IL184257A0 - Solid peroral contraceptive drug - Google Patents
Solid peroral contraceptive drugInfo
- Publication number
- IL184257A0 IL184257A0 IL184257A IL18425707A IL184257A0 IL 184257 A0 IL184257 A0 IL 184257A0 IL 184257 A IL184257 A IL 184257A IL 18425707 A IL18425707 A IL 18425707A IL 184257 A0 IL184257 A0 IL 184257A0
- Authority
- IL
- Israel
- Prior art keywords
- dienogest
- ethinyl estradiol
- contraceptive drug
- solid peroral
- released
- Prior art date
Links
- 239000003433 contraceptive agent Substances 0.000 title abstract 2
- 239000007787 solid Substances 0.000 title abstract 2
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 abstract 3
- AZFLJNIPTRTECV-FUMNGEBKSA-N dienogest Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)CC#N)CC3)C3=C21 AZFLJNIPTRTECV-FUMNGEBKSA-N 0.000 abstract 3
- 229960003309 dienogest Drugs 0.000 abstract 3
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 abstract 2
- 229960002568 ethinylestradiol Drugs 0.000 abstract 2
- 239000003937 drug carrier Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gynecology & Obstetrics (AREA)
- Organic Chemistry (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Abstract
Disclosed is a solid peroral contraceptive drug containing 17a-cyanomethyI-17-ß-hydroxyestra-4,9-dien-3on (dienogest) at a daily dose that is equal to or smaller than 2.0 mg as one active component and 17a-ethinyl estradiol (ethinyl estradiol) at a daily dose of less than 0.03 mg as another active component along with one or several pharmaceutically acceptable carriers. The dienogest is proportionately released in at least two phases while the ethinyl estradiol is released at the same time as the first phase of the dienogest.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05003181A EP1690529A1 (en) | 2005-02-15 | 2005-02-15 | Peroral solid dosage form for contraception comprising Dienogest and Ethinylestradiol |
| EP05003179A EP1690543A1 (en) | 2005-02-15 | 2005-02-15 | Pharmaceutical composition for contraception |
| PCT/EP2006/001358 WO2006087177A2 (en) | 2005-02-15 | 2006-02-15 | Solid peroral contraceptive drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL184257A0 true IL184257A0 (en) | 2007-10-31 |
Family
ID=37951746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL184257A IL184257A0 (en) | 2005-02-15 | 2007-06-27 | Solid peroral contraceptive drug |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1848406B1 (en) |
| JP (1) | JP2008527019A (en) |
| KR (1) | KR20070087141A (en) |
| AT (1) | ATE395047T1 (en) |
| AU (1) | AU2006215822B2 (en) |
| BR (1) | BRPI0606297A2 (en) |
| CA (1) | CA2594939A1 (en) |
| CY (1) | CY1108265T1 (en) |
| DE (1) | DE502006000771D1 (en) |
| DK (1) | DK1848406T3 (en) |
| EA (1) | EA200701389A1 (en) |
| ES (1) | ES2310907T3 (en) |
| HR (1) | HRP20080394T3 (en) |
| IL (1) | IL184257A0 (en) |
| NO (1) | NO20072893L (en) |
| PL (1) | PL1848406T3 (en) |
| PT (1) | PT1848406E (en) |
| RS (1) | RS50597B (en) |
| SI (1) | SI1848406T1 (en) |
| WO (1) | WO2006087177A2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008033254B4 (en) * | 2007-07-31 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Process for the preparation of a monophasic pharmaceutical preparation for oral therapy of the regulation of blood pressure |
| JP2010529063A (en) * | 2007-07-31 | 2010-08-26 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | Single-phase pharmaceutical complex preparations (dienogest and ethinylestradiol) for oral therapy for the regulation of blood pressure |
| JP6759478B2 (en) * | 2019-02-13 | 2020-09-23 | 富士製薬工業株式会社 | Oral solid composition, a method for producing the same, and an oral tablet obtained by the method for producing the oral solid composition. |
| EP3954364A1 (en) * | 2020-08-14 | 2022-02-16 | Chemo Research, S.L. | New modified release oral contraceptive composition |
| KR102652671B1 (en) | 2023-12-26 | 2024-03-29 | 주식회사 스몰랩 | Microsphere composition for microneedles of contraception and microneedles of contraception prepared by using the same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19525017A1 (en) * | 1995-06-28 | 1997-01-02 | Schering Ag | Pharmaceutical combination preparation, kit and method for hormonal contraception |
| AU726091B2 (en) * | 1996-07-26 | 2000-11-02 | Wyeth | Monophasic contraceptive method and kit comprising a combination of a progestin and estrogen |
-
2006
- 2006-02-15 EA EA200701389A patent/EA200701389A1/en unknown
- 2006-02-15 WO PCT/EP2006/001358 patent/WO2006087177A2/en not_active Ceased
- 2006-02-15 DE DE502006000771T patent/DE502006000771D1/en active Active
- 2006-02-15 JP JP2007551647A patent/JP2008527019A/en not_active Withdrawn
- 2006-02-15 RS RSP-2008/0358A patent/RS50597B/en unknown
- 2006-02-15 KR KR1020077016400A patent/KR20070087141A/en not_active Abandoned
- 2006-02-15 AU AU2006215822A patent/AU2006215822B2/en not_active Ceased
- 2006-02-15 PT PT06706961T patent/PT1848406E/en unknown
- 2006-02-15 SI SI200630062T patent/SI1848406T1/en unknown
- 2006-02-15 BR BRPI0606297-0A patent/BRPI0606297A2/en not_active Application Discontinuation
- 2006-02-15 CA CA002594939A patent/CA2594939A1/en not_active Abandoned
- 2006-02-15 HR HR20080394T patent/HRP20080394T3/en unknown
- 2006-02-15 PL PL06706961T patent/PL1848406T3/en unknown
- 2006-02-15 AT AT06706961T patent/ATE395047T1/en active
- 2006-02-15 DK DK06706961T patent/DK1848406T3/en active
- 2006-02-15 EP EP06706961A patent/EP1848406B1/en active Active
- 2006-02-15 ES ES06706961T patent/ES2310907T3/en active Active
-
2007
- 2007-06-06 NO NO20072893A patent/NO20072893L/en not_active Application Discontinuation
- 2007-06-27 IL IL184257A patent/IL184257A0/en unknown
-
2008
- 2008-08-14 CY CY20081100871T patent/CY1108265T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1848406B1 (en) | 2008-05-14 |
| PL1848406T3 (en) | 2009-06-30 |
| ES2310907T3 (en) | 2009-01-16 |
| RS50597B (en) | 2010-05-07 |
| WO2006087177A2 (en) | 2006-08-24 |
| WO2006087177A8 (en) | 2007-05-24 |
| CY1108265T1 (en) | 2014-02-12 |
| PT1848406E (en) | 2008-08-21 |
| DE502006000771D1 (en) | 2008-06-26 |
| WO2006087177A3 (en) | 2007-08-30 |
| JP2008527019A (en) | 2008-07-24 |
| KR20070087141A (en) | 2007-08-27 |
| SI1848406T1 (en) | 2008-10-31 |
| AU2006215822B2 (en) | 2008-09-04 |
| ATE395047T1 (en) | 2008-05-15 |
| BRPI0606297A2 (en) | 2009-06-09 |
| CA2594939A1 (en) | 2006-08-24 |
| WO2006087177B1 (en) | 2007-10-11 |
| DK1848406T3 (en) | 2008-09-15 |
| HRP20080394T3 (en) | 2008-11-30 |
| NO20072893L (en) | 2007-09-12 |
| EA200701389A1 (en) | 2008-02-28 |
| EP1848406A2 (en) | 2007-10-31 |
| AU2006215822A1 (en) | 2006-08-24 |
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