. Kopreski Method that allows the use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate a cancer
CA2270132A1 (en) 1996-11-06 1998-05-14 Sequenom, Inc. Dna diagnostics based on mass spectrometry
EP0985148A4 (en) 1997-05-28 2004-03-10 Inst Medical W & E Hall NUCLEIC ACID DIAGNOSTICS BY MASS SPECTROMETRY OR MASS SEPARATION AND SPECIFIC BASE DIVISION
US6004755A (en) 1998-04-07 1999-12-21 Incyte Pharmaceuticals, Inc. Quantitative microarray hybridizaton assays
US6204375B1 (en) * 1998-07-31 2001-03-20 Ambion, Inc. Methods and reagents for preserving RNA in cell and tissue samples
FR2788780B1 (en) 1999-01-27 2001-03-30 Ap Cells Inc PROCESS FOR THE PREPARATION OF MEMBRANE VESICLES
GB9927320D0 (en) 1999-11-18 2000-01-12 Chiron Spa Exosome separation
EP1927604A1 (en) * 2000-01-28 2008-06-04 MIP Technologies AB Functional monomers for molecular recognition and catalysis
US20040241176A1 (en) * 2000-04-27 2004-12-02 Ap Cells. Inc. Method of producing membrane vesicles
US6812023B1 (en) 2000-04-27 2004-11-02 Anosys, Inc. Methods of producing membrane vesicles
US6913879B1 (en) 2000-07-10 2005-07-05 Telechem International Inc. Microarray method of genotyping multiple samples at multiple LOCI
US6525154B1 (en) 2000-07-20 2003-02-25 The Regents Of The University Of California Molecular imprinting for the recognition of peptides in aqueous solution
WO2002092763A2 (en) * 2001-05-11 2002-11-21 Regents Of The University Of Minnesota Intron associated with myotonic dystrophy type 2 and methods of use
WO2002099064A2 (en) * 2001-06-05 2002-12-12 Gene Logic, Inc. Rna purification methods
US6696271B2 (en) 2001-08-23 2004-02-24 The Regents Of The University Of California Frozen tissue microarray technology for analysis of RNA, DNA, and proteins
WO2003023065A1 (en) 2001-09-06 2003-03-20 Syngenta Participations Ag Dna methylation patterns
US20030162190A1 (en) 2001-11-15 2003-08-28 Gorenstein David G. Phosphoromonothioate and phosphorodithioate oligonucleotide aptamer chip for functional proteomics
CA2489360C (en) 2002-06-26 2013-01-29 Cold Spring Harbor Laboratory Methods and compositions for determining methylation profiles
JP2005537002A (en) 2002-09-02 2005-12-08 パムジーン ベー.ベー. New integrated microarray analysis
US7141371B2 (en) 2002-09-06 2006-11-28 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods for detecting and localizing DNA mutations by microarray
EP1498144A1 (en) * 2003-07-15 2005-01-19 Universite Pierre Et Marie Curie Paris Vi Extracellular vesicles from non-pathogenic amoebae useful as vehicle for transferring a molecule of interest to an eukaryotic cell
US7384589B2 (en) 2003-08-01 2008-06-10 Lawrence Livermore National Security, Llc Nanoscale molecularly imprinted polymers and method thereof
EP1766053A4 (en) * 2004-06-02 2007-12-12 Sourcepharm Inc Rna-containing microvesicles and methods therefor
US8021847B2 (en) * 2004-06-02 2011-09-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
KR20070058441A (en) * 2004-07-01 2007-06-08 유니버시티 오브 피츠버그 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 Immunosuppressive exosomes
US20060223072A1 (en) * 2005-03-31 2006-10-05 Boyes Barry E Methods of using a DNase I-like enzyme
WO2006113590A2 (en) 2005-04-15 2006-10-26 Cedars-Sinai Medical Center Flow-cytometric heteroduplex analysis for detection of genetic alterations
AU2006243757B2 (en) * 2005-05-03 2012-02-09 Altheadx, Inc. Compositions and methods for the analysis of degraded nucleic acids
CA2643322C (en) * 2006-02-24 2015-07-21 Novartis Ag Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions
JP2008035779A (en) * 2006-08-07 2008-02-21 Mitsubishi Rayon Co Ltd Method for measuring nucleic acid degradation and nucleic acid array
US20080287669A1 (en) * 2007-05-16 2008-11-20 Braman Jeffrey C Methods and compositions for identifying compounds useful in nucleic acid purification
CA2676113C (en) * 2007-07-25 2014-07-08 University Of Louisville Research Foundation, Inc. Exosome-associated microrna as a diagnostic marker
EP2176665B1 (en) * 2007-08-16 2016-03-02 The Royal Institution for the Advancement of Learning / McGill University Tumor cell-derived microvesicles
EP2198296B1 (en) * 2007-09-05 2015-11-11 Laurentian University Method of using tumour rna integrity to measure response to chemotherapy in cancer patients
US8455199B2 (en) * 2007-09-14 2013-06-04 The Ohio State University Research Foundation MicroRNA expression in human peripheral blood microvesicles and uses thereof
EP2604704B1 (en) * 2008-02-01 2018-10-03 The General Hospital Corporation Use of microvesicles in diagnosis and prognosis of brain tumor

Also Published As

Publication number Publication date
US20160348095A1 (en) 2016-12-01
BR112012001077A2 (en) 2020-08-11
JP5909444B2 (en) 2016-04-26
AU2010273928A2 (en) 2012-02-09
CN102498397B (en) 2016-04-06
KR20180029105A (en) 2018-03-19
SG2014014617A (en) 2014-05-29
CN105779436A (en) 2016-07-20
HK1171083A1 (en) 2013-03-15
EP2454588A1 (en) 2012-05-23
WO2011009104A1 (en) 2011-01-20
EP2454588B1 (en) 2015-07-15
US20110195426A1 (en) 2011-08-11
EP2454588A4 (en) 2012-12-12
CA2768371A1 (en) 2011-01-20
SG177677A1 (en) 2012-02-28
ES2547715T3 (en) 2015-10-08
JP2012533308A (en) 2012-12-27
KR20120037992A (en) 2012-04-20
US20170114389A1 (en) 2017-04-27
JP2017131244A (en) 2017-08-03
AU2010273928A1 (en) 2012-02-09
HK1173213A1 (en) 2013-05-10
JP2016116512A (en) 2016-06-30
DK2454588T3 (en) 2015-09-28
CN102498397A (en) 2012-06-13

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