IL134395A - Compressed nitrogylycerin tablet and its method of manufacture - Google Patents
Compressed nitrogylycerin tablet and its method of manufactureInfo
- Publication number
- IL134395A IL134395A IL13439598A IL13439598A IL134395A IL 134395 A IL134395 A IL 134395A IL 13439598 A IL13439598 A IL 13439598A IL 13439598 A IL13439598 A IL 13439598A IL 134395 A IL134395 A IL 134395A
- Authority
- IL
- Israel
- Prior art keywords
- nitroglycerin
- tablets
- tablet
- stable
- direct compression
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 abstract 4
- 239000000006 Nitroglycerin Substances 0.000 abstract 4
- 229960003711 glyceryl trinitrate Drugs 0.000 abstract 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 2
- 230000003247 decreasing effect Effects 0.000 abstract 2
- 238000007907 direct compression Methods 0.000 abstract 2
- 239000008101 lactose Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000003826 tablet Substances 0.000 abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 abstract 1
- 235000013539 calcium stearate Nutrition 0.000 abstract 1
- 239000008116 calcium stearate Substances 0.000 abstract 1
- 239000007891 compressed tablet Substances 0.000 abstract 1
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 229910021485 fumed silica Inorganic materials 0.000 abstract 1
- 230000005012 migration Effects 0.000 abstract 1
- 238000013508 migration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000006190 sub-lingual tablet Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6110597P | 1997-10-03 | 1997-10-03 | |
| PCT/US1998/019356 WO1999017766A1 (en) | 1997-10-03 | 1998-09-16 | Compressed nitroglycerin tablet and its method of manufacture |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL134395A0 IL134395A0 (en) | 2001-04-30 |
| IL134395A true IL134395A (en) | 2005-08-31 |
Family
ID=22033623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13439598A IL134395A (en) | 1997-10-03 | 1998-09-16 | Compressed nitrogylycerin tablet and its method of manufacture |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6500456B1 (pt) |
| EP (1) | EP1019039B1 (pt) |
| JP (1) | JP2001518500A (pt) |
| KR (1) | KR100569763B1 (pt) |
| AT (1) | ATE209911T1 (pt) |
| AU (1) | AU759018B2 (pt) |
| BR (1) | BR9812605B1 (pt) |
| CA (1) | CA2299231C (pt) |
| DE (1) | DE69802832T2 (pt) |
| DK (1) | DK1019039T3 (pt) |
| ES (1) | ES2169558T3 (pt) |
| IL (1) | IL134395A (pt) |
| NZ (1) | NZ502878A (pt) |
| PT (1) | PT1019039E (pt) |
| TW (1) | TWI228989B (pt) |
| WO (1) | WO1999017766A1 (pt) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7815937B2 (en) * | 1998-10-27 | 2010-10-19 | Biovail Laboratories International Srl | Quick dissolve compositions and tablets based thereon |
| EP1128817A1 (en) * | 1998-10-27 | 2001-09-05 | Biovail Technologies Ltd | Microparticles containing peg and/or peg glyceryl esters |
| US7815936B2 (en) | 2001-10-30 | 2010-10-19 | Evonik Degussa Gmbh | Use of granular materials based on pyrogenically produced silicon dioxide in pharmaceutical compositions |
| US20040109889A1 (en) | 2002-12-04 | 2004-06-10 | Bunick Frank J. | Surface treatment composition for soft substrates |
| US9254294B2 (en) | 2003-02-24 | 2016-02-09 | Pharmaceutical Productions Inc. | Transmucosal hormone delivery system |
| WO2004075877A1 (en) * | 2003-02-24 | 2004-09-10 | Pharmaceutical Productions, Inc. | Transmucosal drug delivery system |
| US9358296B2 (en) | 2003-02-24 | 2016-06-07 | Pharmaceutical Productions Inc. | Transmucosal drug delivery system |
| US10172810B2 (en) | 2003-02-24 | 2019-01-08 | Pharmaceutical Productions, Inc. | Transmucosal ketamine delivery composition |
| US9498454B2 (en) | 2003-02-24 | 2016-11-22 | Pharmaceutical Productions Inc. | Transmucosal drug delivery system |
| CA2530843A1 (en) * | 2003-07-01 | 2005-01-20 | Todd Maibach | Film comprising therapeutic agents |
| US7999003B2 (en) * | 2003-08-26 | 2011-08-16 | Mannatech, Incorporated | Antioxidant compositions and methods thereto |
| US20060134202A1 (en) * | 2004-12-22 | 2006-06-22 | Hack Jacob C | Homeopathic sublingual dosage forms and methods thereof |
| US8753308B2 (en) | 2006-01-06 | 2014-06-17 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
| US8252329B2 (en) | 2007-01-05 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| US8535714B2 (en) | 2006-01-06 | 2013-09-17 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
| US8252328B2 (en) * | 2006-01-06 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| US8202535B2 (en) | 2006-01-06 | 2012-06-19 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage forms |
| US9289583B2 (en) | 2006-01-06 | 2016-03-22 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
| US8357114B2 (en) | 2006-01-06 | 2013-01-22 | Acelrx Pharmaceuticals, Inc. | Drug dispensing device with flexible push rod |
| US9066847B2 (en) | 2007-01-05 | 2015-06-30 | Aceirx Pharmaceuticals, Inc. | Storage and dispensing devices for administration of oral transmucosal dosage forms |
| US8865743B2 (en) | 2006-01-06 | 2014-10-21 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
| US20100215774A1 (en) * | 2007-02-09 | 2010-08-26 | Todd Maibach | Film comprising nitroglycerin |
| US20090004254A1 (en) * | 2007-06-19 | 2009-01-01 | Todd Maibach | Film comprising active drugs |
| KR101606944B1 (ko) * | 2007-08-07 | 2016-03-28 | 아셀알엑스 파마슈티컬스 인코퍼레이티드 | 경구 경점막 투여형을 사용한 시술시 진정과 무통을 위한 조성물 및 방법 |
| US8945592B2 (en) * | 2008-11-21 | 2015-02-03 | Acelrx Pharmaceuticals, Inc. | Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same |
| US20110091544A1 (en) * | 2009-10-16 | 2011-04-21 | Acelrx Pharmaceuticals, Inc. | Compositions and Methods for Mild Sedation, Anxiolysis and Analgesia in the Procedural Setting |
| EP2990032A1 (en) | 2010-08-03 | 2016-03-02 | G. Pohl-Boskamp GmbH & Co. KG | Use of glyceryl trinitrate for treating traumatic edema |
| PL2678006T3 (pl) | 2011-02-25 | 2016-06-30 | G Pohl Boskamp Gmbh & Co Kg | Pakowanie stałych preparatów farmaceutycznych zawierających substancję aktywną triazotan glicerolu |
| EP2668947B1 (en) | 2012-05-31 | 2016-11-30 | G. Pohl-Boskamp GmbH & Co. KG | Induction of arteriogenesis with a nitric oxide-donor such as nitroglycerin |
| US9248099B2 (en) | 2012-05-31 | 2016-02-02 | Desmoid Aktiengesellschaft | Use of stabilized granules containing glyceryl trinitrate for arteriogenesis |
| EP2668948A1 (en) * | 2012-05-31 | 2013-12-04 | G. Pohl-Boskamp GmbH & Co. KG | Use of stabilized granules containing glyceryl trinitrate for arteriogenesis |
| EP2891493A4 (en) * | 2012-08-31 | 2016-05-18 | Astellas Pharma Inc | MEDICAL COMPOSITION ADMINISTERED ORALLY |
| HK1216240A1 (zh) | 2012-11-14 | 2016-10-28 | W. R. Grace & Co.-Conn. | 含有生物活性材料与无序无机氧化物的组合物 |
| US20140303227A1 (en) * | 2013-03-14 | 2014-10-09 | Pharmaceutical Productions Inc. | Transmucosal hormone delivery system |
| EP2878310B1 (en) | 2013-11-29 | 2017-01-11 | G. Pohl-Boskamp GmbH & Co. KG | Sprayable aqueous composition comprising glyceryl trinitrate |
| MX2015006022A (es) * | 2014-02-07 | 2015-10-14 | Scilabs Pharmaceuticals | Sistemas de administracion de farmacos sublinguales, totalmente naturales, no toxicos. |
| CA3182156A1 (en) | 2020-05-08 | 2021-11-11 | Psilera Inc. | Novel compositions of matter and pharmaceutical compositions |
| CN113679682A (zh) * | 2020-05-19 | 2021-11-23 | 珠海润都制药股份有限公司 | 一种硝酸甘油舌下片及其制备方法 |
| US12378194B2 (en) | 2021-05-25 | 2025-08-05 | Atai Therapeutics, Inc. | N, n-dimethyltryptamine salts and crystalline salt forms |
| CN114469881A (zh) * | 2022-03-14 | 2022-05-13 | 河北坤安药业有限公司 | 一种硝酸甘油片及其制备方法 |
| CN115154431B (zh) * | 2022-07-21 | 2024-03-12 | 南京卓康医药科技有限公司 | 一种硝酸甘油片剂及其制备方法 |
| WO2025024637A1 (en) * | 2023-07-25 | 2025-01-30 | Atai Therapeutics, Inc. | Compositions for limiting sympathomimetic effects of psychedelic therapeutics |
| CN117653610B (zh) * | 2023-09-28 | 2024-07-05 | 海南卓科制药有限公司 | 一种硝酸甘油片及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2357503A1 (de) * | 1973-11-17 | 1975-05-28 | Cassella Farbwerke Mainkur Ag | Verfahren zur herstellung von festen carbocromen-hydrochlorid enthaltenden praeparaten |
| US4389393A (en) * | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| WO1996036330A2 (en) * | 1995-05-17 | 1996-11-21 | Cedars-Sinai Medical Center | Compositions containing fatty acids for improving digestion and absorption in the small intestine |
| US5874418A (en) * | 1997-05-05 | 1999-02-23 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use |
-
1998
- 1998-09-16 BR BRPI9812605-9A patent/BR9812605B1/pt not_active IP Right Cessation
- 1998-09-16 DK DK98948293T patent/DK1019039T3/da active
- 1998-09-16 PT PT98948293T patent/PT1019039E/pt unknown
- 1998-09-16 WO PCT/US1998/019356 patent/WO1999017766A1/en not_active Ceased
- 1998-09-16 CA CA002299231A patent/CA2299231C/en not_active Expired - Fee Related
- 1998-09-16 KR KR1020007003497A patent/KR100569763B1/ko not_active Expired - Fee Related
- 1998-09-16 EP EP98948293A patent/EP1019039B1/en not_active Expired - Lifetime
- 1998-09-16 US US09/508,705 patent/US6500456B1/en not_active Expired - Lifetime
- 1998-09-16 DE DE69802832T patent/DE69802832T2/de not_active Expired - Fee Related
- 1998-09-16 NZ NZ502878A patent/NZ502878A/en unknown
- 1998-09-16 JP JP2000514637A patent/JP2001518500A/ja active Pending
- 1998-09-16 AT AT98948293T patent/ATE209911T1/de not_active IP Right Cessation
- 1998-09-16 ES ES98948293T patent/ES2169558T3/es not_active Expired - Lifetime
- 1998-09-16 AU AU94893/98A patent/AU759018B2/en not_active Ceased
- 1998-09-16 IL IL13439598A patent/IL134395A/xx not_active IP Right Cessation
- 1998-09-29 TW TW087116123A patent/TWI228989B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2299231C (en) | 2003-03-18 |
| DK1019039T3 (da) | 2002-03-25 |
| AU9489398A (en) | 1999-04-27 |
| JP2001518500A (ja) | 2001-10-16 |
| CA2299231A1 (en) | 1999-04-15 |
| BR9812605A (pt) | 2000-08-01 |
| PT1019039E (pt) | 2002-04-29 |
| IL134395A0 (en) | 2001-04-30 |
| EP1019039A1 (en) | 2000-07-19 |
| EP1019039B1 (en) | 2001-12-05 |
| KR20010030839A (ko) | 2001-04-16 |
| DE69802832D1 (de) | 2002-01-17 |
| AU759018B2 (en) | 2003-04-03 |
| KR100569763B1 (ko) | 2006-04-11 |
| BR9812605B1 (pt) | 2009-01-13 |
| DE69802832T2 (de) | 2002-06-20 |
| ES2169558T3 (es) | 2002-07-01 |
| WO1999017766A1 (en) | 1999-04-15 |
| NZ502878A (en) | 2002-03-01 |
| US6500456B1 (en) | 2002-12-31 |
| TWI228989B (en) | 2005-03-11 |
| ATE209911T1 (de) | 2001-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |