IL117474A - Removable precise dosing unit containing inhaled drugs for a hearing aid device - Google Patents

Removable precise dosing unit containing inhaled drugs for a hearing aid device

Info

Publication number: IL117474A
Authority: IL; Israel
Prior art keywords: dosating unit; unit according; dosating; plunger; housing
Prior art date: 1995-03-14

Application number

IL11747496A

Other languages

English (en)

Hebrew (he)

Other versions

IL117474A0 (en

Original Assignee

Siemens Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-14

Filing date

1996-03-14

Publication date

2001-04-30

1996-03-14 Application filed by Siemens Ag filed Critical Siemens Ag

1996-07-23 Publication of IL117474A0 publication Critical patent/IL117474A0/xx

2001-04-30 Publication of IL117474A publication Critical patent/IL117474A/en

Links

239000003814 drug Substances 0.000 title description 69
239000003708 ampul Substances 0.000 claims abstract description 33
239000012530 fluid Substances 0.000 claims abstract description 29
230000033001 locomotion Effects 0.000 claims abstract description 20
239000007788 liquid Substances 0.000 claims description 37
230000007246 mechanism Effects 0.000 claims description 14
238000007789 sealing Methods 0.000 claims description 10
230000005540 biological transmission Effects 0.000 claims description 9
229920001971 elastomer Polymers 0.000 claims description 9
238000011109 contamination Methods 0.000 claims description 5
239000002991 molded plastic Substances 0.000 claims description 2
239000007787 solid Substances 0.000 claims description 2
238000000889 atomisation Methods 0.000 abstract description 32
230000008878 coupling Effects 0.000 abstract description 17
238000010168 coupling process Methods 0.000 abstract description 17
238000005859 coupling reaction Methods 0.000 abstract description 17
239000003795 chemical substances by application Substances 0.000 abstract description 7
230000000694 effects Effects 0.000 abstract description 4
230000000572 bronchospasmolytic effect Effects 0.000 abstract description 3
238000002604 ultrasonography Methods 0.000 abstract 1
230000004913 activation Effects 0.000 description 13
239000011521 glass Substances 0.000 description 12
229940079593 drug Drugs 0.000 description 9
230000008901 benefit Effects 0.000 description 7
238000003860 storage Methods 0.000 description 6
239000000443 aerosol Substances 0.000 description 5
238000004140 cleaning Methods 0.000 description 5
230000013011 mating Effects 0.000 description 5
150000003839 salts Chemical class 0.000 description 5
230000008859 change Effects 0.000 description 4
238000010586 diagram Methods 0.000 description 4
239000000463 material Substances 0.000 description 4
JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 3
230000002411 adverse Effects 0.000 description 3
NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 3
239000005557 antagonist Substances 0.000 description 3
229940124630 bronchodilator Drugs 0.000 description 3
229960000265 cromoglicic acid Drugs 0.000 description 3
VLARUOGDXDTHEH-UHFFFAOYSA-L disodium cromoglycate Chemical compound [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C([O-])=O)O2 VLARUOGDXDTHEH-UHFFFAOYSA-L 0.000 description 3
239000007789 gas Substances 0.000 description 3
239000000314 lubricant Substances 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
239000012528 membrane Substances 0.000 description 3
229910052751 metal Inorganic materials 0.000 description 3
239000002184 metal Substances 0.000 description 3
238000000034 method Methods 0.000 description 3
238000003825 pressing Methods 0.000 description 3
239000012858 resilient material Substances 0.000 description 3
229960002052 salbutamol Drugs 0.000 description 3
LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 description 2
208000006673 asthma Diseases 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
229960001022 fenoterol Drugs 0.000 description 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
229960001317 isoprenaline Drugs 0.000 description 2
230000007257 malfunction Effects 0.000 description 2
239000000203 mixture Substances 0.000 description 2
230000008569 process Effects 0.000 description 2
229960002720 reproterol Drugs 0.000 description 2
WVLAAKXASPCBGT-UHFFFAOYSA-N reproterol Chemical compound C1=2C(=O)N(C)C(=O)N(C)C=2N=CN1CCCNCC(O)C1=CC(O)=CC(O)=C1 WVLAAKXASPCBGT-UHFFFAOYSA-N 0.000 description 2
229920002379 silicone rubber Polymers 0.000 description 2
239000004945 silicone rubber Substances 0.000 description 2
239000000243 solution Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
-1 terbuteline Chemical compound 0.000 description 2
238000013519 translation Methods 0.000 description 2
229960005486 vaccine Drugs 0.000 description 2
238000009423 ventilation Methods 0.000 description 2
239000002699 waste material Substances 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
PDNHLCRMUIGNBV-UHFFFAOYSA-N 1-pyridin-2-ylethanamine Chemical compound CC(N)C1=CC=CC=N1 PDNHLCRMUIGNBV-UHFFFAOYSA-N 0.000 description 1
KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 description 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 description 1
201000003883 Cystic fibrosis Diseases 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
229940122459 Glutamate antagonist Drugs 0.000 description 1
229920000544 Gore-Tex Polymers 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
208000026350 Inborn Genetic disease Diseases 0.000 description 1
102000004877 Insulin Human genes 0.000 description 1
108090001061 Insulin Proteins 0.000 description 1
102000036770 Islet Amyloid Polypeptide Human genes 0.000 description 1
108010041872 Islet Amyloid Polypeptide Proteins 0.000 description 1
239000000867 Lipoxygenase Inhibitor Substances 0.000 description 1
229940121948 Muscarinic receptor antagonist Drugs 0.000 description 1
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 description 1
208000027771 Obstructive airways disease Diseases 0.000 description 1
GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 description 1
229910000831 Steel Inorganic materials 0.000 description 1
229920006362 Teflon® Polymers 0.000 description 1
DXEXNWDGDYUITL-FXSSSKFRSA-N Tipredane Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1CC[C@@](SC)(SCC)[C@@]1(C)C[C@@H]2O DXEXNWDGDYUITL-FXSSSKFRSA-N 0.000 description 1
OEXHQOGQTVQTAT-BZQJJPTISA-N [(1s,5r)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate Chemical compound C([C@H]1CC[C@@H](C2)[N+]1(C)C(C)C)C2OC(=O)C(CO)C1=CC=CC=C1 OEXHQOGQTVQTAT-BZQJJPTISA-N 0.000 description 1
230000009471 action Effects 0.000 description 1
230000003213 activating effect Effects 0.000 description 1
239000000556 agonist Substances 0.000 description 1
239000002386 air freshener Substances 0.000 description 1
239000003194 amino acid receptor blocking agent Substances 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000002421 anti-septic effect Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
229940125715 antihistaminic agent Drugs 0.000 description 1
239000000739 antihistaminic agent Substances 0.000 description 1
230000003190 augmentative effect Effects 0.000 description 1
229950000210 beclometasone dipropionate Drugs 0.000 description 1
230000033228 biological regulation Effects 0.000 description 1
239000003152 bradykinin antagonist Substances 0.000 description 1
239000000168 bronchodilator agent Substances 0.000 description 1
229960004436 budesonide Drugs 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
239000000812 cholinergic antagonist Substances 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
239000003086 colorant Substances 0.000 description 1
238000010276 construction Methods 0.000 description 1
230000001276 controlling effect Effects 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
230000007423 decrease Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
239000002781 deodorant agent Substances 0.000 description 1
239000000645 desinfectant Substances 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
210000005069 ears Anatomy 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
229940088598 enzyme Drugs 0.000 description 1
229960002714 fluticasone Drugs 0.000 description 1
MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 description 1
238000001415 gene therapy Methods 0.000 description 1
208000016361 genetic disease Diseases 0.000 description 1
239000008266 hair spray Substances 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
238000005286 illumination Methods 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
229940125396 insulin Drugs 0.000 description 1
229960001361 ipratropium bromide Drugs 0.000 description 1
KEWHKYJURDBRMN-ZEODDXGYSA-M ipratropium bromide hydrate Chemical compound O.[Br-].O([C@H]1C[C@H]2CC[C@@H](C1)[N@@+]2(C)C(C)C)C(=O)C(CO)C1=CC=CC=C1 KEWHKYJURDBRMN-ZEODDXGYSA-M 0.000 description 1
229940039009 isoproterenol Drugs 0.000 description 1
230000002045 lasting effect Effects 0.000 description 1
239000003199 leukotriene receptor blocking agent Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
239000003120 macrolide antibiotic agent Substances 0.000 description 1
230000002906 microbiologic effect Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000000465 moulding Methods 0.000 description 1
229960004398 nedocromil Drugs 0.000 description 1
RQTOOFIXOKYGAN-UHFFFAOYSA-N nedocromil Chemical class CCN1C(C(O)=O)=CC(=O)C2=C1C(CCC)=C1OC(C(O)=O)=CC(=O)C1=C2 RQTOOFIXOKYGAN-UHFFFAOYSA-N 0.000 description 1
229960002259 nedocromil sodium Drugs 0.000 description 1
XDRYMKDFEDOLFX-UHFFFAOYSA-N pentamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCOC1=CC=C(C(N)=N)C=C1 XDRYMKDFEDOLFX-UHFFFAOYSA-N 0.000 description 1
229960004448 pentamidine Drugs 0.000 description 1
230000002572 peristaltic effect Effects 0.000 description 1
239000013612 plasmid Substances 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229960001539 poliomyelitis vaccine Drugs 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
239000003380 propellant Substances 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
230000001141 propulsive effect Effects 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000000246 remedial effect Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
229960001225 rifampicin Drugs 0.000 description 1
229960004017 salmeterol Drugs 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000010959 steel Substances 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
229920003002 synthetic resin Polymers 0.000 description 1
239000000057 synthetic resin Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
229950001669 tipredane Drugs 0.000 description 1
238000012546 transfer Methods 0.000 description 1
229960002117 triamcinolone acetonide Drugs 0.000 description 1
YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
239000013598 vector Substances 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
- B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
- B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
- B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
- A61M11/007—Syringe-type or piston-type sprayers or atomisers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0085—Inhalators using ultrasonics

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Anesthesiology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Bioinformatics & Cheminformatics (AREA)
Mechanical Engineering (AREA)
Biophysics (AREA)
Infusion, Injection, And Reservoir Apparatuses (AREA)
Special Spraying Apparatus (AREA)
Catching Or Destruction (AREA)
Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
Sanitary Device For Flush Toilet (AREA)
Medicinal Preparation (AREA)

IL11747496A 1995-03-14 1996-03-14 Removable precise dosing unit containing inhaled drugs for a hearing aid device IL117474A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19509193		1995-03-14
DE19509194		1995-03-14

Publications (2)

Publication Number	Publication Date
IL117474A0 IL117474A0 (en)	1996-07-23
IL117474A true IL117474A (en)	2001-04-30

Family

ID=26013358

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11747496A IL117474A (en)	1995-03-14	1996-03-14	Removable precise dosing unit containing inhaled drugs for a hearing aid device

Country Status (13)

Country	Link
US (1)	US5970974A (xx)
EP (1)	EP0814861B1 (xx)
JP (1)	JP3142577B2 (xx)
AT (1)	ATE218381T1 (xx)
AU (1)	AU701843B2 (xx)
CA (1)	CA2215248A1 (xx)
DE (1)	DE69621604T2 (xx)
DK (1)	DK0814861T3 (xx)
ES (1)	ES2177771T3 (xx)
IL (1)	IL117474A (xx)
NZ (1)	NZ304285A (xx)
PT (1)	PT814861E (xx)
WO (1)	WO1996028205A1 (xx)

Families Citing this family (220)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6540154B1 (en)	1991-04-24	2003-04-01	Aerogen, Inc.	Systems and methods for controlling fluid feed to an aerosol generator
US7628339B2 (en)	1991-04-24	2009-12-08	Novartis Pharma Ag	Systems and methods for controlling fluid feed to an aerosol generator
US6051256A (en)	1994-03-07	2000-04-18	Inhale Therapeutic Systems	Dispersible macromolecule compositions and methods for their preparation and use
EP0814860B1 (en) *	1995-03-14	1999-11-03	Siemens Aktiengesellschaft	Ultrasonic atomizer device with removable precision dosating unit
DK0814861T3 (da) *	1995-03-14	2002-10-07	Siemens Ag	Udskiftelig præcisionsdoseringsenhed til ultralydforstøveranordning
US5758637A (en)	1995-08-31	1998-06-02	Aerogen, Inc.	Liquid dispensing apparatus and methods
US6085740A (en) *	1996-02-21	2000-07-11	Aerogen, Inc.	Liquid dispensing apparatus and methods
US20030203036A1 (en)	2000-03-17	2003-10-30	Gordon Marc S.	Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
JP3386050B2 (ja) *	1997-10-06	2003-03-10	オムロン株式会社	噴霧装置
US6703050B1 (en) *	1998-09-04	2004-03-09	The Regents Of The University Of Michigan	Methods and compositions for the prevention or treatment of cancer
US6234167B1 (en)	1998-10-14	2001-05-22	Chrysalis Technologies, Incorporated	Aerosol generator and methods of making and using an aerosol generator
JP4267206B2 (ja) *	1998-10-29	2009-05-27	メドトロニックミニメドインコーポレイテッド	貯蔵器接続具
US6196218B1 (en) *	1999-02-24	2001-03-06	Ponwell Enterprises Ltd	Piezo inhaler
SE9902627D0 (sv)	1999-07-08	1999-07-08	Siemens Elema Ab	Medical nebulizer
US6235177B1 (en)	1999-09-09	2001-05-22	Aerogen, Inc.	Method for the construction of an aperture plate for dispensing liquid droplets
US6962151B1 (en) *	1999-11-05	2005-11-08	Pari GmbH Spezialisten für effektive Inhalation	Inhalation nebulizer
DE19953317C1 (de) *	1999-11-05	2001-02-01	Pari Gmbh	Inhalationsvernebler
US6302101B1 (en) *	1999-12-14	2001-10-16	Daniel Py	System and method for application of medicament into the nasal passage
TW441919U (en) *	2000-04-19	2001-06-16	High Tech Comp Corp	Protection cover
MY136453A (en)	2000-04-27	2008-10-31	Philip Morris Usa Inc	"improved method and apparatus for generating an aerosol"
US6883516B2 (en)	2000-04-27	2005-04-26	Chrysalis Technologies Incorporated	Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution
MXPA02010884A (es)	2000-05-05	2003-03-27	Aerogen Ireland Ltd	Aparato y metodo para el suministro de medicamentos al sistema respiratorio.
US7600511B2 (en)	2001-11-01	2009-10-13	Novartis Pharma Ag	Apparatus and methods for delivery of medicament to a respiratory system
US7100600B2 (en)	2001-03-20	2006-09-05	Aerogen, Inc.	Fluid filled ampoules and methods for their use in aerosolizers
US7971588B2 (en)	2000-05-05	2011-07-05	Novartis Ag	Methods and systems for operating an aerosol generator
US8336545B2 (en)	2000-05-05	2012-12-25	Novartis Pharma Ag	Methods and systems for operating an aerosol generator
US6948491B2 (en)	2001-03-20	2005-09-27	Aerogen, Inc.	Convertible fluid feed system with comformable reservoir and methods
US7575761B2 (en)	2000-06-30	2009-08-18	Novartis Pharma Ag	Spray drying process control of drying kinetics
US6629524B1 (en) *	2000-07-12	2003-10-07	Ponwell Enterprises Limited	Inhaler
US6543443B1 (en) *	2000-07-12	2003-04-08	Aerogen, Inc.	Methods and devices for nebulizing fluids
WO2002009669A2 (en) *	2000-08-01	2002-02-07	Inhale Therapeutic Systems, Inc.	Apparatus and process to produce particles having a narrow size distribution and particles made thereby
US6339107B1 (en)	2000-08-02	2002-01-15	Syntex (U.S.A.) Llc	Methods for treatment of Emphysema using 13-cis retinoic acid
US6443164B1 (en)	2000-09-22	2002-09-03	Spectrum Products, Inc.	Apparatus for automatic application of compositions to the skin
SE517229C2 (sv) *	2000-09-25	2002-05-14	Microdrug Ag	Kontinuerlig inhalator för torrt pulver
EP1935869A1 (en)	2000-10-02	2008-06-25	F. Hoffmann-La Roche Ag	Retinoids for the treatment of emphysema
US6701921B2 (en)	2000-12-22	2004-03-09	Chrysalis Technologies Incorporated	Aerosol generator having heater in multilayered composite and method of use thereof
US6681998B2 (en)	2000-12-22	2004-01-27	Chrysalis Technologies Incorporated	Aerosol generator having inductive heater and method of use thereof
US7077130B2 (en)	2000-12-22	2006-07-18	Chrysalis Technologies Incorporated	Disposable inhaler system
US6799572B2 (en)	2000-12-22	2004-10-05	Chrysalis Technologies Incorporated	Disposable aerosol generator system and methods for administering the aerosol
US6501052B2 (en)	2000-12-22	2002-12-31	Chrysalis Technologies Incorporated	Aerosol generator having multiple heating zones and methods of use thereof
US6491233B2 (en)	2000-12-22	2002-12-10	Chrysalis Technologies Incorporated	Vapor driven aerosol generator and method of use thereof
US20030072717A1 (en) *	2001-02-23	2003-04-17	Vapotronics, Inc.	Inhalation device having an optimized air flow path
AU2002247280A1 (en) *	2001-03-09	2002-09-24	Antares Pharma, Inc.	Ocular drug delivery nebulizer
EP1370318B1 (en)	2001-03-15	2005-07-20	The Government of the United States of America, as represented by the Secretary, Department of Health & Human Services	Systems and methods for aerosol delivery of agents
US6550472B2 (en) *	2001-03-16	2003-04-22	Aerogen, Inc.	Devices and methods for nebulizing fluids using flow directors
US6732944B2 (en)	2001-05-02	2004-05-11	Aerogen, Inc.	Base isolated nebulizing device and methods
EP1389137B1 (en) *	2001-05-21	2006-07-19	InJet Digital Aerosols Limited	Compositions for protein delivery via the pulmonary route
US6640050B2 (en)	2001-09-21	2003-10-28	Chrysalis Technologies Incorporated	Fluid vaporizing device having controlled temperature profile heater/capillary tube
US6568390B2 (en)	2001-09-21	2003-05-27	Chrysalis Technologies Incorporated	Dual capillary fluid vaporizing device
WO2003037303A1 (en) *	2001-11-01	2003-05-08	Nektar Therapeutics	Spray drying methods and compositions thereof
US6681769B2 (en)	2001-12-06	2004-01-27	Crysalis Technologies Incorporated	Aerosol generator having a multiple path heater arrangement and method of use thereof
US6804458B2 (en)	2001-12-06	2004-10-12	Chrysalis Technologies Incorporated	Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate
US6701922B2 (en)	2001-12-20	2004-03-09	Chrysalis Technologies Incorporated	Mouthpiece entrainment airflow control for aerosol generators
US7677467B2 (en)	2002-01-07	2010-03-16	Novartis Pharma Ag	Methods and devices for aerosolizing medicament
JP4477355B2 (ja)	2002-01-07	2010-06-09	エアロジェン，インコーポレイテッド	吸入のために流体を噴霧するためのデバイスおよび方法
US20040009953A1 (en) *	2002-01-10	2004-01-15	Comper Wayne D.	Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof
US20030181416A1 (en) *	2002-01-10	2003-09-25	Comper Wayne D.	Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof
WO2003059424A1 (en) *	2002-01-15	2003-07-24	Aerogen, Inc.	Methods and systems for operating an aerosol generator
USD481795S1 (en)	2002-03-26	2003-11-04	Rajiv Dave	Dispensing instrument
USD482441S1 (en)	2002-03-26	2003-11-18	Rajiv Dave	Dispensing controller
GB0216562D0 (en)	2002-04-25	2002-08-28	Bradford Particle Design Ltd	Particulate materials
US9339459B2 (en)	2003-04-24	2016-05-17	Nektar Therapeutics	Particulate materials
AU2003222642A1 (en) *	2002-05-10	2003-11-11	Chrysalis Technologies Incorporated	Aerosol generator for drug formulation and methods of generating aerosol
US6915962B2 (en)	2002-05-20	2005-07-12	Aerogen, Inc.	Apparatus for providing aerosol for medical treatment and methods
USD492769S1 (en)	2002-05-24	2004-07-06	Glaxosmithkline K.K.	Lens for an inhaler
US7189865B2 (en) *	2002-07-23	2007-03-13	Attenuon, Llc	Thiomolybdate analogues and uses thereof
CA2493341A1 (en)	2002-07-23	2004-01-29	The Regents Of The University Of Michigan	Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies
AU2003276988B2 (en) *	2002-09-27	2009-11-05	Bioenvision, Inc.	Methods and compositions for the treatment of autoimmune disorders using clofarabine
US20060135463A1 (en) *	2002-09-27	2006-06-22	Wood Christopher B	Methods and compositions for the treatment of lupus using clofarabine
WO2004032864A2 (en) *	2002-10-07	2004-04-22	Radiorx, Inc.	X-nitro compounds, pharmaceutical compositions thereof and uses therof
US20040073186A1 (en) *	2002-10-15	2004-04-15	Cameron Mickey G.	Apparatus for automatic application of compositions to the skin
BR0316550A (pt) *	2002-11-25	2005-10-04	Attenuon Llc	Composto, composição farmacêutica, e, métodos para tratar ou prevenir câncer em um paciente, e para detectar câncer em um paciente
USD492771S1 (en)	2002-12-18	2004-07-06	Smithkline Beecham Corporation	Mouthpiece for an inhalation device
USD492993S1 (en)	2002-12-18	2004-07-13	Smith Kline Beecham	Mouthpiece for an inhalation device
KR20050088243A (ko)	2002-12-30	2005-09-02	넥타르 테라퓨틱스	프리필름화 분무기
ZA200504940B (en) *	2003-01-28	2006-09-27	Xenoport Inc	Amino acid derived prodrugs of propofol, compositions and uses thereof
US6969008B2 (en) *	2003-01-29	2005-11-29	S. C. Johnson & Son, Inc.	Point of purchase fragrance sampling
DE10306683A1 (de) *	2003-02-13	2004-09-09	Ing. Erich Pfeiffer Gmbh	Mikrodosiereinrichtung
NZ542671A (en)	2003-03-12	2008-12-24	Celgene Corp	7-Amido-isoindolyl compounds and their pharmaceutical uses
JP4259157B2 (ja) *	2003-03-25	2009-04-30	オムロンヘルスケア株式会社	液体アンプル容器
US6992096B2 (en)	2003-04-11	2006-01-31	Ptc Therapeutics, Inc.	1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
US8545463B2 (en)	2003-05-20	2013-10-01	Optimyst Systems Inc.	Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device
ATE501766T1 (de)	2003-05-20	2011-04-15	James F Collins	Ophthalmisches arzneimittelabgabesystem
AU2004247059A1 (en) *	2003-05-27	2004-12-23	Attenuon L.L.C.	Thiotungstate analogues and uses thereof
US20050009782A1 (en) *	2003-07-09	2005-01-13	Comper Wayne D.	Antiviral charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and methods of use thereof
US8616195B2 (en)	2003-07-18	2013-12-31	Novartis Ag	Nebuliser for the production of aerosolized medication
US7367334B2 (en)	2003-08-27	2008-05-06	Philip Morris Usa Inc.	Fluid vaporizing device having controlled temperature profile heater/capillary tube
WO2005023204A2 (en) *	2003-09-09	2005-03-17	Xenoport, Inc.	Aromatic prodrugs of propofol, compositions and uses thereof
CA2546493A1 (en)	2003-11-19	2005-06-09	Signal Pharmaceuticals, Llc	Indazole compounds and methods of use thereof as protein kinase inhibitors
US7723899B2 (en)	2004-02-03	2010-05-25	S.C. Johnson & Son, Inc.	Active material and light emitting device
US7538473B2 (en) *	2004-02-03	2009-05-26	S.C. Johnson & Son, Inc.	Drive circuits and methods for ultrasonic piezoelectric actuators
DE102004006451B4 (de) *	2004-02-05	2010-01-28	Ing. Erich Pfeiffer Gmbh	Mikrodosiervorrichtung
EP1729784A1 (en) *	2004-02-23	2006-12-13	Attenuon, LLC	Formulations of thiomolybdate or thiotungstate compounds and uses thereof
CA2561845C (en) *	2004-04-02	2014-03-25	The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention	Aerosol delivery systems and methods
GB2412870A (en) *	2004-04-07	2005-10-12	Reckitt Benckiser	Electronic drive system for a droplet spray generation device
US7290541B2 (en)	2004-04-20	2007-11-06	Aerogen, Inc.	Aerosol delivery apparatus and method for pressure-assisted breathing systems
US7946291B2 (en)	2004-04-20	2011-05-24	Novartis Ag	Ventilation systems and methods employing aerosol generators
US7267121B2 (en)	2004-04-20	2007-09-11	Aerogen, Inc.	Aerosol delivery apparatus and method for pressure-assisted breathing systems
WO2005102058A2 (en) *	2004-04-23	2005-11-03	Mystic Pharmaceuticals, Inc.	Multiple unit dose drug delivery system
USD533658S1 (en)	2004-05-20	2006-12-12	James F. Collins, Jr.	Misting device
PT1781596E (pt) *	2004-07-12	2009-01-12	Xenoport Inc	Pró-fármacos de propofol derivados de aminoácidos, composições e utilizações dos mesmos
US7241807B2 (en) *	2004-07-12	2007-07-10	Xenoport, Inc.	Prodrugs of propofol, compositions and uses thereof
US20060128676A1 (en) *	2004-07-13	2006-06-15	Pharmacofore, Inc.	Compositions of nicotinic agonists and therapeutic agents and methods for treating or preventing diseases or pain
DK1824482T3 (en)	2004-12-17	2014-03-24	Anadys Pharmaceuticals Inc	AND 3,5-disubstituted 3,5,7-trisubstituted-3H-oxazolo AND 3H-thiazolo [4,5-d] pyrimidin-2-one compounds and prodrugs thereof
ATE456552T1 (de) *	2004-12-23	2010-02-15	Xenoport Inc	Von serinaminosäure abgeleitete prodrugs von propofol, zusammensetzungen, anwendungen und kristalline formen davon
EP1853389A2 (en) *	2005-02-25	2007-11-14	Battelle Memorial Institute	Spray indication
KR101314052B1 (ko)	2005-05-25	2013-10-02	노바르티스 아게	진동 시스템 및 방법
AU2006272922A1 (en)	2005-07-22	2007-02-01	Amgen Inc.	Aniline sulfonamide derivatives and their uses
US9101949B2 (en)	2005-08-04	2015-08-11	Eilaz Babaev	Ultrasonic atomization and/or seperation system
US20070031611A1 (en) *	2005-08-04	2007-02-08	Babaev Eilaz P	Ultrasound medical stent coating method and device
US7507842B2 (en)	2005-08-12	2009-03-24	Radiorx, Inc.	Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof
US20070135380A1 (en)	2005-08-12	2007-06-14	Radiorx, Inc.	O-nitro compounds, pharmaceutical compositions thereof and uses thereof
DE102005038619A1 (de) *	2005-08-16	2007-02-22	Pari GmbH Spezialisten für effektive Inhalation	Inhalationstherapievorrichtung mit einer Ampulle für die Bevorratung eines zu vernebelnden Medikaments
WO2007022535A2 (en)	2005-08-19	2007-02-22	Pharmacofore, Inc.	Prodrugs of active agents
JP2009530390A (ja) *	2006-03-23	2009-08-27	アムゲンインコーポレイティッド	１−フェニルスルホニル−ジアザ複素環アミド化合物およびヒドロキシステロイドデヒドロゲナーゼ調節因子としてのその使用
US7909033B2 (en)	2006-05-03	2011-03-22	Comedica Incorporated	Breathing treatment apparatus
SG172633A1 (en)	2006-05-26	2011-07-28	Pharmacofore Inc	Controlled release of phenolic opioids
EP2029540B1 (en) *	2006-06-08	2010-08-04	Amgen Inc.	Benzamide derivatives and uses related thereto
TW200808695A (en) *	2006-06-08	2008-02-16	Amgen Inc	Benzamide derivatives and uses related thereto
US7462611B2 (en)	2006-06-22	2008-12-09	Anadys Pharmaceuticals, Inc.	Pyrro[1,2-b]pyridazinone compounds
JP5345527B2 (ja)	2006-06-22	2013-11-20	アナディスファーマシューティカルズインク	プロドラッグである５−アミノ−３−（３’−デオキシ−β−Ｄ−リボフラノシル）−チアゾロ［４，５−ｄ］ピリミジン−２，７−ジオン
DE102006030833A1 (de) *	2006-07-04	2008-01-10	Pari GmbH Spezialisten für effektive Inhalation	Verfahren und Vorrichtung für die Reinigung der Verneblermembran in einem Inhalationstherapiegerät
JP5225991B2 (ja)	2006-07-18	2013-07-03	アナディスファーマシューティカルズインク	チアゾロ［４，５−ｄ］ピリミジンのカーボネート及びカルバメートプロドラッグ
CA2659155A1 (en) *	2006-07-20	2008-01-24	Amgen Inc.	Substituted azole aromatic heterocycles as inhibitors of 11.beta.-hsd-1
FR2905612B1 (fr) *	2006-09-12	2008-11-14	Oreal	Recharge pour appareil de pulverisation
US8051854B2 (en)	2006-09-15	2011-11-08	Comedica Incorporated	Continuous high-frequency oscillation breathing treatment apparatus
FR2910253B1 (fr) *	2006-12-20	2010-03-12	Oreal	Procede de distribution d'un produit pulverise par un systeme de pulverisation piezoelectrique et systeme de pulverisation pour la mise en oeuvre d'un tel procede
FR2910254B1 (fr) *	2006-12-20	2009-04-17	Oreal	Systeme de pulverisation piezoelectrique et recharge correspondante
WO2008088540A2 (en) *	2006-12-26	2008-07-24	Amgen Inc.	N-cyclohexyl benzamides and benzeneacetamides as inhibitors of 11-beta-hydroxysteroid dehydrogenases
BRPI0806474A2 (pt)	2007-01-09	2011-09-27	Mystic Pharmaceuticals Inc	dispositivos de cartucho intranasal
US7793861B2 (en) *	2007-01-17	2010-09-14	The Dial Corporation	Piston actuated vapor-dispersing device
US7793860B2 (en) *	2007-01-17	2010-09-14	The Dial Corporation	Piston actuated vapor-dispersing device
USD597206S1 (en)	2007-02-16	2009-07-28	Optimyst Systems, Inc.	Ophthalmic misting device
US8616199B2 (en) *	2007-03-16	2013-12-31	Canon Kabushiki Kaisha	Inhaler and ejection head unit attachable to the inhaler
US8683995B2 (en)	2007-05-16	2014-04-01	Mystic Pharmaceuticals, Inc.	Dose dispensing containers
US9248076B2 (en)	2007-05-16	2016-02-02	Mystic Pharmaceuticals, Inc.	Dose dispensing containers
US7669597B2 (en) *	2007-05-16	2010-03-02	Mystic Pharmaceuticals, Inc.	Combination unit dose dispensing containers
US9050434B2 (en)	2007-05-18	2015-06-09	Comedica Incorporated	Lung therapy device
US7928111B2 (en)	2007-06-08	2011-04-19	Senomyx, Inc.	Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US20080306076A1 (en) *	2007-06-08	2008-12-11	Senomyx, Inc.	Modulation of chemosensory receptors and ligands associated therewith
US8633186B2 (en) *	2007-06-08	2014-01-21	Senomyx Inc.	Modulation of chemosensory receptors and ligands associated therewith
US9603848B2 (en) *	2007-06-08	2017-03-28	Senomyx, Inc.	Modulation of chemosensory receptors and ligands associated therewith
US8268263B2 (en)	2007-09-06	2012-09-18	Siemens Healthcare Diagnostics Inc.	Reagent cartridge
US7963089B2 (en) *	2007-09-14	2011-06-21	Mystic Pharmaceuticals, Inc.	Deep draw container forming method
DE102007056462B4 (de) *	2007-11-23	2011-10-27	Pari Pharma Gmbh	Einwegampulle für eine Vorrichtung zur Erzeugung von Aerosolen
US8016208B2 (en)	2008-02-08	2011-09-13	Bacoustics, Llc	Echoing ultrasound atomization and mixing system
US7950594B2 (en) *	2008-02-11	2011-05-31	Bacoustics, Llc	Mechanical and ultrasound atomization and mixing system
US7830070B2 (en) *	2008-02-12	2010-11-09	Bacoustics, Llc	Ultrasound atomization system
WO2010014813A2 (en)	2008-07-31	2010-02-04	Senomyx, Inc.	Compositions comrpising sweetness enhancers and methods of making them
ES2915065T3 (es)	2008-07-31	2022-06-20	Firmenich Incorporated	Procedimientos para hacer potenciadores del sabor dulce
WO2010042834A1 (en)	2008-10-09	2010-04-15	Anadys Pharmaceuticals, Inc.	A method of inhibiting hepatitis c virus by combination of a 5,6-dihydro-1h-pyridin-2-one and one or more additional antiviral compounds
US9151425B2 (en)	2009-11-02	2015-10-06	Comedica Incorporated	Multiple conduit connector apparatus and method
WO2011055243A1 (en) *	2009-11-04	2011-05-12	Koninklijke Philips Electronics N.V.	Medication delivery apparatus including a medication metering system
US8471041B2 (en) *	2010-02-09	2013-06-25	Alliant Techsystems Inc.	Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same
KR101618933B1 (ko)	2010-05-18	2016-05-09	아이박스 파마슈티컬즈 아일랜드	흡입기용 용량 계수기, 흡입기 및 그의 샤프트
EP2593055A1 (en)	2010-07-15	2013-05-22	Corinthian Ophthalmic, Inc.	Method and system for performing remote treatment and monitoring
CN103118642B (zh)	2010-07-15	2015-09-09	艾诺维亚股份有限公司	液滴生成装置
US10154923B2 (en)	2010-07-15	2018-12-18	Eyenovia, Inc.	Drop generating device
CA2805425C (en)	2010-07-15	2019-07-23	Corinthian Ophthalmic, Inc.	Ophthalmic drug delivery
RU2576451C2 (ru)	2010-08-12	2016-03-10	Синомикс, Инк.	Способ улучшения стабильности усилителей сладкого вкуса и композиция, содержащая стабилизированный усилитель сладкого вкуса
US20120321590A1 (en)	2011-04-06	2012-12-20	Anadys Pharmaceuticals, Inc.	Bridged polycyclic compounds
JP5405533B2 (ja) *	2011-07-20	2014-02-05	パナソニック株式会社	ミスト発生装置及び美容装置
US8664247B2 (en)	2011-08-26	2014-03-04	Radiorx, Inc.	Acyclic organonitro compounds for use in treating cancer
EP2763667B1 (en)	2011-10-07	2022-10-26	EpicentRx, Inc.	Organonitro thioether compounds and medical uses thereof
US20140308260A1 (en)	2011-10-07	2014-10-16	Radiorx, Inc.	Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products
US20130150812A1 (en)	2011-12-12	2013-06-13	Corinthian Ophthalmic, Inc.	High modulus polymeric ejector mechanism, ejector device, and methods of use
RU2018129982A (ru)	2012-08-06	2019-03-15	Сеномикс, Инк.	Модификатор сладкого вкуса и аромата
EP2708219A1 (en) *	2012-09-12	2014-03-19	PARI Pharma GmbH	Opening element for opening an ampoule in an aerosol generation device and aerosol generation device comprising the opening element
US9795752B2 (en)	2012-12-03	2017-10-24	Mhs Care-Innovation, Llc	Combination respiratory therapy device, system, and method
US12080401B2 (en)	2012-12-03	2024-09-03	Metrohealth Ventures Llc	Combination respiratory therapy device, system and method
JO3155B1 (ar)	2013-02-19	2017-09-20	Senomyx Inc	معدِّل نكهة حلوة
US10292424B2 (en)	2013-10-31	2019-05-21	Rai Strategic Holdings, Inc.	Aerosol delivery device including a pressure-based aerosol delivery mechanism
US10307550B2 (en) *	2014-06-09	2019-06-04	Dance Biopharm Inc.	Liquid drug cartridges and associated dispenser
DE102014215064A1 (de)	2014-07-31	2016-02-04	Pari GmbH Spezialisten für effektive Inhalation	Vernebler
US10300228B2 (en)	2014-08-26	2019-05-28	Innovosciences, Llc	Thermal modulation of an inhalable medicament
US10737042B2 (en)	2014-08-26	2020-08-11	Michael Edward Breede	Thermal modulation of an inhalable medicament
US10561806B2 (en) *	2014-10-02	2020-02-18	Mannkind Corporation	Mouthpiece cover for an inhaler
EP4186548A1 (en)	2015-04-02	2023-05-31	Hill-Rom Services PTE. LTD.	Mask leakage detection for a respiratory device
AU2016332071B2 (en)	2015-10-01	2019-04-18	Elysium Therapeutics, Inc.	Polysubunit opioid prodrugs resistant to overdose and abuse
US10335406B2 (en)	2015-10-01	2019-07-02	Elysium Therapeutics, Inc.	Opioid compositions resistant to overdose and abuse
US10342778B1 (en)	2015-10-20	2019-07-09	Epicentrx, Inc.	Treatment of brain metastases using organonitro compound combination therapy
US9987270B1 (en)	2015-10-29	2018-06-05	Epicentrix, Inc.	Treatment of gliomas using organonitro compound combination therapy
EP3374011B1 (en)	2015-11-09	2023-07-19	Boehringer Ingelheim International GmbH	System comprising nebulizer and container
RU2732830C2 (ru)	2015-11-30	2020-09-23	Санофи-Авентис Дойчланд Гмбх	Упаковочный узел
KR20180090843A (ko)	2015-11-30	2018-08-13	사노피-아벤티스 도이칠란트 게엠베하	장착 부착부를 가지는 패키징 조립체
EA201891606A1 (ru)	2016-01-11	2019-02-28	Эписентарикс, Инк.	Композиции и способы для внутривенного введения 2-бром-1-(3,3-динитроазетидин-1-ил)этанона
US10455863B2 (en)	2016-03-03	2019-10-29	Altria Client Services Llc	Cartridge for electronic vaping device
US10433580B2 (en)	2016-03-03	2019-10-08	Altria Client Services Llc	Methods to add menthol, botanic materials, and/or non-botanic materials to a cartridge, and/or an electronic vaping device including the cartridge
US10368580B2 (en)	2016-03-08	2019-08-06	Altria Client Services Llc	Combined cartridge for electronic vaping device
US20170258140A1 (en) *	2016-03-11	2017-09-14	Altria Client Services Llc	Multiple dispersion generator e-vaping device
US10368581B2 (en)	2016-03-11	2019-08-06	Altria Client Services Llc	Multiple dispersion generator e-vaping device
US10357060B2 (en)	2016-03-11	2019-07-23	Altria Client Services Llc	E-vaping device cartridge holder
CN105876873B (zh) *	2016-06-30	2018-12-07	湖南中烟工业有限责任公司	一种组合式超声雾化器及其雾化方法、电子烟
WO2018031693A1 (en) *	2016-08-09	2018-02-15	Cashman Kathryn	Ampoule for inhalant device
JP7332469B2 (ja)	2016-10-14	2023-08-23	エピセントアールエックス，インコーポレイテッド	スルホキシアルキル有機窒素および関連のある化合物ならびに医学における使用のための医薬組成物
DE102017100012A1 (de) *	2017-01-02	2018-07-05	Nebu-Tec Med. Produkte Eike Kern Gmbh	Verneblereinheit mit direkt anschließbarer Ampulle
US11565034B2 (en)	2017-02-24	2023-01-31	Sanofi	Packaging assembly
DK3585458T3 (da)	2017-02-24	2021-08-30	Sanofi Sa	Emballageenhed
AU2018234911B2 (en)	2017-03-17	2024-04-18	Elysium Therapeutics, Inc.	Polysubunit opioid prodrugs resistant to overdose and abuse
WO2018227190A1 (en)	2017-06-10	2018-12-13	Eyenovia, Inc.	Methods and devices for handling a fluid and delivering the fluid to the eye
WO2019010447A1 (en)	2017-07-07	2019-01-10	Epicentrx, Inc.	COMPOSITIONS FOR PARENTERAL ADMINISTRATION OF THERAPEUTIC AGENTS
WO2019164593A2 (en)	2018-01-08	2019-08-29	Epicentrx, Inc.	Methods and compositions utilizing rrx-001 combination therapy for radioprotection
WO2019200274A1 (en)	2018-04-12	2019-10-17	MatRx Therapeutics Corporation	Compositions and methods for treating elastic fiber breakdown
WO2019229042A1 (en) *	2018-05-30	2019-12-05	Softhale Nv	Inhalation device with a pumping unit
CN112703193A (zh)	2018-08-07	2021-04-23	弗门尼舍公司	5-取代的4-氨基-1H-苯并[c][1,2,6]噻二嗪2,2-二氧化物及其制剂和用途
US11690963B2 (en)	2018-08-22	2023-07-04	Qnovia, Inc.	Electronic device for producing an aerosol for inhalation by a person
US11517685B2 (en)	2019-01-18	2022-12-06	Qnovia, Inc.	Electronic device for producing an aerosol for inhalation by a person
TWI888357B (zh) *	2018-08-22	2025-07-01	美商奎諾維亞公司	用於產生供人體吸入的氣霧的電子裝置
CA3116862A1 (en)	2018-10-18	2020-04-23	Respira Technologies, Inc.	Electronic device for producing an aerosol for inhalation by a person
US12070554B2 (en)	2019-11-11	2024-08-27	Hill-Rom Services Pte. Ltd.	Pneumatic connector apparatus and method
EP4065199B1 (en) *	2019-11-28	2024-01-03	Chiesi Farmaceutici S.p.A.	Electronic module for an inhaler and inhaler assembly comprising the electronic module
CN115038414A (zh)	2019-12-11	2022-09-09	艾诺维亚股份有限公司	用于向眼睛输送流体的系统和装置及使用方法
US12471625B2 (en)	2020-11-01	2025-11-18	Qnovia, Inc.	Electronic devices and liquids for aerosolizing and inhaling therewith
WO2023178283A1 (en)	2022-03-18	2023-09-21	Epicentrx, Inc.	Co-crystals of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone and methods
TW202404490A (zh)	2022-04-22	2024-02-01	美商奎諾維亞公司	用於霧化和吸入液體的電子設備
US20250288555A1 (en)	2022-05-02	2025-09-18	Epicentrx, Inc.	Systems and methods to improve exercise tolerance
WO2023215229A1 (en)	2022-05-02	2023-11-09	Epicentrx, Inc.	Compositions and methods for treatment of pulmonary hypertension
EP4536222A1 (en)	2022-06-13	2025-04-16	EpicentRx, Inc.	Compositions and methods for reducing adverse side effects in cancer treatment
WO2024098009A1 (en)	2022-11-04	2024-05-10	Epicentrx, Inc.	Rrx-001 for minimizing post-infarct adverse ventricular remodeling and complications
WO2024124152A1 (en)	2022-12-08	2024-06-13	Epicentrx, Inc.	Rrx-001 for the treatment of a hemoglobinopathy

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2734504A (en) *		1956-02-14		Hypodermic injection devices
BE531640A (xx) *
DE1103522B (de) *	1957-10-24	1961-03-30	Transform Roentgen Matern Veb	Abatmungseinrichtung fuer mittels Ultraschall erzeugte Aerosole
CH447637A (de) *	1964-09-18	1967-11-30	Ceskoslovenska Akademie Ved	Vorrichtung zur genauen Dosierung von Flüssigkeiten
US3392916A (en) *	1965-12-08	1968-07-16	Carl Gunnar Daniel Engstrom	Ultrasonic atomizer
US3415419A (en) *	1966-10-27	1968-12-10	Jewett	Fluid administering system
CH520530A (fr) *	1970-02-11	1972-03-31	Battelle Memorial Institute	Atomiseur portatif
US3738574A (en) *	1971-06-15	1973-06-12	Siemens Ag	Apparatus for atomizing fluids with a piezoelectrically stimulated oscillator system
US3720211A (en) *	1971-08-18	1973-03-13	G Kyrias	Automatic injection system
DE2239950C3 (de) *	1972-08-14	1979-05-23	Siemens Ag, 1000 Berlin Und 8000 Muenchen	Handgerät zur Flüssigkeitszerstäubung
US3812854A (en) *	1972-10-20	1974-05-28	A Michaels	Ultrasonic nebulizer
US3812843A (en) *	1973-03-12	1974-05-28	Lear Siegler Inc	Method and apparatus for injecting contrast media into the vascular system
US3989042A (en) *	1974-06-06	1976-11-02	Tdk Electronics Company, Limited	Oscillator-exciting system for ultrasonic liquid nebulizer
DE2445791C2 (de) *	1974-09-25	1984-04-19	Siemens AG, 1000 Berlin und 8000 München	Ultraschall-Flüssigkeitszerstäuber
US4128407A (en) *	1975-11-03	1978-12-05	James Frederick Chapel	Sterile oxygen system and replaceable filter therefore
US4094317A (en) *	1976-06-11	1978-06-13	Wasnich Richard D	Nebulization system
US4273122A (en) *	1976-11-12	1981-06-16	Whitney Douglass G	Self contained powered injection system
GB1595972A (en) *	1977-03-09	1981-08-19	Nat Res Dev	Syringe driving apparatus
US4113809A (en) *	1977-04-04	1978-09-12	Champion Spark Plug Company	Hand held ultrasonic nebulizer
US4155490A (en) *	1977-07-05	1979-05-22	Beckman Instruments, Inc.	Fluid dispenser
US4196730A (en) *	1977-08-01	1980-04-08	Wilson Dennis R	Liquid drug dispenser
US4109863A (en) *	1977-08-17	1978-08-29	The United States Of America As Represented By The United States Department Of Energy	Apparatus for ultrasonic nebulization
DE2811248C3 (de) *	1978-03-15	1981-11-26	Bosch-Siemens Hausgeräte GmbH, 7000 Stuttgart	Flüssigkeitszerstäuber
DE2849493C2 (de) *	1978-11-15	1982-01-14	Carl Heyer Gmbh, Inhalationstechnik, 5427 Bad Ems	In der Hand zu haltender Aerosolspender
DE2854841C2 (de) *	1978-12-19	1981-03-26	Bosch-Siemens Hausgeräte GmbH, 7000 Stuttgart	Flüssigkeitszerstäuber, vorzugsweise Inhalationsgerät
DE7917568U1 (de) *	1979-06-19	1979-09-20	Bosch-Siemens Hausgeraete Gmbh, 7000 Stuttgart	Inhalationsgeraet
DE2934732C2 (de) *	1979-08-28	1983-12-01	Bosch-Siemens Hausgeräte GmbH, 7000 Stuttgart	Dosiereinrichtung für Inhalate
JPS57501146A (xx) *	1980-06-06	1982-07-01
US4417889A (en) *	1980-12-31	1983-11-29	Choi Soo Bong	Device for a portable automatic syringe
NL8202262A (nl) *	1981-06-06	1983-01-03	Rowenta Werke Gmbh	Transportmiddel voor ultrasonore respirators en dergelijke.
DE3244836C2 (de) *	1982-12-03	1984-09-27	Bosch-Siemens Hausgeräte GmbH, 7000 Stuttgart	Inhaliervorrichtung mit einer Dosiereinrichtung für Inhalate
DE3468173D1 (en) *	1983-09-07	1988-02-04	Disetronic Ag	Portable infusion apparatus
DE3339180C2 (de) *	1983-10-28	1993-10-14	Pfeiffer Erich Gmbh & Co Kg	Austragvorrichtung für Medien
US4749109A (en) *	1983-11-15	1988-06-07	Kamen Dean L	Volumetric pump with replaceable reservoir assembly
DE3403957A1 (de) *	1984-02-04	1985-08-08	Ferring Biotechnik GmbH, 2300 Kiel	Vorrichtung zum abnehmen von blutproben fuer die diagnose von koerperfunktionen
DE3474412D1 (en) *	1984-04-14	1988-11-10	Ferring Biotechnik	Device for the intermittent delivery of medicaments
DE3428655A1 (de) *	1984-08-03	1986-02-13	Fresenius AG, 6380 Bad Homburg	Spritzenpumpe
EP0173334B1 (en) *	1984-08-29	1989-11-23	Omron Tateisi Electronics Co.	Ultrasonic atomizer
EP0174033B1 (en) *	1984-09-07	1991-03-27	OMRON Corporation	Oscillating construction for an ultrasonic atomizing inhaler
DE3508560A1 (de) *	1985-03-11	1986-09-11	Sigrid 8000 München Bechter	Dosiereinrichtung fuer ein inhalationsgeraet
DE3534853A1 (de) *	1985-09-30	1987-04-02	Siemens Ag	Verfahren zum betrieb eines ultraschallzerstaeubers zur fluessigkeitszerstaeubung
EP0245312B1 (de) *	1985-11-08	1990-05-02	Disetronic Ag	Injektionsgerät
DE3616713A1 (de) *	1986-05-20	1987-11-26	Siemens Ag	Ultraschall-mhz-schwinger, insbesondere zur fluessigkeitszerstaeubung
US4731058A (en) *	1986-05-22	1988-03-15	Pharmacia Deltec, Inc.	Drug delivery system
DE3625461A1 (de) *	1986-07-28	1988-02-04	Siemens Ag	Erregerkreis fuer einen ultraschall-zerstaeuber
DE3627222A1 (de) *	1986-08-11	1988-02-18	Siemens Ag	Ultraschall-taschenzerstaeubergeraet
US4976259A (en) *	1986-12-22	1990-12-11	Mountain Medical Equipment, Inc.	Ultrasonic nebulizer
EP0315656B1 (de) *	1987-05-18	1993-07-07	Disetronic Ag	Infusionsgerät
DE3724629A1 (de) *	1987-07-22	1989-02-02	Siemens Ag	Piezoelektrisch anregbares resonanzsystem
DE3833821A1 (de) *	1988-10-05	1990-04-12	Braun Melsungen Ag	Injektionsvorrichtung
DE3841442C2 (de) *	1988-12-09	1993-12-16	Barlian Reinhold	Ultraschallflüssigkeitszerstäubervorrichtung
EP0373237A1 (de) *	1988-12-13	1990-06-20	Siemens Aktiengesellschaft	Inhalationsgerät, insbesondere Taschen-Inhalationsgerät
GB8905407D0 (en)	1989-03-09	1989-04-19	Fisons Plc	Atomisation device
DK0401060T3 (da) *	1989-05-31	1993-10-25	Conceptair Anstalt	Fremgangsmåde og elektrisk, elektronisk og mekanisk indretning til fordeling, dosering eller diffusion af flydende eller gasformige aromastoffer, medikamenter og andre flydende eller viskøse produkter
GB9015077D0 (en) *	1990-07-09	1990-08-29	Riker Laboratories Inc	Inhaler
DE4034025A1 (de) *	1990-10-25	1992-04-30	Heyer Gmbh Carl	Einrichtung an inhalationsgeraeten mit einer behaelteraufnahme zum lagern eines fluessigkeitsbehaelters
NZ241034A (en) *	1990-12-17	1995-03-28	Minnesota Mining & Mfg	Inhaler device with a dosage control that deactivates an aerosol generator after predetermined time or dosage
US5360410A (en) *	1991-01-16	1994-11-01	Senetek Plc	Safety syringe for mixing two-component medicaments
AU6130394A (en) *	1991-03-05	1994-08-15	Miris Medical Corporation	Apparatus for providing a timed release of an amount of aerosol medication
DE4107479A1 (de) *	1991-03-08	1992-09-10	Dynamic Antriebstechnik Gmbh	Dosiervorrichtung fuer fluessige oder pastoese medien
US5601077A (en) *	1991-08-07	1997-02-11	Becton, Dickinson And Company	Nasal syringe sprayer with removable dose limiting structure
GB2262452B (en) *	1991-12-19	1995-12-20	Minnesota Mining & Mfg	Inhalation device
US5363842A (en) *	1991-12-20	1994-11-15	Circadian, Inc.	Intelligent inhaler providing feedback to both patient and medical professional
EP0557553A1 (de) *	1992-02-26	1993-09-01	Siemens Aktiengesellschaft	Ultraschallzerstäuber
US5269762A (en) *	1992-04-21	1993-12-14	Sterling Winthrop, Inc.	Portable hand-held power assister device
DE59208726D1 (de) *	1992-05-13	1997-08-28	Siemens Ag	Zerstäubungsgerät, insbesondere Taschen-Zerstäubungsgerät
GB2272389B (en) *	1992-11-04	1996-07-24	Bespak Plc	Dispensing apparatus
DE4310808C2 (de) *	1993-04-02	1995-06-22	Boehringer Mannheim Gmbh	System zur Dosierung von Flüssigkeiten
CH686872A5 (de) *	1993-08-09	1996-07-31	Disetronic Ag	Medizinisches Inhalationsgeraet.
DE59405227D1 (de) *	1993-12-10	1998-03-12	Siemens Ag	Ultraschallzerstäuber
GB9411624D0 (en)	1994-06-10	1994-08-03	Fisons Plc	Inhalation device
JPH0824739A (ja) *	1994-06-29	1996-01-30	Siemens Ag	超音波噴霧器
EP0814860B1 (en) *	1995-03-14	1999-11-03	Siemens Aktiengesellschaft	Ultrasonic atomizer device with removable precision dosating unit
DK0814861T3 (da) *	1995-03-14	2002-10-07	Siemens Ag	Udskiftelig præcisionsdoseringsenhed til ultralydforstøveranordning

1996
- 1996-03-14 DK DK96908034T patent/DK0814861T3/da active
- 1996-03-14 AT AT96908034T patent/ATE218381T1/de not_active IP Right Cessation
- 1996-03-14 IL IL11747496A patent/IL117474A/en active IP Right Grant
- 1996-03-14 EP EP96908034A patent/EP0814861B1/en not_active Expired - Lifetime
- 1996-03-14 CA CA002215248A patent/CA2215248A1/en not_active Abandoned
- 1996-03-14 NZ NZ304285A patent/NZ304285A/xx unknown
- 1996-03-14 US US08/913,247 patent/US5970974A/en not_active Expired - Fee Related
- 1996-03-14 PT PT96908034T patent/PT814861E/pt unknown
- 1996-03-14 DE DE69621604T patent/DE69621604T2/de not_active Expired - Fee Related
- 1996-03-14 JP JP08527281A patent/JP3142577B2/ja not_active Expired - Fee Related
- 1996-03-14 WO PCT/EP1996/001092 patent/WO1996028205A1/en not_active Ceased
- 1996-03-14 ES ES96908034T patent/ES2177771T3/es not_active Expired - Lifetime
- 1996-03-14 AU AU51436/96A patent/AU701843B2/en not_active Ceased

Also Published As

Publication number	Publication date
EP0814861B1 (en)	2002-06-05
WO1996028205A1 (en)	1996-09-19
ES2177771T3 (es)	2002-12-16
ATE218381T1 (de)	2002-06-15
JP3142577B2 (ja)	2001-03-07
DE69621604D1 (de)	2002-07-11
IL117474A0 (en)	1996-07-23
JPH10504220A (ja)	1998-04-28
PT814861E (pt)	2002-09-30
NZ304285A (en)	1998-12-23
DE69621604T2 (de)	2002-11-28
DK0814861T3 (da)	2002-10-07
AU5143696A (en)	1996-10-02
AU701843B2 (en)	1999-02-04
MX9706978A (es)	1997-11-29
CA2215248A1 (en)	1996-09-19
EP0814861A1 (en)	1998-01-07
US5970974A (en)	1999-10-26

Publication	Publication Date	Title
US5970974A (en)	1999-10-26	Dosating unit for an ultrasonic atomizer device
US5950619A (en)	1999-09-14	Ultrasonic atomizer device with removable precision dosating unit
JP6506257B2 (ja)	2019-04-24	薬物供給モジュール
AU711059B2 (en)	1999-10-07	Liquid dispensing apparatus and methods
AU2011205443B2 (en)	2015-09-24	Preservative-free single dose inhaler systems
US6085740A (en)	2000-07-11	Liquid dispensing apparatus and methods
RU2232032C2 (ru)	2004-07-10	Аэрозольный генератор и способы изготовления и использования аэрозольного генератора
JP2005533585A (ja)	2005-11-10	薬剤ディスペンサ
CN105209098B (zh)	2019-07-26	用于物质输送组件的筒
US20210330899A1 (en)	2021-10-28	Ultrasonic nebulizer
US6742721B2 (en)	2004-06-01	Shock wave aerosolization method and apparatus
US6981660B2 (en)	2006-01-03	Shock wave aerosolization apparatus and method
MXPA97006976A (es)	1998-07-03	Dispositivo atomizador ultrasonico previsto de una unidad dosificadora de precision desmontable
MXPA97006978A (es)	1998-07-03	Unidad dosificadora de precision desmontable para un dispositivo atomizador ultrasonico
HK1134057A (en)	2010-04-16	Device for discharging liquids, a cartridge suited therefor
HK1174579B (en)	2021-08-06	Preservative-free single dose inhaler systems

Legal Events

Date	Code	Title	Description
1996-10-16	HK	Corrigendum	Free format text: JOURNAL NO. 4/96, PAGE 955, APPLICATION NO. 117474 THE APPLICATION SHOULD BE CORRECTED BY THE ADDITION OF A FURTHER PRIORITY CLAIM DE 19509194.9 14.03.1995
2001-10-31	FF	Patent granted
2001-11-25	KB	Patent renewed
2006-06-18	KB	Patent renewed