IN2009DN05670A - - Google Patents
Download PDFInfo
- Publication number
- IN2009DN05670A IN2009DN05670A IN5670DEN2009A IN2009DN05670A IN 2009DN05670 A IN2009DN05670 A IN 2009DN05670A IN 5670DEN2009 A IN5670DEN2009 A IN 5670DEN2009A IN 2009DN05670 A IN2009DN05670 A IN 2009DN05670A
- Authority
- IN
- India
- Prior art keywords
- carbolines
- producing
- intermediates
- fused gamma
- methods
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90647307P | 2007-03-12 | 2007-03-12 | |
| PCT/US2008/003340 WO2008112280A1 (fr) | 2007-03-12 | 2008-03-12 | Synthèse de gamma-carbolines fusionnées à hétérocycles substitués |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2009DN05670A true IN2009DN05670A (fr) | 2015-07-24 |
Family
ID=39759858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN5670DEN2009 IN2009DN05670A (fr) | 2007-03-12 | 2008-03-12 |
Country Status (12)
| Country | Link |
|---|---|
| US (11) | US8309722B2 (fr) |
| EP (2) | EP3663294A1 (fr) |
| JP (7) | JP5567349B2 (fr) |
| KR (7) | KR102238390B1 (fr) |
| CN (2) | CN103626766B (fr) |
| AU (5) | AU2008226814C1 (fr) |
| CA (1) | CA2679754C (fr) |
| DK (1) | DK2134710T3 (fr) |
| ES (1) | ES2776889T3 (fr) |
| IN (1) | IN2009DN05670A (fr) |
| MX (3) | MX394214B (fr) |
| WO (1) | WO2008112280A1 (fr) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102238390B1 (ko) | 2007-03-12 | 2021-04-08 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 치환된 헤테로환 융합 감마-카르볼린 합성 |
| ES2523580T3 (es) | 2008-01-11 | 2014-11-27 | Albany Molecular Research, Inc. | Piridoindoles substituidos con (1-Azinona) |
| DK2262505T3 (en) * | 2008-03-12 | 2015-01-05 | Intra Cellular Therapies Inc | Substituted heterocyclic-CONCENTRATED GAMMA -carboline-SOLID |
| MX377802B (es) | 2008-05-27 | 2025-03-11 | Intra Cellular Therapies Inc | Metodos y composiciones para trastornos del sueño y otros trastornos. |
| US9107696B2 (en) * | 2008-08-06 | 2015-08-18 | Emory University | Method of embryo transfer that eliminates transferred air while hormonally inducing implantation and apparatus |
| JP2012504137A (ja) | 2008-09-29 | 2012-02-16 | アボット・ラボラトリーズ | インドール誘導体およびインドリン誘導体ならびにそれらの使用方法 |
| US9625475B2 (en) | 2008-09-29 | 2017-04-18 | Abbvie Inc. | Indole and indoline derivatives and methods of use thereof |
| US8637501B2 (en) | 2009-07-01 | 2014-01-28 | Albany Molecular Research, Inc. | Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof |
| US9073925B2 (en) | 2009-07-01 | 2015-07-07 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
| US8618299B2 (en) | 2009-07-01 | 2013-12-31 | Albany Molecular Research, Inc. | Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof |
| US8629158B2 (en) | 2009-07-01 | 2014-01-14 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
| US8993572B2 (en) | 2010-04-22 | 2015-03-31 | Intra-Cellular Therapies, Inc. | Pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalines derivatives and [1,4]oxazino[2,3,4-hi]pyrido[4,3-b]indole derivatives |
| WO2012088038A2 (fr) | 2010-12-21 | 2012-06-28 | Albany Molecular Research, Inc. | Antagonistes de mch-1 consistant en tétrahydro-carbolines substituées par pipérazinone, leurs procédés de fabrication et utilisations |
| US8993765B2 (en) | 2010-12-21 | 2015-03-31 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof |
| RU2014145682A (ru) | 2012-04-14 | 2016-06-10 | Интра-Селлулар Терапиз, Инк | Органические соединения |
| US9708322B2 (en) | 2013-03-15 | 2017-07-18 | Intra-Cellular Therapies, Inc. | Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for inhibiting serotonin reuptake transporter activity |
| CA3205777A1 (en) | 2013-12-03 | 2015-06-11 | Intra-Cellular Therapies, Inc. | Heterocycle fused gamma-carboline compounds for use in treatment of schizophrenia |
| WO2015154030A1 (fr) | 2014-04-04 | 2015-10-08 | Intra-Cellular Therapies, Inc. | Composés organiques |
| US10077267B2 (en) | 2014-04-04 | 2018-09-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US10179776B2 (en) | 2014-06-09 | 2019-01-15 | Intra-Cellular Therapies, Inc. | Compounds and methods of use to treat schizophrenia |
| US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| WO2016176634A1 (fr) * | 2015-04-30 | 2016-11-03 | The Regents Of The University Of Colorado, A Body Corporate | Composés d'indoline et d'indolénine polycycliques |
| PL3838274T3 (pl) | 2016-01-26 | 2024-04-02 | Intra-Cellular Therapies, Inc. | Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN |
| CA3016353C (fr) | 2016-03-25 | 2021-04-27 | Intra-Cellular Therapies, Inc. | Gamma-carbolines fusionnees a heterocycles deuteries et leurs compositions utiles dans le traitement de troubles du systeme nerveux central |
| WO2017172811A1 (fr) * | 2016-03-28 | 2017-10-05 | Intra-Cellular Therapies, Inc. | Nouveaux co-cristaux |
| WO2017172784A1 (fr) * | 2016-03-28 | 2017-10-05 | Intra-Cellular Therapies, Inc. | Nouveaux sels et cristaux |
| EP3436083A4 (fr) | 2016-03-28 | 2019-11-27 | Intra-Cellular Therapies, Inc. | Nouvelles compositions et méthodes |
| HRP20211666T1 (hr) | 2016-08-09 | 2022-02-18 | Teva Pharmaceuticals International Gmbh | Oblici soli lumateperon ditozilata u krutom stanju |
| WO2018064465A1 (fr) | 2016-09-29 | 2018-04-05 | The Regents Of The University Of California | Composés pour l'augmentation de la plasticité neuronale |
| EP3525763B1 (fr) | 2016-10-12 | 2025-03-05 | Intra-Cellular Therapies, Inc. | Dispersions solides amorphes |
| US10961245B2 (en) | 2016-12-29 | 2021-03-30 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders |
| JP6987868B2 (ja) | 2016-12-29 | 2022-01-05 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
| KR102398194B1 (ko) | 2017-03-24 | 2022-05-18 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 조성물 및 방법 |
| CN110636845A (zh) | 2017-04-10 | 2019-12-31 | 雷迪博士实验室有限公司 | 卢美哌隆对甲苯磺酸盐的无定形形式和固体分散体 |
| BR112020001666A2 (pt) | 2017-07-26 | 2020-07-21 | Intra-Cellular Therapies, Inc. | compostos orgânicos |
| KR102667268B1 (ko) | 2017-07-26 | 2024-05-17 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| MX2020007271A (es) | 2017-09-26 | 2020-08-17 | Intra Cellular Therapies Inc | Sales y cristales novedosos. |
| US11655251B2 (en) | 2017-11-27 | 2023-05-23 | Egis Gyogyszergyar Zrt. | Method for the production of lumateperone and its salts |
| MX2020009668A (es) | 2018-03-16 | 2021-01-08 | Intra Cellular Therapies Inc | Métodos novedosos. |
| WO2019183341A1 (fr) | 2018-03-23 | 2019-09-26 | Intra-Cellular Therapies, Inc. | Composés organiques |
| WO2019183546A1 (fr) | 2018-03-23 | 2019-09-26 | Intra-Cellular Therapies, Inc. | Composés organiques |
| KR102888393B1 (ko) | 2018-06-06 | 2025-11-18 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 염 및 결정 |
| WO2019237037A1 (fr) | 2018-06-08 | 2019-12-12 | Intra-Cellular Therapies, Inc. | Nouvelles méthodes |
| AU2019287460B2 (en) * | 2018-06-11 | 2024-02-15 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines synthesis |
| AU2019288476A1 (en) | 2018-06-21 | 2021-03-18 | Aquestive Therapeutics, Inc. | System and method for making personalized individual unit doses containing pharmaceutical actives |
| MA53219B1 (fr) | 2018-08-13 | 2024-09-30 | F. Hoffmann-La Roche Ag | Nouveaux composés hétérocycliques en tant qu'inhibiteurs de monoacylglycérol lipase |
| WO2020047241A1 (fr) | 2018-08-29 | 2020-03-05 | Intra-Cellular Therapies, Inc. | Nouvelles compositions et méthodes |
| BR112021003655A2 (pt) | 2018-08-31 | 2021-05-18 | Intra-Cellular Therapies, Inc. | métodos novos |
| KR20210052472A (ko) | 2018-08-31 | 2021-05-10 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 방법 |
| CN112955124A (zh) | 2018-09-07 | 2021-06-11 | 阿奎蒂夫疗法公司 | 具有精确的活性物溶出谱的口腔膜组合物和剂型 |
| WO2020112941A2 (fr) | 2018-11-27 | 2020-06-04 | Teva Czech Industries S.R.O | Formes à l'état solide de sels de lumatépérone et procédés de préparation de lumatépérone et de ses sels |
| ES3047409T3 (en) * | 2018-12-17 | 2025-12-03 | Intra Cellular Therapies Inc | Substituted heterocycle fused gamma-carbolines synthesis |
| IL283959B2 (en) * | 2018-12-17 | 2025-01-01 | Intra Cellular Therapies Inc | Synthesis of condensed gamma-carbolines and converted heterocycles |
| EP3898221A4 (fr) | 2018-12-17 | 2022-09-14 | Intra-Cellular Therapies, Inc. | Composé organique |
| JP7377871B2 (ja) | 2018-12-21 | 2023-11-10 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
| US12331052B2 (en) | 2018-12-21 | 2025-06-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
| BR112021016620A2 (pt) | 2019-02-27 | 2021-11-03 | Univ California | Azepino-indóis e outros heterociclos para o tratamento de distúrbios cerebrais |
| AU2020311894B2 (en) | 2019-07-07 | 2025-06-26 | Intra-Cellular Therapies, Inc. | Novel methods |
| JP2022549335A (ja) | 2019-09-25 | 2022-11-24 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 新規方法 |
| KR20220126286A (ko) | 2019-11-01 | 2022-09-15 | 어퀘스티브 테라퓨틱스, 아이엔씨. | 전구약물 조성물 및 치료 방법 |
| JP2023502069A (ja) | 2019-11-14 | 2023-01-20 | アクエスティブ セラピューティクス インコーポレイテッド | マルチモーダルな組成物及び治療方法 |
| CN110698474B (zh) * | 2019-11-14 | 2021-11-02 | 福州大学 | 一种α位取代四氢-γ-咔啉类化合物及其制备方法和应用 |
| US11753419B2 (en) | 2019-12-11 | 2023-09-12 | Intra-Cellular Therapies, Inc. | 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)-1-(4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3′4′:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)phenyl)butan-1-one for treating conditions of the central nervous system and cardiac disorders |
| JP7727634B2 (ja) | 2019-12-19 | 2025-08-21 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 統合失調症処置方法 |
| CN112062767B (zh) * | 2020-10-20 | 2022-03-11 | 杭州科巢生物科技有限公司 | 一种卢美哌隆的制备方法及其中间体 |
| CA3208345A1 (fr) | 2021-01-15 | 2022-07-21 | Aquestive Therapeutics, Inc. | Compositions de promedicament et procedes de traitement |
| EP4304554A1 (fr) | 2021-03-09 | 2024-01-17 | Aquestive Therapeutics, Inc. | Formes pharmaceutiques ayant des profils biocomparables équivalents |
| CN113024554B (zh) * | 2021-03-24 | 2023-03-14 | 上海法默生物科技有限公司 | 一种卢美哌隆中间体的制备方法 |
| CN114105985B (zh) * | 2021-12-13 | 2024-04-16 | 南方科技大学坪山生物医药研究院 | 不对称氢化构建卢美哌隆中间体的方法及卢美哌隆中间体 |
| CN114105980B (zh) * | 2021-12-13 | 2024-04-16 | 南方科技大学坪山生物医药研究院 | 卢美哌隆中间体化合物的制备方法及卢美哌隆中间体化合物 |
| CA3239565A1 (fr) | 2021-12-15 | 2023-06-22 | Delix Therapeutics, Inc. | Psychoplastogenes substitues par phenoxy et benzyloxy et leurs utilisations |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
| WO2024145659A1 (fr) | 2022-12-30 | 2024-07-04 | Intra-Cellular Therapies, Inc. | Gamma-carbolines hétérocycliques fusionnées agissant sur le récepteur 5-ht2a de la sérotonine |
| EP4665344A1 (fr) | 2023-02-17 | 2025-12-24 | Intra-Cellular Therapies, Inc. | Lumatépérone et ses dérivés pour moduler le système nerveux |
| WO2025223504A1 (fr) * | 2024-04-26 | 2025-10-30 | 浙江奥翔药业股份有限公司 | Intermédiaire de lumatépérone et son procédé de préparation |
| WO2025240804A1 (fr) | 2024-05-16 | 2025-11-20 | Intra-Cellular Therapies, Inc. | Nouvelles compositions, dispositifs et procédés |
| WO2025257090A1 (fr) | 2024-06-10 | 2025-12-18 | Interquim, S.A. | Procédé de préparation d'intermédiaires de synthèse de lumatépérone et d'analogues de lumatépérone |
| CN119912455B (zh) * | 2025-01-22 | 2025-09-23 | 成都臻拓医药科技有限公司 | 一种卢美哌隆中间体化合物的制备方法 |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6713A (en) | 1849-09-11 | Hobse-poweb | ||
| US471A (en) | 1837-11-20 | Mode of | ||
| US39680A (en) | 1863-08-25 | Improvement in machines for breaking and cleaning flax | ||
| US38679A (en) | 1863-05-26 | Improvement in water-elevators | ||
| US2490813A (en) | 1944-11-29 | 1949-12-13 | Standard Oil Co | Continuous process for making aryl amines |
| US3299078A (en) | 1962-10-01 | 1967-01-17 | Smith Kline French Lab | Pyrido [3', 4': 4, 5] pyrrolo [3, 2, 1-hi] indoles and-[3, 2, 1-ij] quinolines |
| US3813392A (en) | 1969-06-09 | 1974-05-28 | J Sellstedt | Pyrrolo(1,2,3-alpha epsilon)quinoxalin-2(3h)-ones and related compounds |
| US4115577A (en) | 1972-06-19 | 1978-09-19 | Endo Laboratories, Inc. | Pyridopyrrolobenzheterocycles |
| US3914421A (en) | 1972-06-19 | 1975-10-21 | Endo Lab | Pyridopyrrolobenzheterocycles for combatting depression |
| US4183936A (en) | 1972-06-19 | 1980-01-15 | Endo Laboratories, Inc. | Pyridopyrrolobenzheterocycles |
| US4238607A (en) | 1972-06-19 | 1980-12-09 | Endo Laboratories Inc. | Pyridopyrrolo benzheterocycles |
| US4219550A (en) | 1978-11-09 | 1980-08-26 | E. I. Du Pont De Nemours And Company | Cis- and trans- octahydropyridopyrrolobenzheterocycles |
| US4522944A (en) | 1982-12-23 | 1985-06-11 | Erba Farmitalia | Carboxamido-derivatives of 5H-1,3,4-thiadiazolo[3,2-a]pyrimidines, compositions and use |
| ES2058068T3 (es) | 1986-03-19 | 1994-11-01 | Kumiai Chemical Industry Co | Derivados de 5h-1,3,4-tiadiazol-(3,2-a)-pirimidin-5-ona y compuestos fungicidas con contenido en dichos derivados. |
| EP0242690B1 (fr) | 1986-04-07 | 1993-06-30 | Kumiai Chemical Industry Co., Ltd. | Dérivés de la 5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one et composition fongicide, agricole et horticole les contenant |
| US5576460A (en) | 1994-07-27 | 1996-11-19 | Massachusetts Institute Of Technology | Preparation of arylamines |
| US5648539A (en) | 1996-02-29 | 1997-07-15 | Xerox Corporation | Low temperature arylamine processes |
| US5654482A (en) | 1996-02-29 | 1997-08-05 | Xerox Corporation | Triarylamine processes |
| US5648542A (en) | 1996-02-29 | 1997-07-15 | Xerox Corporation | Arylamine processes |
| US5847166A (en) | 1996-10-10 | 1998-12-08 | Massachusetts Institute Of Technology | Synthesis of aryl ethers |
| US5705697A (en) | 1997-01-30 | 1998-01-06 | Xerox Corporation | Arylamine processes |
| US5723671A (en) | 1997-01-30 | 1998-03-03 | Xerox Corporation | Arylamine processes |
| US5723669A (en) | 1997-01-30 | 1998-03-03 | Xerox Corporation | Arylamine processes |
| US6323366B1 (en) | 1997-07-29 | 2001-11-27 | Massachusetts Institute Of Technology | Arylamine synthesis |
| GB2328686B (en) | 1997-08-25 | 2001-09-26 | Sankio Chemical Co Ltd | Method for producing arylamine |
| US6395939B1 (en) | 1997-10-06 | 2002-05-28 | Massachusetts Institute Of Technology | Diaryl ether condensation reactions |
| ATE229499T1 (de) | 1998-02-26 | 2002-12-15 | Massachusetts Inst Technology | Metallkatalysierte arylierungen und vinylierungen von hydrazinen, hydrazonen, hydroxylaminen und oximen |
| US6235936B1 (en) | 1998-02-26 | 2001-05-22 | Massachusetts Institute Of Technology | Metal-catalyzed arylations of hydrazines, hydrazones, and related substrates |
| US5902901A (en) | 1998-05-07 | 1999-05-11 | Xerox Corporation | Arylamine processes |
| US6307087B1 (en) | 1998-07-10 | 2001-10-23 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
| EP1097158B1 (fr) | 1998-07-10 | 2006-01-25 | Massachusetts Institute Of Technology | Ligands pour metaux et procedes de catalyse par metaux |
| US7223879B2 (en) | 1998-07-10 | 2007-05-29 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
| US6395916B1 (en) | 1998-07-10 | 2002-05-28 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
| US20010008942A1 (en) | 1998-12-08 | 2001-07-19 | Buchwald Stephen L. | Synthesis of aryl ethers |
| US6407092B1 (en) | 1999-04-23 | 2002-06-18 | Pharmacia & Upjohn Company | Tetracyclic azepinoindole compounds |
| AR023574A1 (es) | 1999-04-23 | 2002-09-04 | Pharmacia & Upjohn Co Llc | Compuestos de azepinindol tetraciclico,composiciones farmaceuticas y el uso de dichos compuestos para preparar un medicamento, e intermediarios |
| US7071186B2 (en) | 1999-06-15 | 2006-07-04 | Bristol-Myers Squibb Pharma Co. | Substituted heterocycle fused gamma-carbolines |
| BR0012084A (pt) | 1999-06-15 | 2002-04-02 | Bristol Myers Squibb Pharma Co | Compostos, composição farmacêutica e usos dos compostos |
| US6713471B1 (en) | 1999-06-15 | 2004-03-30 | Bristol-Myers Squibb Pharma Company | Substituted heterocycle fused gamma-carbolines |
| US6541639B2 (en) | 2000-07-26 | 2003-04-01 | Bristol-Myers Squibb Pharma Company | Efficient ligand-mediated Ullmann coupling of anilines and azoles |
| US6849619B2 (en) | 2000-12-20 | 2005-02-01 | Bristol-Myers Squibb Company | Substituted pyridoindoles as serotonin agonists and antagonists |
| CA2432185C (fr) | 2000-12-20 | 2011-11-08 | Bristol-Myers Squibb Company | Pyridoindoles substitues en tant qu'agonistes et antagonistes de serotonine |
| CN1266112C (zh) | 2001-04-24 | 2006-07-26 | 麻省理工学院 | 铜－催化的碳－杂原子键和碳－碳键的形成 |
| JP2005526691A (ja) * | 2001-08-08 | 2005-09-08 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 治療剤１Ｈ−ピリド［４，３−ｂ］インドール |
| CN1684944A (zh) | 2002-08-02 | 2005-10-19 | 麻省理工学院 | 铜催化形成碳－杂原子和碳－碳键的方法 |
| US7223870B2 (en) | 2002-11-01 | 2007-05-29 | Pfizer Inc. | Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction |
| ES2364046T3 (es) * | 2002-12-19 | 2011-08-23 | Bristol-Myers Squibb Company | Gamma-carbolinas tricíclicas sustituidas utilizadas como agonistas y antagonistas de los receptores de la serotonina. |
| JP2005259113A (ja) | 2004-02-12 | 2005-09-22 | Ricoh Co Ltd | プロセス編集装置、プロセス管理装置、プロセス編集プログラム、プロセス管理プログラム、記録媒体、プロセス編集方法及びプロセス管理方法 |
| US7592454B2 (en) * | 2004-04-14 | 2009-09-22 | Bristol-Myers Squibb Company | Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists |
| ES2338139T3 (es) * | 2004-12-15 | 2010-05-04 | F. Hoffmann-La Roche Ag | Fenil-metanonas bi- y triciclicas sustituidas como inhibidores del transportador de la glicina i (glyt-1) para el tratamiento de la enfermedad de alzheimer. |
| KR102238390B1 (ko) * | 2007-03-12 | 2021-04-08 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 치환된 헤테로환 융합 감마-카르볼린 합성 |
| DK2262505T3 (en) | 2008-03-12 | 2015-01-05 | Intra Cellular Therapies Inc | Substituted heterocyclic-CONCENTRATED GAMMA -carboline-SOLID |
| MX377802B (es) | 2008-05-27 | 2025-03-11 | Intra Cellular Therapies Inc | Metodos y composiciones para trastornos del sueño y otros trastornos. |
| US8309772B2 (en) | 2008-07-31 | 2012-11-13 | Celanese International Corporation | Tunable catalyst gas phase hydrogenation of carboxylic acids |
| US8993572B2 (en) * | 2010-04-22 | 2015-03-31 | Intra-Cellular Therapies, Inc. | Pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalines derivatives and [1,4]oxazino[2,3,4-hi]pyrido[4,3-b]indole derivatives |
| RU2014145682A (ru) | 2012-04-14 | 2016-06-10 | Интра-Селлулар Терапиз, Инк | Органические соединения |
| US9708322B2 (en) | 2013-03-15 | 2017-07-18 | Intra-Cellular Therapies, Inc. | Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for inhibiting serotonin reuptake transporter activity |
| CA3205777A1 (en) | 2013-12-03 | 2015-06-11 | Intra-Cellular Therapies, Inc. | Heterocycle fused gamma-carboline compounds for use in treatment of schizophrenia |
| US10077267B2 (en) | 2014-04-04 | 2018-09-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
| CA3016353C (fr) | 2016-03-25 | 2021-04-27 | Intra-Cellular Therapies, Inc. | Gamma-carbolines fusionnees a heterocycles deuteries et leurs compositions utiles dans le traitement de troubles du systeme nerveux central |
| US11655251B2 (en) | 2017-11-27 | 2023-05-23 | Egis Gyogyszergyar Zrt. | Method for the production of lumateperone and its salts |
-
2008
- 2008-03-12 KR KR1020207012082A patent/KR102238390B1/ko active Active
- 2008-03-12 DK DK08742074.1T patent/DK2134710T3/da active
- 2008-03-12 ES ES08742074T patent/ES2776889T3/es active Active
- 2008-03-12 EP EP20153727.1A patent/EP3663294A1/fr active Pending
- 2008-03-12 AU AU2008226814A patent/AU2008226814C1/en active Active
- 2008-03-12 KR KR1020097019338A patent/KR101805914B1/ko active Active
- 2008-03-12 MX MX2020001497A patent/MX394214B/es unknown
- 2008-03-12 KR KR1020197019369A patent/KR102065319B1/ko active Active
- 2008-03-12 KR KR1020217009724A patent/KR102372149B1/ko active Active
- 2008-03-12 EP EP08742074.1A patent/EP2134710B1/fr active Active
- 2008-03-12 CA CA2679754A patent/CA2679754C/fr active Active
- 2008-03-12 KR KR1020157033684A patent/KR101981840B1/ko active Active
- 2008-03-12 WO PCT/US2008/003340 patent/WO2008112280A1/fr not_active Ceased
- 2008-03-12 KR KR1020197013610A patent/KR102107954B1/ko active Active
- 2008-03-12 US US12/531,016 patent/US8309722B2/en active Active
- 2008-03-12 IN IN5670DEN2009 patent/IN2009DN05670A/en unknown
- 2008-03-12 CN CN201310464631.4A patent/CN103626766B/zh active Active
- 2008-03-12 KR KR1020187017827A patent/KR101999300B1/ko active Active
- 2008-03-12 MX MX2009009773A patent/MX2009009773A/es active IP Right Grant
- 2008-03-12 JP JP2009553626A patent/JP5567349B2/ja active Active
- 2008-03-12 CN CN2008800157710A patent/CN101796051B/zh active Active
-
2009
- 2009-09-11 MX MX2022008904A patent/MX2022008904A/es unknown
-
2012
- 2012-08-23 US US13/593,097 patent/US8779139B2/en active Active
-
2014
- 2014-06-19 JP JP2014126495A patent/JP5918306B2/ja active Active
- 2014-06-26 AU AU2014203483A patent/AU2014203483B2/en active Active
- 2014-07-03 US US14/323,545 patent/US9315504B2/en active Active
-
2016
- 2016-03-10 US US15/066,962 patent/US9751883B2/en active Active
- 2016-04-07 JP JP2016077538A patent/JP6231151B2/ja active Active
- 2016-09-27 AU AU2016234905A patent/AU2016234905B2/en active Active
-
2017
- 2017-07-26 US US15/660,762 patent/US10221176B2/en active Active
- 2017-10-18 JP JP2017201937A patent/JP6522710B2/ja active Active
-
2018
- 2018-03-14 AU AU2018201818A patent/AU2018201818B2/en active Active
-
2019
- 2019-01-10 US US16/244,796 patent/US10597395B2/en active Active
- 2019-04-24 JP JP2019082541A patent/JP6773837B2/ja active Active
- 2019-06-12 US US16/439,361 patent/US10464938B2/en active Active
- 2019-09-10 AU AU2019229334A patent/AU2019229334B2/en active Active
- 2019-10-07 US US16/594,603 patent/US11407751B2/en active Active
- 2019-12-12 US US16/711,790 patent/US11066407B2/en active Active
-
2020
- 2020-10-01 JP JP2020166874A patent/JP2021006559A/ja not_active Withdrawn
-
2022
- 2022-06-24 US US17/808,836 patent/US12139490B2/en active Active
- 2022-09-09 JP JP2022144080A patent/JP2022180440A/ja active Pending
-
2024
- 2024-10-03 US US18/905,607 patent/US20250101022A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2009DN05670A (fr) | ||
| TW200604184A (en) | Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors | |
| PH12013502230A1 (en) | Multispecific antibodies | |
| MX345909B (es) | Anticuerpos anti-fgfr3 y métodos que los utilizan. | |
| MY181898A (en) | Heterocyclic compounds and uses thereof | |
| TN2011000673A1 (en) | Bace inhibitors | |
| MX2011001679A (es) | Derivados de flavina. | |
| MX2010004374A (es) | Armazones proteinicos. | |
| PH12012501346A1 (en) | Heteroaryl compounds and uses thereof | |
| MX2011010012A (es) | NUEVOS ANTICUERPOS ANTI-A5ß1 Y SUS USOS. | |
| MY152749A (en) | Pyrazole and fused pyrazole glucokinase activators | |
| SG179085A1 (en) | Pi3 kinase inhibitors and uses thereof | |
| MX2009008430A (es) | Anticuerpos anti-robo4 y sus usos. | |
| MY170720A (en) | Antibody formulations | |
| CA2705357C (fr) | Formulations pour proteines hybrides taci-immunoglobuline | |
| MX2012002387A (es) | Aminas de triazol fusionadas como moduladores p2x7. | |
| PH12013500500A1 (en) | Fused heteroaryls and their uses | |
| TW200624426A (en) | BACE inhibitors | |
| WO2009015037A3 (fr) | Indazoles substitués par du 5-pyridinone | |
| MX2009004030A (es) | Articulos antimicrobianos y metodos de fabricacion. | |
| TW200738751A (en) | Anti-EphrinB2 antibodies and methods using same | |
| WO2008085900A3 (fr) | Procédé permettant de générer de nouvelles protéines stabilisées | |
| IL200000A0 (en) | Process for the preparation of 2-substituted-5-(1-alkylthio) alkylpyridines | |
| WO2011005554A3 (fr) | Bactéries éthanologènes recombinantes | |
| MX2011013790A (es) | Derivados de flavina. |