[go: up one dir, main page]

IL125884A0 - Modified rapid expansion methods ("modified-rem") for in vitro propagation of t lymphocytes - Google Patents

Modified rapid expansion methods ("modified-rem") for in vitro propagation of t lymphocytes

Info

Publication number
IL125884A0
IL125884A0 IL12588497A IL12588497A IL125884A0 IL 125884 A0 IL125884 A0 IL 125884A0 IL 12588497 A IL12588497 A IL 12588497A IL 12588497 A IL12588497 A IL 12588497A IL 125884 A0 IL125884 A0 IL 125884A0
Authority
IL
Israel
Prior art keywords
modified
rem
lymphocytes
rapid expansion
expansion methods
Prior art date
Application number
IL12588497A
Other languages
English (en)
Original Assignee
Targeted Genetics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Targeted Genetics Corp filed Critical Targeted Genetics Corp
Publication of IL125884A0 publication Critical patent/IL125884A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/58—Adhesion molecules, e.g. ICAM, VCAM, CD18 (ligand), CD11 (ligand), CD49 (ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL12588497A 1996-03-04 1997-03-03 Modified rapid expansion methods ("modified-rem") for in vitro propagation of t lymphocytes IL125884A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61071096A 1996-03-04 1996-03-04
PCT/US1997/003293 WO1997032970A1 (en) 1996-03-04 1997-03-03 Modified rapid expansion methods ('modified-rem') for in vitro propagation of t lymphocytes

Publications (1)

Publication Number Publication Date
IL125884A0 true IL125884A0 (en) 1999-04-11

Family

ID=24446115

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12588497A IL125884A0 (en) 1996-03-04 1997-03-03 Modified rapid expansion methods ("modified-rem") for in vitro propagation of t lymphocytes

Country Status (4)

Country Link
AU (1) AU726198B2 (xx)
CA (1) CA2247131A1 (xx)
IL (1) IL125884A0 (xx)
WO (1) WO1997032970A1 (xx)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4389039B2 (ja) * 1998-04-09 2009-12-24 株式会社リンフォテック アロジェニックな活性化ｃｄ４陽性細胞を主成分とする医薬組成物、およびその製造方法、ならびに該医薬組成物調製用キット
US7541184B2 (en) 2000-02-24 2009-06-02 Invitrogen Corporation Activation and expansion of cells
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
CN1222612C (zh) * 2000-08-16 2005-10-12 宝生物工程株式会社 抗原特异细胞毒性t细胞的扩大培养方法
EP2016930B1 (en) * 2001-02-20 2014-10-15 Janssen Pharmaceuticals, Inc. CD8 cell suspension for use in the treatment of melanoma
US20040071671A1 (en) 2001-02-20 2004-04-15 Leturcq Didier J. Cell therapy method for the treatment of tumors
DE10120505A1 (de) * 2001-04-26 2002-11-07 Rudolf Wank Verwendung von stimulierten mononukleären Zellen des peripheren Blutes zur Behandlung von Krebserkrankungen
WO2003016511A1 (fr) * 2001-08-15 2003-02-27 Takara Bio Inc. Procede permettant une culture etendue de lymphocytes t cytotoxiques specifiques d'un antigene
ES2397319T3 (es) 2002-03-25 2013-03-06 Takara Bio Inc. Proceso para producir linfocitos citotóxicos
JP4562353B2 (ja) * 2002-04-08 2010-10-13 株式会社リンフォテック Ｈｌａ一致他人由来活性化リンパ球を含有してなる腫瘍・感染症および自己免疫疾患の予防・治療用製剤
US20050084967A1 (en) 2002-06-28 2005-04-21 Xcyte Therapies, Inc. Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
EP1596871A4 (en) 2003-02-28 2006-08-23 Drew M Pardoll T-CELL REGULATION
JP4870432B2 (ja) 2003-08-22 2012-02-08 タカラバイオ株式会社 細胞傷害性リンパ球の製造方法
KR101279172B1 (ko) 2005-08-17 2013-06-27 다카라 바이오 가부시키가이샤 림프구의 제조 방법
EP2028266A4 (en) 2006-06-09 2010-08-11 Takara Bio Inc Method of producing lymphocytes
EP2155873B1 (en) * 2007-05-23 2016-11-09 Sangamo BioSciences, Inc. Methods and compositions for increased transgene expression
US9834753B2 (en) * 2011-12-22 2017-12-05 Green Cross Labcell Method for producing natural killer cells, natural killer cells produced thereby, and composition for treating cancers and infectious diseases containing the same
EP3060059A4 (en) 2013-10-25 2017-11-01 Board of Regents, The University of Texas System Polyclonal gamma delta t cells for immunotherapy
LT3689899T (lt) 2014-04-25 2021-12-10 2Seventy Bio, Inc. Mnd promotorių chimerinių antigenų receptoriai
RU2741899C2 (ru) 2014-04-25 2021-01-29 Блубёрд Био, Инк. Улучшенные способы производства средств адоптивной клеточной терапии
RS61406B1 (sr) 2014-06-06 2021-03-31 Bluebird Bio Inc Poboljšane kompozicije t ćelija
SG10201900455YA (en) 2014-07-24 2019-02-27 Bluebird Bio Inc Bcma chimeric antigen receptors
KR101697473B1 (ko) 2014-11-26 2017-01-18 주식회사 녹십자랩셀 T 세포를 이용한 자연살해세포의 배양방법
CN107207598B (zh) 2014-12-12 2020-12-08 蓝鸟生物公司 Bcma嵌合抗原受体
WO2017099712A1 (en) 2015-12-07 2017-06-15 Bluebird Bio, Inc. Improved t cell compositions
NZ753088A (en) 2016-11-04 2025-05-30 2Seventy Bio Inc Anti-bcma car t cell compositions
KR102460173B1 (ko) 2017-05-26 2022-10-31 주식회사 지씨셀 형질전환된 t세포를 이용한 자연살해세포의 배양방법
KR102338957B1 (ko) 2018-11-14 2021-12-14 주식회사 지씨셀 형질전환된 t세포를 이용한 제대혈 유래 자연살해세포의 배양방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0348413A1 (en) * 1987-03-11 1990-01-03 The Children's Hospital, Incorporated Method for the generation of antigen-specific t cell lines and therapeutic use thereof
US5057423A (en) 1987-12-18 1991-10-15 University Of Pittsburgh Method for the preparation of pure LAK-active lymphocytes
ZA91463B (en) * 1990-01-25 1992-09-30 Bristol Myers Squibb Co Method of activating cytolytic activity of lymphocytes using anti-cd28 antibody
AU651397B2 (en) * 1990-09-28 1994-07-21 Fred Hutchinson Cancer Research Center Method for producing TH-independent cytotoxic T lymphocytes
CA2096222C (en) * 1990-11-13 1998-12-29 Stephen D. Lupton Bifunctional selectable fusion genes
DE4410136A1 (de) * 1993-03-31 1994-10-06 Boehringer Mannheim Gmbh Tumorizide T-Lymphozyten
US5827642A (en) * 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes

Also Published As

Publication number Publication date
WO1997032970A1 (en) 1997-09-12
CA2247131A1 (en) 1997-09-12
AU726198B2 (en) 2000-11-02
AU2194797A (en) 1997-09-22

Similar Documents

Publication Publication Date Title
IL125884A0 (en) Modified rapid expansion methods ("modified-rem") for in vitro propagation of t lymphocytes
PL329766A1 (en) Improvement in degree of inbreeding after in vitro insemination
PL335168A1 (en) Compositions for and methods of reducing intracocular hypertension
IL109008A0 (en) Immunoassy for determination of cells
AU6546996A (en) Cell growing device for in vitro cell population expansion
EP0902834A4 (en) STABLE AVIDIN COMPOSITION AND METHODS OF USE THEREOF
IL127912A0 (en) Method of activating dendritic cells
ZA964733B (en) Ob protein compositions and methods
PL327443A1 (en) Methods of and compositions for effecting synthesis of dioxolanic nucleosides of beta configuration
AU1367499A (en) Method and apparatus for producing karyotypes
IL92777A0 (en) Method and agent for the determination of maleimide groups
AU8068694A (en) Dendritic cell-specific antibodies and methods for their preparation
ZA9410099B (en) Methods of inhibiting fertility in women
AU4965797A (en) Process for producing nucleoside 5'-triphosphates and application of the same
EP0795027A4 (en) IN VITRO SYNTHESIS OF PROTEINS
HUP9902963A3 (en) Process for the preparation of amino alcohols and derivatives thereof
AU1685895A (en) Hematopoietic cell expansion and transplantation methods
AU3152797A (en) Methods for (in vitro) protein synthesis
HK1014555A (en) Rapid expansion method ("rem") for in vitro propagation of t lymphocytes
HUP9700441A2 (en) Process for producing and using of (3-alcoxy-phenyl)-magnesium-chlorides
AU6147396A (en) Long term maintenance of lymphocytes in vitro
AU5227898A (en) Method for detecting (in vitro) the transmembrane potential of the mitochondrion
IL117017A0 (en) Locating wedge for separating mass of articles
SG47484A1 (en) Methods of assaying dna-repairing enzymes and their alkylated derivatives
PL326269A1 (en) Method of and system for generating refrigeration capacity