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IN2013CN02463A - - Google Patents

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Publication number
IN2013CN02463A
IN2013CN02463A IN2463CHN2013A IN2013CN02463A IN 2013CN02463 A IN2013CN02463 A IN 2013CN02463A IN 2463CHN2013 A IN2463CHN2013 A IN 2463CHN2013A IN 2013CN02463 A IN2013CN02463 A IN 2013CN02463A
Authority
IN
India
Prior art keywords
nampt
antidotes
inhibition
compositions
compounds
Prior art date
Application number
Inventor
Kenneth W Bair
Timm Baumeister
Alexandre J Buckmelter
Karl H Clodfelter
Peter DRAGOVICH
Francis Gosselin
Bingsong Han
Jian Lin
Dominic J Reynolds
Bruce Roth
Chase C Smith
Zhongguo Wang
Po Wai Yuen
Xiaozhang Zheng
Original Assignee
Forma Tm Llc
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Tm Llc, Genentech Inc filed Critical Forma Tm Llc
Publication of IN2013CN02463A publication Critical patent/IN2013CN02463A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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Abstract

The present invention relates to compounds and compositions for the inhibition of NAMPT their synthesis applications and antidotes. An illustrative compound of the invention is shown below:
IN2463CHN2013 2010-09-03 2011-09-02 IN2013CN02463A (en)

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US201161475813P 2011-04-15 2011-04-15
US201161483242P 2011-05-06 2011-05-06
PCT/US2011/050321 WO2012031197A1 (en) 2010-09-03 2011-09-02 Novel compounds and compositions for the inhibition of nampt

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