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IL111467A0 - Pharmaceutical compositions comprising 7 beta -substituted -4-aza 5 alpha -cholestan-3-ones and 5 alpha reductase 1 inhibitors - Google Patents

Pharmaceutical compositions comprising 7 beta -substituted -4-aza 5 alpha -cholestan-3-ones and 5 alpha reductase 1 inhibitors

Info

Publication number
IL111467A0
IL111467A0 IL11146794A IL11146794A IL111467A0 IL 111467 A0 IL111467 A0 IL 111467A0 IL 11146794 A IL11146794 A IL 11146794A IL 11146794 A IL11146794 A IL 11146794A IL 111467 A0 IL111467 A0 IL 111467A0
Authority
IL
Israel
Prior art keywords
alpha
cholestan
aza
inhibitors
beta
Prior art date
Application number
IL11146794A
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL111467A0 publication Critical patent/IL111467A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
IL11146794A 1993-11-12 1994-10-31 Pharmaceutical compositions comprising 7 beta -substituted -4-aza 5 alpha -cholestan-3-ones and 5 alpha reductase 1 inhibitors IL111467A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15300693A 1993-11-12 1993-11-12

Publications (1)

Publication Number Publication Date
IL111467A0 true IL111467A0 (en) 1994-12-29

Family

ID=22545401

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11146794A IL111467A0 (en) 1993-11-12 1994-10-31 Pharmaceutical compositions comprising 7 beta -substituted -4-aza 5 alpha -cholestan-3-ones and 5 alpha reductase 1 inhibitors

Country Status (4)

Country Link
AU (1) AU8133294A (en)
IL (1) IL111467A0 (en)
WO (1) WO1995013077A1 (en)
ZA (1) ZA948909B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9507663A (en) 1994-05-19 1997-10-07 Merck & Co Inc Process for oxidation of a delta-5-steroidal alkene to the corresponding delta-5-7-keto-steroidal alkene and compound
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
CA2199979A1 (en) * 1994-10-21 1996-05-02 Joanne Waldstreicher Combination method for acne treatment
CA2287924A1 (en) * 1997-05-07 1998-11-12 Novopharm Limited 4-aza-steroids as inhibitors of testosterone-5-alpha-reductase
US20080125403A1 (en) * 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
GB201102913D0 (en) 2011-02-18 2011-04-06 Univ Birmingham Novel therapeutic

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9006023D0 (en) * 1990-03-16 1990-05-09 Smithkline Beecham Corp Synergistic compositions
EP0555309A1 (en) * 1990-10-31 1993-08-18 BEECHAM GROUP plc Topical composition with retinoid penetration enhancer
IL101245A0 (en) * 1991-03-20 1992-11-15 Merck & Co Inc Pharmaceutical compositions for the treatment of prostatic cancer
HUT71484A (en) * 1992-05-20 1995-11-28 Merck & Co Inc Process for producing of 7beta-substituted-4-aza-5alpha-cholestan-ones as 5-alpha-reductase inhibitors and pharmaceuticals compositions containing them
US5237064A (en) * 1992-05-20 1993-08-17 Merck & Co., Inc. Process for producing 7β-substituted-aza-5αandrostan-3-ones

Also Published As

Publication number Publication date
WO1995013077A1 (en) 1995-05-18
ZA948909B (en) 1995-10-10
AU8133294A (en) 1995-05-29

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