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IL320057A - GABAA receptor modulators and their uses - Google Patents

GABAA receptor modulators and their uses

Info

Publication number
IL320057A
IL320057A IL320057A IL32005725A IL320057A IL 320057 A IL320057 A IL 320057A IL 320057 A IL320057 A IL 320057A IL 32005725 A IL32005725 A IL 32005725A IL 320057 A IL320057 A IL 320057A
Authority
IL
Israel
Prior art keywords
receptor modulators
gabaa receptor
gabaa
modulators
receptor
Prior art date
Application number
IL320057A
Other languages
English (en)
Hebrew (he)
Original Assignee
Engrail Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Engrail Therapeutics Inc filed Critical Engrail Therapeutics Inc
Publication of IL320057A publication Critical patent/IL320057A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
IL320057A 2022-10-04 2023-10-03 GABAA receptor modulators and their uses IL320057A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263413065P 2022-10-04 2022-10-04
PCT/US2023/075849 WO2024076999A2 (fr) 2022-10-04 2023-10-03 Modulateurs du récepteur gabaa et leurs utilisations

Publications (1)

Publication Number Publication Date
IL320057A true IL320057A (en) 2025-06-01

Family

ID=90609009

Family Applications (1)

Application Number Title Priority Date Filing Date
IL320057A IL320057A (en) 2022-10-04 2023-10-03 GABAA receptor modulators and their uses

Country Status (9)

Country Link
EP (1) EP4601742A2 (fr)
JP (1) JP2025535716A (fr)
KR (1) KR20250079211A (fr)
CN (1) CN120548183A (fr)
AU (1) AU2023356939A1 (fr)
CA (1) CA3268994A1 (fr)
IL (1) IL320057A (fr)
MX (1) MX2025004018A (fr)
WO (1) WO2024076999A2 (fr)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE396187T1 (de) * 1997-08-27 2008-06-15 Solvay Pharm Gmbh Indolmethyl-n,n'-bisacylpiperazine als neurokininrezeptorantagonisten
AU2016368622B2 (en) * 2015-12-08 2022-09-08 Ardea Biosciences, Inc. Pharmaceutical composition comprising a potent inhibitor of URAT1
CN112384513A (zh) * 2018-04-18 2021-02-19 纽罗塞克医疗公司 Gabaa正变构调节剂化合物、其制备方法和用途
EP3898617A4 (fr) * 2018-12-17 2022-08-17 Achillion Pharmaceuticals, Inc. Dosage ciblé pour le traitement des troubles induits par le complément
JP2023533903A (ja) * 2020-05-15 2023-08-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ｆｇｆｒ４阻害剤の経口製剤によるがんの治療方法

Also Published As

Publication number Publication date
WO2024076999A2 (fr) 2024-04-11
EP4601742A2 (fr) 2025-08-20
MX2025004018A (es) 2025-05-02
WO2024076999A3 (fr) 2024-05-23
CN120548183A (zh) 2025-08-26
KR20250079211A (ko) 2025-06-04
AU2023356939A1 (en) 2025-04-10
JP2025535716A (ja) 2025-10-28
CA3268994A1 (fr) 2024-04-11

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