IL137040A0 - Hypolipidemic benzothiazepin compounds - Google Patents
Hypolipidemic benzothiazepin compoundsInfo
- Publication number
- IL137040A0 IL137040A0 IL13704099A IL13704099A IL137040A0 IL 137040 A0 IL137040 A0 IL 137040A0 IL 13704099 A IL13704099 A IL 13704099A IL 13704099 A IL13704099 A IL 13704099A IL 137040 A0 IL137040 A0 IL 137040A0
- Authority
- IL
- Israel
- Prior art keywords
- benzothiazepin
- hypolipidemic
- compounds
- hypolipidemic benzothiazepin
- benzothiazepin compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9800428.6A GB9800428D0 (en) | 1998-01-10 | 1998-01-10 | Chemical compounds |
| PCT/EP1999/000021 WO1999035135A1 (en) | 1998-01-10 | 1999-01-07 | Hypolipidemic benzothiazepine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL137040A0 true IL137040A0 (en) | 2001-06-14 |
Family
ID=10825042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13704099A IL137040A0 (en) | 1998-01-10 | 1999-01-07 | Hypolipidemic benzothiazepin compounds |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6465451B1 (xx) |
| EP (1) | EP1045840A1 (xx) |
| JP (1) | JP2002500220A (xx) |
| KR (1) | KR20010033988A (xx) |
| CN (1) | CN1292785A (xx) |
| AP (1) | AP2000001860A0 (xx) |
| AR (1) | AR014261A1 (xx) |
| AU (1) | AU2515599A (xx) |
| BR (1) | BR9906799A (xx) |
| CA (1) | CA2317651A1 (xx) |
| CO (1) | CO4820391A1 (xx) |
| EA (1) | EA200000623A1 (xx) |
| GB (1) | GB9800428D0 (xx) |
| HR (1) | HRP20000468A2 (xx) |
| HU (1) | HUP0201343A3 (xx) |
| ID (1) | ID25495A (xx) |
| IL (1) | IL137040A0 (xx) |
| IS (1) | IS5551A (xx) |
| MA (1) | MA26595A1 (xx) |
| NO (1) | NO20003514L (xx) |
| NZ (1) | NZ505453A (xx) |
| PE (1) | PE20000179A1 (xx) |
| PL (1) | PL341672A1 (xx) |
| SK (1) | SK10242000A3 (xx) |
| TR (1) | TR200001816T2 (xx) |
| WO (1) | WO1999035135A1 (xx) |
| ZA (1) | ZA9981B (xx) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6638969B1 (en) * | 1998-12-23 | 2003-10-28 | G.D. Searle, Llc | Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications |
| WO2000038721A1 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications |
| SE0000772D0 (sv) * | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | Chemical compounds |
| AU2001247331A1 (en) * | 2000-03-10 | 2001-09-24 | Pharmacia Corporation | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders |
| US20020183307A1 (en) * | 2000-07-26 | 2002-12-05 | Tremont Samuel J. | Novel 1,4-benzothiazephine and 1,5-benzothiazepine compounds as inhibitors of apical sodium co-dependent bile acid transport and taurocholate uptake |
| SE0003766D0 (sv) * | 2000-10-18 | 2000-10-18 | Astrazeneca Ab | Novel formulation |
| EG26979A (en) * | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
| GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| RU2305681C2 (ru) | 2001-09-08 | 2007-09-10 | Астразенека Аб | Производные бензотиадиазепина, способ их получения (варианты) |
| WO2003061604A2 (en) | 2002-01-17 | 2003-07-31 | Pharmacia Corporation | Novel alkyl/aryl hydroxy or keto thiepines. |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| FR2849024B1 (fr) * | 2002-12-20 | 2007-11-02 | Aventis Pharma Sa | Nouveaux composes chiraux derives d'esters de l'acide hexanoique, procede et intermediaires de preparation, utilisation a la synthese de l'acide 2-(bromomethyl)2-ethyl hexanoique chiral |
| GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| EP2367554A4 (en) | 2008-11-26 | 2020-03-25 | Satiogen Pharmaceuticals, Inc. | BILIARY ACID RECYCLING INHIBITORS FOR THE TREATMENT OF OBESITY AND DIABETES |
| EP2995317A1 (en) | 2010-05-26 | 2016-03-16 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| KR101890959B1 (ko) | 2010-11-04 | 2018-08-22 | 알비레오 에이비 | 간질환 치료를 위한 ｉｂａｔ 억제제 |
| CN103228270B (zh) | 2010-11-08 | 2016-02-10 | 阿尔比里奥公司 | 含ibat抑制剂和胆汁酸结合剂的药物组合 |
| KR20190135545A (ko) | 2011-10-28 | 2019-12-06 | 루메나 파마수티컬즈, 인코포레이티드 | 고담혈증 및 담즙 정체성 간 질환 치료용 담즙산 재순환 억제제 |
| MX369466B (es) | 2011-10-28 | 2019-11-08 | Lumena Pharmaceuticals Inc | Inhibidores de la recirculación de ácidos biliares para el tratamiento de enfermedades hepáticas colestásicas pediátricas. |
| JP2016514684A (ja) | 2013-03-15 | 2016-05-23 | ルメナ ファーマシューティカルズ エルエルシー | 原発性硬化性胆管炎および炎症性腸疾患の処置のための胆汁酸再循環阻害剤 |
| AU2014229050A1 (en) | 2013-03-15 | 2015-10-22 | Lumena Pharmaceuticals Llc | Bile acid recycling inhibitors for treatment of Barrett's esophagus and gastroesophageal reflux disease |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| KR102560954B1 (ko) | 2014-06-25 | 2023-07-31 | 이에이 파마 가부시키가이샤 | 고형 제제 및 그의 착색 방지 또는 착색 감소 방법 |
| EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
| CA3011619C (en) | 2016-02-09 | 2024-01-02 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
| US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| JP6954926B2 (ja) | 2016-02-09 | 2021-10-27 | アルビレオ・アクチボラグ | 経口コレスチラミン製剤及びその使用 |
| US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| CA3071182A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | Cholestyramine pellets, oral cholestyramine formulations and use thereof |
| WO2019032026A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | CHOLESTYRAMINE GRANULES, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE |
| US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| TW202015699A (zh) | 2018-06-05 | 2020-05-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽汁酸調節劑之用途 |
| JP7504032B2 (ja) | 2018-06-20 | 2024-06-21 | アルビレオ・アクチボラグ | オデビキシバットの結晶変態 |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| SG11202108566VA (en) | 2019-02-06 | 2021-09-29 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| CA3127408A1 (en) | 2019-02-06 | 2020-08-13 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| JP7562546B2 (ja) | 2019-02-12 | 2024-10-07 | ミルム ファーマシューティカルズ インコーポレイテッド | 胆汁うっ滞性肝疾患を有する小児対象の成長を増加させる方法 |
| JP7665620B2 (ja) | 2019-12-04 | 2025-04-21 | アルビレオ・アクチボラグ | ベンゾチアジアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| WO2021110885A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| AR120674A1 (es) * | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzotiazepina y su uso como ácido biliar |
| CN114761080B (zh) * | 2019-12-04 | 2024-07-23 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| JP7665621B2 (ja) * | 2019-12-04 | 2025-04-21 | アルビレオ・アクチボラグ | ベンゾチアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| BR112022010505A2 (pt) * | 2019-12-04 | 2022-09-06 | Albireo Ab | Compostos de benzotia(di)azepina e seu uso como moduladores do ácido biliar |
| WO2021110883A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| TWI871392B (zh) * | 2019-12-04 | 2025-02-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| CN114786772B (zh) * | 2019-12-04 | 2024-04-09 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| WO2021110884A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CA3186857A1 (en) | 2020-08-03 | 2022-02-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
| JP2023549226A (ja) | 2020-11-12 | 2023-11-22 | アルビレオ エービー | 進行性家族性肝内胆汁うっ滞症（ｐｆｉｃ）を処置するためのオデビキシバット |
| BR112023010799A2 (pt) | 2020-12-04 | 2023-10-03 | Albireo Ab | Compostos de benzotia(di)azepina e seus usos como moduladores de ácidos biliares |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| US20230398125A1 (en) | 2022-06-09 | 2023-12-14 | Albireo Ab | Treating hepatitis |
| WO2025146508A1 (en) | 2024-01-05 | 2025-07-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2025146507A1 (en) | 2024-01-05 | 2025-07-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995004534A1 (en) | 1993-08-06 | 1995-02-16 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
| ZA956647B (en) | 1994-08-10 | 1997-02-10 | Wellcome Found | Hypolipidaemic compounds. |
| GB9423172D0 (en) * | 1994-11-17 | 1995-01-04 | Wellcom Foundation The Limited | Hypolipidemic benzothiazepines |
-
1998
- 1998-01-10 GB GBGB9800428.6A patent/GB9800428D0/en not_active Ceased
-
1999
- 1999-01-06 PE PE1999000007A patent/PE20000179A1/es not_active Application Discontinuation
- 1999-01-06 ZA ZA9900081A patent/ZA9981B/xx unknown
- 1999-01-06 AR ARP990100035A patent/AR014261A1/es unknown
- 1999-01-07 WO PCT/EP1999/000021 patent/WO1999035135A1/en not_active Application Discontinuation
- 1999-01-07 HR HR20000468A patent/HRP20000468A2/hr not_active Application Discontinuation
- 1999-01-07 SK SK1024-2000A patent/SK10242000A3/sk unknown
- 1999-01-07 TR TR2000/01816T patent/TR200001816T2/xx unknown
- 1999-01-07 CN CN998036447A patent/CN1292785A/zh active Pending
- 1999-01-07 EA EA200000623A patent/EA200000623A1/ru unknown
- 1999-01-07 JP JP2000527536A patent/JP2002500220A/ja active Pending
- 1999-01-07 HU HU0201343A patent/HUP0201343A3/hu unknown
- 1999-01-07 IL IL13704099A patent/IL137040A0/xx unknown
- 1999-01-07 MA MA25421A patent/MA26595A1/fr unknown
- 1999-01-07 BR BR9906799-4A patent/BR9906799A/pt not_active IP Right Cessation
- 1999-01-07 AU AU25155/99A patent/AU2515599A/en not_active Abandoned
- 1999-01-07 PL PL99341672A patent/PL341672A1/xx not_active Application Discontinuation
- 1999-01-07 EP EP99904742A patent/EP1045840A1/en not_active Withdrawn
- 1999-01-07 AP APAP/P/2000/001860A patent/AP2000001860A0/en unknown
- 1999-01-07 ID IDW20001337A patent/ID25495A/id unknown
- 1999-01-07 CA CA002317651A patent/CA2317651A1/en not_active Abandoned
- 1999-01-07 NZ NZ505453A patent/NZ505453A/xx unknown
- 1999-01-07 US US09/582,907 patent/US6465451B1/en not_active Expired - Fee Related
- 1999-01-07 KR KR1020007007581A patent/KR20010033988A/ko not_active Withdrawn
- 1999-01-08 CO CO99001036A patent/CO4820391A1/es unknown
-
2000
- 2000-06-27 IS IS5551A patent/IS5551A/is unknown
- 2000-07-07 NO NO20003514A patent/NO20003514L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20003514D0 (no) | 2000-07-07 |
| WO1999035135A1 (en) | 1999-07-15 |
| GB9800428D0 (en) | 1998-03-04 |
| ID25495A (id) | 2000-10-05 |
| CO4820391A1 (es) | 1999-07-28 |
| IS5551A (is) | 2000-06-27 |
| PL341672A1 (en) | 2001-04-23 |
| MA26595A1 (fr) | 2004-12-20 |
| SK10242000A3 (sk) | 2001-02-12 |
| US6465451B1 (en) | 2002-10-15 |
| HRP20000468A2 (en) | 2000-10-31 |
| TR200001816T2 (tr) | 2000-11-21 |
| AR014261A1 (es) | 2001-02-07 |
| EP1045840A1 (en) | 2000-10-25 |
| JP2002500220A (ja) | 2002-01-08 |
| CA2317651A1 (en) | 1999-07-15 |
| PE20000179A1 (es) | 2000-03-16 |
| HUP0201343A2 (hu) | 2003-06-28 |
| CN1292785A (zh) | 2001-04-25 |
| ZA9981B (en) | 2000-07-06 |
| AU2515599A (en) | 1999-07-26 |
| NZ505453A (en) | 2002-11-26 |
| KR20010033988A (ko) | 2001-04-25 |
| HUP0201343A3 (en) | 2003-08-28 |
| EA200000623A1 (ru) | 2001-04-23 |
| NO20003514L (no) | 2000-09-07 |
| AP2000001860A0 (en) | 2000-09-30 |
| BR9906799A (pt) | 2000-10-10 |
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