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IL84504A - Benzimidazole derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

Benzimidazole derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL84504A
IL84504A IL8450487A IL8450487A IL84504A IL 84504 A IL84504 A IL 84504A IL 8450487 A IL8450487 A IL 8450487A IL 8450487 A IL8450487 A IL 8450487A IL 84504 A IL84504 A IL 84504A
Authority
IL
Israel
Prior art keywords
compound
carbon atoms
methoxy
alkyl
formula
Prior art date
Application number
IL8450487A
Other languages
English (en)
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE8604998A external-priority patent/SE8604998D0/xx
Priority claimed from SE8605551A external-priority patent/SE8605551D0/xx
Priority claimed from SE8704049A external-priority patent/SE8704049D0/xx
Application filed by Haessle Ab filed Critical Haessle Ab
Publication of IL84504A publication Critical patent/IL84504A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL8450487A 1986-11-21 1987-11-17 Benzimidazole derivatives, their preparation and pharmaceutical compositions containing them IL84504A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE8604998A SE8604998D0 (sv) 1986-11-21 1986-11-21 Novel pharmacological compounds
SE8605551A SE8605551D0 (sv) 1986-12-23 1986-12-23 Novel pharmacological compounds
SE8704049A SE8704049D0 (sv) 1987-10-16 1987-10-16 Novel pharmacological compounds

Publications (1)

Publication Number Publication Date
IL84504A true IL84504A (en) 1994-10-07

Family

ID=27355365

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8450487A IL84504A (en) 1986-11-21 1987-11-17 Benzimidazole derivatives, their preparation and pharmaceutical compositions containing them

Country Status (24)

Country Link
EP (3) EP0510719A1 (fr)
JP (1) JPH02500744A (fr)
KR (1) KR890700125A (fr)
AT (1) ATE84032T1 (fr)
AU (1) AU612129B2 (fr)
DE (1) DE3783356T2 (fr)
DK (1) DK365488A (fr)
EG (1) EG18379A (fr)
ES (1) ES2052603T3 (fr)
FI (1) FI892454A7 (fr)
GR (1) GR3007385T3 (fr)
HU (1) HU204814B (fr)
IE (2) IE940326L (fr)
IL (1) IL84504A (fr)
IS (1) IS1565B (fr)
LV (1) LV10954B (fr)
MY (1) MY101784A (fr)
NO (1) NO173998C (fr)
NZ (2) NZ222495A (fr)
PL (1) PL157655B1 (fr)
PT (1) PT86186B (fr)
RU (1) RU2062778C1 (fr)
WO (1) WO1988003921A1 (fr)
YU (1) YU47116B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8801907D0 (sv) * 1988-05-20 1988-05-20 Haessle Ab Novel pharmacological compounds
WO1990003373A1 (fr) * 1988-09-20 1990-04-05 Hisamitsu Pharmaceutical Co., Inc. NOUVEAUX DERIVES DE DIBENZ[b,e]OXEPINE
IE64199B1 (en) * 1988-12-22 1995-07-12 Haessle Ab Compound with gastric acid inhibitory effect and process for its preparation
SE8804629D0 (sv) * 1988-12-22 1988-12-22 Ab Haessle New therapeutically active compounds
US5049674A (en) * 1989-12-20 1991-09-17 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US5274099A (en) * 1989-12-20 1993-12-28 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
SE9002206D0 (sv) 1990-06-20 1990-06-20 Haessle Ab New compounds
CA2083606C (fr) * 1990-06-20 2001-08-21 Arne Elof Brandstrom Derives de dialcoxypyridinylbenzimidazole; methode de preparation et utilisation en pharmacie
ATE191213T1 (de) * 1990-10-17 2000-04-15 Takeda Chemical Industries Ltd Pyridin-derivate, verfahren zu deren herstellung und anwendung
SE9103776D0 (sv) * 1991-12-19 1991-12-19 Astra Ab New compounds
JP2759228B2 (ja) * 1992-05-21 1998-05-28 株式会社大塚製薬工場 ホスホン酸ジエステル誘導体
WO1994026279A1 (fr) * 1993-05-18 1994-11-24 The Upjohn Company Esters de biphosphonate pour traiter les troubles gastriques
US6875872B1 (en) 1993-05-28 2005-04-05 Astrazeneca Compounds
SE508669C2 (sv) * 1996-04-26 1998-10-26 Astra Ab Nytt förfarande
US6051570A (en) * 1997-05-30 2000-04-18 Dr. Reddy's Research Foundation Benzimidazole derivatives as antiulcer agents, process for their preparation and pharmaceutical compositions containing them
WO1999033846A2 (fr) * 1997-12-31 1999-07-08 The University Of Kansas Remedes contenant des precurseurs hydrosolubles d'amines secondaires et tertiaires, et leurs procedes d'obtention
ZA9810765B (en) * 1998-05-28 1999-08-06 Ranbaxy Lab Ltd Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole.
AU2583901A (en) * 1999-12-17 2001-06-25 Ariad Pharmaceuticals, Inc. Proton pump inhibitors
CA2425363A1 (fr) * 2000-10-12 2003-04-10 Fumihiko Sato Composes derives de benzimidazole, leur procede de production et leur utilisation
US20040248941A1 (en) * 2001-09-25 2004-12-09 Keiji Kamiyama Benzimidazone compound, process for producing the same, and use thereof
AU2003259154B2 (en) * 2002-07-19 2006-12-07 The Regents Of The University Of California Benzimidazole derivatives and their use as prodrugs of proton pump inhibitor
GB0400781D0 (en) * 2004-01-14 2004-02-18 Novartis Ag Organic compounds
KR20070046194A (ko) * 2004-08-27 2007-05-02 라보라토리오스 델 드라. 에스테브.에스.에이. 시그마 수용체 저해제
EP1913009B1 (fr) * 2005-07-28 2010-05-12 Intervet International BV Nouveaux benzimidazolyl(thio)carbamates ayant une activite antiparasitaire et synthese de ceux-ci
US10272070B2 (en) 2014-10-14 2019-04-30 The Board of Trustees of the Leland Stanford Junio r University Method for treating neurodegenerative diseases
DK3390367T3 (da) 2015-12-15 2020-10-26 Univ Leland Stanford Junior Fremgangsmåde til forebyggelse og/eller behandling af aldersrelateret kognitiv funktionsnedsættelse og neuroinflammation
EP3833344A4 (fr) 2018-08-06 2022-07-06 The Board of Trustees of the Leland Stanford Junior University 2-arylbenzimidazoles utiles en tant qu'activateurs de ppargc1a pour le traitement de maladies neurodégénératives
BR112022002632A2 (pt) * 2019-08-20 2022-05-03 Ono Pharmaceutical Co Sal e forma de cristal de composto que tem atividade de agonista do receptor s1p5

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE418966B (sv) 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (fr) 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS5836312B2 (ja) * 1978-08-21 1983-08-08 日本電信電話株式会社 通信用平衡ケ−ブル線路の障害位置測定方式
JPS5687818A (en) * 1979-12-19 1981-07-16 Ishikawajima Harima Heavy Ind Co Ltd Reflex type position detector
US4359465A (en) 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
JPS57137860A (en) * 1981-02-20 1982-08-25 Sumitomo Electric Ind Ltd Optical tachometer
JPS5999597A (ja) * 1982-11-30 1984-06-08 株式会社東芝 光学測定装置
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
JPS6020051U (ja) * 1983-07-19 1985-02-12 三洋電機株式会社 カセツト収納装置
AU568441B2 (en) 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds

Also Published As

Publication number Publication date
IE940326L (en) 1988-05-21
AU8330287A (en) 1988-06-16
NZ234564A (en) 1991-04-26
IE61178B1 (en) 1994-10-05
LV10954B (en) 1996-08-20
YU47116B (sh) 1994-12-28
DK365488D0 (da) 1988-07-01
AU612129B2 (en) 1991-07-04
MY101784A (en) 1992-01-17
NO173998C (no) 1994-03-02
NO173998B (no) 1993-11-22
PT86186A (en) 1987-12-01
HU204814B (en) 1992-02-28
PL157655B1 (pl) 1992-06-30
EP0279149B1 (fr) 1992-12-30
EG18379A (en) 1992-11-30
ATE84032T1 (de) 1993-01-15
WO1988003921A1 (fr) 1988-06-02
ES2052603T3 (es) 1994-07-16
DE3783356D1 (de) 1993-02-11
YU211087A (en) 1988-12-31
FI892454L (fi) 1989-05-19
LV10954A (lv) 1995-12-20
GR3007385T3 (fr) 1993-07-30
IE873125L (en) 1988-05-21
NO883229L (no) 1988-09-16
DE3783356T2 (de) 1993-04-15
PT86186B (pt) 1990-08-31
FI892454A0 (fi) 1989-05-19
IS3284A7 (is) 1988-05-22
FI892454A7 (fi) 1989-05-19
EP0332647A1 (fr) 1989-09-20
NZ222495A (en) 1991-04-26
IS1565B (is) 1994-12-13
KR890700125A (ko) 1989-03-02
JPH02500744A (ja) 1990-03-15
RU2062778C1 (ru) 1996-06-27
EP0279149A2 (fr) 1988-08-24
EP0279149A3 (en) 1988-08-31
EP0510719A1 (fr) 1992-10-28
HUT51269A (en) 1990-04-28
PL268927A1 (en) 1989-01-23
NO883229D0 (no) 1988-07-20
DK365488A (da) 1988-07-01

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