IN2013DE02677AIN2677DE2013AIN2013DE02677AIN 2013DE02677 AIN2013DE02677 AIN 2013DE02677AIN 2677DE2013 AIN2677DE2013 AIN 2677DE2013AIN 2013DE02677 AIN2013DE02677 AIN 2013DE02677A
Authority
IN
India
Prior art keywords
preparation
carboxylic acid
pure form
tapentadol
tapentadol hydrochloride
Prior art date
Application number
Inventor
Rajesh Vinodrai Naik
Gurdeep Singh Sarin
Pranav Gupta
Original Assignee
Ind Swift Lab Ltd
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Filing date
Publication date
Application filed by Ind Swift Lab LtdfiledCriticalInd Swift Lab Ltd
Priority to IN2677DE2013priorityCriticalpatent/IN2013DE02677A/en
Publication of IN2013DE02677ApublicationCriticalpatent/IN2013DE02677A/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions
(AREA)
Abstract
ABSTRACT OF THE INVENTION Process for the preparation of pure Form B of Tapentadol Hydrochloride The present invention relates to an improved and industrially advantageous process for the preparation of pure Form B of tapentadol hydrochloride in consistent manner by treating tapentadol base with a suitable source of hydrogen chloride in a suitable solvent in the presence of a suitable carboxylic acid other than lower aliphatic carboxylic acid.