IL142999A0 - Process for making 5-substituted pyrazoles using dithietanes - Google Patents
Process for making 5-substituted pyrazoles using dithietanesInfo
- Publication number
- IL142999A0 IL142999A0 IL14299999A IL14299999A IL142999A0 IL 142999 A0 IL142999 A0 IL 142999A0 IL 14299999 A IL14299999 A IL 14299999A IL 14299999 A IL14299999 A IL 14299999A IL 142999 A0 IL142999 A0 IL 142999A0
- Authority
- IL
- Israel
- Prior art keywords
- dithietanes
- making
- substituted pyrazoles
- substituted
- pyrazoles
- Prior art date
Links
- -1 5-substituted pyrazoles Chemical class 0.000 title abstract 2
- UPNNXUSUOSTIIM-UHFFFAOYSA-N 1,2-dithietane Chemical class C1CSS1 UPNNXUSUOSTIIM-UHFFFAOYSA-N 0.000 title 1
- 229940111134 coxibs Drugs 0.000 abstract 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 abstract 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10917798P | 1998-11-20 | 1998-11-20 | |
| PCT/US1999/026011 WO2000031072A1 (fr) | 1998-11-20 | 1999-11-18 | Procede de preparation de pyrazoles a substitution en position 5 a l'aide de dithietanes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL142999A0 true IL142999A0 (en) | 2002-04-21 |
Family
ID=22326224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14299999A IL142999A0 (en) | 1998-11-20 | 1999-11-18 | Process for making 5-substituted pyrazoles using dithietanes |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US6143892A (fr) |
| EP (1) | EP1131318B1 (fr) |
| JP (1) | JP2002530404A (fr) |
| AT (1) | ATE262523T1 (fr) |
| AU (1) | AU758811B2 (fr) |
| CA (1) | CA2350081A1 (fr) |
| DE (1) | DE69915862T2 (fr) |
| DK (1) | DK1131318T3 (fr) |
| ES (1) | ES2219092T3 (fr) |
| IL (1) | IL142999A0 (fr) |
| NZ (1) | NZ511594A (fr) |
| PT (1) | PT1131318E (fr) |
| WO (1) | WO2000031072A1 (fr) |
| ZA (1) | ZA200103759B (fr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
| US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| DE69917296T2 (de) | 1998-08-20 | 2005-05-25 | Smithkline Beecham Corp. | Neue substituierte triazolverbindungen |
| EP1126852B1 (fr) | 1998-11-04 | 2004-01-21 | SmithKline Beecham Corporation | Pyrazines substitues pyridin-4-yle ou pyrimidin-4-yle |
| CA2350081A1 (fr) | 1998-11-20 | 2000-06-02 | G.D. Searle & Co. | Procede de preparation de pyrazoles a substitution en position 5 a l'aide de dithietanes |
| US7122666B2 (en) | 1999-07-21 | 2006-10-17 | Sankyo Company, Limited | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses |
| US6759410B1 (en) * | 1999-11-23 | 2004-07-06 | Smithline Beecham Corporation | 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors |
| ES2230171T3 (es) | 1999-11-23 | 2005-05-01 | Smithkline Beecham Corporation | Compuestos 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de csbp/p38 quinasa. |
| JP2003514900A (ja) | 1999-11-23 | 2003-04-22 | スミスクライン・ビーチャム・コーポレイション | ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４−ジヒドロ−（１Ｈ）−キナゾリン−２−オン化合物 |
| EP1233950B1 (fr) | 1999-11-23 | 2005-10-05 | Smithkline Beecham Corporation | 3,4-dihydro-(1h)quinazolin-2-ones comme inhibiteurs de csbp/p38 kinase |
| CO5261556A1 (es) | 1999-12-08 | 2003-03-31 | Pharmacia Corp | Composiciones inhibidoras de ciclooxigenasa-2 que tiene rapido acceso de efecto terapeutico |
| US7235551B2 (en) | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
| US7057049B2 (en) * | 2001-09-25 | 2006-06-06 | Pharmacia Corporation | Process for making substituted pyrazoles |
| US6897318B2 (en) | 2001-09-25 | 2005-05-24 | Pharmacia Corporation | Process for making substituted pyrazoles |
| MXPA04008680A (es) * | 2002-02-19 | 2004-12-06 | Pharmacia Italia Spa | Derivados de pirazol triciclicos, procedimientos para su preparacion y su uso como agentes anti-tumorales. |
| US20040082551A1 (en) * | 2002-06-05 | 2004-04-29 | Benson Alan G. | Novel pyrazoles and their use as p38 kinase inhibitors |
| JP2005538066A (ja) | 2002-07-09 | 2005-12-15 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 新規な抗コリン作用薬及びｐ３８キナーゼ阻害剤を用いた新規な医薬組成物 |
| TW200413351A (en) | 2002-08-21 | 2004-08-01 | Astrazeneca Ab | Chemical compounds |
| ZA200504898B (en) * | 2002-12-20 | 2006-11-29 | Pharmacia Corp | Acyclic pyrazole compounds |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| JP5178515B2 (ja) * | 2005-08-12 | 2013-04-10 | シンタ ファーマシューティカルズ コーポレーション | Ｈｓｐ９０活性を調節するピラゾール化合物 |
| EP1992344A1 (fr) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha comme cible therapeutique pour les maladies associées á une mutation de FGFR3 |
| WO2008145681A2 (fr) * | 2007-05-31 | 2008-12-04 | Boehringer Ingelheim International Gmbh | Antagonistes des récepteurs ccr2 et utilisations de ceux-ci |
| CN102256963B (zh) | 2008-12-19 | 2014-06-11 | 贝林格尔.英格海姆国际有限公司 | 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺 |
| EP2308866A1 (fr) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazoles et leur utilisation comme fongicides |
| PT2513093E (pt) | 2009-12-17 | 2014-10-22 | Boehringer Ingelheim Int | Novos antagonistas do receptor ccr2 e suas utilizações |
| EP2569298B1 (fr) | 2010-05-12 | 2015-11-25 | Boehringer Ingelheim International GmbH | Nouveaux antagonistes du récepteur ccr2, son procédé de production et utilisation associée en tant que médicaments |
| US8946218B2 (en) | 2010-05-12 | 2015-02-03 | Boehringer Ingelheim International Gmbh | CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| JP5647339B2 (ja) | 2010-05-17 | 2014-12-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ２アンタゴニスト及びこれらの使用 |
| JP5636094B2 (ja) | 2010-05-25 | 2014-12-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ２受容体アンタゴニスト |
| US8962656B2 (en) | 2010-06-01 | 2015-02-24 | Boehringer Ingelheim International Gmbh | CCR2 antagonists |
| JP5786258B2 (ja) | 2011-07-15 | 2015-09-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規かつ選択的なｃｃｒ２拮抗薬 |
| EP2763987B1 (fr) | 2011-10-06 | 2018-07-18 | Bayer CropScience AG | Hétérocyclylpyridinylpyrazole et hétérocyclylpyrimidinylpyrazole utilisés comme fongicides |
| UA127459C2 (uk) | 2015-05-18 | 2023-08-30 | Шеньян Сайнокем Аґрокемікалз Р&Д Ко., Лтд. | Сполуки заміщеного піразолу, який містить піримідиніл, їхнє одержання і застосування |
| AU2016287584B2 (en) | 2015-07-02 | 2020-03-26 | Centrexion Therapeutics Corporation | (4-((3R,4R)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2R,6S)-6-(p-tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate |
| WO2017151409A1 (fr) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Méthodes de chimiothérapie |
| CN111004180A (zh) * | 2019-09-11 | 2020-04-14 | 浙江埃森化学有限公司 | 一种制备氟虫腈的方法 |
| CN115124471B (zh) * | 2021-03-24 | 2024-02-13 | 中国工程物理研究院化工材料研究所 | 一类具有高能和低熔点特性的吡唑环类炸药及其合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63119468A (ja) * | 1986-11-05 | 1988-05-24 | Takeda Chem Ind Ltd | ピラゾ−ル誘導体の製造法 |
| CA2350081A1 (fr) | 1998-11-20 | 2000-06-02 | G.D. Searle & Co. | Procede de preparation de pyrazoles a substitution en position 5 a l'aide de dithietanes |
-
1999
- 1999-11-18 CA CA002350081A patent/CA2350081A1/fr not_active Abandoned
- 1999-11-18 IL IL14299999A patent/IL142999A0/xx unknown
- 1999-11-18 DE DE69915862T patent/DE69915862T2/de not_active Expired - Fee Related
- 1999-11-18 AT AT99961578T patent/ATE262523T1/de not_active IP Right Cessation
- 1999-11-18 NZ NZ511594A patent/NZ511594A/xx unknown
- 1999-11-18 US US09/442,971 patent/US6143892A/en not_active Expired - Fee Related
- 1999-11-18 DK DK99961578T patent/DK1131318T3/da active
- 1999-11-18 EP EP19990961578 patent/EP1131318B1/fr not_active Expired - Lifetime
- 1999-11-18 WO PCT/US1999/026011 patent/WO2000031072A1/fr not_active Ceased
- 1999-11-18 AU AU18126/00A patent/AU758811B2/en not_active Ceased
- 1999-11-18 ES ES99961578T patent/ES2219092T3/es not_active Expired - Lifetime
- 1999-11-18 JP JP2000583900A patent/JP2002530404A/ja active Pending
- 1999-11-18 PT PT99961578T patent/PT1131318E/pt unknown
-
2000
- 2000-08-07 US US09/633,726 patent/US6242612B1/en not_active Expired - Fee Related
-
2001
- 2001-01-30 US US09/772,743 patent/US6342608B1/en not_active Expired - Fee Related
- 2001-05-09 ZA ZA200103759A patent/ZA200103759B/xx unknown
- 2001-08-06 US US09/922,819 patent/US6482955B2/en not_active Expired - Fee Related
-
2002
- 2002-10-10 US US10/268,818 patent/US6750338B2/en not_active Expired - Fee Related
-
2004
- 2004-02-14 US US10/778,432 patent/US20040220232A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2350081A1 (fr) | 2000-06-02 |
| AU1812600A (en) | 2000-06-13 |
| US20040220232A1 (en) | 2004-11-04 |
| US6750338B2 (en) | 2004-06-15 |
| US20020115868A1 (en) | 2002-08-22 |
| ES2219092T3 (es) | 2004-11-16 |
| US6342608B1 (en) | 2002-01-29 |
| DE69915862D1 (de) | 2004-04-29 |
| US6143892A (en) | 2000-11-07 |
| DK1131318T3 (da) | 2004-06-01 |
| US6242612B1 (en) | 2001-06-05 |
| EP1131318A1 (fr) | 2001-09-12 |
| ZA200103759B (en) | 2002-11-27 |
| JP2002530404A (ja) | 2002-09-17 |
| EP1131318B1 (fr) | 2004-03-24 |
| AU758811B2 (en) | 2003-04-03 |
| ATE262523T1 (de) | 2004-04-15 |
| US6482955B2 (en) | 2002-11-19 |
| WO2000031072A1 (fr) | 2000-06-02 |
| US20030135057A1 (en) | 2003-07-17 |
| DE69915862T2 (de) | 2004-08-05 |
| NZ511594A (en) | 2003-01-31 |
| PT1131318E (pt) | 2004-07-30 |
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