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IL174726A - Nonhuman animal comprising transgenic nucleic acid sequence coding for mutant presenilin 1 protein - Google Patents

Nonhuman animal comprising transgenic nucleic acid sequence coding for mutant presenilin 1 protein

Info

Publication number
IL174726A
IL174726A IL174726A IL17472606A IL174726A IL 174726 A IL174726 A IL 174726A IL 174726 A IL174726 A IL 174726A IL 17472606 A IL17472606 A IL 17472606A IL 174726 A IL174726 A IL 174726A
Authority
IL
Israel
Prior art keywords
protein
nucleic acid
acid sequence
sequence coding
nonhuman animal
Prior art date
Application number
IL174726A
Other languages
Hebrew (he)
Other versions
IL174726A0 (en
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of IL174726A0 publication Critical patent/IL174726A0/en
Publication of IL174726A publication Critical patent/IL174726A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/107—Rabbit
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/02—Cells from transgenic animals

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention relates to non-human transgenic animals with serious disorders related to Alzheimer's disease. The animals can be used for the discovery of compounds for the treatment of Alzheimer's disease.
IL174726A 2003-10-02 2006-04-02 Nonhuman animal comprising transgenic nucleic acid sequence coding for mutant presenilin 1 protein IL174726A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0311578A FR2860391B1 (en) 2003-10-02 2003-10-02 TRANSGENIC ANIMALS WITH MAJOR DISORDERS RELATED TO ALZHEIMER'S DISEASE
PCT/FR2004/002436 WO2005032244A1 (en) 2003-10-02 2004-09-27 Transgenic animals with serious disorders related to alzheimer's disease

Publications (2)

Publication Number Publication Date
IL174726A0 IL174726A0 (en) 2006-08-20
IL174726A true IL174726A (en) 2013-05-30

Family

ID=34307379

Family Applications (1)

Application Number Title Priority Date Filing Date
IL174726A IL174726A (en) 2003-10-02 2006-04-02 Nonhuman animal comprising transgenic nucleic acid sequence coding for mutant presenilin 1 protein

Country Status (22)

Country Link
EP (1) EP1670309B1 (en)
JP (1) JP4806635B2 (en)
KR (1) KR101164691B1 (en)
CN (1) CN1889826A (en)
AT (1) ATE471661T1 (en)
AU (1) AU2004277357B2 (en)
BR (1) BRPI0415032A (en)
CA (1) CA2540622C (en)
CY (1) CY1110788T1 (en)
DE (1) DE602004027823D1 (en)
DK (1) DK1670309T3 (en)
ES (1) ES2347961T3 (en)
FR (1) FR2860391B1 (en)
IL (1) IL174726A (en)
MX (2) MXPA06003685A (en)
NO (1) NO334611B1 (en)
PL (1) PL1670309T3 (en)
PT (1) PT1670309E (en)
RU (1) RU2373707C2 (en)
SI (1) SI1670309T1 (en)
WO (1) WO2005032244A1 (en)
ZA (1) ZA200602670B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2963791B1 (en) * 2010-08-11 2012-09-21 Assist Publ Hopitaux De Paris METHOD OF DIAGNOSING NEURODEGENERATIVE DISEASES
JPWO2014007367A1 (en) * 2012-07-05 2016-06-02 国立大学法人 東京大学 Method for detecting or measuring two substances in the same sample
JP6583011B2 (en) * 2016-01-20 2019-10-02 コニカミノルタ株式会社 Method for washing immunostained slides using acidic aqueous solution
CN109776665B (en) * 2019-02-02 2021-02-05 首都医科大学宣武医院 New mutation of Alzheimer's disease, its stable transfection cell model and its medical use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2798556B1 (en) * 1999-09-17 2004-02-27 Aventis Pharma Sa NEW ANIMAL MODEL OF ALZHEIMER'S DISEASE WITH BOTH AMYLOID PLATES AND MITOCHONDRIAL MALFUNCTIONS
EP1235482A1 (en) * 1999-09-17 2002-09-04 Aventis Pharma S.A. Novel animal model of alzheimer disease with amyloid plaques and mitochondrial dysfunctions
DK1255437T3 (en) * 1999-09-27 2010-08-09 Aventis Pharma Sa Transgenic animal expressing a form of presenilin 1 that is mutated several times
CA2416381A1 (en) * 2000-07-20 2002-01-31 Cephalon, Inc. Gene-targeted non-human mammal with human fad presenilin mutation and generational offspring

Also Published As

Publication number Publication date
PL1670309T3 (en) 2010-11-30
RU2006114692A (en) 2007-11-10
IL174726A0 (en) 2006-08-20
FR2860391A1 (en) 2005-04-08
ATE471661T1 (en) 2010-07-15
ZA200602670B (en) 2007-07-25
ES2347961T3 (en) 2010-11-26
JP2007507217A (en) 2007-03-29
DK1670309T3 (en) 2010-10-25
MXPA06003670A (en) 2006-06-20
JP4806635B2 (en) 2011-11-02
NO20061954L (en) 2006-06-26
BRPI0415032A (en) 2006-12-12
RU2373707C2 (en) 2009-11-27
CY1110788T1 (en) 2015-06-10
EP1670309A1 (en) 2006-06-21
CA2540622C (en) 2014-01-14
KR20060090988A (en) 2006-08-17
AU2004277357A1 (en) 2005-04-14
DE602004027823D1 (en) 2010-08-05
NO334611B1 (en) 2014-04-22
FR2860391B1 (en) 2006-01-27
WO2005032244A1 (en) 2005-04-14
PT1670309E (en) 2010-09-28
MXPA06003685A (en) 2006-06-20
EP1670309B1 (en) 2010-06-23
CN1889826A (en) 2007-01-03
CA2540622A1 (en) 2005-04-14
KR101164691B1 (en) 2012-07-11
SI1670309T1 (en) 2010-11-30
AU2004277357B2 (en) 2011-11-03

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Legal Events

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FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees