IL112700A0 - Indole derivatives useful for treating estrogen-related neoplasms and disorders - Google Patents
Indole derivatives useful for treating estrogen-related neoplasms and disordersInfo
- Publication number
- IL112700A0 IL112700A0 IL11270095A IL11270095A IL112700A0 IL 112700 A0 IL112700 A0 IL 112700A0 IL 11270095 A IL11270095 A IL 11270095A IL 11270095 A IL11270095 A IL 11270095A IL 112700 A0 IL112700 A0 IL 112700A0
- Authority
- IL
- Israel
- Prior art keywords
- indole derivatives
- derivatives useful
- disorders
- neoplasms
- treating estrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20005794A | 1994-02-22 | 1994-02-22 | |
| US36204694A | 1994-12-22 | 1994-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL112700A0 true IL112700A0 (en) | 1995-05-26 |
Family
ID=26895427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11270095A IL112700A0 (en) | 1994-02-22 | 1995-02-20 | Indole derivatives useful for treating estrogen-related neoplasms and disorders |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5877202A (es) |
| EP (1) | EP0746544B1 (es) |
| JP (1) | JP3536258B2 (es) |
| KR (1) | KR100362864B1 (es) |
| CN (1) | CN1141627A (es) |
| AT (1) | ATE170839T1 (es) |
| AU (1) | AU680740B2 (es) |
| CA (1) | CA2183731C (es) |
| DE (1) | DE69504637T2 (es) |
| DK (1) | DK0746544T3 (es) |
| ES (1) | ES2122555T3 (es) |
| FI (1) | FI963272L (es) |
| HU (1) | HUT76133A (es) |
| IL (1) | IL112700A0 (es) |
| NO (1) | NO963483L (es) |
| NZ (1) | NZ281431A (es) |
| WO (1) | WO1995022524A1 (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5880137A (en) * | 1996-04-19 | 1999-03-09 | American Home Products Corporation | 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents |
| TW397821B (en) * | 1996-04-19 | 2000-07-11 | American Home Produits Corp | 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof |
| AU6015098A (en) * | 1997-02-24 | 1998-09-09 | Cornell Research Foundation Inc. | Method of screening agents as candidates for drugs or sources of drugs |
| US6150395A (en) | 1997-05-30 | 2000-11-21 | The Regents Of The University Of California | Indole-3-carbinol (I3C) derivatives and methods |
| US6069153A (en) * | 1998-05-12 | 2000-05-30 | American Home Products Corporation | Indenoindoles and benzocarbazoles as estrogenic agents |
| AU3894299A (en) * | 1998-05-15 | 1999-12-06 | American Home Products Corporation | Compositions comprising 2-phenyl-indole compounds and estrogen formulations |
| US6479535B1 (en) | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
| US6207700B1 (en) * | 1999-01-07 | 2001-03-27 | Vanderbilt University | Amide derivatives for antiangiogenic and/or antitumorigenic use |
| US6159959A (en) * | 1999-05-06 | 2000-12-12 | American Home Products Corporation | Combined estrogen and antiestrogen therapy |
| WO2001019839A1 (en) * | 1999-09-13 | 2001-03-22 | American Home Products Corporation | Glucopyranosides conjugates of 2-(4-hydroxy-phenyl)-1-[4-(2-amin-1-yl-ethoxy)-benzyl]-1h-indol-5-ols |
| DE19962300A1 (de) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung |
| EP1254115A2 (en) * | 2000-02-11 | 2002-11-06 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases |
| US20020013327A1 (en) * | 2000-04-18 | 2002-01-31 | Lee Andrew G. | Compositions and methods for treating female sexual dysfunction |
| US6326501B1 (en) * | 2000-04-19 | 2001-12-04 | Hoffmann-La Roche Inc. | Methylation of indole compounds using dimethyl carbonate |
| EP1324985A4 (en) * | 2000-10-02 | 2004-10-06 | Merck & Co Inc | PRENYL PROTEIN TRANSFERASE INHIBITORS |
| US20030130199A1 (en) * | 2001-06-27 | 2003-07-10 | Von Hoersten Stephan | Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents |
| FR2842526B1 (fr) | 2002-07-16 | 2007-07-13 | Aventis Pharma Sa | Compositions pharmaceutiques contenant un derive de 3-guanidinocarbonyl-1-heteroaryl-indole, procede de preparation a titre de medicaments |
| CA2519899A1 (en) * | 2003-03-27 | 2004-10-14 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
| WO2005112921A2 (en) | 2004-04-26 | 2005-12-01 | Vanderbilt University | Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity |
| US8765488B2 (en) | 2004-07-22 | 2014-07-01 | The Board Of Trustees Of The University Of Illinois | Sensors employing single-walled carbon nanotubes |
| AU2006318212C1 (en) | 2005-11-23 | 2012-08-30 | The Board Of Regents Of The University Of Texas System | Oncogenic ras-specific cytotoxic compound and methods of use thereof |
| JP5758395B2 (ja) | 2009-10-15 | 2015-08-05 | ザ チルドレンズ メディカル センター コーポレイション | 疼痛を治療するためのセピアプテリンレダクターゼ阻害薬 |
| CN107098807B (zh) | 2010-08-30 | 2020-07-10 | 阿泽达公司 | 用于生产乙酰丙酸、乙酰丙酸酯、戊内酯、以及其衍生物的发酵路径 |
| US9346803B2 (en) | 2011-10-17 | 2016-05-24 | Vanderbilt University | Indomethacin analogs for the treatment of castrate-resistant prostate cancer |
| ES2802251T3 (es) | 2012-01-06 | 2021-01-18 | Novartis Ag | Compuestos heterocíclicos y métodos para su uso |
| EP2778161B1 (en) * | 2012-03-05 | 2015-05-06 | Dalian University Of Technology | Two-photon fluorescent probe using naphthalene as matrix and preparation method and use thereof |
| TWI854164B (zh) | 2016-02-01 | 2024-09-01 | 美商百歐克斯製藥公司 | 苯并吡唑化合物及其類似物 |
| JP7161475B2 (ja) * | 2016-12-28 | 2022-10-26 | プロメガ コーポレイション | 官能化ｎａｎｏｌｕｃ阻害剤 |
| EP4334285A4 (en) * | 2021-05-05 | 2025-07-30 | Kare Chemical Tech Inc | CATALYTIC TRYPTAMINE PROCESSES AND PRECURSORS |
| CN116410120A (zh) * | 2023-04-19 | 2023-07-11 | 四川农业大学 | 一种2-苯基吲哚酰胺类抗肿瘤化合物及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1482845A (fr) * | 1964-12-31 | 1967-06-02 | Merck & Co Inc | Composés de l'indol |
| DE69016760T2 (de) * | 1989-12-04 | 1995-07-06 | Searle & Co | Heterozyklische Acylaminodiol-beta-aminosäure-Derivate. |
| EP0518961A1 (fr) * | 1990-03-07 | 1992-12-23 | Aventis Pharma S.A. | Derives de glycinamide, leur preparation et les medicaments les contenant |
| US5312928A (en) * | 1991-02-11 | 1994-05-17 | Cambridge Neuroscience | Calcium channel antagonists and methodology for their identification |
| AU665690B2 (en) * | 1992-05-08 | 1996-01-11 | Otsuka Pharmaceutical Factory, Inc. | Indole derivative |
| JPH0835029A (ja) * | 1994-07-19 | 1996-02-06 | Toyota Motor Corp | 高強度高延性鋳造アルミニウム合金およびその製造方法 |
-
1995
- 1995-01-31 HU HU9602299A patent/HUT76133A/hu unknown
- 1995-01-31 FI FI963272A patent/FI963272L/fi unknown
- 1995-01-31 NZ NZ281431A patent/NZ281431A/en unknown
- 1995-01-31 AT AT95910164T patent/ATE170839T1/de not_active IP Right Cessation
- 1995-01-31 KR KR1019960704579A patent/KR100362864B1/ko not_active Expired - Fee Related
- 1995-01-31 AU AU18373/95A patent/AU680740B2/en not_active Ceased
- 1995-01-31 ES ES95910164T patent/ES2122555T3/es not_active Expired - Lifetime
- 1995-01-31 WO PCT/US1995/001372 patent/WO1995022524A1/en not_active Ceased
- 1995-01-31 JP JP52182295A patent/JP3536258B2/ja not_active Expired - Lifetime
- 1995-01-31 CN CN95191750A patent/CN1141627A/zh active Pending
- 1995-01-31 EP EP95910164A patent/EP0746544B1/en not_active Expired - Lifetime
- 1995-01-31 CA CA002183731A patent/CA2183731C/en not_active Expired - Lifetime
- 1995-01-31 DE DE69504637T patent/DE69504637T2/de not_active Expired - Lifetime
- 1995-01-31 DK DK95910164T patent/DK0746544T3/da active
- 1995-02-20 IL IL11270095A patent/IL112700A0/xx unknown
-
1996
- 1996-01-31 US US08/594,505 patent/US5877202A/en not_active Expired - Lifetime
- 1996-08-21 NO NO963483A patent/NO963483L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0746544B1 (en) | 1998-09-09 |
| ES2122555T3 (es) | 1998-12-16 |
| FI963272A0 (fi) | 1996-08-21 |
| EP0746544A1 (en) | 1996-12-11 |
| DK0746544T3 (da) | 1999-06-07 |
| CA2183731C (en) | 2000-03-21 |
| ATE170839T1 (de) | 1998-09-15 |
| FI963272A7 (fi) | 1996-08-21 |
| NO963483D0 (no) | 1996-08-21 |
| JPH09509169A (ja) | 1997-09-16 |
| NO963483L (no) | 1996-10-22 |
| NZ281431A (en) | 1997-09-22 |
| KR100362864B1 (ko) | 2003-04-16 |
| CN1141627A (zh) | 1997-01-29 |
| AU1837395A (en) | 1995-09-04 |
| US5877202A (en) | 1999-03-02 |
| DE69504637T2 (de) | 1999-05-06 |
| CA2183731A1 (en) | 1995-08-24 |
| AU680740B2 (en) | 1997-08-07 |
| DE69504637D1 (de) | 1998-10-15 |
| JP3536258B2 (ja) | 2004-06-07 |
| FI963272L (fi) | 1996-08-21 |
| HUT76133A (en) | 1997-06-30 |
| HU9602299D0 (en) | 1996-10-28 |
| WO1995022524A1 (en) | 1995-08-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC | Change of name of proprietor(s) |
Owner name: AVENTIS INC. Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC. |