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IL318535A - Jak1/jak2/tyk2 inhibitors for topical treatment of dermatological diseases - Google Patents

Jak1/jak2/tyk2 inhibitors for topical treatment of dermatological diseases

Info

Publication number
IL318535A
IL318535A IL318535A IL31853525A IL318535A IL 318535 A IL318535 A IL 318535A IL 318535 A IL318535 A IL 318535A IL 31853525 A IL31853525 A IL 31853525A IL 318535 A IL318535 A IL 318535A
Authority
IL
Israel
Prior art keywords
jak1
jak2
topical treatment
dermatological diseases
tyk2 inhibitors
Prior art date
Application number
IL318535A
Other languages
Hebrew (he)
Inventor
Congxin Liang
Shuangjiang Li
Xiaojing Tang
Junmin Huang
Original Assignee
Hangzhou Highlightll Pharmaceutical Co Ltd
Congxin Liang
Shuangjiang Li
Xiaojing Tang
Junmin Huang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hangzhou Highlightll Pharmaceutical Co Ltd, Congxin Liang, Shuangjiang Li, Xiaojing Tang, Junmin Huang filed Critical Hangzhou Highlightll Pharmaceutical Co Ltd
Publication of IL318535A publication Critical patent/IL318535A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL318535A 2022-08-22 2023-08-10 Jak1/jak2/tyk2 inhibitors for topical treatment of dermatological diseases IL318535A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2022113873 2022-08-22
PCT/CN2023/112361 WO2024041397A1 (en) 2022-08-22 2023-08-10 Jak1/jak2/tyk2 inhibitors for topical treatment of dermatological diseases

Publications (1)

Publication Number Publication Date
IL318535A true IL318535A (en) 2025-03-01

Family

ID=90012519

Family Applications (1)

Application Number Title Priority Date Filing Date
IL318535A IL318535A (en) 2022-08-22 2023-08-10 Jak1/jak2/tyk2 inhibitors for topical treatment of dermatological diseases

Country Status (8)

Country Link
EP (1) EP4577535A1 (en)
JP (1) JP2025529836A (en)
KR (1) KR20250051678A (en)
AU (1) AU2023328280A1 (en)
CA (1) CA3263043A1 (en)
IL (1) IL318535A (en)
MX (1) MX2025002033A (en)
WO (1) WO2024041397A1 (en)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009064835A1 (en) * 2007-11-16 2009-05-22 Incyte Corporation 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors
CA2815330A1 (en) * 2010-11-09 2012-05-18 Cellzome Limited Pyridine compounds and aza analogues thereof as tyk2 inhibitors
US9745320B2 (en) * 2013-01-18 2017-08-29 Guangzhou Maxinovel Pharmaceuticals Co., Ltd. Five-and-six-membered heterocyclic compound, and preparation method, pharmaceutical composition and use thereof
WO2020118683A1 (en) * 2018-12-14 2020-06-18 Lynk Pharmaceuticals Co. Ltd. Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof
CN110862380A (en) * 2019-10-24 2020-03-06 嘉兴特科罗生物科技有限公司 a small molecule compound
CN110862376A (en) * 2019-10-24 2020-03-06 嘉兴特科罗生物科技有限公司 Small molecule compound
CN114181199B (en) * 2020-09-15 2023-09-26 成都赜灵生物医药科技有限公司 2, 4-disubstituted pyrimidine derivative, preparation method and application thereof
WO2023060202A1 (en) * 2021-10-06 2023-04-13 Aerie Pharmaceuticals, Inc. Janus kinase inhibiting pyrazole compounds and uses thereof

Also Published As

Publication number Publication date
EP4577535A1 (en) 2025-07-02
KR20250051678A (en) 2025-04-17
JP2025529836A (en) 2025-09-09
CA3263043A1 (en) 2024-02-29
MX2025002033A (en) 2025-04-02
AU2023328280A1 (en) 2025-02-13
WO2024041397A1 (en) 2024-02-29

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