[go: up one dir, main page]

IL273479B2 - Pharmaceutical compositions with enhanced permeation - Google Patents

Pharmaceutical compositions with enhanced permeation

Info

Publication number
IL273479B2
IL273479B2 IL273479A IL27347920A IL273479B2 IL 273479 B2 IL273479 B2 IL 273479B2 IL 273479 A IL273479 A IL 273479A IL 27347920 A IL27347920 A IL 27347920A IL 273479 B2 IL273479 B2 IL 273479B2
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
enhanced permeation
permeation
enhanced
pharmaceutical
Prior art date
Application number
IL273479A
Other languages
Hebrew (he)
Other versions
IL273479A (en
IL273479B1 (en
Original Assignee
Aquestive Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/724,234 external-priority patent/US11273131B2/en
Application filed by Aquestive Therapeutics Inc filed Critical Aquestive Therapeutics Inc
Publication of IL273479A publication Critical patent/IL273479A/en
Publication of IL273479B1 publication Critical patent/IL273479B1/en
Publication of IL273479B2 publication Critical patent/IL273479B2/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/075Ethers or acetals
    • A61K31/085Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/11Aldehydes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/55171,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007Drug-containing films, membranes or sheets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Botany (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL273479A 2017-09-27 2020-03-22 Pharmaceutical compositions with enhanced permeation IL273479B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201715717856A 2017-09-27 2017-09-27
US15/724,234 US11273131B2 (en) 2016-05-05 2017-10-03 Pharmaceutical compositions with enhanced permeation
US201862735822P 2018-09-24 2018-09-24
PCT/US2018/053026 WO2019067667A1 (en) 2017-09-27 2018-09-27 Pharmaceutical compositions with enhanced permeation

Publications (3)

Publication Number Publication Date
IL273479A IL273479A (en) 2020-05-31
IL273479B1 IL273479B1 (en) 2025-07-01
IL273479B2 true IL273479B2 (en) 2025-11-01

Family

ID=63858167

Family Applications (2)

Application Number Title Priority Date Filing Date
IL321263A IL321263A (en) 2017-09-27 2018-09-27 Pharmaceutical compositions with enhanced permeation
IL273479A IL273479B2 (en) 2017-09-27 2020-03-22 Pharmaceutical compositions with enhanced permeation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL321263A IL321263A (en) 2017-09-27 2018-09-27 Pharmaceutical compositions with enhanced permeation

Country Status (8)

Country Link
EP (1) EP3687509A1 (en)
JP (2) JP7431724B2 (en)
KR (2) KR20250126144A (en)
CN (1) CN111132670A (en)
BR (1) BR112020005967A2 (en)
CA (1) CA3076815A1 (en)
IL (2) IL321263A (en)
WO (1) WO2019067667A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3022840A1 (en) 2016-05-05 2017-11-09 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
US12427121B2 (en) 2016-05-05 2025-09-30 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
US12433850B2 (en) 2016-05-05 2025-10-07 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine and prodrug compositions
MX2022004983A (en) * 2019-11-01 2022-09-23 Aquestive Therapeutics Inc Prodrug compositions and methods of treatment.
CA3160750A1 (en) 2019-12-09 2021-06-17 Anthony Richard Gerardi Oral product comprising a cannabinoid
DE102020122557A1 (en) * 2020-08-28 2022-03-03 Lts Lohmann Therapie-Systeme Ag mucosal perforation
US11839602B2 (en) 2020-11-25 2023-12-12 Nicoventures Trading Limited Oral cannabinoid product with lipid component
EP4422607A4 (en) 2021-10-25 2025-09-03 Aquestive Therapeutics Inc ORAL AND NASAL COMPOSITIONS AND TREATMENT METHODS
CN114894675B (en) * 2022-05-06 2024-04-19 江苏省农业科学院 A comparative method for the penetration behavior of pesticide adjuvants on plant leaf surfaces

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050042271A1 (en) * 1999-11-19 2005-02-24 Xel Herbaceuticals, Inc . Transdermal delivery system for alkaloids of aconitum species
US20050266085A1 (en) * 2004-05-28 2005-12-01 Warner Kevin S Gelled emulsion and microemulsion formulations for dermal drug delivery
US8840935B2 (en) * 2006-05-01 2014-09-23 Biota Ltd. Orally administrable films and preparation thereof
US20140316333A1 (en) * 2011-10-28 2014-10-23 Sung-Yun Kwon Dissolving solid solution perforator patch for migraine treatment

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960704578A (en) * 1993-09-29 1996-10-09 에드워드 엘. 만델 Monoglyceride / Lactate Ester Permeation Enhancer
AU8206401A (en) * 2000-08-03 2002-02-18 Antares Pharma Ipl Ag Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US7425292B2 (en) 2001-10-12 2008-09-16 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US7666337B2 (en) 2002-04-11 2010-02-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
JP2004043450A (en) * 2002-05-16 2004-02-12 Kyukyu Yakuhin Kogyo Kk Quickly soluble filmy preparation
JP2004131495A (en) * 2002-09-17 2004-04-30 Nippon Boehringer Ingelheim Co Ltd Pharmaceutical compositions for local delivery of non-steroidal anti-inflammatory agents
US20040127531A1 (en) * 2002-11-21 2004-07-01 Lu Guang Wei Adhesive coated sheet for dermal delivery of a selective cyclooxygenase-2 inhibitor
NZ542969A (en) * 2003-04-30 2009-09-25 Purdue Pharma Lp Tamper resistant transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer
BR0302017B1 (en) * 2003-06-02 2014-10-29 Ems Sigma Pharma Ltda Sublingual pharmaceutical composition based on a benzodiazepine central receptor agonist
EP1633326A4 (en) * 2003-06-17 2012-01-18 Sk Holdings Co Ltd TRANSNASAL MICROEMULSIONS CONTAINING DIAZEPAME
CA2689594A1 (en) * 2007-06-07 2008-12-11 Sato Pharmaceutical Co., Ltd. Film preparation with rapidly dissolving property and flexibility
JP5435853B2 (en) * 2007-09-28 2014-03-05 興和株式会社 Phenylephrine hydrochloride-containing fast-dissolving film preparation and method for producing the same
CN104812378B (en) * 2012-10-11 2017-12-01 Ix生物制药有限公司 solid dosage form
HK1222796A1 (en) * 2013-07-31 2017-07-14 因特根克斯公司 Instantly wettable oral film dosage form without surfactant or polyalcohol
WO2017023977A1 (en) * 2015-08-05 2017-02-09 University Of Rochester Antimicrobial compositions comprising mupirocin and neomycin
IL262751B2 (en) * 2016-05-05 2025-07-01 Aquestive Therapeutics Inc Pharmaceutical compositions with enhanced permeation
CA3022840A1 (en) * 2016-05-05 2017-11-09 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
CN105902524A (en) * 2016-06-30 2016-08-31 合肥华方医药科技有限公司 Sublingual zolpidem tartrate pellicle and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050042271A1 (en) * 1999-11-19 2005-02-24 Xel Herbaceuticals, Inc . Transdermal delivery system for alkaloids of aconitum species
US20050266085A1 (en) * 2004-05-28 2005-12-01 Warner Kevin S Gelled emulsion and microemulsion formulations for dermal drug delivery
US8840935B2 (en) * 2006-05-01 2014-09-23 Biota Ltd. Orally administrable films and preparation thereof
US20140316333A1 (en) * 2011-10-28 2014-10-23 Sung-Yun Kwon Dissolving solid solution perforator patch for migraine treatment

Also Published As

Publication number Publication date
IL273479A (en) 2020-05-31
KR20250126144A (en) 2025-08-22
EP3687509A1 (en) 2020-08-05
CA3076815A1 (en) 2019-04-04
JP2020535176A (en) 2020-12-03
CN111132670A (en) 2020-05-08
KR20200060457A (en) 2020-05-29
WO2019067667A1 (en) 2019-04-04
KR102845228B1 (en) 2025-08-14
BR112020005967A2 (en) 2020-10-06
IL321263A (en) 2025-08-01
JP7431724B2 (en) 2024-02-15
IL273479B1 (en) 2025-07-01
JP2024012484A (en) 2024-01-30

Similar Documents

Publication Publication Date Title
IL265260B (en) Pharmaceutical composition
IL265360A (en) Pharmaceutical composition
IL273479B2 (en) Pharmaceutical compositions with enhanced permeation
IL271986A (en) Pharmaceutical composition
IL262654A (en) Pharmaceutical composition
IL265349A (en) Pharmaceutical composition
GB201712159D0 (en) Pharmaceutical composition
PL3583943T3 (en) Pharmaceutical composition
IL272419A (en) Pharmaceutical composition
GB201719447D0 (en) Pharmaceutical composition
PL3646867T3 (en) Pharmaceutical composition
PL3454838T3 (en) Pharmaceutical composition
GB201615917D0 (en) Pharmaceutical composition
GB201615914D0 (en) Pharmaceutical composition
IL263999A (en) Pharmaceutical compositions
GB201615910D0 (en) Pharmaceutical composition
IL265436B (en) Pharmaceutical composition
ZA201705782B (en) Pharmaceutical compositions
GB201620519D0 (en) Pharmaceutical composition
IL265428A (en) Pharmaceutical composition
GB201708329D0 (en) Pharmaceutical composition
GB201708328D0 (en) Pharmaceutical composition
PT3476391T (en) Pharmaceutical composition
ZA201705783B (en) Pharmaceutical compositions
GB201705661D0 (en) Pharmaceutical composition