[go: up one dir, main page]

IL208808A - Antibodies to il-17a homodimer, il-17f homodimer and -il-17a/il-17f heterodimeric complex and uses thereof - Google Patents

Antibodies to il-17a homodimer, il-17f homodimer and -il-17a/il-17f heterodimeric complex and uses thereof

Info

Publication number
IL208808A
IL208808A IL208808A IL20880810A IL208808A IL 208808 A IL208808 A IL 208808A IL 208808 A IL208808 A IL 208808A IL 20880810 A IL20880810 A IL 20880810A IL 208808 A IL208808 A IL 208808A
Authority
IL
Israel
Prior art keywords
homodimer
antibodies
heterodimeric complex
heterodimeric
complex
Prior art date
Application number
IL208808A
Other languages
Hebrew (he)
Other versions
IL208808A0 (en
Original Assignee
Novimmune Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41265089&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL208808(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novimmune Sa filed Critical Novimmune Sa
Publication of IL208808A0 publication Critical patent/IL208808A0/en
Publication of IL208808A publication Critical patent/IL208808A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
IL208808A 2008-05-05 2010-10-19 Antibodies to il-17a homodimer, il-17f homodimer and -il-17a/il-17f heterodimeric complex and uses thereof IL208808A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12646508P 2008-05-05 2008-05-05
US9836908P 2008-09-19 2008-09-19
PCT/IB2009/005796 WO2009136286A2 (en) 2008-05-05 2009-05-05 Anti-il-17a/il-17f cross-reactive antibodies and methods of use thereof

Publications (2)

Publication Number Publication Date
IL208808A0 IL208808A0 (en) 2011-01-31
IL208808A true IL208808A (en) 2015-04-30

Family

ID=41265089

Family Applications (2)

Application Number Title Priority Date Filing Date
IL208808A IL208808A (en) 2008-05-05 2010-10-19 Antibodies to il-17a homodimer, il-17f homodimer and -il-17a/il-17f heterodimeric complex and uses thereof
IL238051A IL238051A0 (en) 2008-05-05 2015-03-31 Anti-il-17a/il-17f cross-reactive antibodies and methods of use thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL238051A IL238051A0 (en) 2008-05-05 2015-03-31 Anti-il-17a/il-17f cross-reactive antibodies and methods of use thereof

Country Status (19)

Country Link
US (4) US20090317400A1 (en)
EP (1) EP2288382B1 (en)
JP (4) JP2011519911A (en)
KR (5) KR20110025649A (en)
CN (2) CN104628855A (en)
AU (1) AU2009245440C1 (en)
BR (1) BRPI0908312A2 (en)
CA (1) CA2721713C (en)
CO (1) CO6351800A2 (en)
EC (1) ECSP10010653A (en)
HK (1) HK1210484A1 (en)
IL (2) IL208808A (en)
MA (1) MA32365B1 (en)
MX (2) MX2010012090A (en)
NZ (3) NZ588674A (en)
RU (2) RU2474588C2 (en)
SG (2) SG190626A1 (en)
WO (1) WO2009136286A2 (en)
ZA (1) ZA201007452B (en)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2784084T4 (en) 2003-07-08 2024-01-08 Novartis Pharma Ag Antagonist antibodies against IL-17A/F heterologous polypeptides
US20110256142A1 (en) * 2007-09-06 2011-10-20 Genmab A/S Novel methods and antibodies for treating cancer
MX2010012090A (en) 2008-05-05 2011-04-11 Novimmune Sa Anti-il-17a/il-17f cross-reactive antibodies and methods of use thereof.
US8790642B2 (en) * 2008-08-29 2014-07-29 Genentech, Inc. Cross-reactive and bispecific anti-IL-17A/F antibodies
KR101811886B1 (en) * 2009-05-05 2017-12-22 노비뮨 에스 에이 Anti-IL-17F Antibodies and Methods of Use Thereof
WO2011032119A1 (en) 2009-09-14 2011-03-17 The Regents Of The University Of Colorado Modulation of yeast-based immunotherapy products and responses
ES2701626T3 (en) * 2009-12-28 2019-02-25 Oncotherapy Science Inc Anti-CDH3 antibodies and their uses
WO2011100567A1 (en) * 2010-02-11 2011-08-18 The Board Of Trustees Of The Leland Stanford Junior University Therapeutic inhibition of granulocyte function in demyelinating disease
CA2798149A1 (en) * 2010-05-06 2011-11-10 Singulex, Inc Methods for diagnosing, staging, predicting risk for developing and identifying treatment responders for rheumatoid arthritis
MX2012013490A (en) 2010-05-20 2013-01-29 Ablynx Nv BIOLOGICAL MATERIALS RELATED TO HER3.
US10208349B2 (en) 2011-01-07 2019-02-19 Ucb Biopharma Sprl Lipocalin 2 as a biomarker for IL-17 inhibitor therapy efficacy
GB201100282D0 (en) 2011-01-07 2011-02-23 Ucb Pharma Sa Biological methods
PL2663577T3 (en) 2011-01-14 2017-09-29 Ucb Biopharma Sprl Antibody binding il-17a and il-17f
WO2012107153A1 (en) 2011-02-08 2012-08-16 Merck Patent Gmbh Amino statin derivativesfor the treatment of arthrosis
UA117218C2 (en) * 2011-05-05 2018-07-10 Мерк Патент Гмбх POLYPEPTIDE AGAINST IL-17A, IL-17F AND / OR IL17-A / F
DK2797951T3 (en) * 2011-12-28 2018-03-12 Immunoqure Ag PROCEDURE FOR ISOLATING HUMAN ANTIBODIES.
US10131709B2 (en) 2011-12-28 2018-11-20 Immunoqure Ag Nucleic acid molecules encoding monoclonal antibodies specific for IL-22
US9708401B2 (en) 2012-05-22 2017-07-18 Bristol-Myers Squibb Company IL-17A/F cross-reactive monoclonal antibodies and methods of using the same
WO2014001368A1 (en) * 2012-06-25 2014-01-03 Orega Biotech Il-17 antagonist antibodies
CA2920686C (en) 2013-09-13 2022-12-06 Genentech, Inc. Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products
EP3043820A4 (en) 2013-09-13 2017-07-12 F. Hoffmann-La Roche AG Methods and compositions comprising purified recombinant polypeptides
HRP20201432T1 (en) * 2013-11-18 2020-12-11 Shanghai Hengrui Pharmaceutical Co., Ltd. Il-17a binding agent and uses thereof
CR20160379A (en) * 2014-02-21 2016-10-07 Genentech Inc BISPECIFIC ANTIBODIES ANTI-IL 13 / IL-17 AND ITS USES
CN107148283A (en) * 2014-10-31 2017-09-08 豪夫迈·罗氏有限公司 Anti-IL-17A and IL-17F cross-reactive antibody variants, compositions comprising the same, and methods of making and using the same
HRP20201351T1 (en) 2014-11-05 2020-11-27 Genentech, Inc. PROCEDURES FOR THE PRODUCTION OF TWO - CHAIN PROTEINS IN BACTERIA
RU2705274C2 (en) * 2014-11-05 2019-11-06 Дженентек, Инк. Methods for producing double-stranded proteins in bacteria
MY192999A (en) 2014-11-20 2022-09-20 Hoffmann La Roche Combination therapy of t cell activating bispecific antigen binding molecules and pd-1 axis binding antagonists
MX2017007747A (en) * 2014-12-15 2018-02-13 Morphosys Ag Antibodies for il-17c.
AR103173A1 (en) 2014-12-22 2017-04-19 Novarits Ag PHARMACEUTICAL PRODUCTS AND STABLE LIQUID COMPOSITIONS OF ANTIBODIES IL-17
EP3250927B1 (en) 2015-01-28 2020-02-19 H. Hoffnabb-La Roche Ag Gene expression markers and treatment of multiple sclerosis
HK1247287A1 (en) * 2015-03-16 2018-09-21 F. Hoffmann-La Roche Ag Methods of detecting and quantifying il-13 and uses in diagnosing and treating th2-associated diseases
AU2016278040B2 (en) 2015-06-16 2019-07-04 Nanophagix LLC Drug delivery and imaging chemical conjugate, formulations and methods of use thereof
WO2017011769A2 (en) * 2015-07-15 2017-01-19 California Institute Of Technology Il-17f-specific capture agents, compositions, and methods of using and making
HK1259368A1 (en) * 2015-08-20 2019-11-29 F. Hoffmann-La Roche Ag Purification of fkpa and uses thereof for producing recombinant polypeptides
MY196489A (en) * 2015-10-27 2023-04-17 UCB Biopharma SRL Methods of Treatment Using Anti-IL-17A/F Antibodies
GB201522391D0 (en) * 2015-12-18 2016-02-03 Ucb Biopharma Sprl Antibody molecules
RU2680011C2 (en) 2016-04-29 2019-02-14 Закрытое Акционерное Общество "Биокад" Trispecific il-17a, il-17f and other proinflammatory molecules antibodies
CN107488227A (en) * 2016-06-12 2017-12-19 三生国健药业（上海）股份有限公司 Anti-human IL-17 A monoclonal antibodies, its preparation method and application
AU2017328310B2 (en) 2016-09-14 2020-10-15 Beijing Hanmi Pharm. Co., Ltd. Antibody specifically binding to IL-17A and functional fragment thereof
CR20190387A (en) 2017-02-10 2019-09-25 Genentech Inc ANTIBODIES AGAINST TRYPTASE, COMPOSITIONS OF THESE AND USES OF THEM
WO2018161340A1 (en) * 2017-03-10 2018-09-13 X-Kang United Biopharmaceutical Science & Technology Co., Ltd. Monoclonal antibody against both il-17a and il-17f and use of the same
JP2021501752A (en) 2017-11-02 2021-01-21 ノバルティス アーゲー How to treat tendon disorders with interleukin-17 (IL-17) antagonists
LT3893924T (en) * 2018-12-13 2024-10-10 argenx BV Antibodies to human complement factor c2b and methods of use
EP3917956A4 (en) * 2019-02-02 2022-12-07 Huahui Health Ltd. ANTI-FGF19 ANTIBODIES
IL297689A (en) * 2020-04-30 2022-12-01 Janssen Pharmaceutica Nv Methods of identifying modulators of the il-17 pathway
JP2024531149A (en) * 2021-08-09 2024-08-29 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Proteins that decouple T cell-mediated tumor cytotoxicity from proinflammatory cytokine release - Patents.com
US20250313618A1 (en) 2022-05-16 2025-10-09 Novartis Ag Methods of treating giant cell arteritis using Interleukin-17 (IL-17) Antagonists
WO2023223263A1 (en) 2022-05-18 2023-11-23 Novartis Ag Methods of selectively treating tendinopathy using interleukin-17 (il-17) antagonists
EP4393948A1 (en) * 2022-12-28 2024-07-03 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Therapeutic vhh antibodies cross-neutralizing the il-17a and il-17f homodimers as well as the il-17af heterodimer
WO2025202213A1 (en) 2024-03-26 2025-10-02 Institut National de la Santé et de la Recherche Médicale Lipid nanoparticle loaded with antitumoral agent and functionnalized to target immosuppressive cells

Family Cites Families (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4738681A (en) * 1985-07-10 1988-04-19 Harrington Arthritis Research Center Femoral-joint prosthetic device
US5605690A (en) * 1989-09-05 1997-02-25 Immunex Corporation Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
US5370870A (en) * 1989-10-06 1994-12-06 Genentech, Inc. Method for protection against reactive oxygen species
SE500903C2 (en) 1989-12-20 1994-09-26 Atlas Copco Constr & Mining Rock drilling rig
US6075181A (en) * 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5364839A (en) 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
US5206023A (en) 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5273033A (en) * 1991-09-19 1993-12-28 Murray Electronics Associates Limited Partnership Electrical stimulation for treatment of osteoarthritis
US5716805A (en) * 1991-10-25 1998-02-10 Immunex Corporation Methods of preparing soluble, oligomeric proteins
WO1993023556A1 (en) * 1992-05-08 1993-11-25 Genentech, Inc. Antibodies to leukemia inhibitory factor
GB9214857D0 (en) 1992-07-13 1992-08-26 Medical Res Council Human nucleic acid fragments and their use
US5536637A (en) * 1993-04-07 1996-07-16 Genetics Institute, Inc. Method of screening for cDNA encoding novel secreted mammalian proteins in yeast
US6562333B1 (en) 1993-06-14 2003-05-13 Schering Corporation Purified mammalian CTLA-8 antigens and related reagents
US6274711B1 (en) 1993-06-14 2001-08-14 Inserm, Institut National De La Sante Et De La Recherche Medicale Purified mammalian CTLA-8 antigens and related reagents
US5830877A (en) 1993-08-26 1998-11-03 The Regents Of The University Of California Method, compositions and devices for administration of naked polynucleotides which encode antigens and immunostimulatory
US5444047A (en) * 1994-06-16 1995-08-22 Dipasquale; Gene Treatment of arthritic and post-surgical orthopedic conditions with Insulin-like Growth Factor-I
WO2000073452A2 (en) 1999-06-02 2000-12-07 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
WO1996029408A1 (en) * 1995-03-23 1996-09-26 Immunex Corporation Il-17 receptor
US5573762A (en) * 1995-04-24 1996-11-12 Genentech, Inc. Use of leukemia inhibitory factor specific antibodies and endothelin antagonists for treatment of cardiac hypertrophy
EP1591529A3 (en) 1995-07-19 2005-11-09 Genetics Institute, LLC Human CLTA-8 and uses of CTLA-8-related proteins
US6902735B1 (en) 1995-07-19 2005-06-07 Genetics Institute, Llc Antibodies to human IL-17F and other CTLA-8-related proteins
US5707829A (en) 1995-08-11 1998-01-13 Genetics Institute, Inc. DNA sequences and secreted proteins encoded thereby
US6074849A (en) * 1995-07-19 2000-06-13 Genetics Institute, Inc. Polynucleotides encoding human CTLA-8 related proteins
WO1997020062A1 (en) 1995-12-01 1997-06-05 University Of Massachusetts Il-12 p40 subunit fusion polypeptides and uses thereof
CA2242340A1 (en) 1996-01-11 1997-07-17 Corixa Corporation Compositions and methods for the treatment and diagnosis of breast cancer
WO2002008284A2 (en) 2000-07-20 2002-01-31 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
WO2002000690A2 (en) 2000-06-23 2002-01-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
AU7408998A (en) 1996-11-27 1998-06-22 Immunex Corporation Method of regulating nitric oxide production
US6054559A (en) * 1997-01-28 2000-04-25 Smithkline Beecham Corporation Interleukin-1 receptor antagonist beta (IL-1raβ)
US6579520B2 (en) * 1998-05-15 2003-06-17 Genentech, Inc. IL-17 related mammalian cytokine polypeptides (IL-17E)
WO2001040465A2 (en) 1999-11-30 2001-06-07 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
WO2000053752A2 (en) 1999-03-08 2000-09-14 Genentech, Inc. Promotion or inhibition of angiogenesis and cardiovascularization
US6569645B2 (en) * 1999-05-14 2003-05-27 Genentech, Inc. IL-17 homologous polypeptides and therapeutic uses thereof
US20020177188A1 (en) * 1998-05-15 2002-11-28 Genentech, Inc. IL-17 homologous polypeptides and therapeutic uses thereof
ATE269901T1 (en) 1997-04-25 2004-07-15 Zymogenetics Inc MAMMAL CYTOKINE-LIKE FACTOR-7
EP1012260A4 (en) 1997-07-16 2001-05-09 Human Genome Sciences Inc Interleukin-20
ZA986596B (en) 1997-07-25 1999-02-08 Schering Corp Mammalian cytokine related reagents
US6060284A (en) * 1997-07-25 2000-05-09 Schering Corporation DNA encoding interleukin-B30
ES2333385T3 (en) 1997-09-17 2010-02-19 Human Genome Sciences, Inc. PROTEIN OF THE INTERLEUQUINE TYPE-17.
US6482923B1 (en) 1997-09-17 2002-11-19 Human Genome Sciences, Inc. Interleukin 17-like receptor protein
US6562578B1 (en) * 1999-01-11 2003-05-13 Schering Corporation IL-17-like cytokine binding compounds and antibodies
JP2002533055A (en) 1997-12-19 2002-10-08 ワイス Transgenic animal model for cartilage degenerative disease
AU2004799A (en) 1997-12-19 1999-07-12 Millennium Biotherapeutics, Inc. Novel embryo-derived interleukin related factor molecules and uses therefor
WO1999035267A1 (en) 1998-01-09 1999-07-15 Immunex Corporation Human and murine il-17d, cytokine related to interleukin-17: dna and polypeptides
ES2312205T3 (en) 1998-03-10 2009-02-16 Genentech, Inc. NEW POLYPEPTIDE AND NUCLEIC ACIDS THAT CODE IT.
ATE325815T1 (en) 1998-03-25 2006-06-15 Genentech Inc HUMAN NEUROTRIMIN HOMOLOGUE
EP1067956B1 (en) 1998-04-03 2007-03-14 University Of Iowa Research Foundation Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines
AU3170199A (en) * 1998-04-14 1999-11-08 Chugai Research Institute For Molecular Medicine, Inc. Novel cytokine-like protein
IL138930A0 (en) * 1998-05-15 2001-11-25 Genentech Inc Il-17 homologies polypeptides and therapeutic uses thereof
US7771719B1 (en) * 2000-01-11 2010-08-10 Genentech, Inc. Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E
US20050147609A1 (en) 1998-05-15 2005-07-07 Genentech, Inc. Use of anti-IL-17 antibody for the treatment of cartilage damaged by osteoarthritis
EP1443055A3 (en) 1998-05-29 2005-06-08 Human Genome Sciences, Inc. Interleukins-21 and 22
US20010023070A1 (en) 1998-05-29 2001-09-20 Reinhard Ebner Interleukins-21 and 22
US20030003545A1 (en) * 1998-05-29 2003-01-02 Reinhard Ebner Interleukins-21 and 22
ATE378408T1 (en) 1998-09-17 2007-11-15 Zymogenetics Inc MAMMAL TRANSFORMING GROWTH FACTOR BETA-9 (ZTGFSS9).
AU6277799A (en) 1998-10-02 2000-04-26 Eli Lilly And Company Il-17 homolog nucleic acids, polypeptides, vectors, host cells, methods and usesthereof
JP2000186046A (en) 1998-10-14 2000-07-04 Snow Brand Milk Prod Co Ltd Therapeutic agent for and diagnosis of chronic rheumatism and
WO2000042187A1 (en) 1999-01-11 2000-07-20 Schering Corporation Interleukin-17 related mammalian cytokine (il-171). polynucleotides encoding them. uses
SI1141297T1 (en) 1999-01-11 2010-01-29 Schering Corp Interleukin-17 related mammalian cytokines. polynucleotides encoding them . uses
KR20140094647A (en) 1999-03-25 2014-07-30 아비에 도이치란트 게엠베하 운트 콤파니 카게 Human antibodies that bind human IL-12 and methods for producing
US6914128B1 (en) * 1999-03-25 2005-07-05 Abbott Gmbh & Co. Kg Human antibodies that bind human IL-12 and methods for producing
AU3632600A (en) 1999-05-14 2000-12-05 Genentech Inc. Compositions and methods for the treatment of immune related diseases
US20030082734A1 (en) * 1999-06-01 2003-05-01 Dowling Lynette M. Mammalian receptor proteins; related reagents and methods
US20030199041A1 (en) * 1999-07-07 2003-10-23 Presnell Scott R. Interleukin-17 receptor homologue
DK1860188T3 (en) 1999-07-07 2011-06-27 Zymogenetics Inc Human cytokine receptor
AU7680300A (en) 1999-08-18 2001-03-13 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Human dna sequences
CA2380355A1 (en) 1999-09-01 2001-03-08 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
JP2003508088A (en) 1999-09-03 2003-03-04 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド 52 human secreted proteins
ES2254224T3 (en) * 1999-09-27 2006-06-16 Chugai Seiyaku Kabushiki Kaisha NEW PROTEIN OF THE HEMATOPOYETINE RECEIVER, NR12.
ES2379101T3 (en) 1999-12-23 2012-04-20 Genentech, Inc. Homologous IL-17 polypeptides and therapeutic uses thereof
US6380362B1 (en) 1999-12-23 2002-04-30 Genesis Research & Development Corporation Ltd. Polynucleotides, polypeptides expressed by the polynucleotides and methods for their use
US20040043397A1 (en) * 2000-01-11 2004-03-04 Genentech, Inc. IL-17 homologous polypeptides and therapeutic uses thereof
AU2404001A (en) 2000-01-06 2001-07-16 Protegene Inc. Human proteins having hydrophobic domains and dnas encoding these proteins
AU2001233041A1 (en) 2000-01-25 2001-08-07 Hyseq, Inc. Novel nucleic acids and polypeptides
AU2001236638A1 (en) 2000-02-04 2001-08-14 The Board Of Trustees Of The University Of Arkansas Evi27 gene sequences and protein encoded thereby
AU6802801A (en) 2000-03-01 2001-09-24 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7094566B2 (en) * 2000-03-16 2006-08-22 Amgen Inc., IL-17 receptor like molecules and uses thereof
AR028256A1 (en) 2000-03-16 2003-04-30 Amgen Inc SIMILAR MOLECULES TO IL-17 RECEPTORS AND USES OF THE SAME
AR030554A1 (en) 2000-03-16 2003-08-27 Amgen Inc SIMILAR MOLECULES TO IL-17 RECEPTORS AND USES OF THE SAME
EP1265630B1 (en) * 2000-03-24 2006-06-07 Genentech, Inc. Use of insulin for the treatment of cartilagenous disorders
US6479636B1 (en) 2000-04-11 2002-11-12 Honiron Corporation (A Louisiana Corporation) Sugarcane fractioning system
ES2317898T3 (en) 2000-04-18 2009-05-01 Schering Corporation MEDICINAL USES OF AGONISTS AND ANTOGONISTS OF IL-174.
DE60134136D1 (en) 2000-05-10 2008-07-03 Schering Corp CYTOKIN RECEPTOR SUBUNITS PROTEINS FROM MAMMALS, ASSOCIATED REAGENTS AND METHODS
US7422743B2 (en) * 2000-05-10 2008-09-09 Schering Corporation Mammalian receptor protein DCRS5;methods of treatment
AU2001274920A1 (en) 2000-05-24 2001-12-03 Schering Corporation Mammalian receptor proteins; related reagents and methods
AU6531101A (en) 2000-06-02 2001-12-17 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20030096969A1 (en) * 2000-06-02 2003-05-22 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
MXPA02012743A (en) 2000-06-22 2003-04-25 Amgen Inc Il-17 molecules and uses thereof.
JP2004514420A (en) 2000-07-20 2004-05-20 ジェネンテック・インコーポレーテッド Secreted and transmembrane polypeptides and nucleic acids encoding them
EP1332211A2 (en) * 2000-07-26 2003-08-06 ZymoGenetics, Inc. Human cytokine receptor
US6902734B2 (en) * 2000-08-07 2005-06-07 Centocor, Inc. Anti-IL-12 antibodies and compositions thereof
JP2002139499A (en) * 2000-08-23 2002-05-17 Sanyo Electric Co Ltd Chemical substance sensor and method for detecting chemical substance
JP2002076897A (en) * 2000-08-29 2002-03-15 Toshiba Corp DA converter
US20060083713A1 (en) 2000-10-13 2006-04-20 Eli Lilly And Company Methods of using a human il-17 related polypeptide to treat disease
GB2372464B (en) 2001-02-22 2003-05-14 Vivascience Ltd Method of isolating a charged compound
US20070160576A1 (en) 2001-06-05 2007-07-12 Genentech, Inc. IL-17A/F heterologous polypeptides and therapeutic uses thereof
PL374118A1 (en) * 2001-08-07 2005-10-03 Immunex Corporation Interleukin-1 receptors in the treatment of diseases
JP2005506342A (en) 2001-10-15 2005-03-03 ジェネンテック・インコーポレーテッド Treatment and diagnosis of insulin resistance status
US7103929B2 (en) * 2002-03-12 2006-09-12 Little Rapids Corporation Disposable bedding with absorbent region
ES2329673T3 (en) 2002-10-30 2009-11-30 Genentech, Inc. INHIBITION OF IL-17 PRODUCTION.
NZ541898A (en) * 2003-03-10 2008-07-31 Schering Corp Uses of IL-23 antagonists for the manufacture of a medicament for the treatment of tumors
CA2530386A1 (en) 2003-06-23 2005-01-06 Jing Li Antibodies against interleukin-22 and uses therefor
DK2784084T4 (en) * 2003-07-08 2024-01-08 Novartis Pharma Ag Antagonist antibodies against IL-17A/F heterologous polypeptides
TW200528106A (en) * 2003-11-10 2005-09-01 Synta Pharmaceuticals Corp Pyridine compounds
TWI344364B (en) * 2003-11-10 2011-07-01 Synta Pharmaceuticals Corp Fused heterocyclic compounds
US7935698B2 (en) 2003-11-10 2011-05-03 Synta Pharmaceuticals Corporation Heteroaryl-hydrazone compounds
EP1983000B1 (en) 2003-11-21 2015-09-02 UCB Biopharma SPRL Method for the treatment of multiple sclerosis by inhibiting IL-17 activity
BRPI0507794A (en) * 2004-02-17 2007-07-17 Schering Corp methods of modulating il-23 activity, related reagents
US20050287593A1 (en) 2004-05-03 2005-12-29 Schering Corporation Use of cytokine expression to predict skin inflammation; methods of treatment
CN1993480A (en) 2004-05-03 2007-07-04 先灵公司 Use of cytokine expression to predict skin inflammation, methods of treatment
CA2569867A1 (en) 2004-06-10 2005-12-29 Zymogenetics, Inc. Soluble zcytor14, anti-zcytor14 antibodies and binding partners and methods of using in inflammation
US7629691B2 (en) 2004-06-16 2009-12-08 Honeywell International Inc. Conductor geometry for electronic circuits fabricated on flexible substrates
GB0417487D0 (en) 2004-08-05 2004-09-08 Novartis Ag Organic compound
AR051444A1 (en) * 2004-09-24 2007-01-17 Centocor Inc PROTEINS DERIVED FROM IL-23P40 SPECIFIC IMMUNOGLOBULIN, COMPOSITIONS, EPITHOPES, METHODS AND USES
GB0425569D0 (en) 2004-11-19 2004-12-22 Celltech R&D Ltd Biological products
EP1819731A4 (en) 2004-12-08 2013-02-13 Immunomedics Inc Methods and compositions for immunotherapy and detection of inflammatory and immune-dysregulatory disease, infectious disease, pathologic angiogenesis and cancer
WO2006088833A2 (en) * 2005-02-14 2006-08-24 Wyeth Interleukin-17f antibodies and other il-17f signaling antagonists and uses therefor
JP2008541781A (en) 2005-06-06 2008-11-27 ジェネンテック・インコーポレーテッド Transgenic animals for different genes and their use for characterizing genes
JP2009507023A (en) 2005-09-01 2009-02-19 シェーリング コーポレイション Use of IL-23 and IL-17 antagonists to treat autoimmune ocular inflammatory diseases
US20070249533A1 (en) 2005-09-28 2007-10-25 Levin Steven D Il-17a and il-17f antagonists and methods of using the same
UA96139C2 (en) 2005-11-08 2011-10-10 Дженентек, Інк. Anti-neuropilin-1 (nrp1) antibody
RS57255B1 (en) 2005-12-13 2018-08-31 Lilly Co Eli Anti-il-17 antibodies
US7981937B2 (en) * 2006-01-11 2011-07-19 Aurora Specialty Chemistries Corp. Aurora Stable dispersion of DBNPA in viscosified brine
RU2430110C2 (en) 2006-01-31 2011-09-27 Новартис Аг Interleukin (il-17) antibody antagonists for cancer treatment
AU2007226627B2 (en) 2006-03-10 2012-09-20 Zymogenetics, Inc. Antibodies that bind both IL-17A and IL-17F and methods of using the same
US7790163B2 (en) 2006-03-10 2010-09-07 Zymogenetics, Inc. Antibodies that bind both IL-17A and IL-17F and methods of using the same
US7910703B2 (en) 2006-03-10 2011-03-22 Zymogenetics, Inc. Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use
CA2655372A1 (en) 2006-06-13 2007-12-21 Zymogenetics, Inc. Il-17 and il-23 antagonists and methods of using the same
TW200815469A (en) 2006-06-23 2008-04-01 Astrazeneca Ab Compounds
GB0612928D0 (en) 2006-06-29 2006-08-09 Ucb Sa Biological products
GB0620729D0 (en) 2006-10-18 2006-11-29 Ucb Sa Biological products
JP2010522564A (en) 2007-03-26 2010-07-08 ザイモジェネティクス， インコーポレイテッド Soluble IL-17RA / RC fusion protein and related methods
WO2008133684A1 (en) * 2007-04-27 2008-11-06 Zymogenetics, Inc. Antibodies that bind both il-17a and il-17f and methods of using the same
EP2392597B1 (en) 2007-04-27 2014-04-02 ZymoGenetics, Inc. Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use
CA2690568A1 (en) 2007-06-20 2008-12-24 Schering Corporation Joint destruction biomarkers for anti-il-17a therapy of inflammatory joint disease
WO2009015063A2 (en) 2007-07-23 2009-01-29 Centocor Methods and compositions for treating fibrosis related disorders using il-17 antagonists
US20110300154A1 (en) 2007-08-21 2011-12-08 Children's Medical Center Corporation Treatment of airway hyperreactivity
GB0807413D0 (en) 2008-04-23 2008-05-28 Ucb Pharma Sa Biological products
MX2010012090A (en) 2008-05-05 2011-04-11 Novimmune Sa Anti-il-17a/il-17f cross-reactive antibodies and methods of use thereof.
US8790642B2 (en) 2008-08-29 2014-07-29 Genentech, Inc. Cross-reactive and bispecific anti-IL-17A/F antibodies
WO2010114859A1 (en) 2009-04-01 2010-10-07 Genentech, Inc. Treatment of insulin-resistant disorders
KR101811886B1 (en) 2009-05-05 2017-12-22 노비뮨 에스 에이 Anti-IL-17F Antibodies and Methods of Use Thereof

Also Published As

Publication number Publication date
AU2009245440C1 (en) 2013-03-14
CN104628855A (en) 2015-05-20
NZ600584A (en) 2014-05-30
KR20110025649A (en) 2011-03-10
WO2009136286A2 (en) 2009-11-12
RU2474588C2 (en) 2013-02-10
JP2011519911A (en) 2011-07-14
JP5898653B2 (en) 2016-04-06
CA2721713A1 (en) 2009-11-12
KR101508086B1 (en) 2015-04-07
MX355256B (en) 2018-04-11
JP2017048191A (en) 2017-03-09
KR20160028505A (en) 2016-03-11
BRPI0908312A2 (en) 2015-08-18
ECSP10010653A (en) 2011-02-28
IL238051A0 (en) 2015-05-31
EP2288382B1 (en) 2018-08-29
JP2014001217A (en) 2014-01-09
HK1210484A1 (en) 2016-04-22
AU2009245440B2 (en) 2012-08-02
US8771697B2 (en) 2014-07-08
IL208808A0 (en) 2011-01-31
US20120141492A1 (en) 2012-06-07
NZ623706A (en) 2015-12-24
WO2009136286A9 (en) 2010-04-22
WO2009136286A3 (en) 2010-06-10
KR20170023209A (en) 2017-03-02
US20120269820A1 (en) 2012-10-25
MX2010012090A (en) 2011-04-11
JP2015166355A (en) 2015-09-24
US8715669B2 (en) 2014-05-06
EP2288382A2 (en) 2011-03-02
KR101711798B1 (en) 2017-03-02
CO6351800A2 (en) 2011-12-20
JP6507133B2 (en) 2019-04-24
AU2009245440A1 (en) 2009-11-12
CN102083858B (en) 2015-01-14
CN102083858A (en) 2011-06-01
RU2012151478A (en) 2014-06-10
KR20130138354A (en) 2013-12-18
SG10201608871XA (en) 2016-12-29
US9650437B2 (en) 2017-05-16
KR20150002874A (en) 2015-01-07
RU2010149746A (en) 2012-06-20
US20090317400A1 (en) 2009-12-24
SG190626A1 (en) 2013-06-28
CA2721713C (en) 2019-07-09
US20130195872A1 (en) 2013-08-01
ZA201007452B (en) 2012-01-25
NZ588674A (en) 2013-02-22
MA32365B1 (en) 2011-06-01

Similar Documents

Publication Publication Date Title
IL208808A (en) Antibodies to il-17a homodimer, il-17f homodimer and -il-17a/il-17f heterodimeric complex and uses thereof
IL196968A0 (en) Antibodies to il-17a
IL271270A (en) Antibodies to il-6 and use thereof
IL257290A (en) Antibodies to il-6 and use thereof
IL232276A0 (en) Antibodies to il-6 and their uses
PL2294083T3 (en) Epitopes of il-17a and il-17f and antibodies specific thereto
IL201281A0 (en) Antibodies that bind both il - 17a and il-17f and methods of using the same
IL193444A0 (en) Antibodies that bind both il-17a and il-17f and methods of using the same
ZA201101047B (en) Antibodies to ccr2
SI2663577T1 (en) Antibody binding il-17a and il-17f
IL224752A (en) Method of using interleukin il-1α antibodies
IL232008A0 (en) Alpha-4-beta-7 heterodimer specific antagonist antibody
IL211087A0 (en) Engineered anti-il-13 antibodies, compositions, methods and uses
EP2125890A4 (en) Antibodies to phosphorylated-irak4
IL210643A0 (en) Anti-hepcidin-25 selective antibodies and uses thereof
ITMO20070024A1 (en) PREFORM TO OBTAIN CONTAINERS
HK1125390A (en) Antibodies to il-17a
AU2008904182A0 (en) Anti-IL-23 heterodimeric specific antibodies
HU0800449D0 (en) Decorative construction brick element for rigid wall-structures built in by adhesive technology, mainly for external wall-cladding without pointing
AU2008904474A0 (en) Social website utility
GB0718832D0 (en) Antibody fusions
GB0718834D0 (en) Antibody fusions

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed