[go: up one dir, main page]

IL159814A0 - Process for the production of beraprost an its salts - Google Patents

Process for the production of beraprost an its salts

Info

Publication number
IL159814A0
IL159814A0 IL15981402A IL15981402A IL159814A0 IL 159814 A0 IL159814 A0 IL 159814A0 IL 15981402 A IL15981402 A IL 15981402A IL 15981402 A IL15981402 A IL 15981402A IL 159814 A0 IL159814 A0 IL 159814A0
Authority
IL
Israel
Prior art keywords
beraprost
salts
production
new
num
Prior art date
Application number
IL15981402A
Other languages
English (en)
Original Assignee
Gyogyszer Es Vegyeszeti Termek
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gyogyszer Es Vegyeszeti Termek filed Critical Gyogyszer Es Vegyeszeti Termek
Publication of IL159814A0 publication Critical patent/IL159814A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Furan Compounds (AREA)
  • Error Detection And Correction (AREA)
IL15981402A 2001-07-30 2002-07-25 Process for the production of beraprost an its salts IL159814A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0103089A HU227157B1 (en) 2001-07-30 2001-07-30 Production of beraprost ester by selective oxidation
PCT/HU2002/000074 WO2003011849A1 (fr) 2001-07-30 2002-07-25 Procede de preparation de beraprost et de sels de ce dernier

Publications (1)

Publication Number Publication Date
IL159814A0 true IL159814A0 (en) 2004-06-20

Family

ID=90001541

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15981402A IL159814A0 (en) 2001-07-30 2002-07-25 Process for the production of beraprost an its salts
IL159814A IL159814A (en) 2001-07-30 2004-01-11 Process for the production of Brafrost and its salts

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL159814A IL159814A (en) 2001-07-30 2004-01-11 Process for the production of Brafrost and its salts

Country Status (25)

Country Link
US (1) US7005527B2 (fr)
EP (1) EP1412342B1 (fr)
JP (1) JP4440506B2 (fr)
KR (1) KR100604699B1 (fr)
CN (2) CN100347165C (fr)
AT (1) ATE407127T1 (fr)
AU (1) AU2002321670B8 (fr)
BR (1) BR0211514A (fr)
CA (1) CA2453649C (fr)
CU (1) CU23324B7 (fr)
DE (1) DE60228724D1 (fr)
ES (1) ES2314083T3 (fr)
HR (1) HRP20040198B1 (fr)
HU (1) HU227157B1 (fr)
IL (2) IL159814A0 (fr)
ME (2) MEP18708A (fr)
MX (1) MXPA04000847A (fr)
NO (1) NO328695B1 (fr)
NZ (1) NZ531264A (fr)
PL (1) PL216072B1 (fr)
RS (1) RS51314B (fr)
RU (1) RU2272033C2 (fr)
UA (1) UA75692C2 (fr)
WO (1) WO2003011849A1 (fr)
ZA (1) ZA200400748B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215757D0 (en) * 2002-07-08 2002-08-14 Cascade Biochem Ltd Benzoprostacyclin intermediates methods for their preparation and products derived therefrom
CN105315247B (zh) * 2011-06-16 2019-07-26 琅歌生物技术股份有限公司 贝前列素的生产方法
CN102952107B (zh) * 2011-08-29 2015-10-07 上海天伟生物制药有限公司 一种高纯度的贝前列素钠及其制备方法和用途
WO2013040068A2 (fr) * 2011-09-12 2013-03-21 Irix Pharmaceuticals, Inc. Procédé de préparation de prostacyclines synthétiques
CN103509044A (zh) * 2012-06-21 2014-01-15 上海天伟生物制药有限公司 贝前列素钠中间体及其制备方法
WO2014151085A1 (fr) * 2013-03-15 2014-09-25 Gemmus Pharma Inc. Isomère de béraprost en tant qu'agent pour le traitement d'infection virale
CN103242274B (zh) * 2013-05-22 2014-11-05 孙威 一种贝前列素钠化合物及其制备方法
KR20170012314A (ko) 2014-05-20 2017-02-02 렁 바이오테크놀로지 인크. 베라프로스트 및 그의 유도체의 제조 방법
US9765047B2 (en) * 2015-08-12 2017-09-19 United Therapeutics Corporation Process for making beraprost
HU231080B1 (hu) * 2016-04-05 2020-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás optikailag aktív Beraprost előállítására
HU231212B1 (hu) * 2018-04-16 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás iloprost előállítására
US10577340B1 (en) * 2018-11-26 2020-03-03 Chirogate International Inc. Beraprost-314d crystals and methods for preparation thereof
CA3167058A1 (fr) 2020-02-12 2021-08-19 Cytoagents, Inc. Compositions et methodes de traitement d'infections a coronavirus
WO2023276983A1 (fr) * 2021-06-28 2023-01-05 大内新興化学工業株式会社 Intermédiaire de synthèse pour beraprost ou forme optiquement active de celui-ci, et son procédé de production
CN115611838A (zh) * 2021-07-15 2023-01-17 四川国为制药有限公司 一种前列环素衍生物的晶型
CN119638659A (zh) * 2024-12-11 2025-03-18 常州博海威医药科技股份有限公司 贝前列腺素钠的纯化方法及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5931510B2 (ja) * 1979-09-03 1984-08-02 東レ株式会社 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
JPS58124778A (ja) * 1982-01-20 1983-07-25 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
JPS59134787A (ja) * 1983-01-19 1984-08-02 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体の製造法
HU197733B (en) * 1985-05-29 1989-05-29 Chinoin Gyogyszer Es Vegyeszet Process for producing ephedrin-salts of 7-oxo-prosta-cyclin derivatives
CA1284642C (fr) * 1986-03-31 1991-06-04 Hikozo Iwakura Analogues de la prostacycline (pgi )
JP2594118B2 (ja) * 1987-07-01 1997-03-26 塩野義製薬株式会社 ベンゾジオキサンプロスタサイクリン類縁体
JP2542429B2 (ja) * 1987-10-27 1996-10-09 三共株式会社 オクタヒドロナフタリン置換オキシム誘導体
GB8929059D0 (en) * 1989-12-22 1990-02-28 Leo Pharm Prod Ltd Chemical compounds
JP3025056B2 (ja) * 1991-03-12 2000-03-27 財団法人微生物化学研究会 ２，６−ジデオキシ−２−フルオロ−ｌ−タロピラノース誘導体の製造法
JP3024298B2 (ja) * 1991-09-13 2000-03-21 住友化学工業株式会社 シクロペンテンエステル類及びその利用
DE4226615C1 (de) * 1992-08-07 1994-05-19 Schering Ag Verwendung von Prostan-Derivaten zur Behandlung von chronischer Polyarthritis
DE19530884C2 (de) * 1995-08-11 1997-07-31 Schering Ag Verwendung von Prostan-Derivaten sowie deren Kombination mit Antibiotika zur Behandlung von bakteriellen Meningitis
JPH09132589A (ja) * 1995-09-08 1997-05-20 Microbial Chem Res Found 糖部分の水酸基をモノ−または−ジ−ｏ−アミノアルカノイル化された含フッ素アンスラサイクリン誘導体

Also Published As

Publication number Publication date
BR0211514A (pt) 2004-09-14
AU2002321670B2 (en) 2008-08-14
HUP0103089D0 (en) 2001-10-28
HUP0103089A2 (hu) 2003-07-28
IL159814A (en) 2008-08-07
HU227157B1 (en) 2010-09-28
HRP20040198B1 (hr) 2012-02-29
CN1680351A (zh) 2005-10-12
RS51314B (sr) 2010-12-31
KR100604699B1 (ko) 2006-07-31
WO2003011849A1 (fr) 2003-02-13
HRP20040198A2 (en) 2005-04-30
NO20040388L (no) 2004-01-29
MXPA04000847A (es) 2004-03-26
CA2453649C (fr) 2009-12-22
HUP0103089A3 (en) 2005-01-28
DE60228724D1 (de) 2008-10-16
JP4440506B2 (ja) 2010-03-24
HK1078857A1 (zh) 2006-03-24
KR20040043169A (ko) 2004-05-22
US20040209945A1 (en) 2004-10-21
US7005527B2 (en) 2006-02-28
RS8604A (sr) 2007-02-05
ME00089B (me) 2010-10-10
CU23324B7 (es) 2008-11-27
MEP18708A (en) 2010-06-10
WO2003011849A8 (fr) 2004-03-11
EP1412342A1 (fr) 2004-04-28
CA2453649A1 (fr) 2003-02-13
CN1537107A (zh) 2004-10-13
NO328695B1 (no) 2010-04-26
HK1068877A1 (en) 2005-05-06
ZA200400748B (en) 2005-01-26
PL216072B1 (pl) 2014-02-28
CN1235896C (zh) 2006-01-11
ATE407127T1 (de) 2008-09-15
RU2004105959A (ru) 2005-03-27
PL367298A1 (en) 2005-02-21
ES2314083T3 (es) 2009-03-16
NZ531264A (en) 2005-09-30
JP2003055368A (ja) 2003-02-26
CN100347165C (zh) 2007-11-07
AU2002321670B8 (en) 2008-09-11
RU2272033C2 (ru) 2006-03-20
UA75692C2 (uk) 2006-05-15
EP1412342B1 (fr) 2008-09-03

Similar Documents

Publication Publication Date Title
IL159814A0 (en) Process for the production of beraprost an its salts
PT1448853E (pt) Melhoramentos relacionados com branqueadores ópticos
EP1238977A4 (fr) Procede de preparation d'un compose pyridinemethanol
MXPA03002493A (es) Proceso eficiente para preparacion de un inhibidor del factor xa.
IL141394A0 (en) Process for the preparation of imidazodiazepine intermediates
IL156768A0 (en) Process for preparing (+/-) trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidine
MXPA03011647A (es) Procedimiento de resolucion para el acido ( r ) - (-) - 2-hidroxi - 2- (2 - clorofenil) acetico.
EA200000924A3 (ru) СПОСОБ ПОЛУЧЕНИЯ ПИРАЗОЛО[4,3-d]ПИРИМИДИН-7-ОН-3-ПИРИДИЛСУЛЬФОНИЛЬНЫХ СОЕДИНЕНИЙ И ИХ ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ
AU3590801A (en) One-pot synthesis of alkyl 3-cyclopropylamino-2-(2,4-dibromo-3-(difluoromethoxy)benzoyl -2-propenoate as a useful intermediate for antibacterial quinolone medicaments
IS2084B (is) Aðferð við að framleiða útskipt imídasópýridínefnasamband
IL162788A0 (en) Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production
PL378179A1 (pl) Sposób wytwarzania podstawionych pochodnych imidazolu i związki pośrednie stosowane w sposobie
DK1320527T3 (da) Fremgangsmåde til fremstilling af 1-substituerede 5-chlor-4-methylpytrazoler
TW200503701A (en) Novel intermediate for the preparation of therapeutically active imidazopyridines
PL352465A1 (en) Novel method of obtaining n-(1,1-dimethyl)-4-[[5'-ethoxy-4-cis[2-[4-morpholin]ethoxy]2'-oxospiro[cycloexane-1,3'-[3h]indol]-1'(2'h)yl]-sulphonyl]-3-methoxybenzamide and its salts
TW200519074A (en) Process
HU0001287D0 (en) New intermediate and process for its production
IL158530A0 (en) Method for producing 1,3-disubstituted 2-nitroguanidines
AP2000001960A0 (en) Process for the preparation of pyrazole(4,3-d)pyrimidin-7-ones-3-pyridylsulphonyl compounds and intermediates thereof.
BG109794A (en) METHOD FOR OBTAINING A CITAL TRAIN
MXPA04004537A (es) Derivados de gabusectina, metodo para produccion de los mismos y uso de los mismos.
IT1317886B1 (it) Procedimento per la preparazione di 9,10-diidro-pirrolo (2,1-b)(1,3)benzotiazepine 9-ammino sostituite.

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed