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IL144816A - Method for the preparation of citalopram - Google Patents

Method for the preparation of citalopram

Info

Publication number
IL144816A
IL144816A IL14481601A IL14481601A IL144816A IL 144816 A IL144816 A IL 144816A IL 14481601 A IL14481601 A IL 14481601A IL 14481601 A IL14481601 A IL 14481601A IL 144816 A IL144816 A IL 144816A
Authority
IL
Israel
Prior art keywords
citalopram
preparation
Prior art date
Application number
IL14481601A
Other languages
English (en)
Other versions
IL144816A0 (en
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of IL144816A0 publication Critical patent/IL144816A0/xx
Publication of IL144816A publication Critical patent/IL144816A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87Benzo [c] furans; Hydrogenated benzo [c] furans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
IL14481601A 2000-08-18 2001-08-09 Method for the preparation of citalopram IL144816A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200001231 2000-08-18

Publications (2)

Publication Number Publication Date
IL144816A0 IL144816A0 (en) 2002-06-30
IL144816A true IL144816A (en) 2005-09-25

Family

ID=8159660

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14481701A IL144817A0 (en) 2000-08-18 2001-08-09 Method for the preparation of citalopram
IL14481601A IL144816A (en) 2000-08-18 2001-08-09 Method for the preparation of citalopram

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL14481701A IL144817A0 (en) 2000-08-18 2001-08-09 Method for the preparation of citalopram

Country Status (41)

Country Link
US (2) US6426422B1 (xx)
EP (2) EP1309582B1 (xx)
JP (2) JP2004506729A (xx)
KR (2) KR100887206B1 (xx)
CN (3) CN1159307C (xx)
AR (3) AR029598A1 (xx)
AT (4) ATE281447T1 (xx)
AU (6) AU2001279609B2 (xx)
BE (2) BE1013443A6 (xx)
BG (2) BG65965B1 (xx)
CA (2) CA2354880C (xx)
CH (2) CH691968A5 (xx)
CL (2) CL2008002412A1 (xx)
CZ (2) CZ294746B6 (xx)
DE (4) DE60106932T2 (xx)
DK (4) DK200101216A (xx)
EA (2) EA005811B1 (xx)
ES (4) ES2230347T3 (xx)
FI (2) FI20011621L (xx)
FR (2) FR2813078B1 (xx)
GB (2) GB2365865B (xx)
GR (1) GR1004074B (xx)
HK (2) HK1044538B (xx)
HR (2) HRP20030064A2 (xx)
HU (2) HUP0103291A3 (xx)
IE (2) IES20010760A2 (xx)
IL (2) IL144817A0 (xx)
IS (2) IS2120B (xx)
ME (2) MEP2308A (xx)
MX (2) MXPA03000913A (xx)
NL (2) NL1018775C1 (xx)
NO (2) NO326772B1 (xx)
NZ (2) NZ523853A (xx)
PL (2) PL359969A1 (xx)
PT (2) PT1309582E (xx)
RS (2) RS50287B (xx)
SI (2) SI1309582T1 (xx)
SK (2) SK287008B6 (xx)
UA (2) UA72340C2 (xx)
WO (2) WO2002016342A1 (xx)
ZA (1) ZA200106683B (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
HK1048122B (zh) * 1999-04-14 2005-01-14 H‧隆德贝克有限公司 製備西酞普蘭的方法
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
PT1298124E (pt) 1999-10-25 2007-05-31 Lundbeck & Co As H Método para a preparação de citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
KR20020073489A (ko) 1999-12-28 2002-09-26 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조 방법
ATE253568T1 (de) 1999-12-30 2003-11-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
PT1254129E (pt) * 2000-01-14 2004-03-31 Lundbeck & Co As H Metodo para a preparacao da 5-cionaftalida
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
WO2001068629A1 (en) * 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
WO2001068631A1 (en) * 2000-03-13 2001-09-20 H. Lundbeck A/S Method for the preparation of citalopram
CN1418205A (zh) 2000-03-14 2003-05-14 H·隆德贝克有限公司 制备西酞普兰的方法
NZ521059A (en) * 2000-03-16 2004-04-30 H Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2354880C (en) 2000-08-18 2003-06-03 H. Lundbeck A/S Method for the preparation of citalopram
PT1181713E (pt) 2000-12-22 2005-02-28 Lundbeck & Co As H Metodo para preparacao de citalopram puro
WO2003057132A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
TWI306846B (en) * 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
US9339500B2 (en) * 2008-03-04 2016-05-17 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms
US20100087664A1 (en) * 2008-10-07 2010-04-08 Ravindra Vedantham Preparation of citalopram and salts thereof
JP6222973B2 (ja) * 2013-04-19 2017-11-01 日本テルペン化学株式会社 ジベンジルトリチオカーボネート誘導体
CN103936702A (zh) * 2014-05-07 2014-07-23 成都诺维尔生物医药有限公司 艾司西酞普兰杂质j的合成方法
BR112017007509B1 (pt) * 2014-10-14 2021-02-02 Syngenta Participations Ag processo para a preparação de 1-(3,5-dicloro-4-fluorofenil)-2,2,2-trifluoro-etanona

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (xx) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
SK283309B6 (sk) * 1997-07-08 2003-05-02 H. Lundbeck A/S Spôsob výroby citalopramu a medziprodukty
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
ATE221522T1 (de) 1997-11-11 2002-08-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
WO2000023431A1 (en) 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
UA70979C2 (uk) 1998-12-23 2004-11-15 Х. Луннбек А/С Спосіб одержання 5-ціанофталіду
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
HK1048122B (zh) 1999-04-14 2005-01-14 H‧隆德贝克有限公司 製備西酞普蘭的方法
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
CH692421A5 (de) 1999-10-25 2002-06-14 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
CA2354880C (en) 2000-08-18 2003-06-03 H. Lundbeck A/S Method for the preparation of citalopram
PT1181713E (pt) 2000-12-22 2005-02-28 Lundbeck & Co As H Metodo para preparacao de citalopram puro
HRP20020005A2 (en) 2000-12-28 2003-04-30 Lundbeck & Co As H Process for the preparation of pure citalopram

Also Published As

Publication number Publication date
CA2354877A1 (en) 2002-02-18
CH691969A5 (de) 2001-12-14
AU2001279608B2 (en) 2006-10-05
SK3202003A3 (en) 2003-08-05
FR2813077A1 (fr) 2002-02-22
IS6047A (is) 2001-10-20
AU2001100271A4 (en) 2001-09-13
DK1309581T3 (da) 2005-03-14
ES2230347T3 (es) 2005-05-01
IS2120B (is) 2006-06-15
IS6048A (is) 2001-10-19
ZA200106683B (en) 2002-08-05
IS2121B (is) 2006-06-15
PL359969A1 (en) 2004-09-06
FI20011622A7 (fi) 2002-02-19
CA2354880A1 (en) 2002-01-22
NZ523877A (en) 2004-08-27
YU11503A (sh) 2006-05-25
FR2813078B1 (fr) 2004-04-02
CN1222517C (zh) 2005-10-12
DE10140028A1 (de) 2002-04-18
CZ20012959A3 (cs) 2002-04-17
MEP2208A (xx) 2010-02-10
PT1309581E (pt) 2005-03-31
AR066694A2 (es) 2009-09-09
ES2170735B2 (es) 2003-09-16
FI20011621A0 (fi) 2001-08-09
NO20013942L (no) 2002-02-19
AU2001100271B4 (en) 2001-11-29
ES2170734A1 (es) 2002-08-01
NO20013943L (no) 2002-02-19
CN1515564A (zh) 2004-07-28
HK1044538A1 (en) 2002-10-25
WO2002016341A1 (en) 2002-02-28
AU7960801A (en) 2002-03-04
NO20013943D0 (no) 2001-08-14
MXPA03001329A (es) 2003-06-06
HUP0103295A3 (en) 2005-01-28
AT4946U1 (de) 2002-01-25
NL1018775C1 (nl) 2001-10-24
AU2001100278B4 (en) 2001-11-29
SI1309582T1 (en) 2005-06-30
GB2362647B (en) 2002-09-18
CN1239490C (zh) 2006-02-01
SI1309581T1 (en) 2005-04-30
EP1309582A1 (en) 2003-05-14
AU2001279609B2 (en) 2007-09-06
NZ523853A (en) 2004-07-30
EP1309582B1 (en) 2004-11-03
HUP0103291A2 (hu) 2002-05-29
EP1309581A1 (en) 2003-05-14
CA2354877C (en) 2006-05-02
EA005811B1 (ru) 2005-06-30
BG107584A (bg) 2004-01-30
DK200101216A (da) 2002-02-19
SK287236B6 (sk) 2010-04-07
CH691968A5 (de) 2001-12-14
EA005946B1 (ru) 2005-08-25
AU7960901A (en) 2002-03-04
CN1159307C (zh) 2004-07-28
BG65964B1 (bg) 2010-07-30
EA200300279A1 (ru) 2003-08-28
FI20011622L (fi) 2002-02-19
IL144816A0 (en) 2002-06-30
FR2813077B1 (fr) 2004-08-20
CZ295863B6 (cs) 2005-11-16
NL1018776C1 (nl) 2001-10-24
CZ294746B6 (cs) 2005-03-16
DE60106933D1 (de) 2004-12-09
ES2170734B2 (es) 2003-09-16
DE60106932T2 (de) 2005-11-03
KR20030022385A (ko) 2003-03-15
IES20010760A2 (en) 2002-02-20
NO326570B1 (no) 2009-01-12
DK200101219A (da) 2002-02-19
KR100887207B1 (ko) 2009-03-06
HU0103291D0 (en) 2001-10-28
GR20010100398A (el) 2002-05-24
SK287008B6 (sk) 2009-09-07
AR029597A1 (es) 2003-07-10
MXPA03000913A (es) 2003-06-24
GB2362647A (en) 2001-11-28
DE10140029A1 (de) 2002-05-02
EA200300277A1 (ru) 2003-08-28
HRP20030065A2 (en) 2005-02-28
WO2002016342A1 (en) 2002-02-28
BG65965B1 (bg) 2010-07-30
BE1013443A6 (fr) 2002-01-15
CN1339436A (zh) 2002-03-13
DE60106933T2 (de) 2005-12-01
BG107583A (bg) 2004-01-30
IES20010761A2 (en) 2002-02-20
GB0119734D0 (en) 2001-10-03
FI20011621A7 (fi) 2002-02-19
AU2001100278A4 (en) 2001-09-13
ES2170735A1 (es) 2002-08-01
HK1044538B (zh) 2006-07-07
NO326772B1 (no) 2009-02-16
HK1047086B (zh) 2005-04-22
GB2365865B (en) 2002-07-17
ATE281447T1 (de) 2004-11-15
GB2365865A (en) 2002-02-27
ES2228920T3 (es) 2005-04-16
BE1013444A6 (fr) 2002-01-15
IL144817A0 (en) 2002-06-30
HK1068069A1 (en) 2005-04-22
US20020025982A1 (en) 2002-02-28
DK1309582T3 (da) 2005-03-14
DE60106932D1 (de) 2004-12-09
CL2008002412A1 (es) 2009-01-02
AT5026U1 (de) 2002-02-25
GB0119733D0 (en) 2001-10-03
SK3222003A3 (en) 2003-08-05
HRP20030064A2 (en) 2005-02-28
FI20011622A0 (fi) 2001-08-09
NO20013942D0 (no) 2001-08-14
CA2354880C (en) 2003-06-03
KR100887206B1 (ko) 2009-03-06
JP2004506729A (ja) 2004-03-04
HUP0103291A3 (en) 2003-02-28
AR029598A1 (es) 2003-07-10
RS50287B (sr) 2009-09-08
YU6903A (sh) 2006-05-25
JP2004506730A (ja) 2004-03-04
RS50258B (sr) 2009-07-15
EP1309581B1 (en) 2004-11-03
CN1339435A (zh) 2002-03-13
CL2008002673A1 (es) 2009-01-02
MEP2308A (xx) 2010-02-10
GR1004074B (el) 2002-11-26
PT1309582E (pt) 2005-03-31
ATE281448T1 (de) 2004-11-15
US20020026062A1 (en) 2002-02-28
UA72340C2 (uk) 2005-02-15
HK1047086A1 (en) 2003-02-07
CZ20012958A3 (cs) 2002-04-17
US6426422B1 (en) 2002-07-30
FR2813078A1 (fr) 2002-02-22
US6509483B2 (en) 2003-01-21
FI20011621L (fi) 2002-02-19
HUP0103295A2 (hu) 2002-05-29
KR20030022378A (ko) 2003-03-15
PL359825A1 (pl) 2004-09-06
UA71676C2 (en) 2004-12-15

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Legal Events

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