IL126157A - Medicinal products containing olenzapine for the treatment of hyper-aggression - Google Patents

Medicinal products containing olenzapine for the treatment of hyper-aggression

Info

Publication number: IL126157A
Authority: IL; Israel
Prior art keywords: olanzapine; aggression; mammal; pharmaceutical compositions; extreme aggression
Prior art date: 1996-03-11

Application number

IL12615796A

Other languages

English (en)

Hebrew (he)

Other versions

IL126157A0 (en

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-03-11

Filing date

1996-12-04

Publication date

2002-09-12

1996-12-04 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1999-05-09 Publication of IL126157A0 publication Critical patent/IL126157A0/xx

2002-09-12 Publication of IL126157A publication Critical patent/IL126157A/en

Links

KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 title claims abstract description 39
229960005017 olanzapine Drugs 0.000 title claims abstract description 38
230000016571 aggressive behavior Effects 0.000 title claims abstract description 22
239000008194 pharmaceutical composition Substances 0.000 title claims description 11
241000124008 Mammalia Species 0.000 claims description 11
208000028017 Psychotic disease Diseases 0.000 claims description 7
239000003814 drug Substances 0.000 claims description 5
150000003839 salts Chemical class 0.000 claims description 5
241000282414 Homo sapiens Species 0.000 claims description 4
239000012453 solvate Substances 0.000 claims 2
238000000034 method Methods 0.000 abstract description 7
239000000203 mixture Substances 0.000 description 15
238000011282 treatment Methods 0.000 description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
239000004480 active ingredient Substances 0.000 description 7
239000003826 tablet Substances 0.000 description 7
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
238000006243 chemical reaction Methods 0.000 description 6
150000001875 compounds Chemical class 0.000 description 6
239000000243 solution Substances 0.000 description 6
239000000843 powder Substances 0.000 description 5
238000002360 preparation method Methods 0.000 description 5
239000000126 substance Substances 0.000 description 5
239000011248 coating agent Substances 0.000 description 4
238000000576 coating method Methods 0.000 description 4
238000009472 formulation Methods 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
239000000725 suspension Substances 0.000 description 4
206010010144 Completed suicide Diseases 0.000 description 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 3
238000002441 X-ray diffraction Methods 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
238000005469 granulation Methods 0.000 description 3
230000003179 granulation Effects 0.000 description 3
239000001863 hydroxypropyl cellulose Substances 0.000 description 3
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 3
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
239000000463 material Substances 0.000 description 3
238000000634 powder X-ray diffraction Methods 0.000 description 3
239000008213 purified water Substances 0.000 description 3
239000007787 solid Substances 0.000 description 3
DUUGKQCEGZLZNO-UHFFFAOYSA-N 5-hydroxyindoleacetic acid Chemical compound C1=C(O)C=C2C(CC(=O)O)=CNC2=C1 DUUGKQCEGZLZNO-UHFFFAOYSA-N 0.000 description 2
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
239000002775 capsule Substances 0.000 description 2
239000003153 chemical reaction reagent Substances 0.000 description 2
239000010949 copper Substances 0.000 description 2
229910052802 copper Inorganic materials 0.000 description 2
229960000913 crospovidone Drugs 0.000 description 2
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
239000008101 lactose Substances 0.000 description 2
235000019359 magnesium stearate Nutrition 0.000 description 2
238000007726 management method Methods 0.000 description 2
239000005022 packaging material Substances 0.000 description 2
230000000144 pharmacologic effect Effects 0.000 description 2
235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 2
229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 2
102000005962 receptors Human genes 0.000 description 2
108020003175 receptors Proteins 0.000 description 2
239000007921 spray Substances 0.000 description 2
238000002411 thermogravimetry Methods 0.000 description 2
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 description 1
102000056834 5-HT2 Serotonin Receptors Human genes 0.000 description 1
108091005479 5-HT2 receptors Proteins 0.000 description 1
244000215068 Acacia senegal Species 0.000 description 1
235000006491 Acacia senegal Nutrition 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
208000019901 Anxiety disease Diseases 0.000 description 1
241000416162 Astragalus gummifer Species 0.000 description 1
108010009685 Cholinergic Receptors Proteins 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
229920000084 Gum arabic Polymers 0.000 description 1
241000282412 Homo Species 0.000 description 1
206010026749 Mania Diseases 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
229920000168 Microcrystalline cellulose Polymers 0.000 description 1
238000005481 NMR spectroscopy Methods 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
208000020186 Schizophreniform disease Diseases 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229920001615 Tragacanth Polymers 0.000 description 1
241000251539 Vertebrata <Metazoa> Species 0.000 description 1
230000005856 abnormality Effects 0.000 description 1
235000010489 acacia gum Nutrition 0.000 description 1
102000034337 acetylcholine receptors Human genes 0.000 description 1
239000002253 acid Substances 0.000 description 1
238000013019 agitation Methods 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
229910021529 ammonia Inorganic materials 0.000 description 1
239000003674 animal food additive Substances 0.000 description 1
230000000561 anti-psychotic effect Effects 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
239000004203 carnauba wax Substances 0.000 description 1
235000013869 carnauba wax Nutrition 0.000 description 1
239000000969 carrier Substances 0.000 description 1
210000003169 central nervous system Anatomy 0.000 description 1
210000001175 cerebrospinal fluid Anatomy 0.000 description 1
238000012512 characterization method Methods 0.000 description 1
238000007906 compression Methods 0.000 description 1
230000006835 compression Effects 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
239000002274 desiccant Substances 0.000 description 1
230000001627 detrimental effect Effects 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
229960003638 dopamine Drugs 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
239000011888 foil Substances 0.000 description 1
239000000499 gel Substances 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000011521 glass Substances 0.000 description 1
229920001903 high density polyethylene Polymers 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
239000004700 high-density polyethylene Substances 0.000 description 1
239000012535 impurity Substances 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
238000011835 investigation Methods 0.000 description 1
239000011344 liquid material Substances 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
239000002609 medium Substances 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical group COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
230000003551 muscarinic effect Effects 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000000902 placebo Substances 0.000 description 1
229940068196 placebo Drugs 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
229960003415 propylparaben Drugs 0.000 description 1
238000000159 protein binding assay Methods 0.000 description 1
230000005855 radiation Effects 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
239000012066 reaction slurry Substances 0.000 description 1
239000013557 residual solvent Substances 0.000 description 1
-1 sachet Substances 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
201000000980 schizophrenia Diseases 0.000 description 1
239000012056 semi-solid material Substances 0.000 description 1
239000011343 solid material Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
235000010356 sorbitol Nutrition 0.000 description 1
DKGZKTPJOSAWFA-UHFFFAOYSA-N spiperone Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCC2(C(NCN2C=2C=CC=CC=2)=O)CC1 DKGZKTPJOSAWFA-UHFFFAOYSA-N 0.000 description 1
229950001675 spiperone Drugs 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000009498 subcoating Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
230000037317 transdermal delivery Effects 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
238000003828 vacuum filtration Methods 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Developing Agents For Electrophotography (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Pyrane Compounds (AREA)

IL12615796A 1996-03-11 1996-12-04 Medicinal products containing olenzapine for the treatment of hyper-aggression IL126157A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1312796P	1996-03-11	1996-03-11
PCT/US1996/019573 WO1997033584A1 (fr)	1996-03-11	1996-12-04	Methode de traitement de l'agressivite excessive

Publications (2)

Publication Number	Publication Date
IL126157A0 IL126157A0 (en)	1999-05-09
IL126157A true IL126157A (en)	2002-09-12

Family

ID=21758447

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12615796A IL126157A (en)	1996-03-11	1996-12-04	Medicinal products containing olenzapine for the treatment of hyper-aggression

Country Status (22)

Country	Link
EP (1)	EP0900085B1 (fr)
JP (1)	JP2000506858A (fr)
KR (1)	KR19990087716A (fr)
CN (1)	CN1124847C (fr)
AT (1)	ATE306269T1 (fr)
AU (1)	AU719517B2 (fr)
BR (1)	BR9612549A (fr)
CA (1)	CA2248753C (fr)
CZ (1)	CZ296579B6 (fr)
DE (1)	DE69635282T2 (fr)
DK (1)	DK0900085T3 (fr)
EA (1)	EA000741B1 (fr)
ES (1)	ES2249789T3 (fr)
HU (1)	HUP9903685A3 (fr)
IL (1)	IL126157A (fr)
NO (1)	NO323579B1 (fr)
NZ (1)	NZ325035A (fr)
PL (1)	PL186975B1 (fr)
RO (1)	RO117347B1 (fr)
TR (1)	TR199801799T2 (fr)
UA (1)	UA57727C2 (fr)
WO (1)	WO1997033584A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69923081T2 (de)	1998-11-23	2005-12-08	Sepracor Inc., Marlborough	Desmethylolanzapine enthaltende zusammensetzungen und verfahren
CA2351719A1 (fr) *	1998-11-23	2000-06-02	Sepracor Inc.	Compositions pharmaceutiques contenant de l'olanzapine-n-oxyde
CA2352611A1 (fr)	1998-11-23	2000-06-02	Sepracor Inc.	Compositions a base de 2-hydroxymethylolanzapine et leurs utilisations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4595535A (en) *	1983-06-06	1986-06-17	Ciba-Geigy Corporation	Diazacycloalkyl-1,2,4-triazolo[2,3-c][1,3]benzodiazepines useful as neuroleptic and/or antihistaminic agents
US5229382A (en) *	1990-04-25	1993-07-20	Lilly Industries Limited	2-methyl-thieno-benzodiazepine
GB9009229D0 (en) *	1990-04-25	1990-06-20	Lilly Industries Ltd	Pharmaceutical compounds
US5605897A (en) *	1991-04-23	1997-02-25	Eli Lilly And Company	2-methyl-thieno-benzodiazepine
JP3274579B2 (ja) *	1995-01-12	2002-04-15	住友製薬株式会社	脳血管障害に伴う精神症候治療剤
EG23659A (en) *	1995-03-24	2007-03-26	Lilly Co Eli	Process and crystal forms of methyl-thieno-benzodiazepine
US5631250A (en) *	1995-03-24	1997-05-20	Eli Lilly And Company	Process and solvate of 2-methyl-thieno-benzodiazepine
US5637584A (en) *	1995-03-24	1997-06-10	Eli Lilly And Company	Solvate of olanzapine
DK0828494T3 (da) *	1995-05-30	2002-09-02	Lilly Co Eli	Fremgangsmåde til behandling af kognitiv dysfunktion

1996
- 1996-04-12 UA UA98094803A patent/UA57727C2/uk unknown
- 1996-12-04 ES ES96943659T patent/ES2249789T3/es not_active Expired - Lifetime
- 1996-12-04 EA EA199800822A patent/EA000741B1/ru not_active IP Right Cessation
- 1996-12-04 RO RO98-01386A patent/RO117347B1/ro unknown
- 1996-12-04 DE DE69635282T patent/DE69635282T2/de not_active Expired - Fee Related
- 1996-12-04 CZ CZ0290598A patent/CZ296579B6/cs not_active IP Right Cessation
- 1996-12-04 KR KR1019980707183A patent/KR19990087716A/ko not_active Ceased
- 1996-12-04 HU HU9903685A patent/HUP9903685A3/hu unknown
- 1996-12-04 CN CN96180206A patent/CN1124847C/zh not_active Expired - Fee Related
- 1996-12-04 TR TR1998/01799T patent/TR199801799T2/xx unknown
- 1996-12-04 JP JP09532569A patent/JP2000506858A/ja not_active Ceased
- 1996-12-04 NZ NZ325035A patent/NZ325035A/en unknown
- 1996-12-04 PL PL96328949A patent/PL186975B1/pl not_active IP Right Cessation
- 1996-12-04 DK DK96943659T patent/DK0900085T3/da active
- 1996-12-04 CA CA002248753A patent/CA2248753C/fr not_active Expired - Fee Related
- 1996-12-04 AT AT96943659T patent/ATE306269T1/de not_active IP Right Cessation
- 1996-12-04 WO PCT/US1996/019573 patent/WO1997033584A1/fr active IP Right Grant
- 1996-12-04 IL IL12615796A patent/IL126157A/en not_active IP Right Cessation
- 1996-12-04 EP EP96943659A patent/EP0900085B1/fr not_active Expired - Lifetime
- 1996-12-04 AU AU12846/97A patent/AU719517B2/en not_active Ceased
- 1996-12-04 BR BR9612549A patent/BR9612549A/pt not_active Application Discontinuation
1998
- 1998-09-11 NO NO19984198A patent/NO323579B1/no unknown

Also Published As

Publication number	Publication date
EA199800822A1 (ru)	1999-02-25
EP0900085B1 (fr)	2005-10-12
ES2249789T3 (es)	2006-04-01
CA2248753C (fr)	2008-11-18
DE69635282D1 (de)	2006-02-23
CA2248753A1 (fr)	1997-09-18
CZ290598A3 (cs)	1999-09-15
WO1997033584A1 (fr)	1997-09-18
ATE306269T1 (de)	2005-10-15
AU719517B2 (en)	2000-05-11
EP0900085A1 (fr)	1999-03-10
KR19990087716A (ko)	1999-12-27
BR9612549A (pt)	1999-07-20
IL126157A0 (en)	1999-05-09
NO984198D0 (no)	1998-09-11
TR199801799T2 (xx)	1999-01-18
CN1124847C (zh)	2003-10-22
DE69635282T2 (de)	2006-04-20
PL328949A1 (en)	1999-03-01
NO984198L (no)	1998-11-02
RO117347B1 (ro)	2002-02-28
HUP9903685A3 (en)	2001-12-28
CN1213969A (zh)	1999-04-14
PL186975B1 (pl)	2004-04-30
UA57727C2 (uk)	2003-07-15
CZ296579B6 (cs)	2006-04-12
JP2000506858A (ja)	2000-06-06
EP0900085A4 (fr)	2000-12-13
NZ325035A (en)	2001-06-29
EA000741B1 (ru)	2000-02-28
NO323579B1 (no)	2007-06-11
HUP9903685A2 (hu)	2000-03-28
DK0900085T3 (da)	2006-01-30
AU1284697A (en)	1997-10-01

Publication	Publication Date	Title
US6159963A (en)	2000-12-12	Method for treating substance abuse
AU709181B2 (en)	1999-08-26	Method for treating autism
AU734011B2 (en)	2001-05-31	Method for treating bipolar disorder
EP0900085B1 (fr)	2005-10-12	Traitement de l'agressivite excessive avec olanzapine
US5744470A (en)	1998-04-28	Method for treating insomnia
EP0831835B1 (fr)	2002-10-30	Traitement de l'anorexie
EP1007050B1 (fr)	2005-05-18	L'olanzapine dans le traitement de la pharmacodependance
US6071902A (en)	2000-06-06	Method for treating excessive aggression
AU724245B2 (en)	2000-09-14	Method for treating insomnia
GB2305860A (en)	1997-04-23	Anti-emetic
GB2305859A (en)	1997-04-23	Treatment of obsessive-compulsive disorder
CA2248905A1 (fr)	1997-09-18	Methode de traitement des troubles bipolaires
AU725940C (en)	2001-05-17	Method for treating substance abuse
HK1023053A (en)	2000-09-01	Method for treating excessive aggression
MXPA98007431A (en)	1999-04-06	Medications to treat the bipo disorder
MXPA98007438A (en)	1999-04-06	Medications to treat the insom

Legal Events

Date	Code	Title
2003-02-12	FF	Patent granted
2003-03-12	KB	Patent renewed
2007-02-12	KB	Patent renewed
2011-07-31	MM9K	Patent not in force due to non-payment of renewal fees