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IN2012DE00794A - - Google Patents

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Publication number
IN2012DE00794A
IN2012DE00794A IN794DE2012A IN2012DE00794A IN 2012DE00794 A IN2012DE00794 A IN 2012DE00794A IN 794DE2012 A IN794DE2012 A IN 794DE2012A IN 2012DE00794 A IN2012DE00794 A IN 2012DE00794A
Authority
IN
India
Prior art keywords
liphagane
meroterpenoid
scaffold
anticancer activity
pi3k
Prior art date
Application number
Inventor
A Vishwakarma Ram
Damodhar Sawant Sanghapal
Pal Singh Parvinder
Hamid Dar Abid
Raj Sharma Parduman
Kumar Saxena Ajit
Nargotra Amit
Yaaravid Kumar Kollurunajane
Ramesh Mudduddla
Khurshid Qazi Asif
Hussain Ashiq
Chanauria Nayan
Original Assignee
Council Scient Ind Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Council Scient Ind Res filed Critical Council Scient Ind Res
Priority to US14/385,808 priority Critical patent/US9206201B2/en
Priority to CA2867452A priority patent/CA2867452C/en
Priority to CN201380026291.5A priority patent/CN104395325B/en
Priority to JP2015501053A priority patent/JP6126197B2/en
Priority to IN794DE2012 priority patent/IN2012DE00794A/en
Priority to EP13723567.7A priority patent/EP2828269B1/en
Priority to PCT/IN2013/000169 priority patent/WO2013140417A1/en
Priority to TW102109708A priority patent/TWI577687B/en
Publication of IN2012DE00794A publication Critical patent/IN2012DE00794A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The analogs of meroterpenoid liphagane scaffold have been designed, synthesized and its biological evaluation results for anticancer activity by inhibiting PI3K pathway is presented in this invention. The field of invention for this work relates and covers the development of novel PI3K-α/ß inhibitors based on meroterpenoid liphagane scaffold for anticancer activity.
IN794DE2012 2012-03-19 2013-03-18 IN2012DE00794A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US14/385,808 US9206201B2 (en) 2012-03-19 2013-03-18 Boronic acid bearing liphagane compounds as inhibitors of P13K-α and/or β
CA2867452A CA2867452C (en) 2012-03-19 2013-03-18 Boronic acid bearing liphagane compounds as inhibitors of pi3k-.alpha. and/or .beta.
CN201380026291.5A CN104395325B (en) 2012-03-19 2013-03-18 With the LIPHAGANE compound of boric acid as the inhibitor of PI3K-α and/or β
JP2015501053A JP6126197B2 (en) 2012-03-19 2013-03-18 Rifagain compound with boronic acid as an inhibitor of PI3K-α and / or β
IN794DE2012 IN2012DE00794A (en) 2012-03-19 2013-03-18
EP13723567.7A EP2828269B1 (en) 2012-03-19 2013-03-18 Boronic acid bearing liphagane compounds as inhibitors of pi3k-alpha and/or beta
PCT/IN2013/000169 WO2013140417A1 (en) 2012-03-19 2013-03-18 BORONIC ACID BEARING LIPHAGANE COMPOUNDS AS INHIBITORS OF PI3K-α AND/OR β
TW102109708A TWI577687B (en) 2012-03-19 2013-03-19 Boronic acid bearing liphagane compounds as inhibitors of pi3k-α and/or β

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN794DE2012 IN2012DE00794A (en) 2012-03-19 2013-03-18

Publications (1)

Publication Number Publication Date
IN2012DE00794A true IN2012DE00794A (en) 2015-08-21

Family

ID=48464053

Family Applications (1)

Application Number Title Priority Date Filing Date
IN794DE2012 IN2012DE00794A (en) 2012-03-19 2013-03-18

Country Status (8)

Country Link
US (1) US9206201B2 (en)
EP (1) EP2828269B1 (en)
JP (1) JP6126197B2 (en)
CN (1) CN104395325B (en)
CA (1) CA2867452C (en)
IN (1) IN2012DE00794A (en)
TW (1) TWI577687B (en)
WO (1) WO2013140417A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3199090B2 (en) 1993-10-19 2001-08-13 東芝ライテック株式会社 Discharge lamp lighting device
WO2018203564A1 (en) 2017-05-02 2018-11-08 国立大学法人東北大学 Liphagal analog and multi-targeted kinase inhibitor containing liphagal or analog thereof
JP2019099537A (en) * 2017-12-07 2019-06-24 コニカミノルタ株式会社 Method for producing nitrogen-containing heterocyclic compound
WO2024222697A1 (en) * 2023-04-23 2024-10-31 纽欧申医药(上海)有限公司 Nitrogen-containing polycyclic compound, and preparation method therefor and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006081659A1 (en) * 2005-02-01 2006-08-10 The University Of British Columbia Meroterpenoid inhibitors of phosphoinositide 3 kinase (pi3k)
GB2465405A (en) * 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy

Also Published As

Publication number Publication date
US9206201B2 (en) 2015-12-08
CA2867452A1 (en) 2013-09-26
CA2867452C (en) 2020-04-14
CN104395325B (en) 2016-12-07
EP2828269A1 (en) 2015-01-28
JP2015514701A (en) 2015-05-21
TWI577687B (en) 2017-04-11
WO2013140417A4 (en) 2013-11-21
JP6126197B2 (en) 2017-05-10
EP2828269B1 (en) 2018-05-16
WO2013140417A1 (en) 2013-09-26
TW201341391A (en) 2013-10-16
US20150051173A1 (en) 2015-02-19
CN104395325A (en) 2015-03-04

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