IL136957A0 - Purification of tramadol - Google Patents
Purification of tramadolInfo
- Publication number
- IL136957A0 IL136957A0 IL13695799A IL13695799A IL136957A0 IL 136957 A0 IL136957 A0 IL 136957A0 IL 13695799 A IL13695799 A IL 13695799A IL 13695799 A IL13695799 A IL 13695799A IL 136957 A0 IL136957 A0 IL 136957A0
- Authority
- IL
- Israel
- Prior art keywords
- tramadol
- purification
- Prior art date
Links
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 229960004380 tramadol Drugs 0.000 title 1
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9800656.2A GB9800656D0 (en) | 1998-01-14 | 1998-01-14 | Improved purification process |
| PCT/GB1999/000013 WO1999036390A1 (en) | 1998-01-14 | 1999-01-14 | Purification of tramadol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL136957A0 true IL136957A0 (en) | 2001-06-14 |
Family
ID=10825209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13695799A IL136957A0 (en) | 1998-01-14 | 1999-01-14 | Purification of tramadol |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1047662A1 (en) |
| KR (1) | KR20010034010A (en) |
| AU (1) | AU744938B2 (en) |
| CA (1) | CA2316991A1 (en) |
| GB (1) | GB9800656D0 (en) |
| HU (1) | HUP0100356A3 (en) |
| IL (1) | IL136957A0 (en) |
| NZ (1) | NZ505129A (en) |
| PL (1) | PL341712A1 (en) |
| SK (1) | SK10352000A3 (en) |
| TR (1) | TR200002022T2 (en) |
| WO (1) | WO1999036390A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100342919B1 (en) * | 1999-10-21 | 2002-07-04 | 박노중 | A preparation and purification for trans isomer of tramadol hydrochloride |
| US6649783B2 (en) | 2001-10-03 | 2003-11-18 | Euro-Celtique, S.A. | Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols |
| EP1346978A1 (en) * | 2002-03-21 | 2003-09-24 | Jubilant Organosys Limited | Process for preparing tramadol hydrochloride and/or tramadol monohydrate |
| DE10236510A1 (en) * | 2002-08-09 | 2004-02-19 | Grünenthal GmbH | 2-((Dimethylamino)-methyl)-1-(3-methoxyphenyl)-cyclohexanol preparation, by Grignard reaction in presence of lithium salt and dialkoxyalkane to give high yield of the analgesic trans-isomer tramadol |
| EP1785412A1 (en) | 2005-11-14 | 2007-05-16 | IPCA Laboratories Limited | Tramadol recovery process |
| WO2010032254A1 (en) * | 2008-09-22 | 2010-03-25 | Kamud Drugs Pvt . Ltd . | Industrial process for cis(+m-2-r(dimethylamino)-methyl-1-(3- methoxyphenyl) cyclohexanol hydrochloride |
| US20160039742A1 (en) | 2013-03-26 | 2016-02-11 | Universite Joseph Fourier - Grenoble 1 | Extraction of tramadol from nauclea latifolia smith |
| USD828429S1 (en) | 2015-02-23 | 2018-09-11 | Samsung Electronics Co., Ltd. | Digital camera |
| CA3110155A1 (en) * | 2018-08-20 | 2020-02-27 | Mylan Laboratories Limited | Tramadol hbr-celecoxib co-crystal |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3652589A (en) * | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
| IL103096A (en) * | 1992-09-08 | 1996-12-05 | Chemagis Ltd | Process for the purification of 2-[(dimethyllamino)methyl]-1-(3-methoxyphenyl) cyclohexanol and its salts |
| US5877351A (en) * | 1997-12-24 | 1999-03-02 | Wyckoff Chemical Company, Inc. | Preparation and purification process for 2- (dimethylamino) methyl!-1-(3-methoxphenyl)-cyclohexanol and its salts |
-
1998
- 1998-01-14 GB GBGB9800656.2A patent/GB9800656D0/en not_active Ceased
-
1999
- 1999-01-14 EP EP99901000A patent/EP1047662A1/en not_active Withdrawn
- 1999-01-14 PL PL99341712A patent/PL341712A1/en unknown
- 1999-01-14 HU HU0100356A patent/HUP0100356A3/en unknown
- 1999-01-14 CA CA002316991A patent/CA2316991A1/en not_active Abandoned
- 1999-01-14 TR TR2000/02022T patent/TR200002022T2/en unknown
- 1999-01-14 AU AU20637/99A patent/AU744938B2/en not_active Ceased
- 1999-01-14 NZ NZ505129A patent/NZ505129A/en unknown
- 1999-01-14 IL IL13695799A patent/IL136957A0/en unknown
- 1999-01-14 WO PCT/GB1999/000013 patent/WO1999036390A1/en not_active Ceased
- 1999-01-14 SK SK1035-2000A patent/SK10352000A3/en unknown
- 1999-01-14 KR KR1020007007604A patent/KR20010034010A/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| SK10352000A3 (en) | 2001-02-12 |
| PL341712A1 (en) | 2001-04-23 |
| HUP0100356A2 (en) | 2002-05-29 |
| NZ505129A (en) | 2001-11-30 |
| WO1999036390A1 (en) | 1999-07-22 |
| EP1047662A1 (en) | 2000-11-02 |
| GB9800656D0 (en) | 1998-03-11 |
| AU744938B2 (en) | 2002-03-07 |
| AU2063799A (en) | 1999-08-02 |
| TR200002022T2 (en) | 2000-11-21 |
| HUP0100356A3 (en) | 2002-08-28 |
| KR20010034010A (en) | 2001-04-25 |
| CA2316991A1 (en) | 1999-07-22 |
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