IL165139A0 - Methods for fragmentation, labeling and immobilization of nucleic acids - Google Patents
Methods for fragmentation, labeling and immobilization of nucleic acidsInfo
- Publication number
- IL165139A0 IL165139A0 IL16513904A IL16513904A IL165139A0 IL 165139 A0 IL165139 A0 IL 165139A0 IL 16513904 A IL16513904 A IL 16513904A IL 16513904 A IL16513904 A IL 16513904A IL 165139 A0 IL165139 A0 IL 165139A0
- Authority
- IL
- Israel
- Prior art keywords
- immobilization
- fragmentation
- labeling
- methods
- nucleic acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00608—DNA chips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/0061—The surface being organic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00614—Delimitation of the attachment areas
- B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00623—Immobilisation or binding
- B01J2219/00626—Covalent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
- B01J2219/00632—Introduction of reactive groups to the surface
- B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38145702P | 2002-05-17 | 2002-05-17 | |
| PCT/US2003/015825 WO2004011665A2 (fr) | 2002-05-17 | 2003-05-19 | Procedes de fragmentation, d'etiquetage et d'immobilisation d'acides nucleiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL165139A0 true IL165139A0 (en) | 2005-12-18 |
Family
ID=31188317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16513904A IL165139A0 (en) | 2002-05-17 | 2004-11-10 | Methods for fragmentation, labeling and immobilization of nucleic acids |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20040005614A1 (fr) |
| EP (1) | EP1573056A4 (fr) |
| JP (2) | JP4551216B2 (fr) |
| AU (1) | AU2003279697A1 (fr) |
| CA (1) | CA2486283A1 (fr) |
| IL (1) | IL165139A0 (fr) |
| WO (1) | WO2004011665A2 (fr) |
| ZA (1) | ZA200409152B (fr) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6955915B2 (en) * | 1989-06-07 | 2005-10-18 | Affymetrix, Inc. | Apparatus comprising polymers |
| US5959098A (en) * | 1996-04-17 | 1999-09-28 | Affymetrix, Inc. | Substrate preparation process |
| US6706875B1 (en) * | 1996-04-17 | 2004-03-16 | Affyemtrix, Inc. | Substrate preparation process |
| US7504213B2 (en) | 1999-07-09 | 2009-03-17 | Agilent Technologies, Inc. | Methods and apparatus for preparing arrays comprising features having degenerate biopolymers |
| US6692918B2 (en) * | 1999-09-13 | 2004-02-17 | Nugen Technologies, Inc. | Methods and compositions for linear isothermal amplification of polynucleotide sequences |
| US7846733B2 (en) * | 2000-06-26 | 2010-12-07 | Nugen Technologies, Inc. | Methods and compositions for transcription-based nucleic acid amplification |
| CA2430329A1 (fr) | 2000-12-13 | 2002-06-20 | Nugen Technologies, Inc. | Methodes et compositions de generation de copies multiples de sequences d'acides nucleiques et methodes de detection correspondantes |
| NZ523167A (en) | 2001-03-09 | 2006-08-31 | Nugen Technologies Inc | Methods, compositions and kits for amplifying RNA sequences of interest which employ an RNA/DNA composite primer |
| EP1390537B1 (fr) | 2001-03-09 | 2013-11-13 | Nugen Technologies, Inc. | Methodes et compositions pour amplification de sequences d'arn |
| US7060441B2 (en) * | 2001-05-04 | 2006-06-13 | Biomerieux | Method for fragmenting and labeling DNA involving abasic sites and phosphate labeling |
| US7078505B2 (en) | 2002-06-06 | 2006-07-18 | Agilent Technologies, Inc. | Manufacture of arrays with varying deposition parameters |
| US20030232140A1 (en) * | 2002-06-14 | 2003-12-18 | Joseph Remick | Methods for reagent removal in flow chambers |
| US20040191777A1 (en) * | 2003-03-24 | 2004-09-30 | Peck Bill J. | Apparatus and methods for isolating droplet dispensing devices |
| JP2006523465A (ja) | 2003-04-14 | 2006-10-19 | ニューゲン テクノロジーズ, インコーポレイテッド | ランダムにプライミングされる複合プライマーを用いる大規模増幅 |
| CA2528577C (fr) * | 2003-06-20 | 2012-08-07 | Illumina, Inc. | Methodes et compositions utiles pour l'amplification et le genotypage du genome tout entier |
| US20050181394A1 (en) * | 2003-06-20 | 2005-08-18 | Illumina, Inc. | Methods and compositions for whole genome amplification and genotyping |
| ATE425250T1 (de) * | 2003-06-30 | 2009-03-15 | Panasonic Corp | Verfahren zur modifizierung einer nukleotidkette |
| US20100291637A1 (en) * | 2003-06-30 | 2010-11-18 | Panasonic Corporation | Method for modifying nucleotide chain |
| US20050208538A1 (en) * | 2003-12-29 | 2005-09-22 | Nurith Kurn | Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids |
| CA2497324A1 (fr) * | 2004-02-17 | 2005-08-17 | Affymetrix, Inc. | Methodes de fragmentation et de marquage d'adn |
| FR2868071B1 (fr) * | 2004-03-26 | 2006-06-09 | Biomerieux Sa | Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques |
| CA2614580A1 (fr) * | 2004-09-02 | 2006-03-09 | Lifeind Ehf. | Separation bidimensionnelle dependante du caractere de brin et de la longueur de fragments d'acide nucleique |
| US20060147966A1 (en) * | 2004-12-30 | 2006-07-06 | Affymetrix, Inc. | Preparation and labeling of polynucleotides for hybridization to a nucleic acid array |
| CA2611671C (fr) | 2005-06-15 | 2013-10-08 | Callida Genomics, Inc. | Reseaux de molecules simples pour analyse genetique et chimique |
| GB0514936D0 (en) | 2005-07-20 | 2005-08-24 | Solexa Ltd | Preparation of templates for nucleic acid sequencing |
| WO2007030759A2 (fr) | 2005-09-07 | 2007-03-15 | Nugen Technologies, Inc. | Procedure d'amplication d'acide nucleique amelioree |
| WO2007100986A2 (fr) * | 2006-02-24 | 2007-09-07 | Rosetta Inpharmatics Llc | Dispositifs de prélèvement et d'examen de fluides, systèmes et méthodes d'utilisation |
| CA2652052A1 (fr) * | 2006-05-16 | 2007-11-29 | Nugen Technologies, Inc. | Procede de separation et de purification d'acides nucleiques reposant sur des interactions de charges reversibles |
| US20100022403A1 (en) * | 2006-06-30 | 2010-01-28 | Nurith Kurn | Methods for fragmentation and labeling of nucleic acids |
| US20080220988A1 (en) * | 2007-03-07 | 2008-09-11 | Ada Technologies, Inc. | Preparing carbohydrate microarrays and conjugated nanoparticles |
| FR2917090B1 (fr) * | 2007-06-11 | 2012-06-15 | Biomerieux Sa | Reactifs de marquage portant des fonctions diazo et nitro, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques |
| CA2692159C (fr) * | 2007-06-22 | 2016-09-13 | Barry S. Cooperman | Marquage fluorescent d'arn de transfert et etude d'une synthese de proteine |
| US8592150B2 (en) | 2007-12-05 | 2013-11-26 | Complete Genomics, Inc. | Methods and compositions for long fragment read sequencing |
| EP2240609A4 (fr) * | 2008-01-22 | 2011-08-03 | Veridex Llc | Stadification moléculaire d'un cancer du côlon de stade ii et iii et pronostic |
| US8034568B2 (en) * | 2008-02-12 | 2011-10-11 | Nugen Technologies, Inc. | Isothermal nucleic acid amplification methods and compositions |
| GB2470672B (en) | 2008-03-21 | 2012-09-12 | Nugen Technologies Inc | Methods of RNA amplification in the presence of DNA |
| FR2934595B1 (fr) * | 2008-07-29 | 2013-04-05 | Biomerieux Sa | Reactifs de marquage ayant un noyau pyridine portant une fonction diazomethyle, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques |
| WO2011019964A1 (fr) * | 2009-08-12 | 2011-02-17 | Nugen Technologies, Inc. | Procédés, compositions, et kits pour générer des produits d'acides nucléiques sensiblement dépourvus d'acide nucléique matrice |
| EP2475777A4 (fr) * | 2009-09-11 | 2013-03-06 | Nugen Technologies Inc | Compositions et méthodes pour analyse transcriptomique complète |
| JP2013511991A (ja) * | 2009-11-25 | 2013-04-11 | クアンタライフ, インコーポレイテッド | 遺伝子材料を検出する方法および組成物 |
| EP2673380B1 (fr) | 2011-02-09 | 2018-12-12 | Bio-Rad Laboratories, Inc. | Analyse d'acides nucléiques |
| GB2497838A (en) | 2011-10-19 | 2013-06-26 | Nugen Technologies Inc | Compositions and methods for directional nucleic acid amplification and sequencing |
| CA2862552A1 (fr) | 2012-01-26 | 2013-08-01 | Nugen Technologies, Inc. | Compositions et procedes pour l'enrichissement en sequence d'acide nucleique ciblee et la generation d'une banque a efficacite elevee |
| WO2013150902A1 (fr) * | 2012-04-02 | 2013-10-10 | 独立行政法人理化学研究所 | Procédé de production d'un oligodésoxynucléotide à terminaison 5' phosphorylée par clivage d'un oligodésoxynucléotide contenant un nucléotide non naturel |
| ES2905448T3 (es) | 2012-05-10 | 2022-04-08 | Massachusetts Gen Hospital | Métodos para determinar una secuencia nucleotídica |
| JP6181751B2 (ja) | 2012-06-18 | 2017-08-16 | ニューゲン テクノロジーズ, インコーポレイテッド | 望まれない核酸配列のネガティブ選択のための組成物および方法 |
| US20150011396A1 (en) | 2012-07-09 | 2015-01-08 | Benjamin G. Schroeder | Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing |
| US20140274729A1 (en) * | 2013-03-15 | 2014-09-18 | Nugen Technologies, Inc. | Methods, compositions and kits for generation of stranded rna or dna libraries |
| US20140274738A1 (en) | 2013-03-15 | 2014-09-18 | Nugen Technologies, Inc. | Sequential sequencing |
| US11331643B2 (en) | 2013-04-02 | 2022-05-17 | Molecular Assemblies, Inc. | Reusable initiators for synthesizing nucleic acids |
| US11384377B2 (en) | 2013-04-02 | 2022-07-12 | Molecular Assemblies, Inc. | Reusable initiators for synthesizing nucleic acids |
| US10683536B2 (en) * | 2013-04-02 | 2020-06-16 | Molecular Assemblies, Inc. | Reusable initiators for synthesizing nucleic acids |
| EP3068883B1 (fr) | 2013-11-13 | 2020-04-29 | Nugen Technologies, Inc. | Compositions et procédés pour l'identification d'une lecture de séquençage en double |
| JP6387606B2 (ja) * | 2013-11-27 | 2018-09-12 | 東ソー株式会社 | 核酸の検出方法 |
| CN106661612A (zh) | 2014-01-27 | 2017-05-10 | 通用医疗公司 | 制备用于测序的核酸的方法 |
| US9745614B2 (en) | 2014-02-28 | 2017-08-29 | Nugen Technologies, Inc. | Reduced representation bisulfite sequencing with diversity adaptors |
| JP6803327B2 (ja) | 2014-08-06 | 2020-12-23 | ニューゲン テクノロジーズ, インコーポレイテッド | 標的化されたシークエンシングからのデジタル測定値 |
| CN107427808B (zh) | 2015-01-12 | 2020-10-23 | 10X基因组学有限公司 | 用于制备核酸测序文库的方法和系统以及用其制备的文库 |
| CA3037185A1 (fr) | 2016-09-15 | 2018-03-22 | ArcherDX, Inc. | Procedes de preparation d'echantillon d'acide nucleique |
| US10683531B2 (en) | 2016-09-15 | 2020-06-16 | ArcherDX, Inc. | Methods of nucleic acid sample preparation for analysis of cell-free DNA |
| US12492430B2 (en) | 2017-04-11 | 2025-12-09 | Tecan Genomics, Inc. | Library quantitation and qualification |
| US11099202B2 (en) | 2017-10-20 | 2021-08-24 | Tecan Genomics, Inc. | Reagent delivery system |
| GB201812283D0 (en) * | 2018-07-27 | 2018-09-12 | Cambridge Entpr Ltd | High resolution detection of DNA abasic sites |
| EP3917660A4 (fr) * | 2019-01-29 | 2022-11-23 | Molecular Assemblies, Inc. | Initiateurs réutilisables pour la synthèse d'acides nucléiques |
| US12059674B2 (en) | 2020-02-03 | 2024-08-13 | Tecan Genomics, Inc. | Reagent storage system |
| JP2025532581A (ja) * | 2022-09-15 | 2025-10-01 | ワイディー バイオラブス カンパニー リミテッド | 核酸の末端標識のための方法、キットおよびシステム |
Family Cites Families (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5011769A (en) * | 1985-12-05 | 1991-04-30 | Meiogenics U.S. Limited Partnership | Methods for detecting nucleic acid sequences |
| US4876187A (en) * | 1985-12-05 | 1989-10-24 | Meiogenics, Inc. | Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences |
| US4996143A (en) * | 1985-12-23 | 1991-02-26 | Syngene, Inc. | Fluorescent stokes shift probes for polynucleotide hybridization |
| US6270961B1 (en) * | 1987-04-01 | 2001-08-07 | Hyseq, Inc. | Methods and apparatus for DNA sequencing and DNA identification |
| US6090591A (en) * | 1987-07-31 | 2000-07-18 | The Board Of Trustees Of The Leland Stanford Junior University | Selective amplification of target polynucleotide sequences |
| JP2650159B2 (ja) * | 1988-02-24 | 1997-09-03 | アクゾ・ノベル・エヌ・ベー | 核酸増幅方法 |
| CA1340807C (fr) * | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Procede d'amplification d'une sequence d'acide nucleique |
| US5082830A (en) * | 1988-02-26 | 1992-01-21 | Enzo Biochem, Inc. | End labeled nucleotide probe |
| US5130238A (en) * | 1988-06-24 | 1992-07-14 | Cangene Corporation | Enhanced nucleic acid amplification process |
| DE68926735T2 (de) * | 1989-01-05 | 1997-02-27 | Leti Lab | Verwendung von spezifischen Eigenschaften der Tierallergene und Verfahren zu ihrer Herstellung |
| US5708154A (en) * | 1989-02-24 | 1998-01-13 | City Of Hope | RNA-DNA hybrid molecules of nucleic acid |
| US5043272A (en) * | 1989-04-27 | 1991-08-27 | Life Technologies, Incorporated | Amplification of nucleic acid sequences using oligonucleotides of random sequence as primers |
| US5683896A (en) * | 1989-06-01 | 1997-11-04 | Life Technologies, Inc. | Process for controlling contamination of nucleic acid amplification reactions |
| US5035996A (en) * | 1989-06-01 | 1991-07-30 | Life Technologies, Inc. | Process for controlling contamination of nucleic acid amplification reactions |
| US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| CA2020958C (fr) * | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Methodes d'amplification de sequences d'acide nucleique |
| EP0731175A3 (fr) * | 1989-07-11 | 2004-05-26 | Gen-Probe Incorporated | Sondes oligonucléotidiques pour d'acide nucléique de VIH |
| US5545522A (en) * | 1989-09-22 | 1996-08-13 | Van Gelder; Russell N. | Process for amplifying a target polynucleotide sequence using a single primer-promoter complex |
| US5391785A (en) * | 1990-01-16 | 1995-02-21 | La Jolla Pharmaceutial Company | Intermediates for providing functional groups on the 5' end of oligonucleotides |
| CA2037349C (fr) * | 1990-03-26 | 2008-06-17 | James G. Wetmur | Migration de la branche des nucleotides |
| HU218095B (hu) * | 1990-05-01 | 2000-05-28 | Amgen Inc. | Eljárás átvitt szennyeződések csökkentésére, amplifikációs eljárásokban |
| US5667976A (en) * | 1990-05-11 | 1997-09-16 | Becton Dickinson And Company | Solid supports for nucleic acid hybridization assays |
| US5194370A (en) * | 1990-05-16 | 1993-03-16 | Life Technologies, Inc. | Promoter ligation activated transcription amplification of nucleic acid sequences |
| JP3392863B2 (ja) * | 1990-07-24 | 2003-03-31 | エフ.ホフマン ― ラ ロシュ アーゲー | 修飾核酸塩基を使用するインビトロ核酸増幅における非特異的増幅の低減 |
| US5090591A (en) * | 1991-03-18 | 1992-02-25 | Longford Equipment International Limited | Article dispenser for use with continuous strip of articles |
| US5856097A (en) * | 1992-03-04 | 1999-01-05 | The Regents Of The University Of California | Comparative genomic hybridization (CGH) |
| ATE205542T1 (de) * | 1992-03-04 | 2001-09-15 | Univ California | Vergleichende genomhybridisierung |
| ATE231920T1 (de) * | 1992-03-11 | 2003-02-15 | Dana Farber Cancer Inst Inc | Methode um mrna zu klonieren |
| CA2135073C (fr) * | 1992-05-06 | 2002-11-19 | Daniel L. Kacian | Procede, composition et trousse d'amplification des sequences d'acides nucleiques |
| US6172208B1 (en) * | 1992-07-06 | 2001-01-09 | Genzyme Corporation | Oligonucleotides modified with conjugate groups |
| WO1994003637A1 (fr) * | 1992-07-31 | 1994-02-17 | Syntex (Usa) Inc. | Procede d'introduction de sequences definies a l'extremite 3' de polynucleotides |
| US6280935B1 (en) * | 1994-10-13 | 2001-08-28 | Lynx Therapeutics, Inc. | Method of detecting the presence or absence of a plurality of target sequences using oligonucleotide tags |
| US5556752A (en) * | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
| US6309843B1 (en) * | 1994-10-25 | 2001-10-30 | The Curators Of The University Of Missouri | Glycoprotein for use in determining endometrial receptivity |
| DE69527444T3 (de) * | 1995-07-11 | 2007-08-16 | Forfas (Trading As Bioresearch Ireland) | Glycosylase verwendende detektion von bestimmten nukleinsäuresequenzen |
| FR2737223B1 (fr) * | 1995-07-24 | 1997-09-12 | Bio Merieux | Procede d'amplification de sequences d'acide nucleique par deplacement, a l'aide d'amorces chimeres |
| US6068829A (en) * | 1995-09-11 | 2000-05-30 | The Burnham Institute | Method of identifying molecules that home to a selected organ in vivo |
| US6190865B1 (en) * | 1995-09-27 | 2001-02-20 | Epicentre Technologies Corporation | Method for characterizing nucleic acid molecules |
| US6197557B1 (en) * | 1997-03-05 | 2001-03-06 | The Regents Of The University Of Michigan | Compositions and methods for analysis of nucleic acids |
| JP2002511767A (ja) * | 1997-08-28 | 2002-04-16 | ピーイー コーポレイション(エヌワイ) | 化学切断による、核酸における変異の改良された検出 |
| US6169194B1 (en) * | 1997-10-16 | 2001-01-02 | Michael Thompson | High surface density covalent immobilization of oligonucleotide monolayers using a 1-(thiotrifluoroacetato)-11-(trichlorososilyl)-undecane linker |
| US6090553A (en) * | 1997-10-29 | 2000-07-18 | Beckman Coulter, Inc. | Use of uracil-DNA glycosylase in genetic analysis |
| US20010000077A1 (en) * | 1998-02-03 | 2001-03-29 | Engelhardt Dean L. | Novel process, construct and conjugate for producing multiple nucleic acid copies |
| US6174680B1 (en) * | 1998-12-30 | 2001-01-16 | Dana-Farber Cancer Institute, Inc. | Method for identifying mismatch repair glycosylase reactive sites, compounds and uses thereof |
| US6087103A (en) * | 1998-03-04 | 2000-07-11 | Lifespan Biosciences, Inc. | Tagged ligand arrays for identifying target-ligand interactions |
| US6225451B1 (en) * | 1998-04-06 | 2001-05-01 | Myriad Genetics, Inc. | Chromosome 11-linked coronary heart disease susceptibility gene CHD1 |
| US6440705B1 (en) * | 1998-10-01 | 2002-08-27 | Vincent P. Stanton, Jr. | Method for analyzing polynucleotides |
| CA2357601A1 (fr) * | 1998-12-30 | 2000-07-06 | Dana-Farber Cancer Institute, Inc. | Reseau de balayage de mutation et methode d'utilisation |
| US7074556B2 (en) * | 1999-03-02 | 2006-07-11 | Invitrogen Corporation | cDNA synthesis improvements |
| US6339147B1 (en) * | 1999-07-29 | 2002-01-15 | Epoch Biosciences, Inc. | Attachment of oligonucleotides to solid supports through Schiff base type linkages for capture and detection of nucleic acids |
| US6692918B2 (en) * | 1999-09-13 | 2004-02-17 | Nugen Technologies, Inc. | Methods and compositions for linear isothermal amplification of polynucleotide sequences |
| AU783873B2 (en) * | 1999-09-13 | 2005-12-15 | Nugen Technologies, Inc. | Methods and compositions for linear isothermal amplification of polynucleotide sequences |
| US6077674A (en) * | 1999-10-27 | 2000-06-20 | Agilent Technologies Inc. | Method of producing oligonucleotide arrays with features of high purity |
| US20010031739A1 (en) * | 1999-12-21 | 2001-10-18 | Dare Akintade Oyedele | Method and kit for quantitating genomic DNA damage and repair capicity |
| US7846733B2 (en) * | 2000-06-26 | 2010-12-07 | Nugen Technologies, Inc. | Methods and compositions for transcription-based nucleic acid amplification |
| EP1356094B1 (fr) * | 2000-06-26 | 2010-01-13 | Nugen Technologies, Inc. | Procedes et compositions permettant l'amplification d'acide nucleique fondee sur la transcription |
| JP2004537257A (ja) * | 2000-10-06 | 2004-12-16 | ニューゲン テクノロジーズ, インコーポレイテッド | 核酸配列の検出および/または定量のための、方法およびプローブ |
| CA2430329A1 (fr) * | 2000-12-13 | 2002-06-20 | Nugen Technologies, Inc. | Methodes et compositions de generation de copies multiples de sequences d'acides nucleiques et methodes de detection correspondantes |
| EP1390537B1 (fr) * | 2001-03-09 | 2013-11-13 | Nugen Technologies, Inc. | Methodes et compositions pour amplification de sequences d'arn |
| NZ523167A (en) * | 2001-03-09 | 2006-08-31 | Nugen Technologies Inc | Methods, compositions and kits for amplifying RNA sequences of interest which employ an RNA/DNA composite primer |
| WO2002081753A1 (fr) * | 2001-04-04 | 2002-10-17 | Advanced Research & Technology Institute | Procede d'identification et de caracterisation de molecules d'adn individuelles |
| US7060441B2 (en) * | 2001-05-04 | 2006-06-13 | Biomerieux | Method for fragmenting and labeling DNA involving abasic sites and phosphate labeling |
| FR2824335A1 (fr) * | 2001-05-04 | 2002-11-08 | Bio Merieux | Procede de marquage et de fragmentation d'adn |
| EP1275735A1 (fr) * | 2001-07-11 | 2003-01-15 | Roche Diagnostics GmbH | Composition et méthode pour l'amplification des acides nucléiques à la facon 'hot start' |
| US20040002371A1 (en) * | 2001-10-01 | 2004-01-01 | Claude Paquin | Method and apparatus for automated system for validating a set of collectible lottery tickets |
| ATE405676T1 (de) * | 2002-03-11 | 2008-09-15 | Nugen Technologies Inc | Verfahren zur erzeugung doppelsträngiger dna mit einem 3'-einzelstranganteil und verwendungen dieser komplexe zur rekombination |
| WO2003078593A2 (fr) * | 2002-03-15 | 2003-09-25 | Epigenomics Ag | Procedes de decouverte et de diagnostic utilisant glycosylase adn 5-methylcytosine |
| JP2005521409A (ja) * | 2002-03-29 | 2005-07-21 | ニューゲン テクノロジーズ, インコーポレイテッド | 単一プライマー等温核酸増幅−増強型被分析物検出および定量 |
| US20040137456A1 (en) * | 2002-04-04 | 2004-07-15 | Hiroki Yokota | Method for identifying and characterizing individual dna molecules |
| WO2003100019A2 (fr) * | 2002-05-24 | 2003-12-04 | Invitrogen Corporation | Pcr nichee par amorces degradables |
| US7189512B2 (en) * | 2003-02-20 | 2007-03-13 | Noga Porat | Methods for variation detection |
| JP2006523465A (ja) * | 2003-04-14 | 2006-10-19 | ニューゲン テクノロジーズ, インコーポレイテッド | ランダムにプライミングされる複合プライマーを用いる大規模増幅 |
| US20050136417A1 (en) * | 2003-12-19 | 2005-06-23 | Affymetrix, Inc. | Amplification of nucleic acids |
| US20050208538A1 (en) * | 2003-12-29 | 2005-09-22 | Nurith Kurn | Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids |
| CA2497324A1 (fr) * | 2004-02-17 | 2005-08-17 | Affymetrix, Inc. | Methodes de fragmentation et de marquage d'adn |
| US20100022403A1 (en) * | 2006-06-30 | 2010-01-28 | Nurith Kurn | Methods for fragmentation and labeling of nucleic acids |
| US8034568B2 (en) * | 2008-02-12 | 2011-10-11 | Nugen Technologies, Inc. | Isothermal nucleic acid amplification methods and compositions |
| GB2470672B (en) * | 2008-03-21 | 2012-09-12 | Nugen Technologies Inc | Methods of RNA amplification in the presence of DNA |
| WO2011019964A1 (fr) * | 2009-08-12 | 2011-02-17 | Nugen Technologies, Inc. | Procédés, compositions, et kits pour générer des produits d'acides nucléiques sensiblement dépourvus d'acide nucléique matrice |
| EP2475777A4 (fr) * | 2009-09-11 | 2013-03-06 | Nugen Technologies Inc | Compositions et méthodes pour analyse transcriptomique complète |
| US20110105364A1 (en) * | 2009-11-02 | 2011-05-05 | Nugen Technologies, Inc. | Compositions and methods for targeted nucleic acid sequence selection and amplification |
-
2003
- 2003-05-19 WO PCT/US2003/015825 patent/WO2004011665A2/fr not_active Ceased
- 2003-05-19 CA CA002486283A patent/CA2486283A1/fr not_active Abandoned
- 2003-05-19 JP JP2004524484A patent/JP4551216B2/ja not_active Expired - Fee Related
- 2003-05-19 US US10/441,663 patent/US20040005614A1/en not_active Abandoned
- 2003-05-19 EP EP03771533A patent/EP1573056A4/fr not_active Withdrawn
- 2003-05-19 AU AU2003279697A patent/AU2003279697A1/en not_active Abandoned
-
2004
- 2004-11-10 IL IL16513904A patent/IL165139A0/xx unknown
- 2004-11-11 ZA ZA200409152A patent/ZA200409152B/en unknown
-
2009
- 2009-10-21 JP JP2009242889A patent/JP2010011872A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2486283A1 (fr) | 2004-02-05 |
| JP2010011872A (ja) | 2010-01-21 |
| WO2004011665A2 (fr) | 2004-02-05 |
| JP4551216B2 (ja) | 2010-09-22 |
| AU2003279697A1 (en) | 2004-02-16 |
| EP1573056A4 (fr) | 2007-11-28 |
| US20040005614A1 (en) | 2004-01-08 |
| ZA200409152B (en) | 2007-11-28 |
| WO2004011665A3 (fr) | 2005-07-21 |
| JP2005534304A (ja) | 2005-11-17 |
| EP1573056A2 (fr) | 2005-09-14 |
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