|
US7875440B2
(en)
|
1998-05-01 |
2011-01-25 |
Arizona Board Of Regents |
Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
|
|
US6780591B2
(en)
|
1998-05-01 |
2004-08-24 |
Arizona Board Of Regents |
Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
|
|
WO2002061127A2
(en)
*
|
2001-01-30 |
2002-08-08 |
Solexa Ltd. |
Arrayed polynucleotides and their use in genome analysis
|
|
US7056661B2
(en)
|
1999-05-19 |
2006-06-06 |
Cornell Research Foundation, Inc. |
Method for sequencing nucleic acid molecules
|
|
US6818395B1
(en)
|
1999-06-28 |
2004-11-16 |
California Institute Of Technology |
Methods and apparatus for analyzing polynucleotide sequences
|
|
US7501245B2
(en)
|
1999-06-28 |
2009-03-10 |
Helicos Biosciences Corp. |
Methods and apparatuses for analyzing polynucleotide sequences
|
|
EP3034627B1
(en)
|
2000-10-06 |
2019-01-30 |
The Trustees of Columbia University in the City of New York |
Massive parallel method for decoding dna and rna
|
|
US9708358B2
(en)
|
2000-10-06 |
2017-07-18 |
The Trustees Of Columbia University In The City Of New York |
Massive parallel method for decoding DNA and RNA
|
|
EP1354064A2
(en)
|
2000-12-01 |
2003-10-22 |
Visigen Biotechnologies, Inc. |
Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
|
|
JP2004523243A
(en)
|
2001-03-12 |
2004-08-05 |
カリフォルニア インスティチュート オブ テクノロジー |
Method and apparatus for analyzing polynucleotide sequences by asynchronous base extension
|
|
DK1370690T3
(en)
|
2001-03-16 |
2012-07-09 |
Kalim Mir |
Arrays and methods for using them
|
|
GB0119719D0
(en)
*
|
2001-08-13 |
2001-10-03 |
Solexa Ltd |
DNA sequence analysis
|
|
US7057026B2
(en)
|
2001-12-04 |
2006-06-06 |
Solexa Limited |
Labelled nucleotides
|
|
GB0129012D0
(en)
|
2001-12-04 |
2002-01-23 |
Solexa Ltd |
Labelled nucleotides
|
|
US11008359B2
(en)
|
2002-08-23 |
2021-05-18 |
Illumina Cambridge Limited |
Labelled nucleotides
|
|
US7414116B2
(en)
|
2002-08-23 |
2008-08-19 |
Illumina Cambridge Limited |
Labelled nucleotides
|
|
EP3795577A1
(en)
|
2002-08-23 |
2021-03-24 |
Illumina Cambridge Limited |
Modified nucleotides
|
|
AU2003267583A1
(en)
*
|
2002-09-19 |
2004-04-08 |
The Chancellor, Master And Scholars Of The University Of Oxford |
Molecular arrays and single molecule detection
|
|
GB0304371D0
(en)
*
|
2003-02-26 |
2003-04-02 |
Solexa Ltd |
DNA Sequence analysis
|
|
GB0324456D0
(en)
|
2003-10-20 |
2003-11-19 |
Isis Innovation |
Parallel DNA sequencing methods
|
|
US8637650B2
(en)
|
2003-11-05 |
2014-01-28 |
Genovoxx Gmbh |
Macromolecular nucleotide compounds and methods for using the same
|
|
US7169560B2
(en)
|
2003-11-12 |
2007-01-30 |
Helicos Biosciences Corporation |
Short cycle methods for sequencing polynucleotides
|
|
CA2557177A1
(en)
|
2004-02-19 |
2005-09-01 |
Stephen Quake |
Methods and kits for analyzing polynucleotide sequences
|
|
US7476734B2
(en)
|
2005-12-06 |
2009-01-13 |
Helicos Biosciences Corporation |
Nucleotide analogs
|
|
JP2008512084A
(en)
|
2004-05-25 |
2008-04-24 |
ヘリコス バイオサイエンシーズ コーポレイション |
Methods and devices for nucleic acid sequencing
|
|
US7170050B2
(en)
|
2004-09-17 |
2007-01-30 |
Pacific Biosciences Of California, Inc. |
Apparatus and methods for optical analysis of molecules
|
|
US7315019B2
(en)
|
2004-09-17 |
2008-01-01 |
Pacific Biosciences Of California, Inc. |
Arrays of optical confinements and uses thereof
|
|
US7220549B2
(en)
|
2004-12-30 |
2007-05-22 |
Helicos Biosciences Corporation |
Stabilizing a nucleic acid for nucleic acid sequencing
|
|
US7482120B2
(en)
|
2005-01-28 |
2009-01-27 |
Helicos Biosciences Corporation |
Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
|
|
EP1902143A1
(en)
|
2005-03-29 |
2008-03-26 |
Applera Corporation |
Nanowire-based system for analysis of nucleic acids
|
|
US7709197B2
(en)
|
2005-06-15 |
2010-05-04 |
Callida Genomics, Inc. |
Nucleic acid analysis by random mixtures of non-overlapping fragments
|
|
US9297036B2
(en)
*
|
2005-07-01 |
2016-03-29 |
Agilent Technologies, Inc |
Nucleic acid probes for analysis of small RNAs and other polynucleotides
|
|
GB0514935D0
(en)
|
2005-07-20 |
2005-08-24 |
Solexa Ltd |
Methods for sequencing a polynucleotide template
|
|
WO2007018601A1
(en)
|
2005-08-02 |
2007-02-15 |
Rubicon Genomics, Inc. |
Compositions and methods for processing and amplification of dna, including using multiple enzymes in a single reaction
|
|
GB0517097D0
(en)
|
2005-08-19 |
2005-09-28 |
Solexa Ltd |
Modified nucleosides and nucleotides and uses thereof
|
|
US7666593B2
(en)
|
2005-08-26 |
2010-02-23 |
Helicos Biosciences Corporation |
Single molecule sequencing of captured nucleic acids
|
|
DK2336315T3
(en)
|
2005-12-01 |
2017-11-06 |
Nuevolution As |
Method for enzymatic coding by efficient synthesis of large libraries
|
|
US7754475B2
(en)
|
2006-01-25 |
2010-07-13 |
Agilent Technologies, Inc. |
Nucleic acid probes and microarrays for analysis of polynucleotides
|
|
US7397546B2
(en)
|
2006-03-08 |
2008-07-08 |
Helicos Biosciences Corporation |
Systems and methods for reducing detected intensity non-uniformity in a laser beam
|
|
WO2007114693A2
(en)
|
2006-04-04 |
2007-10-11 |
Keygene N.V. |
High throughput detection of molecular markers based on aflp and high throughput sequencing
|
|
EP2182079B1
(en)
|
2006-07-12 |
2014-09-10 |
Keygene N.V. |
High throughput physical mapping using AFLP
|
|
WO2008042067A2
(en)
|
2006-09-28 |
2008-04-10 |
Illumina, Inc. |
Compositions and methods for nucleotide sequencing
|
|
US7883869B2
(en)
|
2006-12-01 |
2011-02-08 |
The Trustees Of Columbia University In The City Of New York |
Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
|
|
WO2008096146A1
(en)
|
2007-02-07 |
2008-08-14 |
Solexa Limited |
Preparation of templates for methylation analysis
|
|
EP2725107B1
(en)
|
2007-10-19 |
2018-08-29 |
The Trustees of Columbia University in the City of New York |
DNA sequencing with non-fluorescent nucleotide reversible terminators and cleavable label modified ddNTPs and nucleic acid comprising inosine with reversible terminators
|
|
US20110014611A1
(en)
|
2007-10-19 |
2011-01-20 |
Jingyue Ju |
Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequences by synthesis
|
|
CN102027136A
(en)
|
2008-03-17 |
2011-04-20 |
表现研究有限公司 |
Expression-linked gene discovery
|
|
EP4230747A3
(en)
|
2008-03-28 |
2023-11-15 |
Pacific Biosciences Of California, Inc. |
Compositions and methods for nucleic acid sequencing
|
|
JP2012514977A
(en)
|
2009-01-13 |
2012-07-05 |
キージーン・エン・フェー |
New genome sequencing strategy
|
|
WO2012034007A2
(en)
|
2010-09-10 |
2012-03-15 |
Bio-Rad Laboratories, Inc. |
Size selection of dna for chromatin analysis
|
|
ES2556580T3
(en)
|
2011-07-08 |
2016-01-19 |
Keygene N.V. |
Genotyping based on sequences based on oligonucleotide ligation assays
|
|
SG10201510189WA
(en)
|
2011-10-19 |
2016-01-28 |
Nugen Technologies Inc |
Compositions And Methods For Directional Nucleic Acid Amplification And Sequencing
|
|
GB201119903D0
(en)
|
2011-11-17 |
2011-12-28 |
Univ Vilnius |
Nucleic acid production and sequence analysis
|
|
SG10201504490QA
(en)
|
2012-01-26 |
2015-07-30 |
Nugen Technologies Inc |
Compositions And Methods For Targeted Nucleic Acid Sequence Enrichment And High Efficiency Library Generation
|
|
US9957549B2
(en)
|
2012-06-18 |
2018-05-01 |
Nugen Technologies, Inc. |
Compositions and methods for negative selection of non-desired nucleic acid sequences
|
|
US20150011396A1
(en)
|
2012-07-09 |
2015-01-08 |
Benjamin G. Schroeder |
Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
|
|
EP2964781B1
(en)
|
2013-03-08 |
2018-01-10 |
Roche Diagnostics GmbH |
Egfr mutation blood testing
|
|
EP2964612B1
(en)
|
2013-03-08 |
2017-02-01 |
Illumina Cambridge Limited |
Polymethine compounds and their use as fluorescent labels
|
|
CN105263918B
(en)
|
2013-03-08 |
2018-05-18 |
伊鲁米纳剑桥有限公司 |
Rhodamine compound and its purposes as fluorescent marker
|
|
EP2971130A4
(en)
|
2013-03-15 |
2016-10-05 |
Nugen Technologies Inc |
Sequential sequencing
|
|
US10648026B2
(en)
|
2013-03-15 |
2020-05-12 |
The Trustees Of Columbia University In The City Of New York |
Raman cluster tagged molecules for biological imaging
|
|
BR112015022448B1
(en)
|
2013-03-15 |
2020-12-08 |
Illumina Cambridge Limited |
modified nucleotide or nucleoside molecule, methods for preparing the growth of polynucleotide complementary to single-stranded target polynucleotide in sequencing reaction and to determine the sequence of single-stranded target polynucleotide and kit
|
|
GB201308259D0
(en)
|
2013-05-08 |
2013-06-12 |
Iles Raymond K |
Cancer diagnosis and monitoring
|
|
WO2015026873A1
(en)
|
2013-08-19 |
2015-02-26 |
Singular Bio, Inc. |
Assays for single molecule detection and use thereof
|
|
CN105849264B
(en)
|
2013-11-13 |
2019-09-27 |
纽亘技术公司 |
Compositions and methods for identifying repetitive sequencing reads
|
|
US9745614B2
(en)
|
2014-02-28 |
2017-08-29 |
Nugen Technologies, Inc. |
Reduced representation bisulfite sequencing with diversity adaptors
|
|
GB201408077D0
(en)
|
2014-05-07 |
2014-06-18 |
Illumina Cambridge Ltd |
Polymethine compounds and their use as fluorescent labels
|
|
US10102337B2
(en)
|
2014-08-06 |
2018-10-16 |
Nugen Technologies, Inc. |
Digital measurements from targeted sequencing
|
|
CN113637729B
(en)
|
2015-02-18 |
2024-02-23 |
因威塔公司 |
Assay for single molecule detection and uses thereof
|
|
GB201508858D0
(en)
|
2015-05-22 |
2015-07-01 |
Illumina Cambridge Ltd |
Polymethine compounds with long stokes shifts and their use as fluorescent labels
|
|
EP4006150A1
(en)
|
2015-09-09 |
2022-06-01 |
QIAGEN GmbH |
Polymerase enzyme
|
|
GB201516987D0
(en)
|
2015-09-25 |
2015-11-11 |
Illumina Cambridge Ltd |
Polymethine compounds and their use as fluorescent labels
|
|
US10465232B1
(en)
|
2015-10-08 |
2019-11-05 |
Trace Genomics, Inc. |
Methods for quantifying efficiency of nucleic acid extraction and detection
|
|
EP3411494B1
(en)
|
2015-11-18 |
2025-08-13 |
Kalim U. Mir |
Super-resolution sequencing
|
|
US10385214B2
(en)
|
2016-09-30 |
2019-08-20 |
Illumina Cambridge Limited |
Fluorescent dyes and their uses as biomarkers
|
|
EP3559004B1
(en)
|
2016-12-22 |
2023-07-05 |
Illumina Cambridge Limited |
Coumarin compounds and their uses as fluorescent labels
|
|
WO2018148723A1
(en)
|
2017-02-13 |
2018-08-16 |
Qiagen Waltham Inc. |
Polymerase enzyme from pyrococcus abyssi
|
|
WO2018148727A1
(en)
|
2017-02-13 |
2018-08-16 |
Qiagen Waltham Inc. |
Polymerase enzyme from 9°n
|
|
WO2018148724A1
(en)
|
2017-02-13 |
2018-08-16 |
Qiagen Waltham Inc. |
Polymerase enzyme from pyrococcus furiosus
|
|
WO2018148726A1
(en)
|
2017-02-13 |
2018-08-16 |
Qiagen Waltham Inc. |
Polymerase enzyme from phage t4
|
|
US20200002689A1
(en)
|
2017-02-13 |
2020-01-02 |
Qiagen Sciences, Llc |
Polymerase enzyme from 9°n
|
|
GB201711219D0
(en)
|
2017-07-12 |
2017-08-23 |
Illumina Cambridge Ltd |
Short pendant arm linkers for nucleotides in sequencing applications
|
|
GB201716931D0
(en)
|
2017-10-16 |
2017-11-29 |
Illumina Cambridge Ltd |
New fluorescent compounds and their use as biomarkers
|
|
US11099202B2
(en)
|
2017-10-20 |
2021-08-24 |
Tecan Genomics, Inc. |
Reagent delivery system
|
|
US11293061B2
(en)
|
2018-12-26 |
2022-04-05 |
Illumina Cambridge Limited |
Sequencing methods using nucleotides with 3′ AOM blocking group
|
|
WO2020178231A1
(en)
|
2019-03-01 |
2020-09-10 |
Illumina, Inc. |
Multiplexed fluorescent detection of analytes
|
|
CA3103900A1
(en)
|
2019-03-01 |
2020-09-10 |
Illumina Cambridge Limited |
Exocyclic amine substituted coumarin compounds and their uses as fluorescent labels
|
|
NL2023327B1
(en)
|
2019-03-01 |
2020-09-17 |
Illumina Inc |
Multiplexed fluorescent detection of analytes
|
|
KR102865446B1
(en)
|
2019-03-01 |
2025-09-29 |
일루미나 케임브리지 리미티드 |
Tertiary amine-substituted coumarin compounds and their use as fluorescent labels
|
|
US11421271B2
(en)
|
2019-03-28 |
2022-08-23 |
Illumina Cambridge Limited |
Methods and compositions for nucleic acid sequencing using photoswitchable labels
|
|
IL292961B2
(en)
|
2019-11-27 |
2024-01-01 |
Illumina Cambridge Ltd |
Cyclotetraenes contain dyes and their compounds
|
|
US12059674B2
(en)
|
2020-02-03 |
2024-08-13 |
Tecan Genomics, Inc. |
Reagent storage system
|
|
CN120174072A
(en)
|
2020-06-22 |
2025-06-20 |
伊鲁米纳剑桥有限公司 |
Nucleosides and nucleotides with 3' acetal capping groups
|
|
US11981964B2
(en)
|
2020-07-28 |
2024-05-14 |
Illumina Cambridge Limited |
Substituted coumarin dyes and uses as fluorescent labels
|
|
US20220195516A1
(en)
|
2020-12-17 |
2022-06-23 |
Illumina Cambridge Limited |
Methods, systems and compositions for nucleic acid sequencing
|
|
US20220195196A1
(en)
|
2020-12-17 |
2022-06-23 |
Illumina Cambridge Limited |
Alkylpyridinium coumarin dyes and uses in sequencing applications
|
|
US20220195517A1
(en)
|
2020-12-17 |
2022-06-23 |
Illumina Cambridge Limited |
Long stokes shift chromenoquinoline dyes and uses in sequencing applications
|
|
US20220195518A1
(en)
|
2020-12-22 |
2022-06-23 |
Illumina Cambridge Limited |
Methods and compositions for nucleic acid sequencing
|
|
CA3215598A1
(en)
|
2021-05-05 |
2022-11-10 |
Michael Callingham |
Fluorescent dyes containing bis-boron fused heterocycles and uses in sequencing
|
|
WO2022243480A1
(en)
|
2021-05-20 |
2022-11-24 |
Illumina, Inc. |
Compositions and methods for sequencing by synthesis
|
|
AU2022413575A1
(en)
|
2021-12-16 |
2024-01-18 |
Illumina, Inc. |
Methods for metal directed cleavage of surface-bound polynucleotides
|
|
EP4453243A1
(en)
|
2021-12-20 |
2024-10-30 |
Illumina, Inc. |
Periodate compositions and methods for chemical cleavage of surface-bound polynucleotides
|
|
CA3222842A1
(en)
|
2021-12-20 |
2023-06-29 |
Oliver MILLER |
Periodate compositions and methods for chemical cleavage of surface-bound polynucleotides
|
|
US20240294967A1
(en)
|
2022-01-20 |
2024-09-05 |
Illumina, Inc. |
Methods of detecting methylcytosine and hydroxymethylcytosine by sequencing
|
|
CA3223115A1
(en)
|
2022-03-28 |
2023-10-05 |
Xiaolin Wu |
Labeled avidin and methods for sequencing
|
|
CA3223125A1
(en)
|
2022-03-29 |
2023-10-05 |
Illumina, Inc. |
Chromenoquinoline dyes and uses in sequencing
|
|
EP4499871A1
(en)
|
2022-03-30 |
2025-02-05 |
Illumina, Inc. |
Methods for chemical cleavage of surface-bound polynucleotides
|
|
EP4499659A1
(en)
|
2022-03-31 |
2025-02-05 |
Illumina, Inc. |
Nucleosides and nucleotides with 3' vinyl blocking group useful in sequencing by synthesis
|
|
EP4499870A1
(en)
|
2022-03-31 |
2025-02-05 |
Illumina, Inc. |
Compositions and methods for improving sequencing signals
|
|
AU2023281871A1
(en)
|
2022-05-31 |
2024-11-14 |
Illumina, Inc |
Compositions and methods for nucleic acid sequencing
|
|
CN119604513A
(en)
|
2022-06-28 |
2025-03-11 |
因美纳公司 |
Fluorescent dyes containing fused tetracyclic biboronic heterocycles and their use in sequencing
|
|
WO2024039516A1
(en)
|
2022-08-19 |
2024-02-22 |
Illumina, Inc. |
Third dna base pair site-specific dna detection
|
|
EP4594428A2
(en)
|
2022-09-30 |
2025-08-06 |
Illumina, Inc. |
Compositions and methods for reducing photo damage during sequencing
|
|
US20240240217A1
(en)
|
2022-12-09 |
2024-07-18 |
Illumina, Inc. |
Nucleosides and nucleotides with 3' blocking groups and cleavable linkers
|
|
WO2024137774A1
(en)
|
2022-12-22 |
2024-06-27 |
Illumina, Inc. |
Palladium catalyst compositions and methods for sequencing by synthesis
|
|
CN119095983A
(en)
|
2022-12-22 |
2024-12-06 |
伊路米纳有限公司 |
Transition metal catalyst compositions and methods for sequencing by synthesis
|
|
EP4642931A1
(en)
|
2022-12-27 |
2025-11-05 |
Illumina, Inc. |
Methods of sequencing using 3´ allyl blocked nucleotides
|
|
CN119452044A
(en)
|
2023-03-29 |
2025-02-14 |
因美纳公司 |
Naphthalimide dyes and their use in nucleic acid sequencing
|
|
US20240327909A1
(en)
|
2023-03-30 |
2024-10-03 |
Illumina, Inc. |
Compositions and methods for nucleic acid sequencing
|
|
WO2025049700A1
(en)
|
2023-08-31 |
2025-03-06 |
Illumina, Inc. |
Compositions and methods for nucleic acid sequencing
|
|
WO2025090596A1
(en)
|
2023-10-26 |
2025-05-01 |
Illumina, Inc. |
4,5-substituted naphthalimide dyes and uses in nucleic acid sequencing
|
|
WO2025106715A1
(en)
|
2023-11-17 |
2025-05-22 |
Illumina, Inc. |
Conjugated polymers or polymer dots as fluorescent labels
|
|
WO2025136890A1
(en)
|
2023-12-18 |
2025-06-26 |
Illumina, Inc. |
Hydrogel nanoparticles as labeling scaffold in sequencing
|
|
WO2025144716A1
(en)
|
2023-12-28 |
2025-07-03 |
Illumina, Inc. |
Nucleotides with enzymatically cleavable 3'-o-glycoside blocking groups for sequencing
|
|
WO2025144711A1
(en)
|
2023-12-29 |
2025-07-03 |
Illumina, Inc. |
Tricyclic polymethine dyes for nucleic acid sequencing
|
|
WO2025184226A1
(en)
|
2024-02-28 |
2025-09-04 |
Illumina, Inc. |
Nucleotides with terminal phosphate capping
|
|
WO2025188906A1
(en)
|
2024-03-08 |
2025-09-12 |
Illumina, Inc. |
Modified adenosine nucleotides
|
|
WO2025221895A1
(en)
|
2024-04-19 |
2025-10-23 |
Illumina, Inc. |
Water soluble polymer scaffolds for dye labeling
|
|
WO2025230914A1
(en)
|
2024-04-29 |
2025-11-06 |
Illumina, Inc. |
Nucleotides with enzyme-triggered self-immolative linkers for sequencing by synthesis
|