IL38453A - Anaesthetic composition containing 3alpha-hydroxy-5alpha-pregnane-11,20-dione - Google Patents

Claims (6)

1. 38453/2 WHAT WE CLAIM IS; 1 . A composition adapted for use 1n medicine as an anaesthetic by parenteral administration comprising 3eC -hydroxy-5^-pregnane-l l ,20 dione as active Ingredient 1n suspension in an aqueous suspension medium, comprising at least 0.5% by weight of a parenteral ly acceptable surface active component.

2. A composition as claimed In claim 1 , wherein the surface active component Is present In an amount of 0.5 - 5% by weight.

3. A composition as claimed 1n claim 2 wherein the surface active component has an HLB val ue of at least 9.

4. A composition as claimed in any of claims 1 to 3 in which the surface active component has an HLB value of not more than 15.

5. A composition as cl aimed 1n any one of claims 1 to 4 wherein the surface active component comprises polyoxyethylated derivative of a fatty glycerlde oil , having 12-20 carbon atoms, and containing at least 35 oxyethylene groups per mole of fatty oil; a polyoxyethylene ether of an alcohol having 12-18 carbon atoms and containing 10 - 30 oxyethylene groups; a polyoxyethylene-polyoxypropylene ether containing 5-160 oxyethylene groups and 15-50 oxypropylene grou s; a polyoxyethylated fatty acid (having 12-18 carbon atoms) ester of sorbitan or mannitan containing 15-30 oxyethylene groups; a polyethylene glycol ester of a fatty acid having 12-18 carbon atoms, and containing 6-40 oxyethylene groups; or a phospholipid.

6. Γ1Ι, A composition as claimed in ea\y one of the preceding claims also containing a parenterally acceptable suspending agent. 7 6 8/. A composition as claimed in claim 1 wherein the suspending agent is a hydrophilic colloid, polyvinylpyrrolidone, polyvinyl alcohol, sorbitol, mannitol, a polyoxyethylene glycol, carboxytneth l- cellulose, colloidal silica or a colloidal silicate ,8 ,6 9. A composition as claimed m claim 7 wherein the suspending agent is a dextran having an average molecular weight of 15,000 -to 70,000. g /!/{ ." A. composition as claimed in any one of claims 6 8 7/ to 9 wherein the suspending agent is present in an amount of from 0.1 - 10% by weight of the composition. ]}$! A composition as claimed in any one of the preceding claims also containing an antifoam agent. 11. 10 1/2/ A composition as claimed in claim ϊ/\/ wherein the antifoam agent is dimethyl polysiloxane . 12 0 ίβ. A compo ition as claimed in claim or claim wherein the antifoam agent is present in an amount of 50 to 150 p. p.m. l]$ A composition as claimed in any one of the preceding claims which is isotonic with blood. 14 16. A composition as claimed i any one of the preceding claims wherein the active ingredient has an average particle size of less than 5μηι. 15 f> . A composition as claimed in any one of the preceding claims wherein the. active ingredient is present in an amount of 0.1 to 2.0% by weight of the composition. $f , A composition as claimed in any one of the preceding claims in dosage unit form each dosage un containing 10 to 300 mg of 3 -hydroxy-5 -pregnane- 11,20-dione. N.%. A composition in the form of a wettable powder, for dispersion in sterile water to provide a composition as claimed in any of the preceding claims, said wettable powder comprising 3a-hydroxy- 5a-pregnane-ll , 20-dione and a parenterally acceptable surface active agent. a freeze-dried mixture of the active ingredient and the surface active agent. 19. I . An anaesthetic composition adapted for use as an anaesthetic in medium substantially as described with reference to the Examples. · jt^ , A two-pack composition for use as an anaesthetic j_n medicine comprising a first container containing 3a4rydro>¾-5:c~ pregnane-11 , 20-dione and a second container containing