IL136925A0 - Application of enzyme prodrugs as anti-infective agents - Google Patents
Application of enzyme prodrugs as anti-infective agentsInfo
- Publication number
- IL136925A0 IL136925A0 IL13692598A IL13692598A IL136925A0 IL 136925 A0 IL136925 A0 IL 136925A0 IL 13692598 A IL13692598 A IL 13692598A IL 13692598 A IL13692598 A IL 13692598A IL 136925 A0 IL136925 A0 IL 136925A0
- Authority
- IL
- Israel
- Prior art keywords
- application
- infective agents
- enzyme prodrugs
- prodrugs
- enzyme
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 229960005475 antiinfective agent Drugs 0.000 title 1
- 239000004599 antimicrobial Substances 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6870397P | 1997-12-23 | 1997-12-23 | |
| PCT/US1998/027493 WO1999032113A1 (fr) | 1997-12-23 | 1998-12-22 | Promedicaments enzymatiques appliques comme agents anti-infectieux |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL136925A0 true IL136925A0 (en) | 2001-06-14 |
Family
ID=22084202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13692598A IL136925A0 (en) | 1997-12-23 | 1998-12-22 | Application of enzyme prodrugs as anti-infective agents |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6159706A (fr) |
| EP (1) | EP1041983A4 (fr) |
| JP (1) | JP2001526060A (fr) |
| CN (1) | CN1285745A (fr) |
| AU (1) | AU759639B2 (fr) |
| BR (1) | BR9814319A (fr) |
| CA (1) | CA2315201A1 (fr) |
| IL (1) | IL136925A0 (fr) |
| MX (1) | MXPA00006109A (fr) |
| WO (1) | WO1999032113A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6703374B1 (en) | 1997-10-30 | 2004-03-09 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleosides for imaging and treatment applications |
| WO2001083492A1 (fr) * | 2000-05-02 | 2001-11-08 | Newbiotics, Inc. | Antibiotiques de la famille des beta-lactamines ameliores |
| DE10029185A1 (de) * | 2000-06-19 | 2002-01-03 | Henkel Kgaa | Verfahren zur antimikrobiellen Behandlung von durch mikrobiellen Befallgefährdeten Materialien |
| JP4109123B2 (ja) * | 2001-05-09 | 2008-07-02 | セルメド オンコロジー (ユーエスエイ), インコーポレイテッド | ペプチドデホルミラーゼ活性化プロドラッグ |
| KR100540035B1 (ko) * | 2002-02-01 | 2005-12-29 | 주식회사 태평양 | 다단계 경구 약물 방출 제어 시스템 |
| CA2482029A1 (fr) * | 2002-04-18 | 2003-10-30 | Maria V. Sergeeva | Promedicaments actives par peptide deformylase |
| CA2505914A1 (fr) * | 2002-11-14 | 2004-05-27 | Celmed Oncology (Usa), Inc. | Promedicaments actives par peptide deformylase |
| GB0517957D0 (en) | 2005-09-03 | 2005-10-12 | Morvus Technology Ltd | Method of combating infection |
| GB0526552D0 (en) | 2005-12-29 | 2006-02-08 | Morvus Technology Ltd | New use |
| GB2442202A (en) | 2006-09-30 | 2008-04-02 | Morvus Technology Ltd | Vermin poison |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1348984A (en) * | 1970-06-16 | 1974-03-27 | Merck & Co Inc | Antibiotics and processes for their production |
| DK151027C (da) * | 1974-08-09 | 1988-03-07 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af 7alfa-methoxy-7beta-(2-aminothiazol-4-ylacetamido)cephalosporiner eller farmaceutisk acceptable salte eller estere deraf |
| FR2550200B1 (fr) * | 1983-08-01 | 1988-04-08 | Fujisawa Pharmaceutical Co | Procede de preparation de composes de cephem a activite antimicrobienne et nouveaux produits ainsi obtenus |
| NZ225599A (en) * | 1987-08-04 | 1991-09-25 | Bristol Myers Co | Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells |
| ZA886812B (en) * | 1987-11-23 | 1989-07-26 | Bristol Myers Co | Anti-tumor prodrugs |
| AU649275B2 (en) * | 1990-11-06 | 1994-05-19 | Bristol-Myers Squibb Company | Prodrugs for beta-lactamase and uses thereof |
| US5639603A (en) * | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
| US5525599A (en) * | 1993-07-21 | 1996-06-11 | Eli Lilly And Company | 7-substituted-amino-3-substituted-3-cephem-4-carboxylic acids |
| WO1995026966A1 (fr) * | 1994-04-01 | 1995-10-12 | Microcide Pharmaceuticals, Inc. | Cephalosporines antibiotiques |
| US5679773A (en) * | 1995-01-17 | 1997-10-21 | Affymax Technologies N.V | Reagants and methods for immobilized polymer synthesis and display |
| US5549974A (en) * | 1994-06-23 | 1996-08-27 | Affymax Technologies Nv | Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof |
| JPH08325270A (ja) * | 1995-05-31 | 1996-12-10 | Bristol Myers Squibb Co | β−ラクタマーゼに対するポリマープロドラッグおよびその使用 |
| MY127641A (en) * | 1995-10-12 | 2006-12-29 | Essential Therapeutics Inc | Cephalosporin antibiotics |
-
1998
- 1998-12-18 US US09/215,688 patent/US6159706A/en not_active Expired - Lifetime
- 1998-12-22 AU AU20940/99A patent/AU759639B2/en not_active Ceased
- 1998-12-22 BR BR9814319-0A patent/BR9814319A/pt not_active IP Right Cessation
- 1998-12-22 CA CA002315201A patent/CA2315201A1/fr not_active Abandoned
- 1998-12-22 EP EP98965482A patent/EP1041983A4/fr not_active Withdrawn
- 1998-12-22 JP JP2000525104A patent/JP2001526060A/ja active Pending
- 1998-12-22 WO PCT/US1998/027493 patent/WO1999032113A1/fr not_active Ceased
- 1998-12-22 IL IL13692598A patent/IL136925A0/xx unknown
- 1998-12-22 MX MXPA00006109A patent/MXPA00006109A/es unknown
- 1998-12-22 CN CN98813132A patent/CN1285745A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1285745A (zh) | 2001-02-28 |
| EP1041983A4 (fr) | 2002-09-11 |
| US6159706A (en) | 2000-12-12 |
| AU759639B2 (en) | 2003-04-17 |
| WO1999032113A1 (fr) | 1999-07-01 |
| JP2001526060A (ja) | 2001-12-18 |
| CA2315201A1 (fr) | 1999-07-01 |
| MXPA00006109A (es) | 2002-07-09 |
| EP1041983A1 (fr) | 2000-10-11 |
| BR9814319A (pt) | 2000-10-10 |
| AU2094099A (en) | 1999-07-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL340254A1 (en) | Derivatives of pleuromutillin as antimicrobial agents | |
| SG106036A1 (en) | Novel therapeutic agents that modulate enzymatic processes | |
| PL339551A1 (en) | Derivatives of rezorcin | |
| IL136086A0 (en) | New composition of matter | |
| EP0985017A4 (fr) | Compositions de nettoyage a activite enzymatique accrue | |
| ZA984127B (en) | New composition of matter | |
| PL334846A1 (en) | Sulphamidic inhibitors of metaloproteases | |
| AU8166098A (en) | Removal of biologically active agents | |
| PL334975A1 (en) | Application of gasto-intestinal lipase inhibitors | |
| EP0983347A4 (fr) | Amelioration d'enzymes industrielles | |
| IL136925A0 (en) | Application of enzyme prodrugs as anti-infective agents | |
| PL334769A1 (en) | Derivatives of 5-aroylnaphtene | |
| AU3969099A (en) | Controlled activation of targeted radionuclides | |
| PL338777A1 (en) | Derivative of piperidinylmethyloxazolydinone | |
| ZA985064B (en) | Derivatives of pentaerythrits | |
| AU8602198A (en) | Synaptojanin isoform | |
| GB9706285D0 (en) | Means of assembly | |
| IL130670A0 (en) | Manufacture of elongate members | |
| AP9901651A0 (en) | Nitro-benzamide useful as anti-arrhytmic agent | |
| GB9819137D0 (en) | Component of bromelain | |
| ZA981138B (en) | Manufacture of acryling fibres | |
| GB9713139D0 (en) | Use of enzymes | |
| PL327430A1 (en) | Set of shaped components | |
| PL319263A1 (en) | Novel derivative of pyrimidinylcarbazole | |
| TW319017U (en) | Improved structure of mousetraps |