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IN2011KN02904A - - Google Patents

Info

Publication number
IN2011KN02904A
IN2011KN02904A IN2904KON2011A IN2011KN02904A IN 2011KN02904 A IN2011KN02904 A IN 2011KN02904A IN 2904KON2011 A IN2904KON2011 A IN 2904KON2011A IN 2011KN02904 A IN2011KN02904 A IN 2011KN02904A
Authority
IN
India
Prior art keywords
general formula
solvates
hydrates
compound
optionally
Prior art date
Application number
Inventor
László Czibula
Bálint Juhász
Csongor Éva Ágainé
Ferenc Sebok
János Galambos
Katalin Nógrádi
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of IN2011KN02904A publication Critical patent/IN2011KN02904A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to a new process for the preparation of compounds of general formula (I) and hydrochloric acid alts and/or hydrates and/or solvates thereof, by dissolving suspending trans 4-[2-[4-(2,3-dichlorophenyl)-piperazine1-il]-cyclohexylamine of formula (III) or a salt or a hydrate or a solvate thereof in an inert solvent in the presence base then adding a carbonic acid derivative of general formula (VI) wherein R is alkyl with C1-6 straight or branched chain or C1-2 fully halogenated alkyl, Z is -O-R or -X, wherein R is as described above, X is halogen, and reacting the compound of general formula (IV) obtained wherein R is as described above, in situ or, optionally in isolated state with an amine of general formula (V) wherein R1 and R2 are as described above to obtain the compound of general formula (I) and then optionally forming the hydrochloride salts and/or hydrates and/or solvates thereof.
IN2904KON2011 2008-12-18 2009-12-18 IN2011KN02904A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0800765A HUP0800765A2 (en) 2008-12-18 2008-12-18 A new process for the preparation of piperazine derivatives and their hydrochloric salts
PCT/HU2009/000109 WO2010070370A1 (en) 2008-12-18 2009-12-18 Process for the preparation of piperazine compounds and hydrochloride salts thereof

Publications (1)

Publication Number Publication Date
IN2011KN02904A true IN2011KN02904A (en) 2015-07-10

Family

ID=89988674

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2904KON2011 IN2011KN02904A (en) 2008-12-18 2009-12-18

Country Status (27)

Country Link
US (1) US8569498B2 (en)
EP (1) EP2358691B8 (en)
JP (1) JP5744751B2 (en)
CN (1) CN102256954B (en)
AU (1) AU2009329295B2 (en)
BR (1) BRPI0923380B8 (en)
CA (1) CA2744073C (en)
CY (1) CY1113923T1 (en)
DK (1) DK2358691T3 (en)
EA (1) EA019329B1 (en)
ES (1) ES2407182T3 (en)
GE (1) GEP20125712B (en)
HR (1) HRP20130394T1 (en)
HU (1) HUP0800765A2 (en)
IL (1) IL212640A (en)
IN (1) IN2011KN02904A (en)
MX (1) MX2011006590A (en)
NZ (1) NZ592906A (en)
PL (1) PL2358691T3 (en)
PT (1) PT2358691E (en)
RS (1) RS52738B (en)
SG (1) SG171716A1 (en)
SI (1) SI2358691T1 (en)
SM (1) SMT201300063B (en)
TW (1) TWI460164B (en)
UA (1) UA102422C2 (en)
WO (1) WO2010070370A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US7875610B2 (en) * 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
WO2009104739A1 (en) * 2008-02-21 2009-08-27 田辺三菱製薬株式会社 Solid preparation for oral administration
UA104869C2 (en) 2008-07-16 2014-03-25 Ріхтер Гедеон Нірт. Normal;heading 1;heading 2;heading 3;PHARMACEUTICAL FORMULATIONS CONTAINING DOPAMINE RECEPTOR LIGANDS
HU230067B1 (en) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Novel piperazine salt and preparation method thereof
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
HUP0900790A2 (en) * 2009-12-17 2011-09-28 Richter Gedeon Nyrt A new process for the preparation of piperazine and their hydrochloric salts
EP2508525A1 (en) 2011-04-05 2012-10-10 Bayer Pharma Aktiengesellschaft Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts
CN104140421B (en) 2013-05-08 2017-04-05 上海医药工业研究院 Benzo isothiazole compound and the application in antipsychotic drug is prepared
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
CN110317182B (en) * 2018-03-29 2021-10-15 上虞京新药业有限公司 Preparation method of cariprazine
CN108586389B (en) * 2018-06-29 2020-06-12 成都福柯斯医药技术有限公司 Method for synthesizing Carilazine
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
CN111892556A (en) * 2019-05-06 2020-11-06 北京万全德众医药生物技术有限公司 Process for preparing cariprazine
CN110372557B (en) * 2019-08-06 2021-05-18 上海勋和医药科技有限公司 Cyclohexanamines D3/D2Partial receptor agonists
CN113754580B (en) 2020-06-05 2023-04-25 上海中泽医药科技有限公司 A kind of pyridine morpholine compound, its preparation method and its application
CN113912565A (en) * 2020-07-11 2022-01-11 广东东阳光药业有限公司 A kind of new crystal form of cariprazine and preparation method thereof
KR20240112213A (en) 2023-01-11 2024-07-18 리히터 게데온 닐트. Dopamine d3/d2 receptor modulating compounds

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US4957921A (en) 1989-12-06 1990-09-18 Warner-Lambert Company Substituted cyclohexanols as central nervous system agents
US5047406A (en) 1989-12-06 1991-09-10 Warner-Lambert Co. Substituted cyclohexanols as central nervous system agents
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WO1997011070A1 (en) 1995-09-22 1997-03-27 Warner-Lambert Company Substituted cyclohexylamines as central nervous system agents
RU2230740C2 (en) 1998-03-31 2004-06-20 Акадиа Фармасьютикалз, Инк. Derivatives of nitrogen-containing heterocyclic compounds and pharmaceutical composition based on thereof
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
SE9802208D0 (en) 1998-06-22 1998-06-22 Astra Pharma Inc Novel compounds
US6489341B1 (en) 1999-06-02 2002-12-03 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using sertindole derivatives
BR0207832A (en) 2001-02-27 2004-06-22 Ortho Mcneil Pharm Inc Carbamate compounds for use in preventing or treating bipolar disorder
US6566550B2 (en) 2001-06-21 2003-05-20 Pfizer Inc Substituted aromatic ethers as inhibitors of glycine transport
HU227543B1 (en) 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
SE0200301D0 (en) 2002-02-01 2002-02-01 Axon Biochemicals Bv Thio-carbostyril derivative
US6919342B2 (en) 2003-06-05 2005-07-19 Abbott Gmbh & Co. Kg Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
HU227534B1 (en) 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
DE102004047517A1 (en) 2004-09-28 2006-03-30 Merck Patent Gmbh Novel crystal form of (3-cyano-1H-indol-7-yl) - [4- (4-fluorophenethyl) -piperazin-1-yl] -methanone, hydrochloride
HUP0500170A3 (en) 2005-02-03 2007-11-28 Richter Gedeon Nyrt Piperazine derivatives, process for producing them and pharmaceutical compositions containing them
GT200600414A (en) 2005-09-12 2007-09-20 PIPERAZINE COMPOSITE GLUCURANATE SALT
HU230748B1 (en) 2007-05-11 2018-02-28 Richter Gedeon Nyrt New piperazine salt and process for its preparation
HUE033357T2 (en) 2007-05-11 2017-11-28 Richter Gedeon Nyrt Crystalline form of a carbamoyl-cyclohexane derivative
HUP0700353A2 (en) 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
HUP0700369A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment in the manufacture of a medicament for the treatment of schizophrenia
HUP0700370A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania
US20100256145A1 (en) 2007-08-01 2010-10-07 H. Lundbeck A/S Use of kcnq potassium channel openers for reducing symptoms of or treating disorders or conditions wherein the dopaminergic system is disrupted
US7875610B2 (en) 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
WO2009104739A1 (en) 2008-02-21 2009-08-27 田辺三菱製薬株式会社 Solid preparation for oral administration
UA104869C2 (en) 2008-07-16 2014-03-25 Ріхтер Гедеон Нірт. Normal;heading 1;heading 2;heading 3;PHARMACEUTICAL FORMULATIONS CONTAINING DOPAMINE RECEPTOR LIGANDS
HU230067B1 (en) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Novel piperazine salt and preparation method thereof
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives

Also Published As

Publication number Publication date
EA019329B1 (en) 2014-02-28
HUP0800765A2 (en) 2010-11-29
HRP20130394T1 (en) 2013-06-30
US20110275804A1 (en) 2011-11-10
TW201033180A (en) 2010-09-16
UA102422C2 (en) 2013-07-10
MX2011006590A (en) 2011-07-12
AU2009329295B2 (en) 2014-02-06
EA201170808A1 (en) 2011-12-30
CN102256954B (en) 2016-09-28
SG171716A1 (en) 2011-07-28
NZ592906A (en) 2013-07-26
HK1160849A1 (en) 2012-08-17
BRPI0923380B1 (en) 2022-05-24
CA2744073C (en) 2016-07-12
PL2358691T3 (en) 2013-08-30
CY1113923T1 (en) 2016-07-27
GEP20125712B (en) 2012-12-10
JP2012512861A (en) 2012-06-07
IL212640A (en) 2014-06-30
WO2010070370A8 (en) 2011-04-28
IL212640A0 (en) 2011-07-31
BRPI0923380A2 (en) 2015-07-28
EP2358691A1 (en) 2011-08-24
SMT201300063B (en) 2013-07-09
PT2358691E (en) 2013-05-22
EP2358691B1 (en) 2013-03-20
AU2009329295A1 (en) 2010-06-24
BRPI0923380B8 (en) 2022-07-19
CN102256954A (en) 2011-11-23
DK2358691T3 (en) 2013-05-21
US8569498B2 (en) 2013-10-29
HU0800765D0 (en) 2009-03-02
JP5744751B2 (en) 2015-07-08
SI2358691T1 (en) 2013-07-31
RS52738B (en) 2013-08-30
TWI460164B (en) 2014-11-11
ES2407182T3 (en) 2013-06-12
EP2358691B8 (en) 2013-05-01
CA2744073A1 (en) 2010-06-24
WO2010070370A1 (en) 2010-06-24

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