IL76107A - Method of removing n-terminal amino acid residues from eucaryotic polypeptide analogs and polypeptides produced thereby - Google Patents

Method of removing n-terminal amino acid residues from eucaryotic polypeptide analogs and polypeptides produced thereby

Info

Publication number: IL76107A
Authority: IL; Israel
Prior art keywords: amino acid; acid residues; terminal amino; polypeptide; polypeptides produced
Prior art date: 1984-08-16

Application number

IL76107A

Other languages

English (en)

Other versions

IL76107A0 (en

Original Assignee

Bio Technology General Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-08-16

Filing date

1985-08-15

Publication date

1991-03-10

1985-08-15 Application filed by Bio Technology General Corp filed Critical Bio Technology General Corp

1985-12-31 Publication of IL76107A0 publication Critical patent/IL76107A0/xx

1991-03-10 Publication of IL76107A publication Critical patent/IL76107A/xx

1995-03-08 Priority to US08/400,544 priority Critical patent/US5763215A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Physical Deposition Of Substances That Are Components Of Semiconductor Devices (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL76107A 1984-08-16 1985-08-15 Method of removing n-terminal amino acid residues from eucaryotic polypeptide analogs and polypeptides produced thereby IL76107A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
US08/400,544 US5763215A (en)	1984-08-16	1995-03-08	Method of removing N-terminal amino acid residues from eucaryotic polypeptide analogs and polypeptides produced thereby

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US64148884A	1984-08-16	1984-08-16

Publications (2)

Publication Number	Publication Date
IL76107A0 IL76107A0 (en)	1985-12-31
IL76107A true IL76107A (en)	1991-03-10

Family

ID=24572607

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL76107A IL76107A (en)	1984-08-16	1985-08-15	Method of removing n-terminal amino acid residues from eucaryotic polypeptide analogs and polypeptides produced thereby

Country Status (11)

Country	Link
EP (2)	EP0191827B1 (fr)
JP (1)	JPH0822240B2 (fr)
AT (2)	ATE251217T1 (fr)
AU (1)	AU591464B2 (fr)
CA (1)	CA1318869C (fr)
DE (4)	DE3588249T2 (fr)
HK (1)	HK143096A (fr)
IL (1)	IL76107A (fr)
LU (1)	LU91064I2 (fr)
WO (1)	WO1986001229A1 (fr)
ZA (1)	ZA856194B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK55685A (da) *	1985-02-07	1986-08-08	Nordisk Gentofte	Enzym eller enzymkompleks med proteolytisk aktivitet
WO1986002068A1 (fr) *	1984-09-26	1986-04-10	Takeda Chemical Industries, Ltd.	Separation mutuelle de proteines
IL76360A0 (en) *	1984-09-26	1986-01-31	Takeda Chemical Industries Ltd	Mutual separation of proteins
US4861868A (en)	1985-02-22	1989-08-29	Monsanto Company	Production of proteins in procaryotes
WO1986007380A1 (fr) *	1985-06-04	1986-12-18	Takeda Chemical Industries, Ltd.	Procede de preparation de polypeptides
US5013662A (en) *	1985-09-20	1991-05-07	Cetus Corporation	Bacterial methionine n-terminal peptidase
US4865974A (en) *	1985-09-20	1989-09-12	Cetus Corporation	Bacterial methionine N-terminal peptidase
GB2188322A (en) *	1986-03-26	1987-09-30	Bayer Ag	Aprotinin and analogues thereof produced by a recombinant host
GB8703015D0 (en) *	1987-02-10	1987-03-18	Biogen Nv	Aminopeptidase
US5032573A (en) *	1987-03-23	1991-07-16	Bayer Aktiengesellschaft	Homologs of aprotinin produced from a recombinant host, process, expression vector and recombinant host therefor and pharmaceutical use thereof
DE3811921A1 (de) *	1988-04-09	1989-10-19	Hoechst Ag	Verfahren zur herstellung von proteinen, die n-terminal mit prolin beginnen
US5079345A (en) *	1988-08-19	1992-01-07	Eli Lilly And Company	Proteins having growth hormone anabolic properties with reduced effect on carbohydrate metabolism
US5126249A (en) *	1989-05-09	1992-06-30	Eli Lilly And Company	Enzymatic removal of a protein amino-terminal sequence
US6429186B1 (en)	1991-05-10	2002-08-06	Genentech, Inc.	Ligand antagonists for treatment of breast cancer
ATE196548T1 (de)	1991-05-10	2000-10-15	Genentech Inc	Auswählen von agonisten und antagonisten von liganden
GB9225021D0 (en) *	1992-11-30	1993-01-20	Sandoz Ltd	Organic compounds
KR970010135B1 (ko) *	1993-06-17	1997-06-21	주식회사 엘지화학	신규 아미노펩티다제
DE69505660T2 (de) *	1994-05-09	1999-06-17	Unizyme Laboratories Aps, Horsholm	Ein enzymatisches verfahren zur herstellung eines gewünschten proteins aus einem am aminoterminus verlängerten protein
KR100369839B1 (ko) *	1997-02-28	2003-06-12	주식회사 엘지생명과학	바실러스리케니포미스균주에서유래한아미노펩티다제,그의제조방법및이를이용한천연형단백질의제조방법
DE69941337D1 (de) *	1998-10-05	2009-10-08	Takeda Pharmaceutical	Verfahren zum eliminieren von n-terminalem methionin
US6743600B1 (en)	1999-04-30	2004-06-01	Monsanto Technologies Llc	Method of removing N-terminal alanine residues from polypeptides with Aeromonas aminopeptidase
US6794159B1 (en)	1999-04-30	2004-09-21	Pharmacia Corporation	Method of removing n-terminal alanine residues from polypeptides with aeromonas aminopeptidase
CA2460309C (fr)	2001-09-13	2012-07-10	Genentech, Inc.	Aminopeptidase
RU2241543C1 (ru) *	2003-04-18	2004-12-10	Институт проблем комплексного освоения недр РАН	Мельница для сухого измельчения растиранием
EA200601793A1 (ru)	2004-06-23	2007-02-27	Ю Эс Ви ЛИМИТЕД	Химерный гормон роста человека, полученный из изоформы плаценты и гипофиза, и способы получения указанной химеры
US8685691B2 (en)	2007-10-29	2014-04-01	Jcr Pharmaceuticals Co., Ltd.	Method for producing aminopeptidase
KR20090124204A (ko) *	2008-05-29	2009-12-03	(주)바이오큐어팜	아미노 말단의 메티오닌이 제거된 재조합 사람 변이인터페론-베타 단백질을 생산하는 재조합 대장균 및 이의제조방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL60184A (en) *	1979-05-31	1984-05-31	Schering Ag	Process for the specific cleavage of protein sequences from proteins
DK55685A (da) *	1985-02-07	1986-08-08	Nordisk Gentofte	Enzym eller enzymkompleks med proteolytisk aktivitet
JPS60500043A (ja) *	1982-12-10	1985-01-17	ノルデイスク・インスリンラボラトリウム	原核細胞又は真核細胞中で合成される融合蛋白質から成熟蛋白質を作る方法
US4755465A (en) *	1983-04-25	1988-07-05	Genentech, Inc.	Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
WO1986007380A1 (fr) *	1985-06-04	1986-12-18	Takeda Chemical Industries, Ltd.	Procede de preparation de polypeptides

1985
- 1985-08-09 AU AU47739/85A patent/AU591464B2/en not_active Expired
- 1985-08-09 AT AT92101249T patent/ATE251217T1/de active
- 1985-08-09 AT AT85904198T patent/ATE81673T1/de not_active IP Right Cessation
- 1985-08-09 EP EP85904198A patent/EP0191827B1/fr not_active Expired - Lifetime
- 1985-08-09 EP EP92101249A patent/EP0489711B1/fr not_active Expired - Lifetime
- 1985-08-09 DE DE3588249T patent/DE3588249T2/de not_active Expired - Lifetime
- 1985-08-09 DE DE19853588249 patent/DE122004000009I2/de active Active
- 1985-08-09 DE DE8585904198T patent/DE3586773T2/de not_active Expired - Lifetime
- 1985-08-09 JP JP60503686A patent/JPH0822240B2/ja not_active Expired - Lifetime
- 1985-08-09 DE DE200412000009 patent/DE122004000009I1/de active Pending
- 1985-08-09 WO PCT/US1985/001531 patent/WO1986001229A1/fr not_active Ceased
- 1985-08-15 IL IL76107A patent/IL76107A/xx active IP Right Revival
- 1985-08-15 CA CA000488771A patent/CA1318869C/fr not_active Expired - Lifetime
- 1985-08-15 ZA ZA856194A patent/ZA856194B/xx unknown
1996
- 1996-08-01 HK HK143096A patent/HK143096A/en not_active IP Right Cessation
2004
- 2004-03-26 LU LU91064C patent/LU91064I2/en unknown

Also Published As

Publication number	Publication date
EP0191827B1 (fr)	1992-10-21
IL76107A0 (en)	1985-12-31
EP0489711B1 (fr)	2003-10-01
DE3588249D1 (de)	2003-11-06
EP0191827A1 (fr)	1986-08-27
EP0191827A4 (fr)	1988-09-28
EP0489711A3 (en)	1992-10-07
AU4773985A (en)	1986-03-07
DE122004000009I2 (de)	2006-09-07
ATE81673T1 (de)	1992-11-15
EP0489711A2 (fr)	1992-06-10
ATE251217T1 (de)	2003-10-15
HK143096A (en)	1996-08-09
DE3588249T2 (de)	2004-05-06
DE122004000009I1 (de)	2004-11-18
JPH0822240B2 (ja)	1996-03-06
JPS62500003A (ja)	1987-01-08
CA1318869C (fr)	1993-06-08
LU91064I2 (en)	2004-05-26
DE3586773D1 (de)	1992-11-26
AU591464B2 (en)	1989-12-07
WO1986001229A1 (fr)	1986-02-27
ZA856194B (en)	1986-04-30
DE3586773T2 (de)	1993-03-18

Publication	Publication Date	Title
IL76107A (en)	1991-03-10	Method of removing n-terminal amino acid residues from eucaryotic polypeptide analogs and polypeptides produced thereby
HUT54213A (en)	1991-01-28	Process for the enzymatic removal of n-terminal sequence of proteins
NZ232742A (en)	1991-10-25	Yeast heterologous protein production method, vectors, dna constructs and proteins so produced and aprotinin (1-58) so produced
NZ510385A (en)	2002-12-20	E. coli enterotoxin II signal peptide and a microorganism expressing a fusion protein of the MST peptide and a heterologous protein, such as human growth hormone
DE69112611D1 (de)	1995-10-05	Proteinhydrolysate.
EP0722461A4 (fr)	1997-02-26	Expression de polypeptides de fusion transportes hors du cytoplasme sans sequence de tete
FI88398B (fi)	1993-01-29	Foerfarande foer framstaellning av peptidanaloger
IL85020A0 (en)	1988-06-30	Pancreatic secretory trypsin inhibitor and variants thereof,process expression vector and recombinant host therefor and pharmaceutical compositions containing it
PH30889A (en)	1997-12-23	Dna encoding equuine-gamma interferon and recombination production of equine ifn-polypeptides.
ES2009588A6 (es)	1989-10-01	Un metodo para la preparacion de un polipeptido.
EP0232107A3 (fr)	1988-04-27	Dérivé du polypeptide de la lymphotoxine humaine
EP0330700A4 (fr)	1990-01-08	Polypeptide ressemblant à la prourokinase humaine.
CA2198966A1 (fr)	1997-09-04	Methode de clivage d'une proteine chimere a l'aide d'une enzyme de traitement
EP0300459A3 (fr)	1989-11-15	Inhibitor de trypsine sécrété par le pancréas humain
CA2025350A1 (fr)	1990-07-18	Procede de production d'un peptide .alpha.-amide de terminaison-c
DE69028935D1 (de)	1996-11-28	Methode zur Produktion von Glukagon
GR80059B (en)	1984-12-12	Method for preparing sekretin
DE3686981D1 (de)	1992-11-26	Produktion eines proteins.
EP0750040A3 (fr)	1999-10-27	Variants de la protéine stimulatrice des macrophages et procédés de fabrication

Legal Events

Date	Code	Title
1996-05-14	NF	Patent restored
2000-01-31	KB	Patent renewed
2003-10-31	KB	Patent renewed